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An aptamer-based shear horizontal surface acoustic wave biosensor with a CVD-grown single- layered graphene film for high-sensitivity detection of a label-free endotoxin

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Microsystems & Nanoengineering 2020年第1期6卷 1247-1257页

作者： Junwang Ji yiquan Pang Dongxiao Li Zheng Huang Zuwei Zhang Ning xue Yi Xu Xiaojing Mu Key Laboratory of Optoelectronic Technology&Systems Ministry of EducationInternational R&D Center of Micro-nano Systems and New Materials TechnologyChongqing University400044 ChongqingChina School of Chemistry and Chemical Engineering Chongqing University400030 ChongqingChina Department of Applied Physics Chongqing University401331 ChongqingChina Chongqing Acoustic-Optic-Electric Corporation China Electronic Technology Group Corporation400060 ChongqingChina Institute of Electronics Chinese Academy of Sciences100190 BeijingChina

The thickness of the sensitive layer has an important influence on the sensitivity of a shear horizontal surface acoustic wave(SH-SAW)biosensor with a delay-line structure and lower layer numbers of graphene produce better sensitivity for biological detection.Therefore,a label-free and highly sensitive SH-SAW biosensor with chemical vapor deposition(CVD-)-grown single-layered graphene(SLG)for endotoxin detection was developed in this study.With this methodology,SH-SAW biosensors were fabricated on a 36°Y-90°X quartz substrate with a base frequency of 246.2MHz,and an effective detection cell was fabricated using acrylic material.To increase the surface hydrophilicity,chitosan was applied to the surface of the SLG film.Additionally,the aptamer was immobilized on the surface of the SLG film by cross-linking with glutaraldehyde.Finally,the sensitivity was verified by endotoxin detection with a linear detection ranging from 0 to 100 ng/mL,and the detection limit(LOD)was as low as 3.53 ng/mL.In addition,the stability of this type of SH-SAW biosensor from the air phase to the liquid phase proved to be excellent and the specificity was tested and verified by detecting the endotoxin obtained from Escherichia coli(E.coli),the endotoxin obtained from Pseudomonas aeruginosa(P.aeruginosa),and aflatoxin.Therefore,this type of SH-SAW biosensor with a CVD-grown SLG film may offer a promising approach to endotoxin detection,and it may have great potential in clinical applications.

关键词： film surface layered

曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文长链非编码RNA lnc—DC通过STAT3调控人DC的分化和功能

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中国肿瘤生物治疗杂志 2016年第5期23卷 I0001-I0002页

作者： Pin Wang Yiquan Xue Yanmei Han Li Lin Cong Wu Sheng Xu Zhengping Jiang Junfang Xu Qiuyan Liu xuetao Cao Institute of Immunology Zhejiang University School of Medicine Hangzhou 310058 China.

树突状细胞（DC）是免疫系统中重要的抗原提呈细胞，其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物丛因组能够转录产生大量的长链非编码RNA（10ngnoncodingRNA，IncRNA），其在免疫系统中的功能还知之甚少。

关键词：非编码RNA 学术论文 STAT3 科研团队长链曹雪涛 DC 国际

内部控制、外部环境与企业社会责任——基于模糊集定性比较分析(fsQCA)

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石家庄铁道大学学报（社会科学版） 2022年第2期16卷 19-25,78页

作者：安奕全薛亚军侯丹阳太原理工大学经济管理学院山西太原030000

企业社会责任是涉及经济发展微观载体与社会进步的全球性热点问题。收集2018年中国A股上市公司履行社会责任的数据,采用模糊集定性比较分析方法,对企业积极履行社会责任的影响机制进行整合性分析。研究表明,影响企业积极履行社会责任的... 详细信息

企业社会责任是涉及经济发展微观载体与社会进步的全球性热点问题。收集2018年中国A股上市公司履行社会责任的数据,采用模糊集定性比较分析方法,对企业积极履行社会责任的影响机制进行整合性分析。研究表明,影响企业积极履行社会责任的主要驱动模式可细分为市场和内部主导、法律和内部主导、三方保障主导共3种前因构型,企业高质量内部控制在3种驱动模式下均作为核心影响因素存在。根据实证结果,分别从企业运营、国家法律以及地区市场3个层面提出促进企业社会责任承担意愿的针对性建议。

关键词：企业社会责任制度环境内部控制模糊集定性比较分析

Novel transparent MgGa_(2)O_(4) and Ni^(2+)-doped MgGa_(2)O_(4) ceramics

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Journal of Advanced Ceramics 2022年第3期11卷 470-481页

作者： Guangran ZHANG Adrian GOLDSTEIN yiquan WU Kazuo Inamori School of Engineering New York State College of CeramicsAlfred UniversityAlfredNew York 14802USA Israel Ceramic and Silicate Institute HaifaIsrael

In this study we fabricated, for the first time, magnesium gallate (MgGa_(2)O_(4), a partially inverted spinel) transparent ceramics, both undoped and doped with 1 at% Ni. The specimens were derived from in-house prepared powder, with a crystallite size of ∼10 nm (by wet chemistry) and densified by pulsed electric current sintering (PECS;peak temperature 950 ℃ for 90 min). Densification levels of 99.84% and 99.52% of theoretical density were attained for doped and undoped materials, respectively. Doping with Ni was seen to marginally improve the densification level. Quite transparent specimens were produced: the best showing transmission of ∼89% of the theoretical level (thickness t = 0.85 mm). The absorption spectra revealed that the dopant was accumulated as Ni^(2+) in the octahedral sites of the lattice, as occurs in single-crystal specimens. After excitation at 980 nm, the doped disks exhibited a wide fluorescence band centered at 1264 nm.

关键词： magnesium gallate(MgGa_(2)O_(4)) spinel transparent ceramics pulsed electric current sintering(PECS)

Solid-state single-crystal growth of YAG and Nd: YAG by spark plasma sintering

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Journal of Materials Science & Technology 2022年第11期106卷 118-127页

作者： Iva Milisavljevic Guangran Zhang yiquan Wu Kazuo Inamori School of Engineering New York State College of CeramicsAlfred UniversityAlfredNY 14802USA

Recent studies have shown that many challenges encountered in conventional single crystal growth methods, including high production costs, can be overcome by using the solid-state single-crystal growth(SSCG) approach, which has been recognized as a simple and cost-effective alternative for obtaining single crystals. In this work, YAlO(YAG) and Nd-doped YAG(Nd:YAG) single crystals were grown via the SSCG method using spark plasma sintering(SPS). The growth of single crystals was initiated at the surface of(110) YAG single-crystal seeds embedded inside YAG and Nd:YAG powder beds, and this growth continued as the surrounding polycrystalline matrix was converted into a single crystal. The application of external pressure during the SPS process has been found beneficial for reducing the porosity of the grown single crystals. Moreover, high Nddoping levels had a positive effect on the conversion kinetics,with a growth rate of almost 50 μm/h, which increased the driving force for single-crystal growth through the solute drag effect. EDS elemental mapping and line scans confirmed the compositional uniformity of the grown single crystals, while EBSD images verified their crystallization in the(110) direction. The obtained results confirm the strong potential of the SSCG technique coupled with SPS for the growth of undoped and highly doped YAG single crystals with excellent quality.

关键词： Single-crystal growth Solid-state growth Spark plasma sintering YAG

立德树人视域下中医学八年制医学免疫学课程思政元素的挖掘及应用探索

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中国免疫学杂志 2023年第6期39卷 1134-1138页

作者：钱程薛逸荃郭猛刘娟郭振红(指导) 海军军医大学基础医学院免疫学教研室暨免疫与炎症全国重点实验室上海200433

在新的时代背景下,以“立德树人”为目标的课程思政作为一种新的教育理念已经成为加强高校人才培养和思想政治教育的重要手段。八年制医学教育在培养拔尖创新医学人才方面,承担着重要的历史使命和责任,也对其思政教学提出了更高、更新... 详细信息

在新的时代背景下,以“立德树人”为目标的课程思政作为一种新的教育理念已经成为加强高校人才培养和思想政治教育的重要手段。八年制医学教育在培养拔尖创新医学人才方面,承担着重要的历史使命和责任,也对其思政教学提出了更高、更新的要求。医学免疫学作为中医学专业的一门重要专业基础课,教学内容中蕴含丰富的课程思政元素。而中医学根植于中国古代文化土壤之中,具有浓厚的文化底蕴和丰富的德育资源。在中医八年制医学免疫学课程中深入挖掘具有中医药优秀文化特色的思政元素,找准理论知识与思政元素的“连接点”,巧妙融入思想政治教育,从多角度探索实施免疫学课程思政的有效路径。通过调查问卷形式评价课程思政教学效果并进行分析,为今后进一步优化做准备,以期为国家培养厚德精术、启古纳今的复合型卓越中医学人才奠定坚实基础。

关键词：医学免疫学课程思政中医八年制教学评价

A newly defined dioxygenase system from Mycobacterium vanbaalenii PYR-1 endowed with an enhanced activity of dihydroxylation of high-molecular-weight polyaromatic hydrocarbons

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 163-173页

作者： yiquan Wu Ying Xu Ningyi Zhou State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Joint International Research Laboratory of Metabolic&Developmental Sciences Shanghai Jiao Tong UniversityShanghai 200240China

NidA3B3 is a terminal dioxygenase whose favorable substrates are high-molecular-weight polyaromatic hydrocarbons(PAHs)from Mycobacterium vanbaalenii PYR-1,a powerftil PAHs degradation strain.NidA3B3 was reported to incorporate a dioxygen into the benzene ring of PAHs when equipped with an exogenous electron transport chain components PhdCD from Nocarciioides sp.strain KP7 by biotransformation,but this enzyme system was not particularly efficient.In this study,strain PYR-1 was confirmed to utilize four different PAHs at different growth rates.When PhtAcAd,an endogenous electron transport chain of a phthalate dioxygenase system,was substituted for PhdCD to couple with NidA3B3,the specific activity to convert phenanthrene by strain BL21(DE3)[pNidA3B3-PhAcAd]was 0.15±0.03 U/mg,but the specific activity of strain BL21(DE3)[pNidA3B3-PhdCD]was only 0.025±0.006U/mg.In addition,FNidA3,encoded by a newly defined ORF,has a prolonged 19-amino acid sequence at the N-terminus compared with NidA3.FNidA3B3 increased the activity by 50%approximately than NidA3B3 when using PhtAcAd.Components of the electron transport chain PhtAc and PhtAd were purified and characterized.The Km,kcal,kcat/Km values of the PhtAd were 123±26.9 pM,503±49.9 min^-1,4.1μM^-1·min^-1,respectively.And the,Km,Kcat,Kcat/Km values of the ferredoxin PhtAc were (52.5±9.7)μM,3.8±0.19min^-1 and 0.07μM^-1 min1,respectively.Basing on the phylogenetic analysis,NidA3/FNidA3 were far from its isoenzyme NidA from the same strain.Combining their primary differences of transcriptional pattern in vivo,it indicated that the functionally similar Rieske dioxygenases NidA3B3/FNidA3B3 and NidAB might originate from different ancestors.

关键词： Biodegradation Polyaromatic hydrocarbons Biotransformation Ring-hydroxylating dioxygenase system

煤炭企业高管权力对企业社会责任的影响研究——基于股权集中度和市场化进程的调节作用

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煤炭经济研究 2021年第9期41卷 70-76页

作者：安奕全薛亚军史亚栋太原理工大学经济管理学院山西太原030024

选取2011—2018年中国沪深A股煤炭行业上市公司数据作为研究样本,结合管家理论并基于股权集中度和市场化进程作为调节变量,运用面板回归模型实证研究高管权力对煤炭企业社会责任的影响。研究结果表明:高管权力与企业社会责任呈正向相关... 详细信息

选取2011—2018年中国沪深A股煤炭行业上市公司数据作为研究样本,结合管家理论并基于股权集中度和市场化进程作为调节变量,运用面板回归模型实证研究高管权力对煤炭企业社会责任的影响。研究结果表明:高管权力与企业社会责任呈正向相关关系,股权集中度与市场化进程对于高管权力与企业社会责任之间的关系均具有正向调节作用。通过进一步研究发现,相较于国有企业,在非国有企业中高管权力对企业社会责任的正向作用更为显著。

关键词：企业社会责任高管权力股权集中度市场化进程煤炭企业

考虑环境外部性和风光出力不确定性的虚拟电厂运行优化

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电力系统自动化 2022年第8期46卷 50-59页

作者：孙晶琪王愿郭晓慧周奕全王玉玮薛万磊华北电力大学经济与管理学院北京市102206 华北电力大学经济管理系河北省保定市071003 国网山东省电力公司经济技术研究院山东省济南市250022

虚拟电厂在建设运行中产生的环境外部性影响其运行的经济效益与环境效益。首先,单独核算煤电、风电和光伏发电的单位环境外部性成本,并将其计入虚拟电厂的单位发电量成本。在此基础上,考虑风光出力的不确定性,构建基于Wasserstein距离... 详细信息

虚拟电厂在建设运行中产生的环境外部性影响其运行的经济效益与环境效益。首先,单独核算煤电、风电和光伏发电的单位环境外部性成本,并将其计入虚拟电厂的单位发电量成本。在此基础上,考虑风光出力的不确定性,构建基于Wasserstein距离的风光出力预测误差模糊集的两阶段分布鲁棒优化模型,使虚拟电厂在风光出力预测误差满足模糊集内最坏分布的情况下调整柔性资源,实现运行成本最小,以此研究虚拟电厂的调度决策问题。最后,算例仿真与对比分析验证了考虑环境外部性对虚拟电厂经济、低碳运行的积极作用,以及构建的两阶段分布鲁棒优化模型的适用性与计算简便性。

关键词：虚拟电厂环境外部性不确定性分布鲁棒优化 Wasserstein距离