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Research progress on brain-derived neurotrophic factor and non-suicidal self-injury addictive behavior associated with depressive disorders in adolescents

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Journal of Translational Neuroscience 2022年第3期7卷 7-14页

作者： Lan Jiang Tiankai Jiang Tiantian Jiang Yuhang liang yinhang li Jiepeng Lei Department of Clinical Psychology The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China Department of Children and Adolescents The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent *** associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiological mechanisms to substance ***-derived neurotrophic factor(BDNF)and precursor of BDNF(proBDNF)play an important role in addiction behavior,and they may be related to endogenous opioid *** location and distribution of opioidμre-ceptors in the brain are related to reward,motivation and emotion regulated by behavioral *** purpose of this paper is to review the general situation,mechanism and relationship between the characteristics of NSSI be-havior addiction and brain-derived nutritional factors in adolescents with depression.

关键词： brain-derived neurotrophic factor(BDNF) precursor of BDNF(proBDNF) adolescents depressive disorder non-suicidal self-injury(NSSI) ad-dictivebehavior

Research progress on whether BDNF can be used as a predictive biomarkerfor suicidal behavior

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Journal of Translational Neuroscience 2022年第3期7卷 20-23页

作者： Tiantian Jiang yinhang li Yuhang liang Tiankai Jiang Ming Mo Department of Clinical Psychology The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

In recent years,the serious social phe-nomenon of suicide has been of great concern to society and ***,the study and early risk assess-ment of suicide have been limited by multiple ***,researchers have started to search for a reliable marker for early diagnosis of suicide risk,and one of the widely studied neurotransmitters associated with suicide is the brain-derived neurotrophic factor(BDNF).This re-view aims to summarize the current scientific knowledge on the relevance of BDNF and psychiatric disorders to suicide and to infer whether neurotrophic factors could be a reliable marker for early diagnosis of suicide *** on the results of these studies,a link between BDNF and suicide may exist and act independently of mental ***,there is still controversy and further studies may provide researchers with useful information.

关键词： brain-derived neurotrophic factor(BDNF) psychiatric disorders suicide

The roles of BDNF and ProBDNF in schizophrenia: possibilities for treatment

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Journal of Translational Neuroscience 2023年第2期8卷 13-17页

作者： Yuhang liang Tiantian Jiang yinhang li Hongying Pan Min Mo Department of Clinical Psychology The Afffliated Mental Hospital of Kunming Medical UniversityKunming 650000China

This review discusses the roles of brain-derived neurotrophic factor(BDNF)and precursor BDNF(proBDNF)in schizophrenia(SCZ).SCZ is asso-ciated with neuronal dysfunction,altered synaptic plas-ticity,and cognitive *** positively promotes neuronal growth,differentiation,and synapse forma-tion,and regulates synaptic transmission and *** negatively affects neuronal survival and syn-aptic remodeling,however,by binding to its neurotroph-in receptor p75(p75NTR).A better understanding of the pathogenesis of SCZ vis-à-vis BDNF and proBDNF may provide new directions and strategies for its treatment.

关键词： schizophrenia(SCZ) brain-derived neurotrophic factor(BDNF) precursor BDNF(ProBDNF)

Research progress on benzodiazepines to treat alcohol withdrawal syndrome

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Journal of Translational Neuroscience 2022年第4期7卷 12-16页

作者： Tiankai Jiang Yuhang liang Lan Jiang yinhang li Tiantian Jiang Ye Ruan Department of Clinical Psychology The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

Alcohol withdrawal syndrome(AWS)refers to a series of symptoms and signs that chronic al-coholics experience when they suddenly stop drinking or reduce their drinking,usually 12 to 24 h *** in-clude tremors,fatigue,sweating,hyperreflexia,and gas-trointestinal *** article will analyze the drug treatment of this disease and make a brief review.

关键词： alcohol withdrawal syndrome(AWS) benzodiazepine(BDZ) symptom-triggered regimens

Phenobarbital in the treatment of alcohol withdrawal syndrome

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Journal of Translational Neuroscience 2022年第4期7卷 7-11页

作者： Tiankai Jiang Lan Jiang yinhang li Yuhang liang Tiantian Jiang Hongyan liu Department of Clinical Psychology The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

Alcohol withdrawal syndrome(AWS)is a serious disorder affecting alcohol-dependent patients who abruptly stop or reduce their *** or moderate AWS usually appears within 6 to 24 h after the last drink,and symptoms may include increased blood pressure and rapid pulse,tremors,high fever,irritability,anxiety,headache,nausea,and *** symptoms may progress to a more severe AWS characterized by delirium tremens,seizures,coma,cardiac arrest,and *** article will analyze the phenobarbital(PB)treatment of AWS and make a brief review'.

关键词： alcohol withdrawal syndrome(AWS) benzodiazepine(BDZ) phenobarbital(PB)

Research progress on the mechanism of N6-methylade-nosine methylation modification and proteolipid protein 1 gene in schizophrenia

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Journal of Translational Neuroscience 2022年第1期7卷 6-10页

作者： Zhilan Yang Hongying Pan Lan Jiang Tiankai Jiang yinhang li Jie Wu Department of Clinical Psychology The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

Schizophrenia (SCZ) is a serious mental illness with unknown etiology, high recurrence rate and high disability rate, which has caused a great burden to individuals and society. There is no clear etiology and pathogenesis. Methylation of N6-methyladenosine (m6A) can regulate the nervous and mental system, and affect the function of the nervous system. Proteolipid protein 1 (PLP1) is a risk gene for schizophrenia. In this study we review the research progress on the pathogenesis of schizophrenia, m6A methylation, and PLP1 gene.

关键词： schizophrenia(SCZ) methylation of N6-methy ladenosine(m6A) proteolipid protein 1(PLP1)

Changes and clinical significance of BDNF and MMP9 be-fore and after treatment of depressive episode

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Journal of Translational Neuroscience 2022年第2期7卷 12-17页

作者： Zhian Yang Lan Jiang Tiankai Jiang Yuhang liang Tiantian Jiang yinhang li Changqing Gao Department of Clinical Psychology The Afiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

Objective:to explore brain-derived neu-rotrophic factor(BDNF)and matrix metalloproteinase-9(MMP9)messenger in peripheral blood lymphocytes of patients with depressive episodes before and after anti-depressant treatment changes in RNA(mRNA)expres-sion ***:fifteen patients hospitalized with depression in the Afiliated Mental Hospital of Kunming Medical University from December 2021 to June 2022 were collected as research *** 4 weeks of anti-depressant treatment,BDNF mRNA and MMP9 mRNA in patients with depression were detected before and af-ter treatment,and statistically ***:after 4 weeks of antidepressant treatment,there was no signif-icant difference in BDNF mRNA expression level after treatment compared with before treatment(P>0.05).The mRNA level of MMP9 was higher than that before treatment,and the difference was statistically significant(Plieve depressive symptoms,and the total content of BDNF did not change significantly.

关键词： major depressive episode brain-de-rived neurotrophic factor(BDNF) matrix metalloprotein-ase-9(MMP9)

基于云模型的水光互补清洁能源基地容量配置方案优选

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水利水电科技进展 2024年第1期44卷 44-51页

作者：黄显峰周引航张启凡李大成李旭吴迪河海大学水利水电学院江苏南京210098 武汉大学水利水电学院湖北武汉430072 中国电建集团贵阳勘测设计研究院有限公司贵州贵阳550081 华能澜沧江水电股份有限公司云南昆明650214

为优选水光互补清洁能源基地容量配置方案,从安全性、环保性、经济性、技术性4个方面选取14个指标构建了综合评价指标体系,采用改进云模型方法对容量配置方案进行评价。改进云模型方法以基于层次分析法改进的云模型求解主观权重,以熵权... 详细信息

为优选水光互补清洁能源基地容量配置方案,从安全性、环保性、经济性、技术性4个方面选取14个指标构建了综合评价指标体系,采用改进云模型方法对容量配置方案进行评价。改进云模型方法以基于层次分析法改进的云模型求解主观权重,以熵权法求解客观权重,组合赋权得到指标权重,再利用条件云发生器计算各指标的隶属度,最后根据级别特征值法计算容量方案等级评分,确定最优方案。将该方法应用于我国西南某清洁能源基地水光互补系统容量配置方案的优选,优选结果与集对分析法优选结果和实际选择方案均相符,证明了该方法的有效性与适用性。

关键词：水光互补系统容量配置方案改进云模型组合赋权集对分析

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高效、节能、环保的“绿色加热炉”技术

工业炉 2019年第4期41卷 1-4页

作者：李银行岳阳长岭设备研究所有限公司

节能减排是当前石化企业生产面临的主要问题之一。本文针对加热炉存在的一些问题,提出了针对性的措施,可提高加热炉热效率、有效减少污染气体的排放,使加热炉做到高效、环保、长周期的安全运行。

关键词：加热炉高效环保智能