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Bioinspired Tactile Sensation Based on Synergistic Microcrack-Bristle Structure Design toward High Mechanical Sensitivity and Direction-Resolving Capability

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Research 2024年第1期2023卷 611-624页

作者： yiqun zhang Qi Liu Wenjuan Ren Yangyang Song Hua Luo Yangyang Han Liang He Xiaodong Wu Zhuqing Wang School of Mechanical Engineering Sichuan UniversityChengdu 610065China Med+X Center for Manufacturing West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

Natural tactile sensation is complex,which involves not only contact force intensity detection but also the perception of the force direction,the surface texture,and other mechanical ***,the vast majority of the developed tactile sensors can only detect the normal force,but usually cannot resolve shear force or even distinguish the directions of the ***,we present a new paradigm of bioinspired tactile sensors for resolving both the intensity and the directions of mechanical stimulations via synergistic microcrack-bristle structure design and cross-shaped configuration *** microcrack sensing structure gives high mechanical sensitivity to the tactile sensors,and the synergistic bristle structure further amplifies the sensitivity of the *** cross-shaped configuration engineering of the synergistic microcrack-bristle structure further endows the tactile sensors with good capability to detect and distinguish the directions of the applied mechanical *** as-fabricated tactile sensors exhibit a high sensitivity(25.76 N^(−1)),low detection limit(5.4 mN),desirable stability(over 2,500 cycles),and good capability to resolve both mechanical intensity and directional *** promising application scenarios,surface texture recognition and biomimetic path explorations are successfully demonstrated with these tactile *** newly proposed tactile sensation strategy and technology have great potential applications in ingenious tactile sensation and construction of various robotic and bionic prostheses with high operational dexterity.

关键词： crack sensation directions

Chemical Quenching and Inhibition of Positronium in Cr_2O_3/Al_2O_3 Catalysts

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Wuhan University Journal of Natural Sciences 2011年第4期16卷 308-312页

作者： HUANG Shunhong DAI yiqun zhang Hongjun CHEN Zhiquan Hubei Nuclear Solid Physics Key Laboratory/School of Physics and Technology Wuhan University Wuhan 430072 Hubei China

The pore structure of Cr2O3/Al2O3 catalysts and the surface chemical properties of these pores were characterized by positron lifetime and coincidence Doppler broadening （CDB） measurements. Four lifetime components could be resolved from the positron lifetime spectrum, with two long lifetime components and two short lifetime components. The two long lifetimes τ4 and τ3 are attributed to ortho-positronium （o-Ps） annihilation in large pores and microvoids, respectively. With increasing Cr2O3 content, both τ4 and its intensity I4 show sharp decrease, while τ3 and its intensity I3 keep nearly unchanged. The Doppler broadening S parameters also show sharp decrease with increasing Cr2O3 content. Detailed analysis of the CDB spectrum reveals that the parapositronium （p-Ps） intensity also decreases with increasing Cr2O3 content. This indicates that the change of o-Ps lifetime τ4 is due to the chemical quenching by Cr2O3 but not spin-conversion of positronium. The decrease of o-Ps intensity I4 indicates that Cr2O3 also inhibits positronium formation.

关键词： Cr2O3/Al2O3 catalyst positronium chemical quenching pore structure

General Attribute Based RBAC Model for Web Services

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Wuhan University Journal of Natural Sciences 2008年第1期13卷 81-86页

作者： ZHU yiqun LI Jianhua zhang Quanhai Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200030 China

Growing numbers of users and many access policies that involve many different resource attributes in service-oriented environments cause various problems in protecting resource. This paper analyzes the relationships of resource attributes to user attributes based on access policies for Web services, and proposes a general attribute based role-based access control（GARBAC） model. The model introduces the notions of single attribute expression, composite attribute expression, and composition permission, defines a set of elements and relations among its elements and makes a set of rules, assigns roles to user by inputing user＇s attributes values. The model is a general access control model, can support more granularity resource information and rich access control policies, also can be used to wider application for services. The paper also describes how to use the GARBAC model in Web services environments.

关键词： attribute rule user-role assignment role-based access control (RBAC) access policy

Prescriptions from Traditional Chinese Medicine compared with salbutamol and montelukast for the treatment of pediatric asthma： a randomized controlled trial

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Journal of Traditional Chinese Medicine 2017年第4期37卷 522-529页

作者： Du Hui Wang Yonghong Yu Jian Shi Yumin Li Suhuan Sun Wen zhang yiqun Hu Hong Department of Traditional Chinese Medicine Children's Hospital of Fudan University Shanghai 201102 China

OBJECTIVE: To compare the effects of a series of Traditional Chinese Medicine(TCM) empirical prescriptions with salbutamol and montelukast(SM) in children with ***: A total of 182 children with asthma were randomized into the TCM group(n = 97) or SM group(n = 85). Patients in the TCM group were treated with a series of TCM prescriptions, whereas those in the SM group received salbutamol and montelukast; both groups received their respective treatment for 12 weeks. Asthma control, changes in scores of TCM symptom patterns, and asthma symptom control(SC) scores after treatment were compared between the two ***: A higher percentage of patients in the TCM group had asthma control compared withthose in the SM group(91.67% and 76.83%, respectively, P = 0.006). Scores for abnormal feces(P 0.05).CONCLUSION: Compared with salbutamol and montelukast, the TCM prescriptions tested were better for symptom control in children with asthma.

关键词： Asthma Albuterol Feces Hyperhidrosis Abnormal tongue presentations Syndrome differentiation Chinese medical formula Randomized controlled trial

Synthesis of a Hydrogenated Zigzag Carbon Nanobelt

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CCS Chemistry 2021年第1期3卷 613-619页

作者： Han Chen Shaojun Gui yiqun zhang Zhifeng Liu Qian Miao Department of Chemistry The Chinese University of Hong KongSha TinNew TerritoriesHong Kong

Zigzag carbon nanobelts are a long-sought-after yet unrealized target for organic ***,we report a study toward the synthesis of tetrabenzo[10]cyclacene,an undocumented zigzag carbon *** synthetic precursor of tetrabenzo[10]cyclacene is its box-shaped tetraepoxy derivative,which is synthesized through iterative Diels–Alder reactions utilizing a“C”-shaped building *** aromatization of this tetraepoxy nanobox toward the formation of a fully conjugated nanobelt results in an octahydro derivative of tetrabenzo[10]*** structures of the tetraepoxy nanobox and octahydrotetrabenzo[10]cyclacene were both unambiguously identified with single-crystal X-ray crystallography.

关键词： polycyclic arenes synthesis carbon nanobelts carbon nanotubes strains

IMPROVING ACCURACY OF CNC MACHINE TOOLS THROUGH COMPENSATION FOR THERMAL ERRORS

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Chinese Journal of Mechanical Engineering 1997年第4期10卷 71-75页

作者： Li Shuhe zhang yiqun Yang Shimin zhang Guoxiong Tianjin University

A method for improving accuracy of CNC machine tools through compensation for the thermal errors is studied. The thermal errors are obtained by 1 D ball array and characterized by an auto regressive model based on spindle rotation speed. By revising the workpiece NC machining program, the thermal errors can be compensated before machining. The experiments on a vertical machining center show that the effectiveness of compensation is good.

关键词： CNC machine tool Thermal error Compensation

GoldCLIP： Gel-omitted Ligation-dependent CLIP

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Genomics, Proteomics & Bioinformatics 2018年第2期16卷 136-143页

作者： Jiaqi Gu Ming Wang Yang Yang Ding Qiu yiqun zhang Jinbiao Ma Yu Zhou Gregory J. Hannon Yang Yu State Key Laboratory of Genetic Engineering Department of Biochemistry School of Life Sciences Fudan University Shanghai 200438 China CAS Key Laboratory of RNA Biology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Wuhan University Wuhan 430072 China Cancer Research UK Li Ka Shing Centre University of Cambridge Cambridge CB2 ORE United Kingdom

Protein-RNA interaction networks are essential to understand gene regulation control. Identifying binding sites of RNA-binding proteins （RBPs） by the UV-crosslinking and immunoprecipitation （CLIP） represents one of the most powerful methods to map protein RNA interactions in vivo. However, the traditional CLIP protocol is technically challenging, which requires radioactive labeling and suffers from material loss during PAGE-membrane transfer procedures. Here we introduce a super-efficient CLIP method （GoldCLIP） that omits all gel purification steps. This nonisotopic method allows us to perform highly reproducible CLIP experiments with polypyrimidine tract-binding protein （PTB）, a classical RBP in human cell lines. In principle, our method guarantees sequencing library constructions, providing the protein of interest can be successfully crosslinked to RNAs in living cells. GoldCLIP is readily applicable to diverse proteins to uncover their endogenous RNA targets.

关键词： RNA binding protein UV crosslinking CLIP HaloTag PTB

Merging a Negatively Curved Nanographene and a Carbon Nanoring

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Precision Chemistry 2023年第2期1卷 107-111页

作者： yiqun zhang Daiyue Yang Sai Ho Pun Han Chen Qian Miao Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong KongChina Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic ChemistryChinese Academy of ScienceShanghai 230032China Key Laboratory of Organic Functional Molecules and Drug Innovation School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 453007China

Two molecular nanocarbons result from merging a negatively curved nanographene and a carbon nanoring in two constitutional isomers of D2 and C2v symmetry,*** were synthesized by attachment o f C-shaped paraphenylene precurso rsto 2,11,18,27-tetrabromooctabenzo[8]circulene and the subsequent intramolecular Yamamoto coupling and reductive aromatization *** flexible nature of octabenzo[8]circulene enabled two different ways of connection in the Yamamoto coupling reactions,leading to the two constitutional *** D2 isomer is shaped like a figure eight,as revealed by X-ray crystallography,and is resolved into two enantiomers by chiral *** synthesis of the C2v isomer is regarded as a further step toward precision synthesis of carbon schwarzites through a bottom-up approach.

关键词： molecular nanocarbon negatively curved nanographene cycloparaphenylene synthesis carbon schwarzites

Effect of warm acupuncture on nitric oxide synthase and calcitonin gene-related peptide in a rat model of lumbar nerve root compression

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Neural Regeneration Research 2009年第6期4卷 449-454页

作者： Yaochi Wu yiqun Mi Peng zhang Junfeng zhang Wei Chen Department of Acupuncture Massage and Traumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200233 China

BACKGROUND： Varying degrees of inflammatory responses occur during lumbar nerve root compression. Studies have shown that nitric oxide synthase （NOS） and calcitonin gene-related peptide （CGRP） are involved in secondary disc inflammation. OBJECTIVE： To observe the effects of warm acupuncture on the ultrastructure of inflammatory mediators in a rat model of lumbar nerve root compression, including NOS and CGRP contents. DESIGN, TIME AND SETTING： Randomized, controlled study, with molecular biological analysis, was performed at the Experimental Center, Sixth People＇s Hospital Affiliated to Shanghai Jiao Tong University, between September 2006 and April 2007. MATERIALS： Acupuncture needles and refined Moxa grains were purchased from Shanghai Taicheng Technology Development Co., Ltd., China; Mobic tablets were purchased from Shanghai Boehringer Ingelheim Pharmaceuticals Co., Ltd., China; enzyme linked immunosorbent assay （ELISA） kits for NOS and CGRP were purchased from ADL Biotechnology, Inc., USA. METHODS： A total of 50, healthy, adult Sprague-Dawley rats, were randomly divided into five groups normal, model, warm acupuncture, acupuncture, and drug, with 10 rats in each group. Rats in the four groups, excluding the normal group, were used to establish models of lumbar nerve root compression. After 3 days, Jiaji points were set using reinforcing-reducing manipulation in the warm acupuncture group. Moxa grains were burned on each needle, with 2 grains each daily. The acupuncture group was the same as the warm acupuncture group, with the exception of non-moxibustion. Mobic suspension （3.75 mg/kg） was used in the oral drug group, once a day. Treatment of each group lasted for 14 consecutive days. Modeling and medication were not performed in the normal group. MAIN OUTCOME MEASURES： The ultrastructure of damaged nerve roots was observed with transmission electron microscopy; NOS and CGRP contents were measured using ELISA. RESULTS： The changes of the radicular ultramicrostr

关键词： warm acupuncture nerve root compression model ultrastructure nitric oxide synthase calcitonin gene-related peptide