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Iron-doxorubicin prodrug loaded liposome nanogenerator programs multimodal ferroptosis for efficient cancer therapy

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Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 784-793页

作者： yinxian yang Shiyi Zuo Linxiao Li Xiao Kuang Jinbo Li Bingjun Sun Shujun Wang Zhonggui He Jin Sun Department of Pharmaceutics College of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

Ferroptosis is a new mode of cell death,which can be induced by Fenton reactionmediated lipid ***,the insufficient H2O2 and high GSH in tumor cells restrict the efficiency of Fenton reaction-dependent ***,a self-supplying lipid peroxide nanoreactor was developed to co-delivery of doxorubicin(DOX),iron and unsaturated lipid for efficient *** leveraging the coordination effect between DOX and Fe3+,trisulfide bond-bridged DOX dimeric prodrug was actively loaded into the core of the unsaturated lipids-rich liposome via iron ion gradient ***,Fe3+could react with the overexpressed GSH in tumor cells,inducing the GSH depletion and Fe2+***,the cleavage of trisulfide bond could also consume GSH,and the released DOX induces the generation of H2O2,which would react with the generated Fe2+in step one to induce efficient Fenton reaction-dependent ***,the formed Fe3+/Fe2+couple could directly catalyze peroxidation of unsaturated lipids to boost Fenton reaction-independent *** iron-prodrug liposome nanoreactor precisely programs multimodal ferroptosis by integrating GSH depletion,ROS generation and lipid peroxidation,providing new sights for efficient cancer therapy.

关键词： Ferroptosis Iron Liposome Redox Prodrug

Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

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Asian Journal of Pharmaceutical Sciences 2021年第3期16卷 337-349页

作者： Lingxiao Li Shiyi Zuo Fudan Dong Tian Liu Yanlin Gao yinxian yang Xin Wang Jin Sun Bingjun Sun Zhonggui He Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

Homodimeric prodrug-based self-assembled nanoparticles,with carrier-free structure and ultrahigh drug loading,is drawing more and more *** prodrugs are composed of two drug molecules and a pivotal *** influence of the linkages on the self-assembly,in vivo fate and antitumor activity of homodimeric prodrugs is the focus of ***,three docetaxel(DTX)homodimeric prodrugs are developed using different lengths of diselenide bond-containing ***,compared with the other two linkages,the longest diselenide bond-containing linkage could facilitate the self-delivery of DTX prodrugs,thus improving the stability,circulation time and tumor targeting of prodrug ***,the extension of linkages reduces the redox-triggered drug release and cytotoxicity of prodrug nanoassemblies in tumor *** the longest diselenide bond-containing prodrug nanoassemblies possessed the lowest cytotoxicity to 4T1 cells,their stable nanostructure maintained intact during circulation and achieve the maximum accumulation of DTX in tumor cells,which finally“turned the table”.Our study illustrates the crucial role of linkages in homodimeric prodrugs,and gives valuable proposal for the development of advanced nano-DDS for cancer treatment.

关键词： Diselenide bond Homodimeric prodrug Docetaxel Self-assembly Redox responsive

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基于空间支持向量域分类器的人脸识别

计算机工程与应用 2011年第2期47卷 176-178页

作者：杨定礼严石杨银贤淮阴工学院电子信息工程系江苏淮安223003 冻南大学信息科学与工程学院南京210096

提出了一种基于小波变换、奇异值分解与空间支持向量域分类器相结合的人脸识别方法。在使用空间支持向量分类器对不同人脸图像的奇异特征向量进行分类时,计算所测样本到各个超球球心的距离,并根据其与超球半径的关系来判断其所归属。并... 详细信息

提出了一种基于小波变换、奇异值分解与空间支持向量域分类器相结合的人脸识别方法。在使用空间支持向量分类器对不同人脸图像的奇异特征向量进行分类时,计算所测样本到各个超球球心的距离,并根据其与超球半径的关系来判断其所归属。并在ORL人脸数据库中进行实验。实验表明提出的人脸识别方法识别精度可达97.5%。

关键词：空间支持向量域分类器奇异值分解人脸识别

A fringe jump counting method for the phase measurement in the HCN laser interferometer on EAST and its FPGA-based implementation

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Plasma Science and Technology 2024年第4期26卷 156-161页

作者：姚远杨曜提昂宋扬张家敏王琰张耀刘海庆揭银先 Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Anhui Electrical Engineering Professional Technique College Hefei 230022People’s Republic of China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601People’s Republic of China

Electron density in fusion plasma is usually diagnosed using laser-aided interferometers. The phase difference signal obtained after phase demodulation is wrapped, which is also called a fringe jump. A method has been developed to unwrap the phase difference signal in real time using FPGA, specifically designed to handle fringe jumps in the hydrogen cyanide(HCN) laser interferometer on the EAST superconducting tokamak. This method is designed for a phase demodulator using the fast Fourier transform(FFT) method at the front end. The method is better adapted for hardware implementation compared to complex mathematical analysis algorithms, such as field programmable gate array(FPGA). It has been applied to process the phase measurement results of the HCN laser interferometer on EAST in real time. Electron density results show good confidence in the fringe jump unwrapping method. Further possible application in other laser interferometers, such as the POlarimeter-INTerferometer(POINT)system on EAST tokamak is also discussed.

关键词： electron density laser-aided interferometer fringe jump unwrapping FPGA EAST

Geochemical characteristics and environmental implications of loess sequences in the Loess Plateau

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High Technology Letters 2024年第3期30卷 310-321页

作者： ZHANG Jialin ZHAO Zhongqiang XIA Dinghong LI Zhenyang ZENG Liyuan HE Hongming SONG yinxian CHEN Zhong School of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093P.R.China Key Laboratory of Geological Disaster Prediction and Early Warning and Ecological Protection and Restoration of Plateau Mountain Ministry of Natural ResourcesKunming 650093P.R.China Yunnan Key Laboratory of Geological Disaster Prediction and Warning and Ecological Protection and Restoration of Plateau and Mountain Kunming 650093P.R.China School of Geographical Sciences East China Normal UniversityShanghai 200241P.R.China Institute of Soil and Water Conservation Ministry of Water ResourcesChinese Academy of SciencesYangling 712100P.R.China

The major,trace,and rare earth elements of the Duanjiapo(DJP)section in the south of the Loess Plateau,the Jiaxian(JX)section in the north,and the Jiuzhoutai(JZT)section in the west are *** results show that the main elemental characteristics of loess in three profiles are consistent with the upper continental crust(UCC).In terms of trace elements,Th,Nb,Zr,Hf,Y,Cs,W,Cr,V,Li,and Pb show relative enrichment compared with UCC;Rb,Ba,Sr and Be exhibit relative *** average ofΣREE is 171.91ppm with a negative anomaly forδEu and essentially no anomaly forδ*** results of K_(2)O/Na_(2)O,Rb/Sr ratios,as well as the leaching co-efficient from three profiles,indicate DJP>JX>JZT,suggesting that DJP experiences the strongest weathering leaching *** chemical index of alteration(CIA)reveals that all three profiles of loess are in the primary stage of Ca and Na *** is generally in the early to moderate stage of chemical weathering,while JX and JZT are both in the early stage.

关键词： loess chemical weathering element geochemistry chemical index of alteration(CIA)

Forward modelling of the Cotton-Mouton effect polarimetry on EAST tokamak

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Plasma Science and Technology 2024年第3期26卷 100-117页

作者：沈敏勇张际波张耀揭银先刘海庆谢锦林丁卫星 School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026People's Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China

Measurement of plasma electron density by far-infrared laser polarimetry has become a routine and indispensable tool in magnetic confinement fusion *** article presents the design of a Cotton-Mouton polarimeter interferometer,which provides a reliable density measurement without fringe ***-Mouton effect on Experimental Advanced Superconducting Tokamak(EAST)is studied by Stokes equation with three parameters(s_(1),s_(2),s_(3)).It demonstrates that under the condition of a small Cotton-Mouton effect,parameter s_(2)contains information about Cotton-Mouton effect which is proportional to the line-integrated *** a typical EAST plasma,the magnitude of Cotton-Mouton effects is less than 2πfor laser wavelength of 432μ*** effect due to density gradient is calculated to be *** modulation of Stokes parameters(s_(2),s_(3))provides heterodyne *** to the instabilities arising from laser oscillation and beam refraction in plasmas,it is necessary for the system to be insensitive to variations in the amplitude of the detection ***,it is shown that non-equal amplitude of X-mode and O-mode within a certain range only affects the DC offset of Stokes parameters(s_(2),s_(3))but does not greatly influence the phase measurements of Cotton-Mouton effects.

关键词： EAST Cotton-Mouton effect polarimeter interferometer electron density measurement Stokes vector

Real-time data processing method for CO_(2) dispersion interferometer on EAST

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Plasma Science and Technology 2024年第8期26卷 121-126页

作者：张家敏姚远刘郁阳储宇奇阮天翼张耀刘海庆揭银先凌必利 Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China University of California Los Angeles Los AngelesCalifornia 90095United States of America

A real-time data processing system is designed for the carbon dioxide dispersion interferometer(CO_(2)-DI)on *** system utilizes the parallel and pipelining capabilities of an fieldprogrammable gate array(FPGA)to digitize and process the intensity of signals from the ***,the real-time electron density signals are exported through a digital-to-analog converter(DAC)module in the form of analog *** system has been successfully applied in the CO_(2)-DI system to provide low-latency electron density input to the plasma control system on *** results of the latest campaign with long-pulse discharges on EAST(2022–2023)demonstrate that the system can respond effectively in the case of rapid density changes,proving its reliability and accuracy for future electron density calculation.

关键词： dispersion interferometer real-time electron density FPGA EAST

First results of CO_(2) dispersion interferometer on EAST tokamak

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Plasma Science and Technology 2024年第3期26卷 76-82页

作者：刘郁阳李维明姚远张耀张家敏连辉洪博王守信揭银先刘海庆 Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230031People's Republic of China

A dispersion interferometer(DI)has been installed and operates on the Experimental Advanced Superconducting Tokamak(EAST).This DI system utilizes a continuous-wave 9.3μm CO_(2)laser source to measure line-averaged electron densities *** contrast to conventional interferometers,the DI does not require substantial vibration isolations or compensating systems to reduce the impact of vibrations in the optical *** also employs a ratio of modulation amplitudes,ensuring it remains immune to the variations in detected *** a variation compensation system,the DI system on EAST reaches a density resolution of less than1.8×10^(-2)πrad and a temporal resolution of 20μ*** measurements made by the POlarimeterINTerferometer(POINT)system and the far-infrared hydrogen cyanide(HCN)interferometer are remarkably consistent with the DI’s *** possibility of fringe jumps and the impact of refraction in high-density discharge can be significantly decreased using a shorter wavelength laser source.A rapid density change of 3×10^(19)m^(-3)during 0.15 s has been measured accurately in shot No.114755 of ***,the DI system demonstrates dependability and stability under 305 s long-pulse discharges in shot No.122054.

关键词： dispersion interferometer(DI) electron density plasma diagnostics Experimental Advanced Superconducting Tokamak(EAST)

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噬菌体用于关节假体周围感染治疗的研究进展

中华关节外科杂志（电子版） 2024年第1期18卷 125-130页

作者：杨友涵文印宪陈廖斌武汉大学关节疾病研究中心武汉大学中南医院关节与运动医学科430071

关节假体周围感染(PJI)是关节置换术后的严重并发症。药物治疗是目前PJI治疗的基础，但由于生物膜的屏障作用及耐药机制的存在，目前PJI的药物治疗效果仍不尽满意。近年来，噬菌体疗法受到越来越多人的关注，其在PJI治疗中的应用逐渐受... 详细信息

关节假体周围感染(PJI)是关节置换术后的严重并发症。药物治疗是目前PJI治疗的基础，但由于生物膜的屏障作用及耐药机制的存在，目前PJI的药物治疗效果仍不尽满意。近年来，噬菌体疗法受到越来越多人的关注，其在PJI治疗中的应用逐渐受到重视并涌现出一些新的研究思路和进展。噬菌体是自然存在的病毒，专门攻击和裂解细菌，对生物膜中的细菌也具有杀灭作用，且对细菌种类具有高度特异性而不影响人体微生物群。本文从生物膜的形成及耐药机制、噬菌体的生物类型及其杀菌机制、噬菌体对PJI的诊断作用、噬菌体治疗PJI的优势及限制以及噬菌体治疗PJI的临床进展等方面对噬菌体用于PJI治疗的研究进展进行综述，以求为PJI的治疗提供更多的启发。

关键词：人工关节感染细菌噬菌体生物膜治疗学综述