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Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis

Science China(Life Sciences) 2024年第5期67卷 913-939页

作者： Chinese Society of Cardiology,Chinese Medical Association,Writing Group Jiangang Jiang Hongyang Shu Dao Wen Wang Rutai Hui Chenze Li Xiao Ran Hong Wang Jing Zhang Shaoping Nie Guanglin Cui Dingcheng Xiang Qun Shao Shengyong Xu Discussion experts:Ning Zhou Yuming Li Wei Gao Yuguo Chen Yuan Bian Guoping Wang Liming Xia Yan Wang Chunxia Zhao Zhiren Zhang Yuhua Zhao Jianan Wang Shaoliang Chen Hong Jiang Jing Chen Xianjin Du Mao Chen yinxian sun Sheng Li Hu Ding Xueping Ma Hesong Zeng Li Lin Shenghua Zhou Likun Ma Ling Tao Juan Chen Yiwu Zhou Xiaomei Guo 不详 Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Zhongnan Hospital of Wuhan University Wuhan 430062China Fuwai Huazhong Cardiovascular Hospital Zhengzhou 450003China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010China Harbin Medical University Cancer Hospital Harbin 150081China Union Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Taida Hospital Tianjin 300457China Peking University Third Hospital Beijing 100191China Qilu Hospital of Shandong University Jinan 250012China Kanghua Hospital DongguanGuangzhou 523080China Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003China Nanjing First Hospital Nanjing Medical UniversityNanjing 210006China Renmin Hospital of Wuhan University Wuhan 430060Wuhan West China Hospital Sichuan UniversityChengdu 610044China First Hospital of China Medical University Shenyang 110002China General Hospital of Ningxia Medical University Yinchuan 750003China The Second Xiangya Hospital Central South UniversityChangsha 410012China The First Affiliated Hospital of USTC University of Science and Technology of ChinaHefei 230002China The First Affiliated Hospital of Air Force Medical University Xi’an 710032China Central Hospital of Wuhan City Wuhan 430014China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Fulminant myocarditis is an acute diffuse inflammatory disease of *** is characterized by acute onset,rapid progress and high risk of *** pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory *** to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term *** emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.

关键词： fulminant myocarditis guidelines life support-based comprehensive treatment regimen diagnosis treatment cytokine storm overactivation of immunity

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Stem cell homing-based tissue engineering using bioactive materials

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Frontiers of Materials Science 2017年第2期11卷 93-105页

作者： yinxian YU Binbin sun Chengqing YI Xiumei MO Department of Orthopaedic Surgery Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200080 China State Key Lab for Modification of Chemical Fibers & Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China

Tissue engineering focuses on repairing tissue and restoring tissue functions by employing three elements： scaffolds, cells and biochemical signals. In tissue engineering, bioactive material scaffolds have been used to cure tissue and organ defects with stem cell-based therapies being one of the best documented approaches. In the review, different biomaterials which are used in several methods to fabricate tissue engineering scaffolds were explained and show good properties （biocompatibility, biodegradability, and mechanical properties etc.） for cell migration and infiltration. Stem cell homing is a recruitment process for inducing the migration of the systemically transplanted cells, or host cells, to defect sites. The mechanisms and modes of stem cell homing-based tissue engineering can be divided into two types depending on the source of the stem cells： endogenous and exogenous. Exogenous stem cell-based bioactive scaffolds have the challenge of long-term culturing in vitro and for endogenous stem cells the biochemical signal homing recruitment mechanism is not clear yet. Although the stem cell homing-based bioactive scaffolds are attractive candidates for tissue defect therapies, based on in vitro studies and animal tests, there is still a long way before clinical application.

关键词： stem cell homing cell migration cell proliferation tissue engineering scaffold biochemical signals

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摩擦焊加热过程中变形层和高温区的扩展过程

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焊接学报 1984年第2期 11-18+57-58页

作者：才荫先孙松涛朱桂芝王玺哈尔滨焊接研究所

本文通过对45号钢摩擦加热过程的试验.研究了钢材加热过程中高速摩擦塑性变形层和高温区的扩展规律:摩擦加热开始时,变形层首先在距圆心1/2～2/3半径处的摩擦表面上形成,它是由塑性变形和机械挖掘的表面金属组成的环状加热带。随着摩擦... 详细信息

本文通过对45号钢摩擦加热过程的试验.研究了钢材加热过程中高速摩擦塑性变形层和高温区的扩展规律:摩擦加热开始时,变形层首先在距圆心1/2～2/3半径处的摩擦表面上形成,它是由塑性变形和机械挖掘的表面金属组成的环状加热带。随着摩擦时间的延长,环状加热带向圆心和外圆迅速扩展,摩擦表面全面加热以后,由热传导形成的高温区才显著加宽。摩擦加热扭矩峰值或功率峰值通常在表面加热到60～70%左右出现,而在全面加热以后才出现摩擦扭矩稳定值。环状加热带开始出现的位置、面积、厚度、扩展方向和速度与焊接工艺参数有关。达到扭矩峰值时环状加热带的温度达到700℃左右,出现稳定值以后温度可以达到1000℃以上。

关键词：摩擦焊厚度塑性变形范性变形摩擦加热摩擦表面高温区加热过程扩展过程

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Optimization, characterization and in vitro/vivo evaluation of azilsartan nanocrystals

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Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 344-352页

作者： Jingjing Ma yinxian Yang Yinghua sun Jin sun Shenyang Pharmaceutical University

Azilsartan(AZL), a poorly soluble drug, was considered to be fit for nanocrystals to improve its solubility. Our study intended to prepare AZL nanocrystals by means of bead milling method. Eight stabilizers or their binary combination and the milling time were set to be variable factors to optimize AZL nanosuspension formulation, and six types of freezedrying supports were investigated to reduce the aggregation of particles during the solidification. AZL nanocrystals with or without sodium deoxycholate(NaDC) as combined stabilizer with Poloxamer 188(F68) were prepared owning mean particle sizes of about 300 nm and 460 nm. During the screening processes, the formulation containing NaDC showed a smaller particle size and better stability during lyophilization. The irregular shape and crystal form changing in AZL nanocrystals were discovered by various characterizations. And with physical mixture as reference, nanocrystals showed its improvement about in-vitro dissolution and in-vivo bioavailability. In conclusion, the nanocrystals of AZL could be prepared well in our study. Additionally, our results suggested that NaDC was an appreciated excipient on the nanocrystals platform, which can exhibit the abilities of size-reduction and stabilitymaintaining on freeze-drying.

关键词： Azilsartan Nanocrystals Sodium deoxycholate Freeze drying Dissolution Oral bioavailability

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Iron-doxorubicin prodrug loaded liposome nanogenerator programs multimodal ferroptosis for efficient cancer therapy

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Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 784-793页

作者： yinxian Yang Shiyi Zuo Linxiao Li Xiao Kuang Jinbo Li Bingjun sun Shujun Wang Zhonggui He Jin sun Department of Pharmaceutics College of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

Ferroptosis is a new mode of cell death,which can be induced by Fenton reactionmediated lipid ***,the insufficient H2O2 and high GSH in tumor cells restrict the efficiency of Fenton reaction-dependent ***,a self-supplying lipid peroxide nanoreactor was developed to co-delivery of doxorubicin(DOX),iron and unsaturated lipid for efficient *** leveraging the coordination effect between DOX and Fe3+,trisulfide bond-bridged DOX dimeric prodrug was actively loaded into the core of the unsaturated lipids-rich liposome via iron ion gradient ***,Fe3+could react with the overexpressed GSH in tumor cells,inducing the GSH depletion and Fe2+***,the cleavage of trisulfide bond could also consume GSH,and the released DOX induces the generation of H2O2,which would react with the generated Fe2+in step one to induce efficient Fenton reaction-dependent ***,the formed Fe3+/Fe2+couple could directly catalyze peroxidation of unsaturated lipids to boost Fenton reaction-independent *** iron-prodrug liposome nanoreactor precisely programs multimodal ferroptosis by integrating GSH depletion,ROS generation and lipid peroxidation,providing new sights for efficient cancer therapy.

关键词： Ferroptosis Iron Liposome Redox Prodrug

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Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

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Asian Journal of Pharmaceutical Sciences 2021年第3期16卷 337-349页

作者： Lingxiao Li Shiyi Zuo Fudan Dong Tian Liu Yanlin Gao yinxian Yang Xin Wang Jin sun Bingjun sun Zhonggui He Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

Homodimeric prodrug-based self-assembled nanoparticles,with carrier-free structure and ultrahigh drug loading,is drawing more and more *** prodrugs are composed of two drug molecules and a pivotal *** influence of the linkages on the self-assembly,in vivo fate and antitumor activity of homodimeric prodrugs is the focus of ***,three docetaxel(DTX)homodimeric prodrugs are developed using different lengths of diselenide bond-containing ***,compared with the other two linkages,the longest diselenide bond-containing linkage could facilitate the self-delivery of DTX prodrugs,thus improving the stability,circulation time and tumor targeting of prodrug ***,the extension of linkages reduces the redox-triggered drug release and cytotoxicity of prodrug nanoassemblies in tumor *** the longest diselenide bond-containing prodrug nanoassemblies possessed the lowest cytotoxicity to 4T1 cells,their stable nanostructure maintained intact during circulation and achieve the maximum accumulation of DTX in tumor cells,which finally“turned the table”.Our study illustrates the crucial role of linkages in homodimeric prodrugs,and gives valuable proposal for the development of advanced nano-DDS for cancer treatment.

关键词： Diselenide bond Homodimeric prodrug Docetaxel Self-assembly Redox responsive

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Experimental study of density pump-out on EAST

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Plasma Science and Technology 2017年第1期19卷 36-43页

作者： Shouxin WANG Haiqing LIU yinxian JIE Qing ZANG Bo LYU Tao ZHANG Long ZENG Shoubiao ZHANG Nan SHI Ting LAN Zhiyong ZOU Weiming LI Yuan YAO Xuechao WEI Hui LIAN Gen LI Handong XU Xinjun ZHANG Bin WU Youwen sun EAST Team Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 People's Republic of China University of Science and Technology of China Hefei 230026 People's Republic of China Tianjin University of Technology Tianjin 300384 People's Republic of China

In the experimental advanced superconducting tokamak,density pump-out phenomena were observed by using a multi-channel polarimeter-interferometer system under different heating schemes of ion cyclotron resonant heating,electron cyclotron resonance heating,and neutral beam *** density pump-out was also induced with application of resonant magnetic perturbation,accompanied with a degradation of particle *** the comparison analysis in all heating schemes,the typical plasma parameters are plasma current 400 k A,toroidal field 2 T,and line average density 2×10^19m^-*** experimental results show that the degree of pump-out is concerned with electron density and heating *** density deuterium low confinement（L-mode） plasmas（〈3.5×10^19m^-3） show strong pump-out *** density pump-out correlated with a significant drop of particle confinement.

关键词： density pump-out particle confinement ECRH ICRF NBI RMP

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携载FGF2基因的改性壳聚糖微球促进兔桡骨骨缺损修复的研究

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组织工程与重建外科杂志 2020年第2期16卷 81-86页

作者：陈胤贤蒋健一赵宇孙军安徽医科大学附属省儿童医院骨科安徽省合肥市230041

目的研究携载FGF2基因的改性壳聚糖微球在体内促进兔桡骨临界骨缺损愈合过程中的作用。方法以羟丁基壳聚糖(HBC)、巯基烷基化壳聚糖(TACS)与pFGF2质粒制备HBC@TACS-pFGF2微球,体外与BMSCs共培养。Western-blot检测FGF2蛋白表达水平,CCK... 详细信息

目的研究携载FGF2基因的改性壳聚糖微球在体内促进兔桡骨临界骨缺损愈合过程中的作用。方法以羟丁基壳聚糖(HBC)、巯基烷基化壳聚糖(TACS)与pFGF2质粒制备HBC@TACS-pFGF2微球,体外与BMSCs共培养。Western-blot检测FGF2蛋白表达水平,CCK8检测细胞增殖情况,PCR检测ALP mRNA和CD31 mRNA的表达情况。动物实验选用15只新西兰兔,手术建立双侧桡骨中段18 mm骨缺损模型,左侧植入明胶海绵和HBC@TACS-pFGF2微球(实验组,n=15),右侧不作植入(对照组,n=15)。移植术后第4周、8周、12周收集标本分别进行大体观察、X线检查和Masson染色。结果HBC@TACS-pFGF2微球体外可促进BMSCs增殖,并可显著提高ALP和CD31的表达。动物实验显示,术后4周、8周、12周时,实验组兔桡骨缺损处的断端桥接情况、骨密度以及新生骨矿化程度均优于对照组。结论含pFGF2质粒的HBC@TACS-pFGF2微球可在体内促进兔桡骨临界骨缺损修复。

关键词：壳聚糖基因治疗骨缺损碱性成纤维细胞生长因子

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家兔皮肤真菌病的病原分离与鉴定

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中国人兽共患病杂志 2000年第5期16卷 69-71页

作者：孙融冰杜文金黄引贤青岛农业部动物检疫所 266032 华南农业大学动物医学系

通过对采自广东省 7个发生皮肤真菌病兔场的 146份病料的直接镜检 ,分离培养和生化试验 ,初步鉴定病原真菌有 2个属 3个种和 4个型即 :石膏样毛癣菌 (Ⅰ型 ,Ⅲ型 ,Ⅴ型 ) ,黄癣菌 (许兰氏原型 )及念珠菌属的热带念珠菌 ,未分类

关键词：皮肤真菌病石膏样毛癣菌黄癣菌热带念珠菌

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多学科合作延续护理应用于乳腺癌患者中的效果

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中外医学研究 2020年第13期18卷 111-113页

作者：李银仙何兰满中山大学附属第五医院广东珠海519000

目的:探讨多学科合作延续护理应用于乳腺癌患者中的效果。方法:将2018年1月-2019年2月笔者所在医院收治的86例乳腺癌患者按照随机数字法分为两组,对照组43例予以常规出院指导,研究组43例予以多学科合作延续护理。比较两组抑郁自评量表(S... 详细信息

目的:探讨多学科合作延续护理应用于乳腺癌患者中的效果。方法:将2018年1月-2019年2月笔者所在医院收治的86例乳腺癌患者按照随机数字法分为两组,对照组43例予以常规出院指导,研究组43例予以多学科合作延续护理。比较两组抑郁自评量表(SDS)、焦虑自评量表(SAS)、多维度的Piper疲乏修订量表(PFS-R)、Herth希望量表(HHI)、乳腺癌患者特异量表评分。结果:两组干预前SDS、SAS、PFS-R、HHI、乳腺癌患者特异量表评分比较,差异均无统计学意义(P>0.05);干预后两组SDS、SAS、PFS-R评分均较干预前显著降低,HHI、乳腺癌患者特异量表评分均较干预前显著升高,且研究组改善幅度显著优于对照组,差异均有统计学意义(P<0.05)。结论:将多学科合作延续护理应用于乳腺癌患者中可显著改善其心理状态及癌因疲乏程度,提高希望水平及生活质量。

关键词：乳腺癌多学科合作延续护理癌因疲乏希望水平

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