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Unwavering excellence:How to be a competent cardiovascular doctor in“panvascular medicine+”

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The Innovation 2023年第5期4卷 30-32页

作者： yiqing hu Yongchao Zhao Neng Dai Hao Lu Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China National Clinical Research Center for Interventional Medicine Shanghai 200032China Shanghai Clinical Research Center for Interventional Medicine Shanghai 200032China Key Laboratory of Viral Heart Diseases National Health CommissionShanghai 200032China Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghai 200032China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Cardiology Aflited Hospital of Zunyi Medical UniversityZunyi 563000China

It is essential to create a sustainable and all-encompassing panvascular ecosystem that integrates medical care,industry-academia research,prevention,and management,necessitating the in-depth participation of every cardiovascular doctor on their journey of unwavering excellence.“From doctors,by researchers/engineers,for patients”is the foundation of sustainable development in the“panvascular medicine+”ecosystem.Medical education can make knowledge tangible and serve as a conduit for inheritance and innovation.Prevention covers intelligent decision-making,primary prevention,and the popularization of knowledge.Furthermore,management is a potent tool for promoting development through overall coordination with social governance.Thus,in the“panvascular medicine+”ecosystem,cardiovascular doctors need to prioritize the doctor-patient collaboration,serving patients while possessing capabilities in scientific research,engineering applications,education,prevention,and management.This enables them to promote comprehensive and lifelong health management for patients.

关键词： doctor prevention education

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5727-5768页

作者： Yongchao Zhao Weidong Xiong Chaofu Li Ranzun Zhao Hao Lu Shuai Song You Zhou yiqing hu Bei Shi Junbo Ge Department of Cardiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Key Laboratory of Viral Heart Diseases National Health CommissionShanghai 200032China Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghai 200032China National Clinical Research Center for Interventional Medicine Shanghai 200032China Shanghai Clinical Research Center for Interventional Medicine Shanghai 200032China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China

Hypoxia,characterized by reduced oxygen concentration,is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases.From the research history and milestone events related to hypoxia in cardiovascular development and diseases,The"hypoxia-inducible factors(HIFs)switch"can be observed from both temporal and spatial perspectives,encompassing the occurrence and progression of hypoxia(gradual decline in oxygen concentration),the acute and chronic manifestations of hypoxia,and the geographical characteristics of hypoxia(natural selection at high altitudes).Furthermore,hypoxia signaling pathways are associated with natural rhythms,such as diurnal and hibernation processes.In addition to innate factors and natural selection,it has been found that epigenetics,as a postnatal factor,profoundly influences the hypoxic response and progression within the cardiovascular system.Within this intricate process,interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been established.Thus,it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research,including FDA-approved drugs and ongoing clinical trials,to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases.

关键词： cardiovascular therapeutic organs

生成性公众观:平台社会的来临与“李杜之争”的终结

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传媒观察 2024年第3期483卷 5-12页

作者：胡翼青任依瓯南京大学新闻传播学院江苏南京210093

100年前,李普曼《舆论》与《幻影公众》的相继问世给杜威尚未成形的民主思想带来了巨大的冲击:一方面,杜威认同李普曼揭露的现代工业社会中的民主弊病;另一方面,他无法抛却公众参与的民主理想。因此,杜威在“生成性公众观”之上重建民... 详细信息

100年前,李普曼《舆论》与《幻影公众》的相继问世给杜威尚未成形的民主思想带来了巨大的冲击:一方面,杜威认同李普曼揭露的现代工业社会中的民主弊病;另一方面,他无法抛却公众参与的民主理想。因此,杜威在“生成性公众观”之上重建民主理论。杜威的公众观与他对黑格尔的深入研究息息相关,黑格尔的精神现象学为“生成性公众观”奠定了理论基础。百年后的今天,现代技术解构了“局内人”的神话,而生成性公众不得不与媒介“生成性”缠绕共生,“李杜之争”也因而落下帷幕。

关键词：生成性公众观杜威李普曼黑格尔

媒介视角下的中国新闻传播思想史研究:2017—2023

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全球传媒学刊 2024年第1期11卷 38-51页

作者：胡翼青沙璨南京大学新闻传播学院

本文梳理了2017年以来中国新闻传播思想史的发展轨迹。研究发现,自2017年学界开始尝试以媒介作为新闻传播学独特学科视角以来,无论是传统的新闻传播思想史研究,还是新闻史和媒介史研究,都发生了不同程度的媒介理论转型。其中,又以媒介... 详细信息

本文梳理了2017年以来中国新闻传播思想史的发展轨迹。研究发现,自2017年学界开始尝试以媒介作为新闻传播学独特学科视角以来,无论是传统的新闻传播思想史研究,还是新闻史和媒介史研究,都发生了不同程度的媒介理论转型。其中,又以媒介物质性与媒介本体论的理论叙事所取得的成就最为突出。这一系列的学术成就似乎在提醒我们,应以本土媒介实践为抓手,为新闻传播思想史研究创造新的阐释空间与对话可能,从而为建构中国新闻传播学的自主知识体系奠定基础。

关键词：新闻传播思想史媒介入射角自主知识体系

Oligomeric procyanidins combined with Parabacteroides distasonisameliorate high-fat diet-induced atherosclerosis by regulating lipid metabolism， inflammation reaction and bile acid metabolism in ApoEmice

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Food Science and human Wellness 2023年

作者： Mingjuan Xu Cheng Lü yiqing hu Mo Zhang Jinxin Shen Chunyi Liu Qun Lu Rui Liu Key Laboratory of Environment Correlative Dietology (huazhong Agricultural University)， Ministry of Education Wuhan Engineering Research Center of Bee Products on Quality and Safety Control Key Laboratory of Urban Agriculture in Central China， Ministry of Agriculture and Rural Affairs Institute for Environment and Safety， Wuhan Academy of Agricultural Science College of Food Science and Technology， huazhong Agricultural University

Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases. Hence， the prevention and treatment strategies of AS have attracted great research attention. As a potential probiotic， Pararabacteroides distasonis (P. distasonis) has a positive regulatory effect on lipid metabolism and bile acids (BAs) profile. Oligomeric procyanidins have been confirmed to be conducive to the prevention and treatment of AS， whose anti-atherosclerotic effect may be associated with the promotion of gut probiotics. However， it remains unclear whether and how oligomeric procyanidins and P. distasonis combined (PPC) treatment can effectively alleviate high-fat diet (HFD)-induced AS. In this study， PPC treatment was found to significantly decrease atherosclerotic lesion， as well as alleviate the lipid metabolism disorder， inflammation and oxidative stress injury in ApoE-/-mice. Surprisingly， targeted metabolomics demonstrated that PPC intervention altered the BA profile in mice by regulating the ratio of secondary BAs to primary BAs， and increased fecal BAs excretion. Further， qPCR analysis showed that PPC intervention facilitated reverse cholesterol transport by upregulating Srb1 expression; In addition， PPC intervention promoted bile acid synthesis from cholesterol in liver by upregulating Cyp7a1 expression via suppression of the FXR pathway， thus exhibiting a significant serum cholesterol-lowering effect. In summary， PPC attenuated HFD-induced AS in ApoE-/-mice， which provides new insights into the design of novel and efficient anti-atherosclerotic strategies to prevent AS based on probiotics and prebiotics.

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直肠癌患者术后低位前切除综合征发生风险预测模型的系统评价

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中国循证医学杂志 2024年第3期24卷 295-302页

作者：胡锦蕊赵红彭雨琪何以晴谢伦芳安徽医科大学护理学院合肥230601 安徽医科大学第一附属医院门诊部合肥230022

目的系统评价直肠癌患者术后低位前切除综合征发生风险预测模型。方法计算机检索PubMed、Web of Science、Embase、Cochrane Library、Scopus、CINHAL、CNKI、CBM、WanFang Data和VIP数据库,搜集与研究目的相关的研究,检索时限均为建库... 详细信息

目的系统评价直肠癌患者术后低位前切除综合征发生风险预测模型。方法计算机检索PubMed、Web of Science、Embase、Cochrane Library、Scopus、CINHAL、CNKI、CBM、WanFang Data和VIP数据库,搜集与研究目的相关的研究,检索时限均为建库至2023年6月13日。由2名研究者独立筛选文献,按照预测模型系统评价的关键评估和数据提取清单(CHARMS)提取数据,应用预测模型研究偏倚风险评估工具(PROBAST)评价研究质量。结果共纳入14项研究。所有研究都报告了模型区分度,其中10项研究报告了校准。8项研究对模型进行了内部验证,5项研究进行了外部验证。纳入模型最常见的预测因子为肿瘤距肛缘的距离、新辅助治疗、吻合口瘘、BMI。仅5项研究的整体适用性较好,所有研究均有很高的偏倚风险,偏倚风险主要来源于研究对象、结果、分析领域。结论直肠癌患者术后低位前切除综合征发生风险预测模型尚存在诸多不足,未来研究可考虑对现有模型进行外部验证和重新校准,或参照方法学指南构建新的预测模型并进行验证。

关键词：直肠癌低位前切除综合征风险预测模型系统评价

Current status and development of CMOS SiPM for scintillator-based radiation detectors toward all-digital sensors[Invited]

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Chinese Optics Letters 2024年第2期22卷 17-27页

作者： Nicola D'Ascenzo 胡文韬劳慧华越轩张博房磊奚道明郑睿邱奥 Emanuele Antonecchia 凌怡清刘雨晴李琰俞航肖鹏谢庆国 Wuhan National Laboratory for Optoelectronics Wuhan 430074China Biomedical Engineering Department Huazhong University of Science and TechnologyWuhan 430074China RAYQUANT Technology Co. Ltd.Ezhou 436044China RAYSOLUTION Healthcare Co. Ltd.Hefei 230000China RAYMEASURE Technology Co. Ltd.Suzhou 215000China RAYCAN Technology Co. Ltd.Suzhou 215000China College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China

Modern scintillator-based radiation detectors require silicon photomultipliers(Si PMs)with photon detection efficiency higher than 40%at 420 nm,possibly extended to the vacuum ultraviolet(VUV)region,single-photon time resolution(SPTR)<100 ps,and dark count rate(DCR)<150 kcps/mm^(2).To enable single-photon time stamping,digital electronics and sensitive microcells need to be integrated in the same CMOS substrate,with a readout frame rate higher than 5 MHz for arrays extending over a total area up to 4 mm×4 mm.This is challenging due to the increasing doping concentrations at low CMOS scales,deep-level carrier generation in shallow trench isolation fabrication,and power consumption,among others.The advances at 350 and 110 nm CMOS nodes are benchmarked against available Si PMs obtained in CMOS and commercial customized technologies.The concept of digital multithreshold Si PMs with a single microcell readout is finally reported,proposing a possible direction toward fully digital scintillator-based radiation detectors.

关键词： silicon photomultiplier complementary metal-oxide semiconductor digital SiPM

含有Hénon项的非线性椭圆系统稳定解的Liouville定理

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宁波大学学报（理工版） 2024年第2期37卷 86-95页

作者：黄宇鑫甘怡清胡良根宁波大学数学与统计学院浙江宁波315211 姚江中学浙江余姚315400

本文主要研究含有Hénon项的k-耦合椭圆系统-Δu_(i)=Σ_(j-1)^(k)β_(ij)|χ|^(α)|u_(i)|^(q-1)ui|uj|^(q+1),x∈R^(N)其中k是一个固定的正整数,i=1,2,…,k,q≥1,N≥3,B=(β_(ij))_(i,j=1)^(k)为实对称矩阵.首先使用Pohozaev恒等式构造单调公式,并发现其等价关系.当矩阵B严格余正时,联合使用Pohozaev恒等式、单调公式和爆缩序列方法证明了(无论是正的还是变号的)稳定解的Liouville定理.

关键词： Liouville定理稳定解 Pohozaev恒等式单调公式爆缩序列

钬激光解剖性剜除术治疗大体积良性前列腺增生的临床研究

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中外医疗 2024年第11期43卷 33-36页

作者：刘一庆温开伦赵虎灌云县人医院泌尿外科江苏连云港222200

目的探究应用钬激光解剖性剜除术治疗大体积良性前列腺增生疾病中采取临床效果。方法随机选取灌云县人民医院于2022年7月—2023年11月收治的大体积良性前列腺增生患者130例为研究对象,采用随机数表法进行分组,对照组进行前列腺电切术,... 详细信息

目的探究应用钬激光解剖性剜除术治疗大体积良性前列腺增生疾病中采取临床效果。方法随机选取灌云县人民医院于2022年7月—2023年11月收治的大体积良性前列腺增生患者130例为研究对象,采用随机数表法进行分组,对照组进行前列腺电切术,观察组进行钬激光解剖性剜除术,每组65例。对比尿流动力学指标、围术期指标、国际前列腺症状评分(International Prostate Symptom Score,IPSS)、并发症。结果与对照组残余尿量(24.80±5.90)mL比较,观察组(20.38±5.42)mL更低,差异有统计学意义(t=4.448,P<0.05)。观察组的最大尿流率高于对照组,差异有统计学意义(P<0.05)。与对照组相比,观察组的术中出血量更少,术中切除增生组织量更多,手术时间、膀胱冲洗时间、导尿管留置时间、住院时间均更短,IPSS评分和并发症发生率更低,差异有统计学意义(P均<0.05)。结论针对大体积良性前列腺增生患者,实施钬激光解剖性剜除术,能够改善尿流动力学指标,出血量少,切除组织量更多,改善临床症状,并发症少。

关键词：钬激光解剖性剜除术大体积良性前列腺增生尿流动力学并发症

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