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Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1412-1427页

作者： Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou yipu liu Shiqiang Tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li Jigang Lei Zhihua Wang Xiaoling Gao Jun Chen Shanghai Pudong Hospital&Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Emergency Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Institute of Science and Technology for Brain-Inspired Intelligence&Department of Neurology Fudan UniversityShanghai 201203China Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 201203China Daxing Research Institute University of Science and Technology BeijingBiomedical Industry BaseZhongguancun Science and Technology ParkBeijing 102600China Cellular Biomedicine Group Inc. Shanghai 201210China

Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical *** levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’*** on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC *** system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective *** this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for ***,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate *** engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 *** vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.

关键词： Ischemic stroke Mesenchymal stem cell Cell engineering Hormesis effect Bioorthogonal chemistry Microglia Reactive oxygen spices Proinflammatory cytokines

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An ultrathin two-dimensional iridium-based perovskite oxide electrocatalyst with highly efficient{001}facets for acidic water oxidation

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Journal of Energy Chemistry 2022年第3期31卷 619-627,I0017页

作者： Lan Yang Kexin Zhang Hui Chen Lei Shi Xiao Liang Xiyang Wang yipu liu Qing Feng Mingjie liu Xiaoxin Zou State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012JilinChina Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooOntario N2L 3G1Canada Northwest Institute for Non-ferrous Metal Research Xi'an 710016ShaanxiChina Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

The oxygen evolution reaction(OER)is an electrochemical bottleneck half-reaction in some important energy conversion systems(e.g.,water splitting),which is traditionally mediated by iridium oxides in acidic ***-structured Ir-containing oxides(e.g.,SrIrO_(3))are a family of striking electrocatalysts due to their high specific activity,but this excellent quality is difficultly transferred to a nano-electrocatalyst with large active surface and good structural ***,we present a synthesis method that produces a 2D ultrathin{001}-faceted SrIrO_(3)perovskite(2D-SIO)with a thickness of∼5 nm and high surface area(57.6 m^(2)g^(−1)).We show that 2D-SIO can serve as a highly active and stable electrocatalytic nanomaterial for OER under acidic *** perovskite nanomaterial produces 10 mA cm^(−2)current density at a low overpotential(η,243 mV),and maintains its catalytic activity after 5000 continuous cyclic *** ultrathin structure and large surface area,the exposed{001}facets are found to be the most crucial and unique structural factor for achieving high catalytic activity and structural *** joint experimental and theoretical results demonstrate that these advantageous microstructural features of 2D-SIO endow it with a strong capability to generate the key O^(*)intermediates,and thereby facilitate O–O bond formation and the OER.

关键词： Oxygen evolution reaction Electrocatalysis Nanosheet Two-dimensional material Water splitting

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Iridium‐containing water‐oxidation catalysts in acidic electrolyte

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Chinese Journal of Catalysis 2021年第7期42卷 1054-1077页

作者： yipu liu Xiao Liang Hui Chen Ruiqin Gao Lei Shi Lan Yang Xiaoxin Zou State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012JilinChina School of Biological and Chemical Engineering NingboTech UniversityNingbo 315100ZhejiangChina

With the goal of constructing a carbon‐free energy cycle,proton‐exchange membrane(PEM)water electrolysis is a promising technology that can be integrated effectively with renewable energy resources to produce high‐purity ***2,as a commercial electrocatalyst for the anode side of a PEM water electrolyzer,can both overcome the high corrosion conditions and exhibit efficient catalytic ***,the high consumption of Ir species cannot meet the sustainable development and economic requirements of this ***,it is necessary to understand the OER catalytic mechanisms for Ir species,further designing new types of low‐iridium catalysts with high activity and stability to replace *** this review,we first summarize the related catalytic mechanisms of the acidic oxygen evolution reaction(OER),and then provide general methods for measuring the catalytic performance of ***,we present the structural evolution results of crystalline IrO2 and amorphous IrOx using in situ characterization techniques under catalytic conditions to understand the common catalytic characteristics of the materials and the possible factors affecting the structural evolution ***,we focus on three types of common low‐iridium catalysts,including heteroatom‐doped IrO2(IrOx)‐based catalysts,perovskite‐type iridium‐based catalysts,and pyrochlore‐type iridium‐based catalysts,and try to correlate the structural features with the intrinsic catalytic performance of ***,at the end of the review,we present the unresolved problems and challenges in this field in an attempt to develop effective strategies to further balance the catalytic activity and stability of materials under acidic OER catalytic conditions.

关键词： Electrocatalysis Oxygen evolution reaction Water splitting Iridium Proton exchange membrane electrolyzer

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Export of particulate organic carbon estimated from ^(234)Th-^(238)U disequilibria and its temporal variation in the South China Sea

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Chinese Science Bulletin 2001年第20期46卷 1722-1726页

作者： CAI Pinghe, HUANG yipu, CHEN Min, liu Guangshan & QIU YushengDepartment of Oceanography, Xiamen University, Xiamen 361005, China Department of Oceanography Xiamen University Xiamen China

Activities of 234Th and nutrient concentrations in the upper 500 m water column were measured at a time-series station in the South China Sea over a time span of 12.3 d. Results showed a reduction of dissolved 234Th and an overall increase of particulate 234Th during the period. Meanwhile, activities of total 234Th kept fairly constant, implying rapid transformation of 234Th between the dissolved and particulate forms. Vertical profiles of total 234Th showed evident deficit of 234Th relative to 238U in the upper 500 m water column. Using an irreversible steady-state model of thorium scavenging, export fluxes of particulateorganic carbon (POC) corresponding to time points T1 and T2 were estimated to be 46.5 and 13.1 mmolC .m-2. d-1. It was demonstrated that the estimation of POC export was greatly dependent on the POC/234Thp ratios and the bias caused by the different models of 234Th scavenging, however, was considered to be of minor importance.

关键词： South China Sea 234Th-238U disequilibria POC export.

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Alternating current heating techniques for lithium-ion batteries in electric vehicles:Recent advances and perspectives

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Journal of Energy Chemistry 2024年第9期96卷 679-697页

作者： Xinrong Huang Jinhao Meng Wei Jiang Wenjie liu Kailong liu yipu Zhang Daniel-Ioan Stroe Remus Teodorescu School of Energy and Electrical Engineering Chang’an UniversityXi’an 710018ShaanxiChina School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina School of Highway Chang’an UniversityXi’an 710018ShaanxiChina School of Automation Northwestern Polytechnical UniversityXi’an 710072ShaanxiChina School of Control Science and Engineering Shandong UniversityJinan 250100ShandongChina Department of Energy Aalborg UniversityAalborg 9220Denmark

The significant decrease in battery performance at low temperatures is one of the critical challenges that electric vehicles(EVs)face,thereby affecting the penetration rate in cold *** current(AC)heating has attracted widespread attention due to its low energy consumption and uniform heating *** paper introduces the recent advances in AC heating from the perspective of practical EV ***,the performance degradation of EVs in low-temperature environments is introduced *** concept of AC heating and its research methods are ***,the effects of various AC heating methods on battery heating performance are *** on existing studies,the main factors that affect AC heating performance are ***,various heating circuits based on EVs are categorized,and their cost,size,complexity,efficiency,reliability,and heating rate are elaborated and *** evolution of AC heaters is presented,and the heaters used in brand vehicles are sorted ***,the perspectives and challenges of AC heating are *** paper can guide the selection of heater implementation methods and the optimization of heating effects for future EV applications.

关键词： Lithium-ion battery Low temperature Alternating current heating Heater Electric vehicle

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Distribution of dissolved organic carbon in and near the Prydz Bay, Antarctica

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Acta Oceanologica Sinica 2003年第4期22卷 547-556页

作者： Qiu Yusheng1, Chen Min1, Huang yipu1, liu Guangshan1 1. Department of Oceanography, Xiamen University, Xiamen 361005, China. Department of Oceanography Xiamen University Xiamen 361005 China

During the 16th Chinese National Antarctic Research Expedition (CHINARE) (from November 1999 to April 2000) seawater samples were collected for (DOC) determination in the Prydz Bay and its nearby sea areas. DOC concentrations were determined-by high temperature catalytic oxidation (HTCO) method. The results shows that DOC concentrations, in the upper water column (0 similar to 100 in) range from 14.3 to 181.1 mumol/dm(3), with averaging 52.5 mumol/dm(3) (n = 55). These values are slightly higher than those reported for the Ross Sea, the Pacific Ocean and others. Profiles of DOC concentration in the study areas show a decreasing concentration with increasing depth in the upper 100 m, which is related to biological activities in the water column. DOC concentrations below 100 in are relatively constant with a mean of 40.4 gammamol/dm(3). These DOC are unactive for physical and biological activities and are called refractory DOC. Concentration of the refractory DOC in the study area is consistent with the previous reported values for the Southern Ocean, which is about 41 mumol/dm(3). Based on the difference between the measured DOC concentration and the refractory concentration, the excess DOC concentration in the upper column can be calculated at every station. The excess DOC shows a spatial variability with a higher excess in the north of 64degreesS and little excess in the south of 64degreesS. In conclusion, DOC concentrations in the Prydz Bay and its nearby sea areas,are, consistent with the previous reported values in the Southern Ocean, which show a low DOC concentration with respect to the other oceans. Distribution of surface DOC concentrations in the study areas shows an increase from the southwestern to the northeastern, which is ascribed to the northern spread of continental shelf water from the Prydz Bay in summer. Contents of DOC and their distribution in the Prydz Bay and its nearby sea areas are mainly controlled by physical and biological processes.

关键词： The Prydz Bay Antarctica dissolved organic carbon

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真空加热活化法提高内嵌钴粒子的碳纳米管的水裂解产氢催化活性

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高等学校化学学报 2018年第6期39卷 1249-1254页

作者：邹佳运刘一蒲陈辉李国栋吉林大学化学学院无机合成与制备化学国家重点实验室长春130012

采用真空加热活化法制备出高催化活性的内嵌金属钴纳米粒子的碳纳米管材料.通过增加碳纳米管材料的本征碳缺陷位点,显著提升了材料的催化活性(>7倍).高分辨透射电子显微镜(HRTEM)、X射线光电子能谱(XPS)和拉曼(Raman)光谱表征结果显示,... 详细信息

采用真空加热活化法制备出高催化活性的内嵌金属钴纳米粒子的碳纳米管材料.通过增加碳纳米管材料的本征碳缺陷位点,显著提升了材料的催化活性(>7倍).高分辨透射电子显微镜(HRTEM)、X射线光电子能谱(XPS)和拉曼(Raman)光谱表征结果显示,真空加热活化增加了碳纳米管的本征碳缺陷,并减少了碳纳米管碳层的杂原子含量.电化学表征和电催化水裂解实验结果表明,增加碳纳米管的本征碳缺陷位既可以在碳纳米管上产生更多的催化位点,又可以提高碳纳米管界面的电荷迁移能力,进而提高对水裂解的催化性能.

关键词：碳纳米管钴纳米粒子电催化水裂解

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放弃继承的效力探析

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长沙大学学报 2016年第4期30卷 65-67页

作者：刘乙璞北京化工大学文法学院北京100029

我国继承法自1985年颁行以来始终未予修改过,其中关于放弃继承制度的规定已经无法适应现代社会的高速发展。根据该法,继承人享有放弃继承的自由,但是关于放弃继承的主体和时间的规定过于简单和分散,致使继承法律关系总是呈现不稳定的状... 详细信息

我国继承法自1985年颁行以来始终未予修改过,其中关于放弃继承制度的规定已经无法适应现代社会的高速发展。根据该法,继承人享有放弃继承的自由,但是关于放弃继承的主体和时间的规定过于简单和分散,致使继承法律关系总是呈现不稳定的状态,影响继承活动的有序性。同时,司法实践中出现了许多放弃继承导致债权人利益受到损害的案件,引发了理论界和实务界关于能否将放弃继承行为作为债权人撤销权标的的争议。从民法的价值取向和现有体系的角度考虑,将放弃继承行为作为债权人撤销权的标的更符合现代立法发展潮流。

关键词：放弃继承效力债权人撤销权

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