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Mechanical model of round window membrane under reverse excitation

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Applied Mathematics and Mechanics(English Edition) 2016年第10期37卷 1341-1348页

作者： yiqiang chen Wenjuan YAO Department of Civil Engineering Shanghai University

According to the vibration characteristics of the round window, a mechani- cal model of a round window membrane is established. The Euler equation of the round window and the complementary boundary conditions are derived by the variational prin- ciple. Combined with the Bessel function, an analytical solution of the round window displacement is obtained by MATHEMATICA. Combined with clinical characteristics of round window membrane lesion, the effect of sound transmission due to thickening of the round window membrane caused by the otitis media, shrinkage of the round window membrane area caused by otosclerosis, and hardening of the round window membrane itself is analyzed. The results show that with thickening of the round window membrane, the displacement of the round window membrane is decreased. In the meantime, with hardening of the round window membrane and shrinkage of the membrane area, the max- imum displacement Of the round window membrane is gradually reduced, leading to a decrease in sound transmission. Thus, the analyticM analysis can avoid interference of environment and the technical level of personnel, and it can evaluate transmission per- formance of the round window membrane efficiently, providing a theoretical basis for the reverse excitation of artificial prosthesis.

关键词： round window variational principle Euler equation complementary boundary condition Bessel function

Numerical simulation of Corti stimulated by fluid in tunnel of Corti

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Applied Mathematics and Mechanics(English Edition) 2017年第5期38卷 737-748页

作者： yiqiang chen Wenjuan YAO Shaofeng LIU Department of Civil Engineering Shanghai UniversityShanghai 200444China

In this paper, the effect of fluid in a tunnel of Corti （TC） on organ of Corti （OC） is studied. A three-dimensional OC model including basilar membrane （BM）, tectorial membrane （TM）, inner and outer hair cells （OHCs）, and reticular lamina （RL） is established by COMSOL. An initial pressure is applied to the fluid in the TC. The frequency response of the structure is analyzed, and the displacement of the BM is achieved. The results are in good agreement with the experimental data, confirming validity of the finite element model. Based on the model, the effect of fluid in the TC on the OC is studied. The results show that, when the pressure gradient is absent in the fluid, with the increase of the initial fluid pressure, the displacement of the BM increases. However, when the initial fluid pressure increases to a certain value, the increase rate of the displacement of the BM becomes very slow. The movement of the fluid amplifies the BM movement. Furthermore, the movement of the fluid can strengthen the movement of the OHCs and the shear movement of the stereocilia, especially in the vicinity of the characteristic frequency at which the amplification effect reaches a peak. Nevertheless, a pressure gradient in the fluid affects the BM movement.

关键词： tunnel of Corti (TC) organ of Corti (OC) frequency response fluidpressure

Mechanical model of organ of Corti

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Applied Mathematics and Mechanics(English Edition) 2017年第6期38卷 867-876页

作者： yiqiang chen Wenjuan YAO Shaofeng LIU Department of Civil Engineering Shanghai University

According to the vibration characteristics of the organ of Corti （OC）, seven hypotheses are made to simplify the structure of the model, and a mechanical OC model is established. Using the variational principle, a displacement analytical expression is solved under a certain pressure. The results are in good agreement with experimental data, showing the validity of the formula. Combined with the damage caused by noise in clinic, it is found that the hardening of outer hair cells and outer stereocilia can lead to loss of hearing and generation of threshold shift. In addition, the results show that high frequency resonance occurs at the bottom of the basilar membrane （BM）, and low frequency resonance occurs at the top of the BM. This confirms the frequency selective characteristics of the BM. Further, using this formula can avoid interference of the envi- ronment and the technical level of the test personnel, and can evaluate performance of the OC objectively.

关键词： organ of Corti (OC) variational principle hardening of outer hair cells(OHCs) hardening of outer stereocilia threshold shift

Extracting Integrated Features of Electronic Medical Records Big Data for Mortality and Phenotype Prediction

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Chinese Journal of Electronics 2024年第3期33卷 776-792页

作者： Fei LI yiqiang chen Yang GU Yaowei WANG Institute of Computing Technology University of Chinese Academy of Sciences Pengcheng Laboratory

The key to synthesizing the features of electronic medical records(EMR) big data and using them for specific medical purposes,such as mortality and phenotype prediction,is to integrate the individual medical event and the overall multivariate time series feature extraction automatically,as well as to alleviate data imbalance *** paper provides a general feature extraction method to reduce manual intervention and automatically process large-scale *** processing uses two variational auto-encoders(VAEs) to automatically extract individual and global *** avoids the well-known posterior collapse problem of Transformer VAE through a uniquely designed "proportional and stabilizing" mechanism and forms a unique means to alleviate the data imbalance *** conducted experiments using ICU-STAY patients' data from the MIMIC-Ⅲ database and compared them with the mainstream EMR time series processing *** results show that the method extracts visible and comprehensive features,alleviates data imbalance problems and improves the accuracy in specific predicting tasks.

关键词： Databases Time series analysis MIMICs Manuals Big Data Feature extraction Transformers

Hierarchical microstructure of a titanium alloy fabricated by electron beam selective melting

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Journal of Materials Science & Technology 2020年第7期42卷 1-9页

作者： Jixin Yang yiqiang chen Yongjiang Huang Zhiliang Ning Baokun Liu Chao Guo Jianfei Suna National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China Max-Planck-Institut für Eisenforschung Max-Planck-Straße 140237 DusseldorfGermany Tianjin SciTsinghua QuickBeam Tech.Co. Ltd.Tianjin 300300China

Here,a near alpha-type Ti6.5 Al2 Zr1 Mo1 V alloy has been fabricated by electron beam selective melting(EBSM).Near-equiaxed grains existed in the first few layers,whereas elongated columnar priorβgrains almost parallel to the building direction formed in the subsequent built *** ofβphase gradually decreased as the build height ***α'with twins and dislocations emerged and microhardness value reached the maximum in the top region,whereas onlyα/βphase appeared in other regions in the EBSMed *** phase transformations can be observed with the change of peak temperatures during each thermal *** a sufficient dwell time,martensiteα'in the middle and bottom regions in-situ decomposed intoα+βand coarsened by the heat conduction from the subsequent ***βprecipitates nucleated heterogeneously insideα'plates and at plate-plate interfaces during the subsequent EBSM *** the phase transformation during the heating process and the cooling process,the existence time of different phases was combined with cycle heating and cooling to clarify the dynamic evolution of micro structure under complex thermal history of EBSM,favoring the fabrication of high-performance titanium alloy components.

关键词： Electron beam selective melting Titanium alloys Martensite Microstructure evolution Thermal cycles

InputJump: Augmented reality-facilitated cross-device input fusion based on spatial and semantic information

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虚拟现实与智能硬件（中英文） 2024年第6期6卷 502-526页

作者： Xin ZENG Xiaoyu WANG Tengxiang ZHANG Yukang YAN yiqiang chen Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 101408China Goertek Inc. Bejing 261031China The Hong Kong University of Science and Technology Hong Kong 999077China Department of Computer Science Hajim School of Engineering and Applied SciencesUniversity of RochesterRochesterNY 14627US

The proliferation of computing devices requires seamless cross-device *** reality(AR)headsets can facilitate interactions with existing computers owing to their user-centered views and natural *** this study,we propose InputJump,a user-centered cross-device input fusion method that maps multi-modal cross-device inputs to interactive elements on graphical *** input jump calculates the spatial coordinates of the input target positions and the interactive elements within the coordinate system of the AR *** also extracts semantic descriptions of inputs and elements using large language models(LLMs).Two types of information from different inputs(e.g.,gaze,gesture,mouse,and keyboard)were fused to map onto an interactive *** proposed method is explained in detail and implemented on both an AR headset and a desktop *** then conducted a user study and extensive simulations to validate our proposed *** results showed that InputJump can accurately associate a fused input with the target interactive element,enabling a more natural and flexible interaction experience.

关键词： Mixed reality Spatial Semantic Large language models

Broadband and polarization-independent arbitrary ratio integrated optical power splitter built on thick silicon nitride platform

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Optoelectronics Letters 2024年第10期20卷 577-583页

作者： ZHENG Langteng chen yiqiang XUE Zhengqun HUANG Jiwei ZHU Minmin WANG Linghua College of Physics and Information Engineering Fuzhou UniversityFuzhou350108China

Integrated optical power splitters are basic but indispensable on-chip devices in silicon *** can be used either for power distribution or monitoring,or as the building blocks for more complex devices or *** different types of optical power splitters with different architectures have been proposed and demonstrated,devices that could work with arbitrary power splitting ratio in a large bandwidth without polarization dependence are still rare to be *** this paper,we propose and investigate an optical power splitter with adiabatically tapered waveguide structures on a thick silicon nitride platform,which could meet the requirement mentioned *** optimized structural parameters obtained by three-dimensional finite-difference time-domain(3D-FDTD)simulation,the polarization dependence of different power splitting ratio gets almost eliminated for each specific working *** a broad wavelength range(1340—1800 nm),the insertion loss(IL)of the device is below 1 d B,and the variation of the power splitting ratio(PSR)can be controlled within~±5%if compared with the targeted design value for 1550 nm centered *** structure,relaxed critical dimensions,and good fabrication tolerance make this device compatible with the standard fabrication process in commercial silicon photonic foundries.

关键词： polarization power waveguide

Analysis of ethoxyquin and its oxidation products in swine tissues by gas chromatography-tandem mass spectrometry for evaluating the feed-toanimal tissue transfer of ethoxyquin and its metabolites

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Journal of Animal Science and Biotechnology 2021年第2期12卷 806-814页

作者： Chi Zhang Xiangrong Gai Ying Tian Jiayi Wang Dongting He Wenjun Yang Liying Zhang yiqiang chen State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background:Ethoxyquin(EQ)is a common antioxidant which is widely used in animal *** the supplement of EQ in animal feed may lead to the residues of EQ and its major oxidation products:ethoxyquin quinone imine(EQI)and ethoxyquin dimer(EQDM)in animal ***,it would pose potential health hazards to ***,the method for the simultaneous determination of EQ,EQI and EQDM in animal tissues is currently not available,and the accumulation extend of these chemicals in animal tissues after EQ administration remains to be ***:A gas chromatography-tandem mass spectrometry method was successfully developed for the simultaneous determination of EQ,EQI and EQDM in swine *** quantitative limits of EQ,EQI and EQDM can achieve to 0.5,5.0 and 5.0μg/kg in swine tissues,*** spiked-recovery ratios of the three analytes(5–2000μg/kg)were in the range of 64.7%–100.7%with relative standard deviations below 11.6%.Moreover,the utilization of this method for the analysis of actual swine tissue samples revealed that the application of commercial EQ additive in swine diet would produce the residues of all the three chemicals(EQ,EQI and EQDM)in fat,kidney,liver and ***:The assay accuracy and precision of this GC-MS/MS method can meet the requirement of quantitative ***,the safety of EQ as a feed additive should be seriously considered with regard to food safety concerns since the oxidation product of EQ may have potential carcinogenicity.

关键词： Ethoxyquin Ethoxyquin dimer Ethoxyquin quinone imine Gas chromatography-tandem mass spectrometry Safety evaluation Swine tissues

Use of near-infrared reflectance spectroscopy for the rapid determination of the digestible energy and metabolizable energy content of corn fed to growing pigs

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Journal of Animal Science and Biotechnology 2017年第1期8卷 161-169页

作者： Juntao Li Quanfeng Li Defa Li yiqiang chen Xiaoxiao Wang Wenjun Yang Liying Zhang State Key Lab of Animal Nutrition College of Animal Science&Technology China Agricultural University Beijing 100193China

Background： The ability of near-infrared reflectance spectroscopy（NIRS） to determine the digestible energy（DE）and metabolizable energy（ME） content of corn fed to growing pigs was tested. One hundred and seventeen corn samples, comprising different planting regions and varieties were collected from all over China in a three-year period. The samples were randomly split into a calibration set（n = 88） and a validation set（n = 29）. The actual and calculated DE and ME content of the corn samples was determined by digestion-metabolism experiments and the prediction equations of Noblet and Perez（J Anim Sci. 71：3389–98,1993）. The samples were then subjected to NIRS scanning and calibrations were performed by the modified partial least square（MPLS） regression method based on77 different spectral pre-treatments. The NIRS equations based on the actually determined and calculated DE and ME were built separately and then validated using validation ***： The NIRS equations obtained from actually determined DE, the coefficient of determination for calibration（RSQcal）, cross-validation（R^2CV）, and validation（RSQv） were 0.89, 0.87 and 0.86, and these values for determined ME were 0.87, 0.86 and 0.86. For the NIRS equations built from calculated DE, the RSQcal, R^2CV, and RSQvvalues were 0.88, 0.85 and 0.84, and these values for calculated ME were 0.86, 0.84 and 0.82. Except for the equation based on calculated ME（RPD_v= 2.38, 〈 2.50）, the other three equations built from actually determined energy and calculated DE produced good prediction performance（RPD_vranging from 2.53 to 2.69, 〉 2.50） when applied to validation ***： These results indicate that NIRS can be used as a quantitative method for the rapid determination of the available energy in corn fed to growing pigs, and the NIRS equations based on the actually determined energy produced better predictive performance than those built from calculated energy values.

关键词： Corn Digestible energy Growing pigs Metabolizable energy Near-infrared reflectance spectroscopy