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Exposure to ephedrine attenuates Th1/Th2 imbalance underlying OVA-induced asthma through airway epithelial cell-derived exo-somal lnc-TRPM2-AS

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Chinese Journal of Natural Medicines 2024年第6期22卷 530-540页

作者： HU Yan WANG Mengqing XIE Jing JIAO luojia DING Yi luo yinhe Department of Pediatrics The First Hospital of Hunan University of Chinese MedicineChangsha 410007China Hunan University of Chinese Medicine Changsha 410208China Department of Rehabilitation Medical CollegeChangsha Civil Affairs Vocational and Technical CollegeChangsha 410004Hunan ProvinceChina Teaching and Research Office of Chinese and Western Combination Hunan University of Chinese MedicineChangsha 410208China

Although various anti-inflammatory medications,such as ephedrine,are employed to manage cough-variant asthma,their underlying mechanisms are yet to be fully *** studies suggest that exosomes derived from airway epithelial cells(AECs)contain components like messenger RNAs(mRNAs),micro-RNAs(miRNAs),and long noncoding RNA(lncRNA),which play roles in the occurrence and progression of airway *** study investigates the influence of AEC-derived exosomes on the efficacy of ephedrine in treating cough-variant *** established a mouse model of asthma and measured airway resist-ance and serum inflammatory cell ***-time polymerase chain reaction(RT-qPCR),Western blotting,and enzyme-linked im-munosorbent assay(ELISA)analyses were used to assess gene and protein expression *** were isolated and *** immunoprecipitation(RIP)and RNA pull-down assays were conducted to examine the interaction between hnRNPA2B1 and *** the ovalbumin(OVA)-challenged mouse model,ephedrine treatment reduced inflammatory responses,air-way resistance,and Th1/Th2 cell *** from OVA-treated AECs showed elevated levels of lnc-TRPM2-AS1,which were diminished following ephedrine *** exosomal lnc-TRPM2-AS1 mediated the Th1/Th2 imbalance in CD4^(+)T cells,with its packaging into exosomes being facilitated by *** study unveils a novel mechanism by which ephedrine ameli-orates OVA-induced CD4^(+)T cell imbalance by suppressing AEC-derived exosomal *** findings could provide a theoretical framework for using ephedrine in asthma treatment.

关键词： Asthma Ephedrine Exosomal lnc-TRPM2-AS1 Th1/Th2 imbalance HnRNPA2B1 Airway epithelial cells

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Body Waves Revealed by Spatial Stacking on Long-Term Cross-Correlation of Ambient Noise

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Journal of Earth Science 2014年第6期25卷 977-984页

作者： Kai Wang yinhe luo Kaifeng Zhao Limeng Zhang Institute of Geophysics and Geomatics China University of Geosciences State Key Laboratory of Geological Processes and Mineral Resources Institute of Geophysics and GeomaticsChina University of Geosciences Subsurface Multi-Scale Imaging Key Laboratory (SMIL) of Hubei Province Institute of Geophysics and GeomaticsChina University of Geosciences

Theoretical and experimental studies indicate that complete Green＇s Function can be retrieved from cross-correlation in a diffuse field. High SNR（signal-to-noise ratio） surface waves have been extracted from cross-correlations of long-duration ambient noise across the globe. Body waves, not extracted in most of ambient noise studies, are thought to be more difficult to retrieve from regular ambient noise data processing. By stacking cross-correlations of ambient noise in 50 km inter-station distance bins in China, western United States and Europe, we observed coherent 20–100 s core phases（Sc S, PKIKPPKIKP, PcP PKPPKP） and crustal-mantle phases（Pn, P, PL, Sn, S, SPL, SnS n, SS, SSPL） at distances ranging from 0 to 4000 km. Our results show that these crustal-mantle phases show diverse characteristics due to different substructure and sources of body waves beneath different regions while the core phases are relatively robust and can be retrieved as long as stations are available. Further analysis indicates that the SNR of these body-wave phases depends on a compromise between stacking fold in spatial domain and the coherence of pre-stacked cross-correlations. Spatially stacked cross-correlations of seismic noise can provide new virtual seismograms for paths that complement earthquake data and that contain valuable information on the structure of the Earth. The extracted crustal-mantle phases can be used to study lithospheric heterogeneities and the robust core phases are significantly useful to study the deep structure of the Earth, such as detecting fine heterogeneities of the core-mantle boundary and constraining differential rotation of the inner core.

关键词： ambient noise cross-correlation body wave

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Application of Multifocusing Method for an Irregular Topography Imaging

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Journal of China University of Geosciences 2005年第3期16卷 256-261页

作者： luo yinhe Liu Jiangping Yao Yao Institute of Geophysics ＆ Geomatics China University of Geosciences Wuhan 430074 China

A stack of records becomes one of the main steps in modern seismic data processing. In the stack procedure, the crucial operation is time correction. Conventional methods, e.g. , normal moveout （NMO） and dip moveout （DMO） stacks require a sufficiently accurate macro-velocity model, whereas a multifocusing imaging method does not depend on a macro-velocity model. The multifocusing method proposed by Gelchinsky et al. belongs to a group of methods that can be characterized as macro-model-independent imaging methods. The multifocusing method represents a transformation of 2-D multicoverage reflection data into a simulated zero-offset stack profile. This transformation is based on a completely data-derived spatial stacking operator, and includes stacking large supergathers of seismic traces, each of which can span many CMP gathers. By extending the multifocusing moveout formula to explicitly account for non-zero elevations of the source and receiver, the multifocusing imaging method can yield appropriate results when seismic data are acquired over an irregular topography. In recent years, many applications of multifocusing imaging over an irregular topography have demonstrated its advantages in comparison with conventional CMP processing. This paper illustrates the corresponding formulas for a synthetic data example modeled by the wave equation finite difference method. The result of the synthetic example is very encouraging. By stacking large supergathers and applying multifocusing moveout correction, the reflectors are aligned very well and the S/N is greatly improved. We have also applied multifocusing imaging over an irregular topography to a real data example. The elevation of the data acquisition area varies considerably. Applying multifocusing imaging, a substantial improvement of the simulated section was achieved, compared with a conventional CMP stacked section.

关键词： time correction multifocusing imaging topography

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Heat Shielding Effects in the Earth＇s Crust

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Journal of Earth Science 2017年第1期28卷 161-167页

作者： Yixian Xu Lupei Zhu Qinyan Wang yinhe luo Jianghai Xia School of Earth Sciences Zhejiang University Hangzhou 310027 China State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan 430074 China Hubei Subsurface Multi-Scale lmaging Key Laboratory Institute of Geophysics and Geomatics China University of Geosciences Wuhan 430074 China Department of Earth and Atmospherie Sciences Saint Louis University St. Louis MO 63103 USA School of Earth Sciences China University of Geosciences Wuhan 430074 China

Knowledge of heat flow and associated variations of temperature with depth is crucial for understanding how the Earth functions. Here, we demonstrate possible heat shielding effects that result from the occurrence of mafic intrusions/layers（granulitic rocks） within a dominantly granitic middle crust and/or ultramafic intrusions/layers（peridotitic rocks） within a dominantly granulitic lower crust; heat shielding is a familiar phenomenon in heat engineering and thermal metamaterials. Simple one-dimensional calculations suggest that heat shielding due to the intercalation of granitic, granulitic and peridotitic rocks will increase Moho temperatures substantially. This study may lead to a rethinking of numerous proposed lower crustal processes.

关键词： geotherm crustal laminated structure heat shielding heat conductivity peridotitic in-trusions North Tibet magnetotelluric data.

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基于转录组学探讨外泌体诱导病毒性哮喘动物模型的作用机制及潜在的中药干预

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中药药理与临床 2024年第8期40卷 82-89页

作者：姚冰周智王孟清罗银河谢静刘靖雷丁伊李英湖南中医药大学长沙410208 湖南中医药大学第一附属医院长沙410021 长沙民政职业技术学院长沙410018

目的:基于转录组学探究呼吸道合胞病毒(RSV)干预后的外泌体在哮喘发病中的作用及潜在中医药干预机制。方法:利用呼吸道合胞病毒(RSV)干预骨髓间充质干细胞后提取外泌体,并进行透射电镜、粒径(NTA)及蛋白免疫印迹法(Western blot)鉴定外... 详细信息

目的:基于转录组学探究呼吸道合胞病毒(RSV)干预后的外泌体在哮喘发病中的作用及潜在中医药干预机制。方法:利用呼吸道合胞病毒(RSV)干预骨髓间充质干细胞后提取外泌体,并进行透射电镜、粒径(NTA)及蛋白免疫印迹法(Western blot)鉴定外泌体的形态及标志物等;将24只SPF级雄性C57小鼠随机分为正常对照组、呼吸道合胞病毒组、外泌体组,造模3周后进行肺功能、病理染色验证是否存在哮喘病理改变,并对小鼠气道组织进行RNA-seq高通量转录组测序,明确差异基因;通过中药整合药理学方法对关键靶点潜在中药进行预测并汇总。结果:透射电镜显示外泌体呈典型的双层膜茶托样结构,粒径显示其平均直径为133.1 nm;WB法检测到外泌体膜标志蛋白(CD63、CD9和TSG101)的表达。与正常对照组相比,呼吸道合胞病毒组与外泌体组用力肺活量(FVC)明显下降(P<0.05),动态肺顺应性(CDYN)明显下降(P<0.01),呼吸道合胞病毒组、外泌体组最大呼气流量(PEF)明显下降(P<0.05);而呼吸道合胞病毒组和外泌体组肺阻力(RL)明显升高(P<0.01)。在炎症浸润及气道黏液分泌等方面,外泌体组小鼠有炎症细胞浸润及嗜酸性粒细胞浸润,呼吸道合胞病毒组以中性粒细胞、淋巴细胞浸润为主,杯状细胞黏液分泌较外泌体组明显。气道上皮测序结果提示三组间差异基因多富集在免疫、神经及内分泌系统;差异基因共同富集的通路为过氧化物酶体增殖物激活受体、白介素-17、细胞外基质-受体相互作用信号通路。预测的潜在治疗中药以清热药、补虚药及理气活血药为主,其组分能作用多个靶点及通路调节哮喘神经、内分泌及免疫平衡。结论:病毒干预后的外泌体能够诱导哮喘气道炎症、气道重塑等病理改变;中医药从多环节、多靶点、多系统方面发挥了其整体调节作用。

关键词：病毒性哮喘外泌体呼吸道合胞病毒骨髓间充质干细胞转录组学淋巴细胞中性粒细胞嗜酸性粒细胞

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基于短周期密集台阵接收函数揭示的藏南错那洞穹窿地壳结构

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地学前缘 2024年第1期31卷 170-180页

作者：蔡蔚卢占武黄荣李文辉罗银河王光文穆青程永志陈司王冠陈子龙中国地质科学院地质研究所北京100037 中国地质大学(武汉)地球物理与空间信息学院湖北武汉430074 中国地质科学院自然资源部深地科学与探测技术实验室北京100037 中国地质大学(武汉)地质过程与矿产资源国家重点实验室湖北武汉430074

位于印度-欧亚板块碰撞前缘的北喜马拉雅构造带,是研究陆陆碰撞过程中地壳增厚和深部岩浆活动的典型区域之一。北喜马拉雅穹窿带作为其中重要的伸展构造,其形成过程与造山运动引起的地壳增厚以及地壳深熔作用引起的地壳流动密切相关。... 详细信息

位于印度-欧亚板块碰撞前缘的北喜马拉雅构造带,是研究陆陆碰撞过程中地壳增厚和深部岩浆活动的典型区域之一。北喜马拉雅穹窿带作为其中重要的伸展构造,其形成过程与造山运动引起的地壳增厚以及地壳深熔作用引起的地壳流动密切相关。本文以近年新发现的错那洞穹窿为例,利用短周期密集台阵观测,通过远震P波接收函数共转换叠加成像方法获取了错那洞穹窿区域地壳结构。结果表明:错那洞穹窿区域的地壳结构在东西方向上存在差异,壳内速度间断面存在多处不连续现象,局部区域甚至发生界面错断;而在错那裂谷和错那洞穹窿中、上地壳内存在低速区。综合前人研究,本文认为印度-欧亚板块持续碰撞使喜马拉雅东南缘岩石圈经历过地壳尺度拉伸变形。在地壳增厚及持续的高温变质作用下,中、上地壳随藏南拆离系伸展减压发生部分熔融,而熔融岩浆沿着藏南拆离系薄弱处不断上涌并在错那洞穹窿下方聚集,并使错那洞穹窿及错那裂谷中、上地壳弱化,促进区域东西向伸展,进而发生岩浆底辟形成错那洞穹窿。

关键词：错那洞穹窿短周期密集台阵远震P波接收函数共转换叠加成像地壳结构

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The influences of large earthquake signals on the recovery of surface waves from ambient noise cross-correlation functions

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Earthquake Science 2020年第5期33卷 221-231页

作者： Huayi Zhu Xiaojin Xie Xiaozhou Yang yinhe luo Hubei Subsurface Multi-Scale Imaging Lab Institute of Geophysics and GeomaticsChina University of GeosciencesWuhan430074China

Ambient noise tomography(ANT)has been widely used to image crust and upmost mantle *** assumes that sources of ambient noise are diffuse and evenly distributed in space and the energy of different modes is *** present,the sources of the primary and the secondary microseisms are well studied,but there are only a few on the studies of long-period ambient noise *** this study,we study the effects of large earthquake signals on the recovery of surface waves from seismic ambient noise data recorded by seismic stations from the US permanent networks and Global Seismographic Network(GSN).Our results show that large earthquake signals play an important role on the recovery of long-period surface waves from ambient noise cross-correlation *** results are consistent with previous studies that suggest the contribution of earthquake signals to the recovery of surface waves from cross-correlations of ambient noise is dominant at periods larger than 20–40 s.

关键词： ambient noise tomography long-period surface wave large earthquake signals noise cross-correlation function

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中医药调控NLRP3炎症小体治疗支气管哮喘研究进展

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中医药学报 2024年第6期52卷 111-115页

作者：刘靖雷王孟清罗银河姚冰周智马啸湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007 长沙市妇幼保健院湖南长沙410000

支气管哮喘(简称哮喘)是儿童及成人常见慢性气道炎症性疾病。研究发现哮喘的发病与NLRP3炎症小体密切相关,NLRP3炎症小体能通过促进气道炎症、气道重塑和黏液高分泌影响哮喘的发生发展,抑制NLRP3炎症小体的激活是哮喘治疗的新方向。中... 详细信息

支气管哮喘(简称哮喘)是儿童及成人常见慢性气道炎症性疾病。研究发现哮喘的发病与NLRP3炎症小体密切相关,NLRP3炎症小体能通过促进气道炎症、气道重塑和黏液高分泌影响哮喘的发生发展,抑制NLRP3炎症小体的激活是哮喘治疗的新方向。中医药治疗哮喘疗效确切,中医药能够通过调控NLRP3炎症小体的激活发挥治疗哮喘的作用,其调控机制与一系列的信号通路、信号轴和内质网应激等密切相关。本研究通过查阅近年来有关中医药调控NLRP3炎症小体治疗哮喘的相关文献进行综述,旨在为中医药治疗哮喘的临床应用提供参考。

关键词：中医药 NLRP3炎症小体支气管哮喘

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五虎汤对呼吸道合胞病毒感染细胞外泌体致哮喘小鼠自噬及IL-8、IL-23、muc5ac表达的影响

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中国中医药信息杂志 2024年第7期31卷 69-76页

作者：刘靖雷王孟清罗银河姚冰周智马啸丁伊湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007 长沙市妇幼保健院湖南长沙410000 长沙民政职业技术学院湖南长沙410004

目的观察五虎汤对呼吸道合胞病毒(RSV)感染的骨髓间充质干细胞外泌体(BMSCs-ExoRSV)致哮喘小鼠肺组织自噬及白细胞介素(IL)-8、IL-23、muc5ac表达的影响,探讨其治疗哮喘的作用机制。方法40只SPF级雄性C57小鼠随机分为空白组、模型组、... 详细信息

目的观察五虎汤对呼吸道合胞病毒(RSV)感染的骨髓间充质干细胞外泌体(BMSCs-ExoRSV)致哮喘小鼠肺组织自噬及白细胞介素(IL)-8、IL-23、muc5ac表达的影响,探讨其治疗哮喘的作用机制。方法40只SPF级雄性C57小鼠随机分为空白组、模型组、五虎汤组和利巴韦林组,每组10只。空白组予PBS滴鼻,其余组予BMSCs-Exo-RSV滴鼻,隔日1次,共7次。造模结束后24 h,五虎汤组灌胃五虎汤药液,利巴韦林组灌胃利巴韦林溶液,空白组和模型组灌胃蒸馏水,每日1次,连续7 d。观察小鼠一般状况,检测小鼠呼气峰流速(PEF)和用力肺活量(FVC),HE和Masson染色观察肺组织炎性浸润和胶原沉积情况,RT-qPCR检测肺组织LC3A/B、beclin-1、p62、IL-8、IL-23、muc5ac mRNA表达,Western blot检测肺组织LC3B、beclin-1、p62蛋白表达,免疫组化检测肺组织IL-8、IL-23、muc5ac蛋白表达。结果与空白组比较,模型组小鼠体质量下降,出现呼吸急促、点头样喘息、上肢缩抬、耸肩、竖毛、搔鼻等改变,PEF和FVC降低(P<0.01),肺组织炎性浸润和胶原沉积增多,肺组织LC3A/B、beclin-1、IL-8、IL-23、muc5ac mRNA表达升高(P<0.01),p62 mRNA表达下降(P<0.01),LC3BⅡ、beclin-1、IL-8、IL-23、muc5ac蛋白表达及LC3BⅡ/Ⅰ比值升高(P<0.01),LC3BⅠ、p62蛋白表达下降(P<0.01)。与模型组比较,五虎汤组和利巴韦林组小鼠哮喘症状有所改善,PEF和FVC升高(P<0.01,P<0.05),肺组织炎性浸润和胶原沉积减少,肺组织LC3A/B、beclin-1、IL-8、IL-23、muc5ac mRNA表达下降(P<0.01),p62 mRNA表达升高(P<0.01),LC3BⅡ、beclin-1、IL-8、IL-23、muc5ac蛋白表达及LC3BⅡ/Ⅰ比值下降(P<0.05,P<0.01),LC3BⅠ、p62蛋白表达升高(P<0.01)。结论BMSCs-Exo-RSV能通过促进小鼠肺组织自噬及IL-8、IL-23、muc5ac表达诱发哮喘改变,五虎汤能通过抑制自噬并降低IL-8、IL-23、muc5ac表达对哮喘小鼠发挥治疗作用。

关键词：呼吸道合胞病毒五虎汤外泌体自噬哮喘小鼠

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Evaluating uncertainties of phase velocity measurements from cross-correlations of ambient noise

Evaluating uncertainties of phase velocity measurements from...

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2019年中国地球科学联合学术年会

作者： Yingjie Yang yinhe luo Department of Earth and Planetary Sciences Macquarie University Institude of Geophysics and Geomatics China University of Geosciences (Wuhan)

Ambient noise tomography(ANT) has become a well-established method to image the crust and uppermost mantle structures in the past fifteen years or so due to its readiness to extract interstation surface wave dispersio... 详细信息

关键词： Evaluating uncertainties of phase velocity measurements from cross-correlations of ambient noise

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