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Flexible,high-density,laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy

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Bio-Design and manufacturing 2024年第4期7卷 388-398页

作者： Yafeng Liu Zhouheng Wang Yang Jiao Ying Chen Guangyuan Xu yinji ma Xue Feng Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Laboratory of Flexible Electronics Technology Tsinghua UniversityBeijing 100084China College of Artificial Intelligence Southwest UniversityChongqing 400715China Institute of Flexible Electronics Technology of THU Jiaxing 314000China Qiantang Science and Technology Innovation Center Hangzhou 310016China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China

High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer *** entails connecting hundreds or thousands of electrode wires on a limited *** study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode *** challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology *** flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic *** minimum spacing between electrodes was 15μm,comparable to the diameter of a single *** hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter *** flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.

关键词： Electrocorticogram(ECoG)electrode Epilepsy High density High resolution Laminated structure

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Design theory and dynamic mechanical characterization of the deployable composite tube hinge

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Science China(Physics,Mechanics & Astronomy) 2011年第4期54卷 633-639页

作者： YAO XueFeng ma yinji YIN YaJun FANG DaiNing Key Laboratory of Applied Mechanics Department of Engineering Mechanics Tsinghua University Beijing 100084 China

This paper presents a design theory and dynamic mechanical characterizations of the composite tape-spring hinge made by two parallel single tape ***,the theoretical models of moment-rotation angle on anisotropy tape springs with antisymmetric laminates are ***,the relationships of moment-rotation angle for tape-spring hinges with different sizes are simulated and analyzed by means of the finite element method (FEM),which is in good agreement with the results from theoretical ***,the dynamic vibration analysis for deployable composite tube hinges with different dampings is done during the process of deployment.

关键词： Composite tape-spring hinge deployable dynamic damping

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基于柔性传感技术的高速列车轮轨力在线监测方法

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中国科学：技术科学 2024年第3期54卷 545-552页

作者：陈思宇刘亚风付从艺王海瑞陈颖陆炳卫马寅佶王禾翎冯雪清华大学航天航空学院北京100084 清华大学柔性电子技术实验室北京100084 浙江清华柔性电子技术研究院嘉兴314000

监测轮轨力信号对于保障高速列车的安全运行、提高轨道线路的质量管理具有重要意义.然而,现有的轮轨力测试方法不能保证车轮在任意旋转角度下的测试精度与灵敏度,难以实现列车在高速行驶过程中轮轨力的实时连续测量.本文基于柔性电子技... 详细信息

监测轮轨力信号对于保障高速列车的安全运行、提高轨道线路的质量管理具有重要意义.然而,现有的轮轨力测试方法不能保证车轮在任意旋转角度下的测试精度与灵敏度,难以实现列车在高速行驶过程中轮轨力的实时连续测量.本文基于柔性电子技术设计了一款新型轮轨力传感器,在柔性衬底上设计环形应变栅结构,利用金属的压阻效应,获取环形区域内的整体变形随轮轨力变化的情况.垂向加载实验结果表明,柔性轮轨力传感器不仅具有良好的线性度,且在循环加载测试中表现出优异的稳定性和可重复性.更重要的是,该柔性轮轨力传感器能保证车轮在旋转任意角度情况下的测试精度与灵敏度.有限元仿真结果表明,在车轮内外两侧相对轴心等距离处布置柔性环形传感器,通过两侧传感器的输出信号可实现对轮轨横向力和垂向力的有效解耦.配合无线传感技术,柔性轮轨力传感器可实现高速列车轮轨力实时连续监测,对我国发展下一代智能高铁具有重要意义.

关键词：智能高铁健康监测轮轨力柔性电子传感器

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Review on flexible photonics/electronics integrated devices and fabrication strategy

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Science China(Information Sciences) 2018年第6期61卷 5-31页

作者： Shisheng CAI Zhiyuan HAN Fengle WANG Kunwei ZHENG Yu CAO yinji ma Xue FENG Applied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Interdisciplinary Research Center for Flexible Electronics Technology Tsinghua University

In recent years, to meet the greater demand for next generation electronic devices that are transplantable, lightweight and portable, flexible and large-scale integrated electronics attract much more attention have been of interest in both industry and academia. Organic electronics and stretchable inorganic electronics are the two major branches of flexible electronics. With the semiconductive and flexible properties of the organic semiconductor materials, flexible organic electronics have become a mainstay of our *** to organic electronics, stretchable and flexible inorganic electronics are fabricated via mechanical design with inorganic electronic components on flexible substrates, which have stretchability and flexibility to enable very large deformations without degradation of performance. This review summarizes the recent progress on fabrication strategies, such as hydrodynamic organic nanowire printing and inkjet-assisted nanotransfer printing of flexible organic electronics, and screen printing, soft lithography and transfer printing of flexible inorganic electronics. In addition, this review considers large-scale organic and inorganic flexible electronic systems and the future applications of flexible and stretchable electronics.

关键词： flexible and stretchable electronics organic photonics/electronics inorganic photonics/electronics fabrication strategies flexible electronic system

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A flexible skin-mounted wireless acoustic device for bowel sounds monitoring and evaluation

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Science China(Information Sciences) 2019年第10期62卷 171-181页

作者： Fengle WANG Dong WU Peng JIN Yingchao ZHANG Yingyun YANG yinji ma Aiming YANG Ji FU Xue FENG Key Laboratory of Applied Mechanics Department of Engineering MechanicsTsinghua University Department of Gastroenterology Peking Union Medical College Hospital

Conventional methods of intestinal inspection play an essential role in the assessment of bowel diseases and other relevant health issues, yet fail to obtain intestinal conditions in real time because of radiation limits and operation inconvenience. Herein, a flexible, skin-mounted device is developed for longterm, real-time monitoring, and for the evaluation of bowel sounds based on the integration of a threedimensional printed elastomeric resonator with flexible electronics. The device is capable of being flexibly attached to abdominal surfaces without performance degradation during breathing. Clinical tests conduct in a normal volunteer and in patients with mechanical intestinal obstruction or paralytic ileus illustrate the usefulness of the device in capturing the characteristics of bowel sounds. Furthermore, a demonstration of collection and classification of bowel sounds by the flexible device based on machine learning methods can serve as a reference for possible applications of the system in the auxiliary diagnosis of bowel problems.

关键词： flexible wearable device bowel sounds long-term monitoring machine learning intestinal motility

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Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor

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National Science Review 2020年第5期7卷 849-862页

作者： Haicheng Li yinji ma Ziwei Liang Zhouheng Wang Yu Cao Yuan Xu Hua Zhou Bingwei Lu Ying Chen Zhiyuan Han Shisheng Cai Xue Feng Key Laboratory of Applied Mechanics Department of Engineering Mechanics Tsinghua University Center for Flexible Electronics Technology Tsinghua University Intensive Care Unit Beijing Tsinghua Changgung Hospital Institute of Flexible Electronics Technology of Tsinghua University

According to the statistics of the World Health Organization, an estimated 17.9 million people die from cardiovascular diseases each year, representing 31%of all global deaths. Continuous non-invasive arterial pressure (CNAP) is essential for the management of cardiovascular diseases. However, it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression. Here, we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP. We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts, and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices. We compare the results with the blood pressure acquired by invasive (intra-arterial) blood pressure monitoring for>1500 min in total on 44 subjects in an intensive care unit. The maximum absolute errors of diastolic and systolic blood pressure were±7/±10 mm Hg, respectively, in immobilized, and±10/±14 mm Hg, respectively, in walking scenarios. These strategies provide advanced blood pressure monitoring techniques, which would directly address an unmet clinical need or daily use for a highly vulnerable population.

关键词： skin-like devices optoelectronics blood pressure monitor optical measurement

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Skin-integrated,biocompatible,and stretchable silicon microneedle electrode for long-term EMG monitoring in motion scenario

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npj Flexible Electronics 2023年第1期7卷 79-88页

作者： Huawei Ji Mingyu Wang Yutong Wang Zhouheng Wang yinji ma Lanlan Liu Honglei Zhou Ze Xu Xian Wang Ying Chen Xue Feng School of Mechanical Engineering Hangzhou Dianzi University310018 HangzhouChina AML Department of Engineering MechanicsCenter for Flexible Electronics TechnologyTsinghua University100084 BeijingChina Institute of Flexible Electronics Technology of THU 314000 JiaxingZhejiangChina Qiantang Science and Technology Innovation Center 310018 HangzhouChina

Electromyography(EMG)signal is the electrical potential generated by contracting muscle ***-term and accurate EMG monitoring is desirable for neuromuscular function assessment in clinical and the human–computer ***,we report a skin-integrated,biocompatible,and stretchable silicon microneedle electrode(SSME)inspired by the plant *** silicon microneedles are half encapsulated by the polyimide(PI)to enhance the adaptability to deformation and resistance to ***-like SSME is realized by the semi-additive method with a stretchability of not less than 36%.The biocompatibility of SSME has been verified using cytotoxicity *** monitoring in motion and long-term has been conducted to demonstrate the feasibility and performance of the SSME,which is compared with a commercial wet ***,the strategies reported here can lead to accurate and long-term EMG monitoring,facilitating an effective and reliable human–computer interface.

关键词： needle stretch electrode

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Stable and low-resistance polydopamine methacrylamide-polyacrylamide hydrogel for brain-computer interface

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Science China materials 2022年第8期65卷 2298-2308页

作者： Lanlan Liu Yafeng Liu Ruitao Tang Jun Ai yinji ma Ying Chen Xue Feng Institute of Flexible Electronics Technology of THU ZhejiangJiaxing Key Laboratory of Flexible Electronics based Intelligent Sensing and Advanced Manufacturing TechnologyJiaxing 314000China AML Department of Engineering MechanicsCentre for Flexible Electronics TechnologyTsinghua UniversityBeijing 100084China Qiantang Science and Technology Innovation Center Hangzhou 310016China College of Aerospace Engineering Chongqing UniversityChongqing 400044China

Signal drift and performance instability of brain-computer interface devices induced by the interface failure between rigid metal electrodes and soft human skin hinder the precise data acquisition of electroencephalogram(EEG).Thus,it is desirable to achieve a robust interface for brain-computer interface ***,a kind of polydopamine methacrylamide-polyacrylamide(PDma-PAAM)hydrogel is *** improve the adhesion,dopamine is introduced into the polyacrylamide hydrogel,through the amino and catechol groups of dopamine in an organic-inorganic interface to build a covalent and non-covalent interaction.A strong attachment and an effective modulus transition system can be formed between the metal electrodes and human skin,so that the peeling force between the PDmaPAAM hydrogel and the porcine skin can reach 22 N m^(-1).In addition,the stable conductivity and long-term operating life of the PDma-PAAM hydrogel for more than 60 days at room temperature are achieved by adding sodium chloride(NaCl)and glycerol,*** PDma-PAAM hydrogel membrane fabricated in this work is integrated onto a flexible Au electrode applied in a brain-computer *** comparison,the collected EEG signal intensity and waveform are consistent with that of the commercial *** obviously,the flexible electrode with PDma-PAAM hydrogel membrane is demonstrated to enable a more stable and userfriendly interface.

关键词： flexible electronics dopamine hydrogels braincomputer interface electroencephalogram

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基于数字散斑相关法的弯管残余应力测量系统

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仪器仪表学报 2011年第10期32卷 2382-2387页

作者：陈涛刘检华马寅佶北京理工大学机械与车辆学院北京100081 清华大学工程力学系北京100084

为了测量圆形管件在弯曲后产生的残余应力的情况,提出了一种新的基于数字散斑相关法(DSCM)的残余应力测量方法并且搭建了对应的测量系统。利用该系统对90°弯管外圆弯曲处的残余应力进行了测量。使用电测法作为参考,验证了基于数字散斑... 详细信息

为了测量圆形管件在弯曲后产生的残余应力的情况,提出了一种新的基于数字散斑相关法(DSCM)的残余应力测量方法并且搭建了对应的测量系统。利用该系统对90°弯管外圆弯曲处的残余应力进行了测量。使用电测法作为参考,验证了基于数字散斑相关法的测量方法能够有效测定弯管内残余应力的值。实验结果表明,该方法在保证一定的测量精度的同时能够大幅度地提高测量效率,为进一步研究残余应力对弯管工艺的影响提供了基础。

关键词：光学测量残余应力数字散斑相关法弯管

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Strain-Isolation Bridge Structure to Improve Stretchability of Highly Sensitive Strain Sensors

Strain-Isolation Bridge Structure to Improve Stretchability ...

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中国力学大会-2021+1

作者： Yangchengyi Liu Hanghai Fan Kan Li Nie Zhao Shangda Chen yinji ma Xiaoping Ouyang Xiufeng Wang School of materials Science and Engineering Xiangtan University Department of Engineering University of Cambridge AML Department of Engineering MechanicsTsinghua University

Increasing interests of stretchable strain sensors due to their important applications in skin electronics,soft robotics,and wearable systems require the capability of detecting subtle strain and large stretched deformation,but this remains a challenge.A new strategy based on a simple bridge-like structure design,replacing previous sophisticated mechanics designs or advanced low-dimension materials (carbon-nanotubes,graphene,metal nanowires etc.),is demonstrated to disperse the applied strain effectively and prevent the conductive layer from

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