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Chinese Journal of Chemical Engineering 2020年第6期28卷 1628-1636页

作者： Xinxin Dong Baosheng Jin Zhiwei Kong yiqing sun Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy&EnvironmentSoutheast UniversityNanjing 210096China

The cheap manganese sand was first modified by H2O2 and was further creatively utilized as Ni-based catalyst *** order to enhance the catalytic performance,Re was added into the Ni-based catalyst and the promotion effect of Re on the methanation coupling with water gas shift of biogas was investigated from the perspective of activation *** was found that CH4 and CO2 formation rates,which separately represented the reaction rate of methanation and water gas shift,were both enhanced after Re addition compared to non-added *** kinetics models including empirical model and K-model were employed and from the results of calculation,it showed that Re selectively decreased the activation energy of methanation reaction and had little impact on the activation energy of water gas *** increased CO2 formation rate was owing to the assistance of accelerated H2O production from methanation rather than the activation energy change in water gas shift.

关键词： Promoter Catalyst Nickel Methanation Water gas shift Kinetics

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土体抗拉强度试验研究方法的综述

地下空间与工程学报 2024年第4期20卷 1124-1144页

作者：孙一清沈振中徐力群张宏伟甘磊东南大学交通学院南京211189 南京现代综合交通实验室南京211100 河海大学水利水电学院南京210024

土体抗拉强度比抗压和抗剪强度数值更小,因此时常被忽略,造成理论及试验的落后。文中系统归纳了土体抗拉强度的间接和直接方法,对比分析了现有试验方法的优缺点,结果表明:(1)土体抗拉强度的单轴拉伸方法按照力的加载方向可以分为垂直法... 详细信息

土体抗拉强度比抗压和抗剪强度数值更小,因此时常被忽略,造成理论及试验的落后。文中系统归纳了土体抗拉强度的间接和直接方法,对比分析了现有试验方法的优缺点,结果表明:(1)土体抗拉强度的单轴拉伸方法按照力的加载方向可以分为垂直法和水平法,而垂直法中土样破坏前上半部分的重量会影响试验的准确性;(2)常用的土样固定方式有粘结、锚固、摩擦力和夹持,它们各有优势,但夹持较前三者更便捷和可操作。最后,提出水平单轴拉伸试验的后续仍需优化的问题。如制样脱模中土样的损耗、土样受拉段应力分布差,无法适用于大骨料砾质土、土样固定方式繁琐、土样与平台间的摩擦力难以消除等。

关键词：抗拉强度间接法直接法三轴拉伸试验单轴拉伸试验

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急性敌草快中毒大鼠肠道损伤机制的研究

中华危重病急救医学 2024年第3期36卷 293-297页

作者：张建爽孙艺青高恒波苑霖姚冬奇刘亮吕宝谱田英平河北医科大学第二医院急诊科石家庄050000

目的探讨敌草快(DQ)对大鼠肠道焦亡相关蛋白及紧密连接蛋白表达的影响,分析细胞焦亡在急性DQ中毒大鼠肠道损伤中的作用。方法将36只Wistar雄性大鼠随机分为对照组及染毒3 h、12 h、36 h、3 d组,每组6只。各染毒组均给予1/2半数致死量(LD... 详细信息

目的探讨敌草快(DQ)对大鼠肠道焦亡相关蛋白及紧密连接蛋白表达的影响,分析细胞焦亡在急性DQ中毒大鼠肠道损伤中的作用。方法将36只Wistar雄性大鼠随机分为对照组及染毒3 h、12 h、36 h、3 d组,每组6只。各染毒组均给予1/2半数致死量(LD50)115.5 mg/kg DQ一次性灌胃;对照组给予等量生理盐水灌胃。对照组于DQ灌胃后3 h麻醉取空肠组织;各染毒组分别于DQ灌胃后3 h、12 h、36 h、3 d麻醉取空肠组织。记录大鼠的一般情况;采用苏木素-伊红(HE)染色观察各组大鼠空肠组织病理学改变;采用免疫组织化学染色观察空肠组织焦亡相关蛋白〔NOD样受体蛋白3(NLRP3)、天冬氨酸特异性半胱氨酸蛋白酶1(caspase-1)、Gasdemin D(GSDMD)〕的表达;采用蛋白质免疫印迹试验(Western blotting)检测空肠组织焦亡相关蛋白和紧密连接蛋白〔闭合蛋白(Occludin)、封闭蛋白-1(Claudin-1)〕的表达。结果光镜下显示,大鼠空肠组织在染毒早期(3 h)即出现病理学改变,染毒12 h组损伤最重,可见大量炎症细胞浸润,染毒3 d组损伤明显减轻。免疫组织化学染色结果显示,NLRP3、caspase-1和GSDMD在对照组和各染毒组大鼠空肠黏膜组织中均有表达,其中对照组阳性细胞表达较少,着色浅;各染毒组大鼠上述蛋白表达均明显增加,着色深。Western blotting结果显示,各染毒组大鼠空肠组织NLRP3蛋白表达均较对照组升高,以染毒36 h组升高最显著(NLRP3/β-actin:1.47±0.06比0.43±0.14,P0.05)。与对照组比较,各染毒组Occludin、Claudin-1蛋白表达均降低,其中染毒3 h、12 h、36 h组Occludin蛋白表达明显降低(Occludin/β-actin:0.74±0.17、0.91±0.20、0.79±0.23比1.41±0.08,均P<0.05),各染毒组Claudin-1蛋白表达虽有下降,但差异均无统计学意义。结论急性DQ中毒大鼠肠道损伤可能与激活小肠细胞焦亡途径、细胞间连接致密性降低有关。

关键词：敌草快肠道焦亡相关蛋白紧密连接蛋白

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移动光照下液晶弹性体固支梁的动态响应分析

安徽建筑大学学报 2024年第4期32卷 44-51页

作者：赵俊孙奕清曹绍林唐伟军安徽建筑大学土木工程学院安徽合肥230601 广州市盛通建设工程质量检测有限公司广东广州510075

液晶弹性体(LCE)梁在移动光照作用下会产生弯曲动态响应,为此建立LCE固支梁在移动光照下的动态模型,并推导出动态响应的控制方程。在此基础上,通过模态叠加法和Duhamel积分法获得LCE固支梁在移动光照下动态响应的解析解,并利用Matlab软... 详细信息

液晶弹性体(LCE)梁在移动光照作用下会产生弯曲动态响应,为此建立LCE固支梁在移动光照下的动态模型,并推导出动态响应的控制方程。在此基础上,通过模态叠加法和Duhamel积分法获得LCE固支梁在移动光照下动态响应的解析解,并利用Matlab软件对模型进行编程进而分析物理参数对LCE固支梁动态响应的影响。结果表明:当移动光照的速度达到一阶临界速度时,固支梁跨中动态响应的振幅最大。此外,通过改变光照强度、LCE的材料收缩系数和阻尼系数等参数,可以有效调控动态响应。研究成果在软机器人、智能控制和能量转换等领域具有应用价值。

关键词：液晶弹性体移动光照动态响应模态叠加法杜哈梅尔积分

QuEChERS净化结合超高效液相色谱串联质谱法快速测定动物源性食品中溴虫氟苯双酰胺残留

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食品与发酵工业 2024年第17期50卷 336-342页

作者：朱礼邓航袁列江吴海智陈瑶薛敏敏王秀张可欣李格孙逸清冉丹湖南省产商品质量检验研究院湖南长沙410007 岳阳市检验检测中心湖南岳阳410042 长沙市食品药品检验所湖南长沙410007

该研究建立了一种QuEChERS净化结合超高效液相色谱串联质谱法(ultra performance liquid chromatography tandem mass spectrometry,UPLC-MS/MS)快速测定动物源性食品中溴虫氟苯双酰胺残留量的分析方法。样品使用QuEChERS吸附净化,经含0.1%(体积分数)甲酸的乙腈提取,MgSO_(4)、C18及N-丙基乙二胺净化,净化液离心后过膜上机测定。UPLC-MS/MS法以乙腈和5 mmol/L乙酸铵(含体积分数0.1%甲酸)水溶液为流动相,以0.300 mL/min的流速进行梯度洗脱,使用ACQUITY UPLC BEH C18色谱柱进行分离,电喷雾离子源正离子模式电离,多反应监测模式检测,基质匹配标准曲线外标法定量。结果表明:溴虫氟苯双酰胺在0.200~100μg/L范围内呈良好线性,相关系数(R^(2))均大于0.999,方法的定量限为0.5~1.0μg/kg;以动物源性食品为基质,在低中高(2.0、10.0和50.0μg/kg)添加水平下,溴虫氟苯双酰胺的平均加标回收率为93.9%~102%,相对标准偏差为2.25%~5.86%。该方法便于操作,实验过程短,检测准确性高,可以填补动物源性食品中溴虫氟苯双酰胺的检测方法的空白,并可为动物源性食品中溴虫氟苯双酰胺农药残留限量值的制定提供技术支撑。

关键词： QuEChERS净化溴虫氟苯双酰胺动物源性食品

EXPERIENCE WITH OVERLAY TYMPANOPLASTY IN 83 CHINESE PATIENTS

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Journal of Otology 2014年第1期9卷 43-47页

作者： PENG Bengang MIAO Xutao WANG Xin ZHU Sixiang sun yiqing Department of Otolaryngology Jishuitan Hospital

Background In many European and American hospitals, represented by the House Ear Clinic (HEC), the overlay tympanoplasty is used with rare exception, with simultaneous canal wall up or down mastoidectomy being taken if needed. In China, underlay tympanoplasty is used across the country, but the overlay tech-nique is used rarely. The aim of the current study was to report the authors’experience with overlay tympa-noplasty in 83 Chinese patients and study its value. Methods Eight-three patients (86 ears) underwent over-lay tympanoplasty in accordance to the standard of the HEC. The patients were followed up and conditions of the external auditory canal, tympanic membrane and hearing were reviewed and analyzed. Results All patients gained stage I incision healing. The size of external auditory canal and tympanic membrane mor-phology were satisfactory. Hearing either remained unchanged or improved. There were no hearing deterio-ration or serious complications. Conclusions Overlay tympanoplasty carries positive value in treating chron-ic otitis media and cholesteatoma with the merits of procedure standardization, adequate operative exposure, thorough disease elimination and extensive adaptation.

关键词： Tympanoplasty Overlay technique External auditory canal Surgery

Establishment and evaluation of acute diquat poisoning model in Wistar rats

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China Medical Abstracts(Internal Medicine) 2019年第3期36卷 139-140页

作者： sun yiqing Dept Emerg Med 2nd Hosp Hebei Med Univ

Objective To establish the Wistar rat model of acute diquat poisoning and observe the pathological damage of main target *** Thirty-six Wistar rats were randomly divided into six groups(n=6),including one normal saline control group and five treatment groups which were separately given single-dose of intragastric administration at the doses of 46.2 mg/kg,77.0 mg/kg,115.5 mg/kg,231.0 mg/kg and 346.5 mg/*** pathological changes of lung,liver and kidney were observed by hematoxylin and eosin(HE)and Masson *** optimal dose was determined according to the general situation and pathological ***-six Wistar rats were randomly divided into five treatment groups and one normal saline control *** groups were given single-dose of intragastric administration according to the optimal *** rats were sacrificed on the 1st,3rd,7th,11th and 14th day of exposure,*** activity of serum glutamic-pyruvic transaminase(ALT)and glutamic-oxalacetic transaminase(AST)were measured by chemical *** pathological changes of lung,liver and kidney were observed by HE and Masson *** According to 14 d survival rate,the toxic symptoms and pathological changes,115.50 mg/kg was determined the best *** single-dose of intragastric administration at the doses of 115.50 mg/kg,it was found that the serum AST and ALT activity of rats on the first and third day of exposure was significant higher than those in control *** results of pathological examination exhibited that in 115.50 mg/kg group,the pathological changes of lung,liver and kidney began to appear on the first day of exposure,the pathological changes were the most serious on the third day,and then gradually *** the 14th day,the alveolar septum was slightly widened,with inflammatory cell infiltration,local alveolar cavity became narrow,atrophy,peripheral alveolar compensation,bronchi and alveolar septum collagen fiber proliferation;The local re

关键词： doses organs degeneration

核因子红细胞2相关因子2在毒死蜱毒性机制中的作用

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中国工业医学杂志 2024年第3期37卷 267-270页

作者：路依林高恒波姚冬奇孟娜孙艺青苑霖郑拓康田英平河北医科大学第二医院急诊科河北石家庄050000

毒死蜱(chlorpyrifos,CPF)是一种广泛使用的有机磷农药,其对人类健康和生态系统的潜在风险已引起广泛关注。CPF主要通过抑制乙酰胆碱酯酶(AChE)发挥杀虫作用,但越来越多的研究表明,CPF的毒性作用远不止于此,也与氧化应激、炎症反应、细... 详细信息

毒死蜱(chlorpyrifos,CPF)是一种广泛使用的有机磷农药,其对人类健康和生态系统的潜在风险已引起广泛关注。CPF主要通过抑制乙酰胆碱酯酶(AChE)发挥杀虫作用,但越来越多的研究表明,CPF的毒性作用远不止于此,也与氧化应激、炎症反应、细胞死亡等多种生物学过程密切相关,因而可能导致神经退行性疾病、生殖发育障碍以及其他慢性健康问题。核因子红细胞2相关因子2(Nrf 2)作为一种关键的抗氧化应激调节因子,具有显著的保护作用。本文旨在综述Nrf 2在调节CPF诱导的氧化应激、神经毒性、细胞死亡和炎症反应中的作用机制,探讨其作为潜在治疗靶点的前景,以为开发新的CPF中毒治疗策略提供理论基础。

关键词：有机磷中毒毒死蜱(CPF) 核因子红细胞2相关因子2(Nrf 2) 氧化应激

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河北省体外膜氧合开展情况调查分析

中国体外循环杂志 2024年第4期22卷 263-267页

作者：宋豪杰孙艺青田英平高恒波姚冬奇刘亮吕宝谱肖浩孟庆冰郑拓康张睿崔晓磊河北医科大学第二医院急诊科石家庄050000

目的调查近5年河北省体外膜氧合(ECMO)开展情况。方法河北省医师协会体外生命支持委员会于2024年1月1日至1月20日通过电话随访本省各地委员及各医院中心负责人,收集近5年ECMO开展情况。结果近5年ECMO开展中心数由8个上升到31个,年例数... 详细信息

目的调查近5年河北省体外膜氧合(ECMO)开展情况。方法河北省医师协会体外生命支持委员会于2024年1月1日至1月20日通过电话随访本省各地委员及各医院中心负责人,收集近5年ECMO开展情况。结果近5年ECMO开展中心数由8个上升到31个,年例数由65例上升到489例,ECMO机器数量由28台增加到100台。2023年开展ECMO的科室共计47个,其中急诊ICU有18个,ICU有21个,心内科ICU有3个,呼吸ICU有2个,心外科有3个。近5年呼吸支持和循环支持患者的住院生存率有下降趋势,2022年最低,2023年较2022年有所升高,体外心肺复苏(ECPR)患者的生存率总体有升高趋势。2023年不同适应证成人ECMO患者生存率偏低,呼吸支持患者的住院生存率为41.7%、循环支持为36.4%、ECPR患者为17.9%。2023年11个地市共开展ECMO 489例,开展最多的城市为274例,开展最少的城市为11例,ECMO生存率最高的城市为51.7%,生存率最低的城市为9%。结论近5年来河北省ECMO技术开展中心数和例数均较前明显增多,但仍存在各地区发展不平衡,生存率较国际及国内水平偏低,有待进一步完善三级医疗ECMO救治网络,加强培训与质量控制,从而推动河北省ECMO技术发展。

关键词：体外膜氧合体外心肺复苏住院生存率数据收集质量控制

Zeolitic germanosilicate analogue to pharmacosiderite crystallized in an acidic medium

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Green Carbon 2023年第2期1卷 185-192页

作者： Guangying Fu Qiaolin Lang Xiaolong Liu Haonuan Zhao yiqing sun Lei Zhao Ahmed Omran Peng Lu Xiaobo Yang Bing Yu Valentin Valtchev The ZeoMat Group Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of ScienceLaoshan District266101 QingdaoChina College of Chemistry and Chemical Engineering Qingdao University266071 QingdaoChina Normandie University ENSICAENUNICAENCNRSLaboratoire Catalyse et SpectrochimieF-14000 CaenFrance

Zeolites are typically synthesized in alkaline or fluoride-containing near-neutral *** organic structure-directing agents have been investigated for such systems with the aim of discovering materials with unprecedented structures and properties for novel technical *** contrast,zeolite crystallization in strongly acidic media has yet to be *** study demonstrates that a zeolitic silicate phase crystallizes from acidic gels using trimethylamine as an organic additive with the composition 1 SiO_(2):0.3 TMA:0.3 HCl:0.15 HF:55 H_(2)O:(0.1-0.4)GeO_(2).This phase has an interrupted four-connected framework analog to the octahedron/tetrahedron-mixed framework of the mineral family *** comparison to the pharmacosiderite-type HK_(3)(Ge_(7)O_(16))(H_(2)O)_(4),the four GeO_(6)-octahedra forming the central[HGe_(4)O_(4)O_(12)]-cluster are replaced by four SiO_(4)-tetrahedra in a[Si_(4)O_(6)(OH)2.89]-unit in the new ***,the structure is distorted and may contain connectivity and point defects;thus,healing by the occasional incorporation of GeO_(6)-units is *** refined unit cell has a cubic symmetry,space group P-43m(#215),with a=7.7005(1)Å.Acidic-medium synthesis is a useful way to find new zeolites that move in a fundamentally different direction from sophisticated organic structure-directing agents.

关键词： Zeolite synthesis in acidic medium New germanosilicate zeolite 4-connected analogue of pharmacosiderite Structure analysis Structure-directing agents