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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Spreading Speeds of Time-Dependent Partially Degenerate Reaction-Diffusion Systems

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Chinese Annals of Mathematics,Series B 2022年第1期43卷 79-94页

作者： jia LIU School of Science Chang'an UniversityXi'an 710064China

This paper is concerned with the spreading speeds of time dependent partially degenerate reaction-diffusion systems with monostable *** using the principal Lyapunov exponent theory,the author first proves the existence,uniqueness and stability of spatially homogeneous entire positive solution for time dependent partially degenerate reaction-diffusion *** the author shows that such system has a finite spreading speed interval in any direction and there is a spreading speed for the partially degenerate system under certain *** author also applies these results to a time dependent partially degenerate epidemic model.

关键词： Partially degenerate Reaction-diffusion system Time dependent Spreading speed

Some Results on Cohomology of Twisted Smash Coproduct

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Acta Mathematica Sinica,English Series 2022年第8期38卷 1484-1492页

作者： Ling jia Department of Mathematics and Statistics Ludong UniversityYantai 264025P.R.China

With the main motivation to present some alternatives to the cosemisimplicity of twisted Smash coproduct,this paper first gives some basic constructions which make sense to consider the derived functors of some left exact functors from the category of comodules to vector ***,the Hochschild–Serre spectral sequence for twisted Smash coproduct coalgebras is obtained,which extends some results on homological properties given in the category of comodules over Smash coproduct in the literature.

关键词： Twisted Smash coproduct bicomodule coalgebra Hopf algebra spectral sequence

Vesicular transport-related genes in Diaphorina citri are involved in the process of Candidatus Liberibacter asiaticus infection

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Journal of Integrative Agriculture 2024年第12期23卷 4136-4146页

作者： yingzhe Yuan Tao Peng Aijun Huang Jun He Chenyang Yuan Tianyuan Liu Long Yi Xuejin Cui Xuefeng Wang Changyong Zhou National Citrus Engineering and Technology Research Center Citrus Research InstituteSouthwest UniversityChongqing 400712China College of Life Sciences Yulin CollegeYulin 719000China National Navel Orange Engineering Research Center Gannan Normal UniversityGanzhou 341000China Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqing 400715China

Asian citrus psyllid(ACP,Diaphorina citri)is the major vector of Candidatus Liberibacter asiaticus(CLas),which is a bacterial pathogen causing the devastating citrus Huanglongbing(HLB)*** citri is known to carry CLas in a persistent and propagative *** studies have suggested that CLas may use the vesicular structures of *** cells as its propagation ***,the mechanisms by which CLas enters the *** cells and how vesicle-mediated trafficking is involved remain *** this study,we monitored the titer change of CLas in *** nymphs during the process of CLas acquisition from feeding on infected citrus *** found that the titer of CLas increased with the acquisition access *** infection,there was a significant upregulation in the expression of several vesicular transport-related genes in *** titer of CLas was significantly reduced in the midgut and whole insect body when endocytosis and the endosome network in *** were ***,silencing the *** clathrin-heavy chain gene also led to a reduction in the CLas titer in *** results suggest that CLas infection upregulates the genes related to vesicular transport in ***,which facilitates the invasion of endocytosis-dependent pathogens.

关键词： Huanglongbing endocytosis vesicular trafficking CLas acquisition

Excitation spectra of one-dimensional spin-1/2 Fermi gas with an attraction

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Communications in Theoretical Physics 2022年第12期74卷 154-175页

作者： jia-Feng Pan jia-jia Luo Xi-Wen Guan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Department of Fundamental and Theoretical Physics Research School of PhysicsAustralian National UniversityCanberra ACT 0200Australia University of Chinese Academy of Sciences Beijing 100049China NSFC-SPTP Peng Huanwu Center for Fundamental Theory Xi'an 710127China

Using an exact Bethe ansatz solution,we rigorously study excitation spectra of the spin-1/2 Fermi gas(called Yang–Gaudin model)with an attractive *** excitations of this model involve particle-hole excitation,hole excitation and adding particles in the Fermi seas of pairs and unpaired *** gapped magnon excitations in the spin sector show a ferromagnetic coupling to the Fermi sea of the single *** numerically and analytically solving the Bethe ansatz equations and the thermodynamic Bethe ansatz equations of this model,we obtain excitation energies for various polarizations in the phase of the Fulde–Ferrell–Larkin–Ovchinnikov-like *** a small momentum(long-wavelength limit)and in the strong interaction regime,we analytically obtained their linear dispersions with curvature corrections,effective masses as well as velocities in particle-hole excitations of pairs and unpaired *** a type of particle-hole excitations display a novel separation of collective motions of bosonic modes within paired and unpaired ***,we also discuss magnon excitations in the spin sector and the application of Bragg spectroscopy for testing such separated charge excitation modes of pairs and single fermions.

关键词： Yang-Gaudin model quantum integrability the Bethe ansatz excitation spectrum

Who will win the future of display technologies?

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National Science Review 2018年第3期5卷 427-431页

作者： Hepeng jia Freelance science writer based in Ithaca New York USA and Beijing China

In recent years,China and other countries have invested heavily in the research and manufacturing capacity of display ***,different display technology scenarios,ranging from traditional LCD (liquid crystal display) to rapidly expanding OLED (organic light-emitting diode) and emerging QLED (quantum-dot light-emitting diode),are competing for market *** the trivium strife,OLED,backed by technology

关键词： Who will win the future of display technologies LCD

Extending Structures for Gel'fand-Dorfman Bialgebras

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Acta Mathematica Sinica,English Series 2024年第2期40卷 619-638页

作者： jia jia WEN Yan Yong HONG School of Mathematics Hangzhou Normal UniversityHangzhou 311121P.R.China

Gel'fand-Dorfman bialgebra,which is both a Lie algebra and a Novikov algebra with some compatibility condition,appeared in the study of Hamiltonian pairs in completely integrable *** also emerged in the description of a class special Lie conformal algebras called quadratic Lie conformal *** this paper,we investigate the extending structures problem for Gel'fand-Dorfman bialgebras,which is equivalent to some extending structures problem of quadratic Lie conformal ***,given a Gel'fand-Dorfman bialgebra(A,o,[.,.]),this problem is how to describe and classify all Gel'fand-Dorfman bialgebra structures on a vector space E(A⊂E)such that(A,o,[.,.])is a subalgebra of E up to an isomorphism whose restriction on A is the identity *** by the theories of extending structures for Lie algebras and Novikov algebras,we construct an object gH2(V,A)to answer the extending structures problem by introducing the notion of a unified product for Gel'fand-Dorfman bialgebras,where V is a complement of A in *** particular,we investigate the special case when dim(V)=1 in detail.

关键词： Gel'fand-Dorfman bialgebra Lie conformal algebra Extending structures problem Novikovalgebra

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中国式现代化对西方式现代化的历史性超越

哈尔滨市委党校学报 2025年第01期 8-13+20页

作者：李包庚王佳宁波大学马克思主义学院

西方式现代化受资本逻辑支配，颠倒了人与物的关系，造成了社会两极分化与人的单向度发展、全球生态危机与全球生态治理困境、欺凌剥削他国、逆全球化思潮、西方中心主义等“西方现代性问题”。中国式现代化坚持人民至上原则，追求全体... 详细信息

西方式现代化受资本逻辑支配，颠倒了人与物的关系，造成了社会两极分化与人的单向度发展、全球生态危机与全球生态治理困境、欺凌剥削他国、逆全球化思潮、西方中心主义等“西方现代性问题”。中国式现代化坚持人民至上原则，追求全体人民共同富裕与人的自由而全面的发展，统筹物质文明与生态文明协调发展，构建人类命运共同体，提倡世界不同文明相互尊重交流互鉴，实现了对西方式现代化的全面历史性超越，创造了人类文明新形态。中国式现代化彰显了中国特色社会主义制度的优越性，以建设中华民族现代文明、创造人类文明新形态为时代旨归，破除了“现代化=西方化”的迷思，走出了一条既具有中国特色又推进世界共同发展的现代化道路。

关键词：中国式现代化西方式现代化资本逻辑人民至上人类文明新形态

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苦马豆素对家兔脾脏免疫功能及代谢的影响

动物医学进展 2025年第1期46卷 74-80页

作者：赵金香陶大勇杜国丰张家鸣沈佳宜矫继峰营口理工学院辽宁营口115014 塔里木大学动物科学学院新疆阿拉尔843300

为了探讨苦马豆素通过消化系统对家兔脾脏免疫功能和代谢的影响,将体重为(1.9±0.12)kg的24只家兔随机分成对照组与试验组,每组雌、雄各半。试验组家兔饲喂含有小花棘豆的自制颗粒饲料,饲喂苦马豆素剂量为2 mg/(kg·d),对照组家兔饲喂... 详细信息

为了探讨苦马豆素通过消化系统对家兔脾脏免疫功能和代谢的影响,将体重为(1.9±0.12)kg的24只家兔随机分成对照组与试验组,每组雌、雄各半。试验组家兔饲喂含有小花棘豆的自制颗粒饲料,饲喂苦马豆素剂量为2 mg/(kg·d),对照组家兔饲喂自制颗粒饲料中不含小花棘豆。所有家兔单笼饲养,自由饮水,每天观测并记录家兔的健康状态。在试验的第60天,采取所有家兔脾脏,对脾脏进行基于iTRAQ的定量蛋白质组学分析、生物信息学分析及关键蛋白质的Western blot验证。结果显示,所有试验组家兔均呈现明显的中毒现象。与对照组相比,共鉴定出315个与新陈代谢(81%)及免疫相关(15%)的差异表达蛋白质(>1.5倍或<1/1.5倍)。而且,苦马豆素中毒家兔脾脏细胞分解代谢处于激活状态,但其免疫反应处于抑制状态。说明苦马豆素抑制了家兔脾脏的免疫功能,激活了脾脏组织的分解代谢。

关键词：苦马豆素小花棘豆脾脏同位素标记的相对和绝对定量技术蛋白质组免疫家兔