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The IRAK-1-BCL10-MALT1-TRAF6-TAK1 Cascade Mediates Signaling to NF- k. B from Toll-like Receptor 4

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The IRAK-1-BCL10-MALT1-TRAF6-TAK1 Cascade Mediates Signaling...

缺刻转移和DNA杂交组建枯草杆菌噬菌体DNA的物理图谱

2006年度学术研讨会

作者： Tingle Liu ,Wei Dong , Jinhong Peng, Lu Chen, Tingting Zou, Huazhong Xiao, Zhengxue Liu, Wen Li, Yiwen Bu, qin Xu, Wei Xiao, yipeng qi From the National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, People’s Republic of China

Our previous studies have revealed that the signaling protein BCL10 plays a major role in adaptive immunity by mediating NF-κB activation in LPS/TLR4 pathway. In this paper, we show that IRAK-1 acts as the essential ...

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武汉大学学报(自然科学版) 1986年第1期 100-105页

作者：齐义鹏 J.Lampel 武汉大学病毒学系美国俄亥俄州立大学微生物系

用缺刻转移法制备放射性探针DNA,以脱水的琼脂糖凝胶作为杂交的支持物,进行DNA-DNA的分子杂交,组建了枯草杆菌噬菌体105φDNA的EcoR1和Hpa1片段的物理图谱。EcoR1片段的顺序是DGIEBHFC;Hpa1片段的顺序是DICHGAFEJ.本文对组建物理图谱的... 详细信息

用缺刻转移法制备放射性探针DNA,以脱水的琼脂糖凝胶作为杂交的支持物,进行DNA-DNA的分子杂交,组建了枯草杆菌噬菌体105φDNA的EcoR1和Hpa1片段的物理图谱。EcoR1片段的顺序是DGIEBHFC;Hpa1片段的顺序是DICHGAFEJ.本文对组建物理图谱的几种方法的优缺点进行了讨论。

关键词：物理图谱 EcoRI DNA 缺刻噬菌体枯草杆菌

直视支架象鼻手术治疗合并单发左侧椎动脉的BC型主动脉夹层

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中华胸心血管外科杂志 2017年第8期33卷 482-485页

作者：杨祎朱俊明葛翼鹏齐瑞东里程楠陈雷孙立忠首都医科大学附属北京安贞医院心血管外科北京市大血管疾病诊疗研究中心北京市心肺血管疾病研究所首都医科大学附属北京安贞医院 100029

目的总结直视支架象鼻手术治疗合并单发左侧椎动脉的Bc型主动脉夹层的临床结果。方法2009年2月至2016年9月，共12例合并单发左侧椎动脉的BC型夹层患者，急性7例，慢性5例，在中低温停循环选择性脑灌注下接受直视支架象鼻手术治疗。其中... 详细信息

目的总结直视支架象鼻手术治疗合并单发左侧椎动脉的Bc型主动脉夹层的临床结果。方法2009年2月至2016年9月，共12例合并单发左侧椎动脉的BC型夹层患者，急性7例，慢性5例，在中低温停循环选择性脑灌注下接受直视支架象鼻手术治疗。其中男11例，女1例，年龄（50．9±6．1）岁（42～59岁）。术前下肢缺血2例，肾功能不全1例。结果无手术死亡，1例术后出现永久性声音嘶哑。体外循环（143．1±26．3）min，选择性脑灌注（27．2±11．2）min。术前下肢缺血的2例患者，1例支架释放后改善，1例同期行升主动脉-右股动脉转流后改善。无截瘫＼卒中等神经系统并发症发生。随访6～92个月，平均（40．9±30．6）个月。随访期间无死亡，无神经系统并发症发生；2例因象鼻支架远端动脉瘤形成而分别接受胸主动脉腔内修复术和全胸腹主动脉替换术。结论直视支架象鼻手术治疗合并单发左侧椎动脉的BC型主动脉夹层可获得满意的中期临床效果。

关键词： Stanford B型主动脉夹层直视支架象鼻手术单发左侧椎动脉

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大尺蠖核型多角体病毒DNA和蛋白质的特性

武汉大学学报(自然科学版) 1988年第1期 121-127页

作者：黄永秀齐义鹏魏中一武汉大学病毒学系湖北农学院农学系

大尺蠖核型多角体病毒(BsNPV)是一个感染茶树害虫的杆状病毒。本实验所用多角体、病毒粒子、DNA都达到较好纯度。在SDS—PAGE照片和扫描图谱上,包涵体蛋白呈现7个多肽带,主要结构多肽的分子量(MW)为27.8k dalton,病毒粒子结构多肽为17种... 详细信息

大尺蠖核型多角体病毒(BsNPV)是一个感染茶树害虫的杆状病毒。本实验所用多角体、病毒粒子、DNA都达到较好纯度。在SDS—PAGE照片和扫描图谱上,包涵体蛋白呈现7个多肽带,主要结构多肽的分子量(MW)为27.8k dalton,病毒粒子结构多肽为17种,主要的有两种,MW分别为28.0k和31.3k dalton。BsNPV基因组为环状的dsDNA。用限制性核酸内切酶BamHⅠ,BglⅡ,xhoⅠ,HindⅢ,EcoRI消化,分别产生9,7,10,13和12条带。测出其基因组DNA平均长约为92kb,MW59.6×10~6 dalton。本文着重讨论了杆状病毒包涵体蛋白是由一种多肽还是几种多肽组成的问题。

关键词：杆状病毒 BsNPV DNA 限制性消化包涵体蛋白病毒粒子蛋白

Impact of solar cell failure on the performance of solar arrays in space

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Space Solar Power and Wireless Transmission

Space Solar Power and Wireless Transmission 2024年第2期1卷 108-114页

作者： qi Zhang Junyi Lin Naiying Fan yipeng qie Bin Su Tianjin Institute of Power Source Tianjin 300384China

Space solar power station adopts large-area solar arrays for efficient photovoltaic conversion,making it one of the best solutions to future energy ***-orbit failure of solar arrays can affect the service life of spacecraft,thereby it is crucial to comprehend the impact of solar cell failure on the electrical performance of solar arrays and propose appropriate circuit design *** root cause of solar array failure is the degeneration of solar *** this paper,power loss caused by an open circuit or short circuit failure of solar cells in pure parallel and series–parallel circuits is described,and it reveals that an open circuit of the cell is more harmful in the pure parallel circuit,while a short circuit in the series–parallel circuit is more detrimental,which causes loss of electrical performance in series and parallel units,*** conclusions have been validated through model calculations and corresponding *** electrical loss is also influenced by the control *** the Maximum Power Point Tracking control mode favored by space solar power station,which can significantly increase generated power,application suggestions have been proposed based on the results of cell failure *** research will provide a reference for circuit selection and boundary design for solar arrays,reducing the probability of solar array failure and saving the manufacturing and redeployment costs of space solar power station.

关键词： Space solar power station Space solar array Cell failure Maximum power point tracking

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煤气储罐泄漏扩散模型及仿真

华中科技大学学报（自然科学版） 2006年第4期34卷 42-44页

作者：龙长江齐欢张翼鹏华中科技大学系统工程研究所湖北武汉430074 武汉安全环保研究院湖北武汉430081

基于Fick扩散方程,建立了煤气储罐瞬间完全泄漏的无风情况下的动态扩散模型.根据气体储罐形状为圆柱,确定了介质瞬间完全泄漏后模型的初始条件和边界条件,然后通过坐标变换和傅立叶变换和适用于圆柱(Bessel)函数的Hankel变换,求出了此... 详细信息

基于Fick扩散方程,建立了煤气储罐瞬间完全泄漏的无风情况下的动态扩散模型.根据气体储罐形状为圆柱,确定了介质瞬间完全泄漏后模型的初始条件和边界条件,然后通过坐标变换和傅立叶变换和适用于圆柱(Bessel)函数的Hankel变换,求出了此条件下扩散方程的解析解.根据风力对扩散过程的影响,在无风扩散方程的基础上建立了有风条件下的扩散模型并求取了解析解,然后以一50000m3(r=19m,h=40m)煤气储罐完全破裂后的气体扩散过程为例进行了模拟,模拟结果验证了模型的有效性.

关键词：煤气储罐泄漏动态模型贝塞尔函数仿真

SRSF1 plays a critical role in invariant natural killer T cell development and function

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Cellular & Molecular Immunology 2021年第11期18卷 2502-2515页

作者： Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijingChina Key Laboratory of RNA Biology Institute of BiophysicsChinese Academy of SciencesBeijingChina Clinical Department College of Veterinary MedicineChina Agricultural UniversityBeijingChina Center for Discovery and Innovation Hackensack Meridian HealthNutleyNJUSA

Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)***,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long *** ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRα*** transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient ***1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and *** particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT ***,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of ***,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A *** findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease.

关键词： Invariant natural killer T cell SRSF1 Development Function Alternative splicing

Evaluation of menopausal status among breast cancer patients with chemotherapy-induced amenorrhea

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Chinese Journal of Cancer Research 2018年第4期30卷 468-476页

作者： Bailin Zhang Jinqi Wu Rongshou Zheng qian Zhang Margaret Zhuoer Wang Jun qi Haijing Liu yipeng Wang Yang Guo Feng Chen Jing Wang Wenyue Lyu Jidong Gao Yi Fang Wanqing Chen Xiang Wang Department of Breast Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Breast Surgery Cancer Hospital of Huanxing Chaoyang District Beijing Office for Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Pritzker School of Medicine University of Chicago Department of Clinical Laboratory National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Pharmacy Department Kailuan General Hospital Surgery Department Maternal and Child Health Care Hospital of Yanqing District Beijing Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Objective： In patients with chemotherapy-induced amenorrhea （CIA）, the menopausal status is ambiguous anddifficult to evaluate. This study aimed to establish a discriminative model to predict and classify the menopausalstatus of breast cancer patients with ***： This is a single center hospital-based study from 2013 to 2016. The menopausal age distribution andaccumulated incidence rate of CIA are described. Multivariate models were adjusted for established and potentialconfounding factors including age, serum concentration of estradiol （E2） and follicle-stimulating hormone （FSH）,feeding, pregnancy, parity, abortions, and body mass index （BMI）. The odds ratio （OR） and 95% confidenceinterval （95% CI） of different risk factors were ***： A total of 1,796 breast cancer patients were included in this study, among whom, 1,175 （65.42%） werepremenopausal patients and 621 （34.58%） were post-menopause patients. Five hundred and fifty patients wereincluded in CIA analysis, and a cumulative CIA rate of 81.64% was found in them. Age （OR： 1.856, 95% CI：1.732-1.990）, serum concentration of E2 （OR： 0.976, 95% CI： 0.972-0.980） and FSH （OR： 1.060, 95% CI：1.053-i.066）, and menarche age （OR： 1.074, 95% CI： 1.009-1.144） were found to be associated with the patients＇menopausal status. According to multivariate analysis, the discriminative model to predict the menopausal status isLogit （P）=-28.396＋0.536Age-0.014E2＋0.031FSH. The sensitivities for this model were higher than 85%, and itsspecificities were higher than 89%.Conclusions： The discriminative model obtained from this study for predicting menstrual state is important forpremenopausal patients with CIA. This model has high specificity and sensitivity and should be prudently used.

关键词： Breast neoplasms drug therapy amenorrhea menopause logistic models

Al-Mg合金超高频脉冲VP-GTAW电流参数优化

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稀有金属材料与工程 2018年第11期47卷 3522-3527页

作者：王义朋齐铂金从保强王强周阳北京航空航天大学航空高端装备智能制造工信部重点实验室北京100191

以铝镁系5A06铝合金为对象,开展了复合超高频脉冲变极性钨极气体保护电弧焊(Hybrid Ultrasonic Frequency Pulsed Variable Polarity Gas Tungsten Arc Wending, HPVP-GTAW)焊接电流参数优化研究。利用正交试验方法设计了焊接实验,以接... 详细信息

以铝镁系5A06铝合金为对象,开展了复合超高频脉冲变极性钨极气体保护电弧焊(Hybrid Ultrasonic Frequency Pulsed Variable Polarity Gas Tungsten Arc Wending, HPVP-GTAW)焊接电流参数优化研究。利用正交试验方法设计了焊接实验,以接头薄弱区的显微硬度为评价指标,以HPVP-GTAW焊接电流特征参数为影响因素,分别采用极差分析法和回归分析法对实验结果进行分析与讨论。结果表明,变极性电流频率fL、高频脉冲频率fH和脉冲电流比例系数ψ(定义为高频脉冲基值电流Ib、高频脉冲峰值电流Ip和脉冲占空比δ的综合作用)的最优参数匹配依次为1kHz、20kHz和0.6(Ib为75 A,Ip为180 A,δ为0.2)。fL对显微硬度影响最为显著,fH影响作用次之,ψ对显微硬度影响最弱。最优参数匹配的条件下,接头的显微硬度、抗拉强度、延伸率和断面延伸率分别达到母材性能的84.7%、94.3%、80%和93.4%。

关键词： 5A06铝合金超高频脉冲 VP-GTAW显微硬度参数优化