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Revisiting the upper eyelid blepharoplasty advancement flap:adaptation for the repair of full-thickness upper eyelid defects—a case series

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Annals of Eye Science 2022年第4期7卷 77-83页

作者： yinon shapira Katja Ullrich Raman Malhotra Andre S.Litwin Corneoplastic Unit Queen Victoria Hospital NHS TrustEast GrinsteadWest SussexUK

A blepharoplasty flap has been previously reported as a useful reconstruction approach for anterior lamellar defects lying between the lash line and the eyelid *** herein describe a variation of the blepharoplasty flap and suggest its use as an adjunct in the reconstruction of full-thickness lateral upper eyelid *** description and retrospective interventional case *** reconstruction technique was used by an experienced oculoplastics surgeon(ASL)in 3 adults with malignant lesions involving the lateral upper eyelid margin,resulting in a post-excision 50%full-thickness defect between November 2017 and June *** posterior lamella was reconstructed using an ipsilateral free tarsal graft and an inferiorly hinged transposition periosteal *** anterior lamella reconstruction was then performed using a local advancement flap utilizing the principles of upper blepharoplasty and Burow’s *** full eyelid excursion and full gentle closure were evident at 1–2 weeks follow-up in all three *** case later developed 1–2 mm of gentle closure lagophthalmos and was managed successfully with topical *** all patients,the final eyelid contour and symmetry were adequate,with only minimal scarring,evident already 3 to 4 months *** were no major complications or need for *** technique described herein highlights the utility of the blepharoplasty flap for lateral,full-thickness upper eyelid *** logical variation enables the reconstruction of significant defects using only local tissue,obeying the“like with like”principle,and helps avoid the need for a bridging *** provide preliminary evidence of the potential of a good cosmetic outcome of upper lid appearance and contour,together with a fast recovery of appropriate eyelid function.

关键词： Upper eyelid defect reconstruction blepharoplasty flap tarsal graft periosteal flap case series

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Vitamin D and autoimmune thyroid diseases

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Cellular & Molecular Immunology 2011年第3期8卷 243-247页

作者： Shaye Kivity Nancy Agmon-Levin Michael Zisappl yinon shapira Endre V Nagy Katalin Danko Zoltan Szekanecz Pnina Langevitz Yehuda Shoenfeld The Zabludovicz Center for Autoimmune Diseases Sheba Medical CenterTel-Hashomeraffiliated to Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Medicine‘A&C’ Sheba Medical CenterTel-HashomerIsrael Rheumatic Disease Unit Sheba Medical CenterTel-HashomerIsrael Department of Medicine‘B’ Sheba Medical CenterTel-HashomerIsrael University of Debrecen.Medical and Health Science Center DebrecenHungary Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases Tel Aviv UniversityTel AvivIsrael

The role of vitamin D as an immune modulator has been emphasized in recent years,and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus *** D mediates its effect though binding to vitamin D receptor(VDR),and activation of VDR-responsive *** VDR gene polymorphism was found to associate with autoimmune thyroid diseases(AITDs),few studies examined levels of vitamin D in these patients and those that did yielded conflicting *** therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy *** vitamin D(25-OH)levels were measured in 50 patients with AITDs,42 patients with non-AITDs and 98 healthy subjects,utilizing the LIAISON chemiluminescence immunoassay(DiaSorin,Saluggia,Italy).VitaminD deficiency was designated at levels lower than 10 ng/*** antibodies,thyroid functions and demographic parameters were evaluated in all *** prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals(72% versus 30.6%;P<0.001),as well as in patients with Hashimoto’s thyroiditis compared to patients with non-AITDs(79% versus 52%;P<0.05).Vitamin D deficiency also correlated to the presence of antithyroid antibodies(P=0.01)and abnormal thyroid function tests(P=0.059).Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests,suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation.

关键词： autoantibodies autoimmune thyroid disease Graves’disease Hashimoto’s thyroiditis vitamin D

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Nonlinear optical holograms for spatial and spectral shaping of light waves

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Science Bulletin 2015年第16期60卷 1403-1415页

作者： Asia shapira Liran Naor Ady Arie Department of Physical Electronics School of Electrical Engineering Tel Aviv University

Shaping either the spatial or the spectral output of a nonlinear interaction is accomplished by introducing basic concepts of computer-generated holography into the nonlinear optics regime. The possibilities of arbitrarily spatially shaping the result of a nonlinear interaction are presented for different phase-matching schemes allowing for both one- and two-dimensional shaping. Shaping the spectrum of a beam in nonlinear interaction is also possible by utilizing similar holographic techniques. The novel and complete control of the output of a nonlinear interaction opens exciting options in the fields of particle manipulation, optical communications, spectroscopy and quantum information.

关键词： Nonlinear optics Beam shaping Spectral shaping Computer-generated holograms

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Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

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Neural Regeneration Research 2018年第5期13卷 817-818页

作者： Ronit shapira Shai Efrati Uri Ashery Department of Neurobiology the George S. Wise Faculty of Life Sciences Tel Aviv University Sackler School of Medicine Tel Aviv University Sagol Center for Hyperbaric Medicine & Research Assaf Harofeh Medical Center Sagol School of Neuroscience Tel Aviv University

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease（AD）：Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the *** ... 详细信息

关键词： Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease AD

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Effect of distinct psychological interventions on changes in selfreported distress,depression and loneliness among older adults during COVID-19

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World Journal of Psychiatry 2022年第7期12卷 970-981页

作者： Stav shapira Daphna Yeshua-Katz Orly Sarid School of Public Health Ben-Gurion University of the NegevBeer Sheva 8410501Israel The Spitzer Department of Social Work Ben-Gurion University of the NegevBeer Sheva 8410501Israel

BACKGROUND Older adults have been considered a primary at-risk population during the coronavirus disease 2019(COVID-19)pandemic,and many efforts have been and still are directed toward supporting them and enhancing their capacity to cope with the *** shows that by enhancing proactive coping abilities through psychological interventions,in which cognitive-behavioral and mindfulness techniques are taught and practiced effectively,these interventions have supported older adults throughout the ***,the underlying mechanisms by which specific intervention components affect various mental states such as distress,depression and loneliness among older adults remain unclear and warrant *** To determine the effect of an intervention using cognitive-behavioral and mindfulness techniques on changes in distress,depression and *** We performed a secondary analysis on data from a previous study in which community-dwelling older adults attended a short-term,internet-based intervention during the first COVID-19 wave in *** intervention included seven sessions during which various cognitive-behavioral and mindfulness techniques were learned and ***-session changes in psychological distress were measured using the Subjective Units of Distress Scale(SUDS),which participants rated at the beginning and end of each *** also filled out questionnaires that evaluated levels of depression[Patient Health Questionnaire(PHQ-9)]and loneliness(UCLA loneliness Scale)prior to and after the entire intervention *** effect of in-session changes in the SUDS on changes in post-intervention depression and loneliness levels were assessed,as a proxy for distinct technique *** The findings indicated in-session differences in terms of a decrease in psychological distress(SUDS).Sessions that included relaxation exercises and guided imagery,as well as sessions that included cognitive restructuring a

关键词： COVID-19 Depression Loneliness Aged Cognitive behavioral therapy Subjective Units of Distress Scale Intervention studies

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Protection against Covid-19 by BNT162b2 Booster across Age Groups

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四川生理科学杂志 2021年第10期43卷 1810-1810页

作者： yinon M Bar-On From the Department of Plant and Environmental Sciences Weizmann Institute of Science Rehovot (Y.M.B.-O. R.M.) Technion-Israel Institute of Technology Haifa (Y.G.) the Department of Statistics and Data Science Hebrew University of Jerusalem (M.M.) and Israel Ministry of Health (O.B. S.A.-P. N.A.) Jerusalem the Biostatistical and Biomathematical Unit Gertner Institute for Epidemiology and Health Policy Research Sheba Medical Center Ramat Gan (L.F. A.H.) and the Sackler Faculty of Medicine Tel Aviv University Tel Aviv (L.F. A.H.) - all in Israel.

Background:After promising initial results from the administration of a third(booster)dose of the BNT162b2 messenger RNA vaccine(Pfizer-BioNTech)to persons 60 years of age or older,the booster campaign in Israel was gradually expanded to persons in younger age groups who had received a second dose at least 5 months ***:We extracted data for the period from July 30 to October 10,2021,from the Israel Ministry of Health database regarding 4,696,865 persons 16 years of age or older who had received two doses of BNT162b2 at least 5 months *** the primary analysis,we compared the rates of confirmed coronavirus disease 2019(Covid-19),severe illness,and death among those who had received a booster dose at least 12 days earlier(booster group)with the rates among those who had not received a booster(nonbooster group).In a secondary analysis,we compared the rates in the booster group with the rates among those who had received a booster 3 to 7 days earlier(early postbooster group).We used Poisson regression models to estimate rate ratios after adjusting for possible confounding factors.

关键词： Israel younger founding

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中国科研成果的引用增长是否存在“俱乐部效应”?

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财经研究 2016年第10期42卷 94-107页

作者：唐莉 Philip shapira Jan Youtie 上海财经大学公共经济与管理学院上海200433 佐治亚理工公共政策学院亚特兰大30308 曼彻斯特大学商学院企业创新研究所亚特兰大30308

越来越多的实证数据显示,中国科研发表的被引频次正在迅速上升。不同的解释相继提出。本研究探讨了另一种可能性——中国研究的被引频次激增是否存在"俱乐部效应",(2)即高影响力的中国科研论文会有更高的内部援引率。以纳米技术这一交... 详细信息

越来越多的实证数据显示,中国科研发表的被引频次正在迅速上升。不同的解释相继提出。本研究探讨了另一种可能性——中国研究的被引频次激增是否存在"俱乐部效应",(2)即高影响力的中国科研论文会有更高的内部援引率。以纳米技术这一交叉新兴领域作为研究素材,我们发现中国高被引论文在个体、科研机构以及国家三个层次上较大比例的引用来源于内部网络。描述性和统计检验表明,与美国同类论文相比,中国高被引论文的内部引用更为显著。文末就该"俱乐部现象"进行了诠释并提出相关政策建议。

关键词：科研评估科技政策互引俱乐部引文分析

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基于科学计量的中国人工智能区域知识创新生态系统研究

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中国科技论坛 2021年第8期 90-100页

作者：岳晓旭苏竣 Philip shapira 谢其军清华大学公共管理学院北京100084 曼彻斯特大学联盟商学院曼彻斯特M139PL 佐治亚理工学院公共政策学院亚特兰大GA 30332-0345

本文在提出新兴技术知识创新生态系统研究方法的基础上,选择中国人工智能产业作为案例,以期为中国人工智能区域发展提供政策建议。本文首先建立一个分析框架,以研究新兴技术知识创新生态系统,并使用科学计量学研究方法和社会网络分析方... 详细信息

本文在提出新兴技术知识创新生态系统研究方法的基础上,选择中国人工智能产业作为案例,以期为中国人工智能区域发展提供政策建议。本文首先建立一个分析框架,以研究新兴技术知识创新生态系统,并使用科学计量学研究方法和社会网络分析方法来研究中国人工智能知识创新生态系统。本文主要分析中国人工智能创新过程中的主要参与者,人工智能知识创新的区域分布,核心区域创新集群以及其形成的过程;并从社会网络角度分析参与者在集群形成过程中扮演的角色和他们之间的关系。结果表明,中国人工智能知识创新集群已经广泛出现,受科技资源分布影响明显,地理邻近性仅在同一行政区范围内明显,区域协同发展战略和地方政府的创新发展政策有助于帮助区域打破行政界限,实现人工智能领域的区域协同创新。

关键词：区域创新生态新兴技术人工智能社会网络分析

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Recombinant human luteinizing hormone supplementation may improve embryo quality in in vitro fertilization/intracytoplasmic sperm injection cycles with gonadotropin-releasing hormone antagonist protocol

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Open Journal of Obstetrics and Gynecology 2011年第2期1卷 31-35页

作者： Amir Wiser Ariel Hourvitz Yoav yinon Jacob Levron Jehoshua Dor Shai Elizur 不详

Objective: To evaluate the effects of recombinant LH (rLH) supplementation on embryo quality in IVF/ICSI cycles with GnRH antagonist. Study design: Prospective, randomized controlled study. Thirty women were enrolled, 15 in the study (FSH + rLH) group and 15 in the control (rFSH only) group. On the day GnRH antagonist was started, the study group patients received 75 IU of rLH in addition to rFSH. The main outcome measures were embryo quality, number of oocytes retrieved, and fertilization rate. Results: The rLH group had significantly more top-quality embryos (36/43, 84%) compared to the control group (40/68, 59%;p = 0.006). Fertilization rates and number of oocytes retrieved were similar between groups. Progesterone and estradiol (E2) concentrations in follicular fluid were higher in the study group compared to controls (16.5 ± 2.5 μg/ml vs. 11.4 ± 3.6 μg/ml progesterone, P = 0.07;and 687 ± 112 pg/ml vs. 471 ± 65 pg/ml E2, p = 0.08). Conclusion: Adding rLH to ovarian stimulation with GnRH antagonist can yield higher quality embryos.

关键词： Recombinants LH Antagonist Protocol Embryo Quality IVF Treatment

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Dose-Dense Regimen of Cisplatin and Infusional Fluorouracil in Advanced Gastric Cancer—A Single Institution Experience

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Journal of Cancer Therapy 2013年第2期4卷 529-535页

作者： Ofer Purim Yulia Kundel Roni shapira Baruch Brenner Institute of Oncology Chaim Sheba Medical Center Tel Hashomer Israel Institute of Oncology Davidoff Center Rabin Medical Center Petach Tiqwa and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

Chemotherapy with continuous infusion of 5-fluorouracil and cisplatin in a monthly schedule is one of the most common regimens in the treatment of advanced gastric cancer. In this study, we evaluated the efficacy and safety of a dosedense administration of this regimen in this patient population. Sixty-six consecutive patients with previously untreated histologically confirmed unresectable or metastatic gastric adenocarcinoma were treated with a 2-hour infusion of cisplatin 100 mg/m2 followed by continuous infusion of 5-fluorouracil 1000 mg/m2/day for 5 days, every 21 days. The most common grade ≥3 toxicities were fatigue (42%), nausea/vomiting (30%) and leucopenia (12%). Four patients (6%) died from treatment-related toxicity. The response rate was 35%, the median progression-free survival was 4.3 months and the median survival was 5.9 months. In light of these results, the dose-dense approach seems to offer little, if any, benefit compared with the standard regimens.

关键词： Gastric Cancer Dose-Dense Cisplatin Fluorouracil

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