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Plant Communications 2024年第9期5卷 152-167页

作者： yiqiu zhang Zebin Ke Letian Xu Yang Yang Ling Chang Jiang zhang State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei Hongshan LaboratorySchool of Life SciencesHubei UniversityWuhan 430062China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China

The expression of double-stranded RNAs(dsRNAs)from the plastid genome has been proven to be an effective method for controlling herbivorous pests by targeting essential insect ***,there are limitations to the efficiency of plastid-mediated RNA interference(PM-RNAi)due to the initial damage caused by the insects and their slow response to RNA *** this study,we developed transplastomic poplar plants that express dsRNAs targeting the b-Actin(dsACT)and Srp54k(dsSRP54K)genes of Plagiodera *** experiments showed that transplastomic poplar plants can cause significantly higher mortality in *** larvae compared with nuclear transgenic or wild-type poplar *** efficient killing effect of PM-RNAi on *** larvae was found to be dependent on the presence of gut ***,foliar application of a gut bacterial strain,Pseudomonas putida,will induce dysbiosis in the gut bacteria of *** larvae,leading to a significant acceleration in the speed of killing by ***,our findings suggest that interfering with gut bacteria could be a promising strategy to enhance the effectiveness of PM-RNAi for insect pest control,offering a novel and effective approach for crop protection based on RNAi technology.

关键词： poplar RNA interference gut bacteria plastid transformation Plagiodera versicolora

光生物调节在创伤修复和医学美容中的临床应用

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中华烧伤与创面修复杂志 2024年第4期40卷 307-313页

作者：姚敏张逸秋上海交通大学医学院附属第九人民医院整复外科上海200011

近年来,随着对光生物调节作用分子生物学机制研究的深入,光生物调节已被逐步应用于临床,为各类疾病提供了有效的治疗手段和方法。相较于传统的光热治疗,光生物调节具有疗效好、几乎无不良反应、操作简便等特点,且临床疗效日益显著。该... 详细信息

近年来,随着对光生物调节作用分子生物学机制研究的深入,光生物调节已被逐步应用于临床,为各类疾病提供了有效的治疗手段和方法。相较于传统的光热治疗,光生物调节具有疗效好、几乎无不良反应、操作简便等特点,且临床疗效日益显著。该文就光生物调节的机制及其在创伤修复、医学美容等领域中的应用特点及发展趋势进行详细阐述,以期为该疗法在临床中的广泛应用提供理论基础。

关键词：光疗法激光美容技术创伤修复

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光学遥感高精度时标设计实现与定位精度分析

光学学报 2024年第18期44卷 386-396页

作者：郑君张孝弘褚备张弈秋郑永超北京空间机电研究所先进光学遥感技术北京市重点实验室北京市航空智能遥感装备工程技术研究中心

为实现高精度时标要求，光学遥感相机基于卫星高精度秒脉冲信号，结合对应的卫星整秒时刻数据，采用高精度本地时钟和计数同源设计以及图像辅助数据嵌入方案，能够计算出每行遥感图像对应的成像时刻。从相机成像时刻标定的设计原理出发... 详细信息

为实现高精度时标要求，光学遥感相机基于卫星高精度秒脉冲信号，结合对应的卫星整秒时刻数据，采用高精度本地时钟和计数同源设计以及图像辅助数据嵌入方案，能够计算出每行遥感图像对应的成像时刻。从相机成像时刻标定的设计原理出发，分析得出相机成像时刻标定的设计误差为±3 2μs，并且提出了相机时标精度的验证方法。依据本系统设计，时标精度测试误差为±2μs。通过实例验证了光学遥感相机时标设计的高精度实现。根据时间延迟积分推扫成像原理及实例分析，在遥感卫星时间同步系统精度层面，证明了光学遥感相机时标设计能够保证在轨影像几何定位的精度。

关键词：光学遥感几何定位时标精度秒脉冲

2018-2022年广州市荔湾区茶滘街学校及托幼机构传染病预警特征分析

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中国社区医师 2024年第23期40卷 137-139页

作者：林明道张益秋广州市荔湾区茶滘街道社区卫生服务中心广东广州510000

目的:了解广州市荔湾区茶滘街2018—2022年学校及托幼机构传染病预警情况,为更有效地预防控制学校传染病疫情提供科学依据。方法:收集来源于广州市学生健康监测系统及荔湾区茶滘街道社区卫生服务中心传染病预警处置相关资料,时间跨度为2... 详细信息

目的:了解广州市荔湾区茶滘街2018—2022年学校及托幼机构传染病预警情况,为更有效地预防控制学校传染病疫情提供科学依据。方法:收集来源于广州市学生健康监测系统及荔湾区茶滘街道社区卫生服务中心传染病预警处置相关资料,时间跨度为2018—2022年,采用回顾性研究进行流行病学分析,剔除资料不完整或缺失的资料。结果:广州市荔湾区茶滘街2018—2022年学校及托幼机构共报告传染病预警157起,涉及病例640例,平均罹患率1.23%;其中中小学传染病罹患率为1.42%,高于托幼机构的0.72%,差异有统计学意义(P<0.05);上报传染病预警以丙类为多(101起,占64.33%),主要是流行性感冒(86起,占54.78%);中小学校以流行性感冒为主(78起,占59.09%),托幼机构亦以流行性感冒为主(8起,占32.00%);3—6月为上半年传染病预警高峰期,11、12月为下半年高峰期。结论:中小学校及托幼机构是传染病预警的高发场所,根据各类传染病疫情的流行特征采取针对性的防控措施是有效预防控制传染病疫情的关键。

关键词：学校传染病预警流行特征

Dilon 6800多晶体伽马相机质量控制方案研究与实践

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中国医疗设备 2024年第3期39卷 63-67,79页

作者：宋骏逸何依波陈曙光张一秋复旦大学附属中山医院核医学科上海200032 复旦大学附属中山医院厦门医院核医学科福建厦门361015

目的对Dilon 6800多晶体伽马相机进行系统均匀性测试,分析数据并探讨质控方案,提高图像质量,确保设备正常运行。方法根据用户手册、美国国家电气制造商协会标准、美国医学物理学家学会报告、美国核医学会指南和生产厂商建议,测试并收... 详细信息

目的对Dilon 6800多晶体伽马相机进行系统均匀性测试,分析数据并探讨质控方案,提高图像质量,确保设备正常运行。方法根据用户手册、美国国家电气制造商协会标准、美国医学物理学家学会报告、美国核医学会指南和生产厂商建议,测试并收集2016—2021年的每月系统均匀性数据,若其有效视野积分均匀性数值≥9.50%则加以校正。分析数据并根据每月平均湿度将其分为高低湿度组,比较2组有效视野均匀性均值的差异。结果 2016—2021年每月的有效视野积分均匀性的校正后最终值保持在10.00%以下,在可接受范围内。校正后均匀性显著优于校正前。高湿度组的有效视野均匀性原始值显著高于低湿度组。结论通过总结Dilon 6800多晶体伽马相机的质控方案,并采用系统均匀性测试,评估得出观察有效视野积分均匀性比微分均匀性更有效。及时校正可恢复并保持设备的均匀性指标,且湿度与机器均匀性性能有关,因此应关注高湿度对设备的影响。

关键词：多晶体伽马相机质量控制系统均匀性

Development and Deformation Characteristics of Large Ancient Landslides in the Intensely Hazardous Xiongba-Sela Section of the Jinsha River, Eastern Tibetan Plateau, China

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Journal of Earth Science 2024年第3期35卷 980-997页

作者： yiqiu Yan Changbao Guo Yanan zhang Zhendong Qiu Caihong Li Xue Li Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China

The upstream Jinsha River,located in the eastern Tibetan Plateau,has been experiencing intense geological hazards characterized by a high density of ancient landslides,significant deformation and reactivation *** this study,remote sensing interpretation,field investigations,and Small Baseline Subset Interferometric Synthetic Aperture Radar(SBAS-InSAR)technologies have been *** a 17 km stretch of the Jinsha River,specifically in the Xiongba-Sela segment,16 large-scale ancient landslides were identified,9 of which are currently undergoing creeping ***,the Sela and Xiongba ancient landslides exhibit significant deformation,with a maximum deformation rate of-192 mm/yr,indicating a high level of sliding *** volume of the Sela ancient landslide is estimated to be 1.8×108 to 4.5×108 m3,and characterized by extensive fissures and long-term creeping *** SBAS-InSAR results revealed significant spatial variations in the deformation of the Sela ancient landslide,generally displaying two secondary zones of intense deformation,and landslide deformation exhibits nonlinear behavior with *** January 2016 and February 2022,Zone III1 on the southwest side of the Sela ancient landslide,experienced a maximum cumulative deformation of-857 mm,with a maximum deformation rate of-108 mm/*** III2,on the northeast side of the Sela ancient landslide,the maximum cumulative deformation was-456 mm,with a maximum deformation rate of-74 mm/yr;among these,the H2 and H4 secondary bodies on the south side of III1 are in the accelerative deformation stage and at the Warn warning *** propose that the large-scale flood and debris flow disasters triggered by the Baige landslide-dammed lake-dam broken disaster chain in Tibetan Plateau during October and November 2018 caused severe erosion at the foot of downstream *** far-field triggering effect accelerated the creep of the downstream ancient ***,the defo

关键词： Jinsha River SBAS-InSAR landslides surface deformation disasters.

Graphene as adsorbent for highly efficient extraction of modified nucleosides in urine prior to liquid chromatography-tandem mass spectrometry analysis

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Chinese Chemical Letters 2024年第4期35卷 490-495页

作者： Cheng Guo Xiaoxiao zhang Xiujuan Hong yiqiu Hu Lingna Mao Kezhi Jiang Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory of Organosilicon Chemistry and Material Technology College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Department of General Practice The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 17 modified nucleosides in human urine. We found graphene could effectively adsorb various modified nucleosides in human urine samples. With this method, we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy *** revealed that the levels of 12 modified nucleosides were all diminished in urine from lung cancer patients, compared with healthy controls. It is worth noting that we demonstrated, for the first time, the presence of 5,2-O-dimethyluridine(m~5U_m) in human urine. Together, we established a robust analytical method for simultaneous determinations of 17 modified nucleosides in human urine, and our results revealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer, implying the potential applications of these modified nucleosides as noninvasive biomarkers for the early detection of lung cancer. Moreover, this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.

关键词： Mass spectrometry RNA modification Modified nucleosides Graphene Biomarker Urine

Effect of coir geotextile and geocell on ephemeral gully erosion in the Mollisol region of Northeast China

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Journal of Arid Land 2024年第4期16卷 518-530页

作者： QIN Xijin SUN yiqiu zhang Yan GUAN Yinghui WU Hailong WANG Xinyu WANG Guangyu School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China Tianjin Eco-Environmental Protection Design&Research Institute Tianjin 300042China College of Environmental Science and Safety Engineering Tianjin University of TechnologyTianjin 300384China Faculty of Forestry University of British Columbia2424 Main MallVancouver BC V6T 1Z4Canada

The unique geomorphological features and farming methods in the Mollisol region of Northeast China increase water catchment flow and aggravate the erosion of ephemeral gully(EG).Vegetation suffers from rain erosion and damage during the growth stage,which brings serious problems to the restoration of grass in the early ***,effects of coir geotextile and geocell on EG erosion under four confluence intensities were researched in this *** of the simulated water discharge erosion test showed that when the confluence strength was less than 30 L/min,geocell and coir geotextile had a good effect on controlling EG erosion,and sediment yield of geocell and coir geotextile was reduced by 25.95%–37.82%and 73.73%–88.96%,***,when confluence intensity increased to 40 L/min,protective effect of coir geotextile decreased,and sediment yield rate increased sharply by 189.03%.When confluence intensity increased to 50 L/min,the protective effect of coir geotextile was *** the other hand,geocell showed that the greater the flow rate,the better the protective *** addition,with the increase in confluence intensity,erosion pattern of coir geotextile developed from sheet erosion to intermittent fall and then to completion of main rill,and the protective effect was gradually *** contrast,the protective effect of EG under geocell was gradually enhanced from the continuous rill to the intermittent rill and finally to the intermittent *** study shows that coir geotextile and geocell can prevent EG erosion,and the effect of geocell is better than that of coir geotextile on the surface of EG.

关键词： geocell coir geotextile ephemeral gully confluence intensity erosion control

Combined Treatment with Electrocauterization,Carbon Dioxide Laser,and Microneedle Fractional Radiofrequency for Facial Angiofibromas in Tuberous Sclerosis Complex:A Case Report and Literature Review

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第1期3卷 41-45页

作者： Jiying DONG Shen WANG Min YAN Jing MI Ying ZENG Huyan LIN yiqiu zhang Min YAO Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Tuberous sclerosis complex is a type of genetic multisystem disease that causes hamartomas in various *** angiofibromas commonly occur in 80%of patients and are prominently distributed over the cheek,chin,and nasolabial folds with severe disfigurement and emotional ***,photoelectric devices have been identified for the treatment of angiofibromas with great efficacy and fewer side *** report a case of a 42-year-old man with facial angiofibromas,who was treated with a combination of high-frequency electrocauterization,Ultrapulse CO_(2) laser,and microneedle fractional radiofrequency with 7 sessions and a 6-month *** patient showed great improvement in relation to the elevated lesions and nodules.A low recurrence rate was *** is the first study to investigate the efficacy of high-frequency electrocauterization and microneedle fractional radiofrequency in *** may provide an optimal approach for clinicians wherein a combined treatment of various lasers and electric devices is effective for complicated,protuberant,and firm angiofibromas of specific patients.

关键词： Electrocauterization CO_(2)laser Radiofrequency Angiofibromas Tuberous sclerosis

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河流砾-砂过渡(GST)研究进展

沉积学报 2022年第4期40卷 883-893页

作者：张艺秋胡修棉南京大学地球科学与工程学院南京210023

河流从上游山区流经下游宽阔地带时,所搬运物质在磨损和分选作用下逐步变细,当沉积物减小到中粗卵砾级别时(10~20 mm),会在相对短距离内(几倍河道宽度)快速转变为极粗砂(1~2 mm),这种粒度突变现象被称为砾—砂过渡(gravelsand transitio... 详细信息

河流从上游山区流经下游宽阔地带时,所搬运物质在磨损和分选作用下逐步变细,当沉积物减小到中粗卵砾级别时(10~20 mm),会在相对短距离内(几倍河道宽度)快速转变为极粗砂(1~2 mm),这种粒度突变现象被称为砾—砂过渡(gravelsand transition,GST)。对河流砾—砂过渡进行了系统调研,介绍了其在河流中的基本特征;分析了砾—砂过渡的发生机理,包括粒度突变的外因假说、2~10 mm粒径空缺的内因解释,以及GST中加剧砾砂流动性差异的过程;也介绍了GST的空间普适性、其前后的河流转变和位置稳定性。GST的深入研究对于理解河流演化、泥沙运移、洪水风险管理、沉积物源分析具有重要意义。

关键词：砾—砂过渡河流沉积粒度沉积学地貌学