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Arabidopsis cryptochrome 1 promotes stomatal development through repression of AGB1 inhibition of SPEECHLESS DNA-binding activity

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Journal of Integrative Plant Biology 2021年第11期63卷 1967-1981页

作者： Xiaoli Cao Pengbo Xu Yao Liu Guangqiong Yang Minqing Liu Li Chen yingyu Cheng Peng Xu Langxi Miao Zhilei Mao Wenxiu Wang Shuang Kou Tongtong Guo Hong‐Quan Yang State Key Laboratory of Genetic Engineering Institute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Plant Sciences School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China

Cryptochromes are blue light photoreceptors that mediate various light responses in plants and mammals. The heterotrimeric G-protein is known to regulate various physiological processes in plants and mammals. In Arabidopsis, cryptochrome 1(CRY1) and the G-protein β subunit AGB1 act antagonistically to regulate stomatal *** molecular mechanism by which CRY1 and AGB1 regulate this process remains ***, we show that Arabidopsis CRY1 acts partially through AGB1, and AGB1 acts through SPEECHLESS(SPCH), a master transcription factor that drives stomatal initiation and proliferation, to regulate stomatal development. We demonstrate that AGB1 physically interacts with SPCH to block the b HLH DNA-binding domain of SPCH and inhibit its DNA-binding activity. Moreover, we demonstrate that photoexcited CRY1 represses the interaction of AGB1 with SPCH to release AGB1 inhibition of SPCH DNA-binding activity, leading to the expression of SPCH-target genes promoting stomatal development. Taken together, our results suggest that the mechanism by which CRY1 promotes stomatal development involves positive regulation of the DNA-binding activity of SPCH mediated by CRY1 inhibition of the AGB1-SPCH interaction. We propose that the antagonistic regulation of SPCH DNA-binding activity by CRY1 and AGB1 may allow plants to balance light and G-protein signaling and optimize stomatal density and pattern.

关键词： cryptochrome 1(CRY1) heterotrimeric G-proteinβ-subunit AGB1 SPEECHLESS DNA-binding activity stomatal development

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Surface Modification and Suspension Stability of Ultrafine Al(OH)_3 Particles

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沈阳建筑大学学报（自然科学版） 2011年第1期27卷 84-90页

作者： ZHAO Su,QIU Liyuan,TIAN Jing,ZHAO yingyu(School of Material Science and Engineering,Shenyang Jianzhu University,Shenyang,China,110168) School of Material Science and Engineering Shenyang Jianzhu UniversityShenyangChina110168

The influence of single and compound dispersant on the sedimentation performance of modifiedultrafine Al(OH)3powder aqueous suspension was studied by the determination of the settlement rate and the Zeta *** results showed that the type and dosage of the dispersant have remarkable impacts on the dispersion *** the mixture of DP-270and Sodium C16alkylbenzenesulfonate(mass ratio=1∶1)in the Al(OH)3aqueous suspension,the dispersion stability was improved *** for spherical partic...

关键词： Modification Ultrafine Al(OH)3Powder Suspension Stability

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Acoustic impedance inversion of zero-offset VSP data

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Applied Geophysics 2009年第2期6卷 150-158页

作者： Wang Jing Liu Yang Sun Zhe Tian Hong Su Hua Zhao Qianhua Liu yingyu State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum Beijing 102249 China CNPC Key Laboratory of Geophysical Exploration China University of Petroleum Beijing 102249 China Oilfield Technology Department China Oilfield Services Limited Beijing 101149 China

Highly precise acoustic impedance inversion is a key technology for pre-drilling prediction by VSP data. In this paper, based on the facts that VSP data has high resolution, high signal to noise ratio, and the downgoing and upgoing waves can be accurately separated, we propose a method of predicting the impedance below the borehole in front of the bit using VSP data. First, the method of nonlinear iterative inversion is adopted to invert for impedance using the VSP corridor stack. Then, by modifying the damping factor in the iteration and using the preconditioned conjugate gradient method to solve the equations, the stability and convergence of the inversion results can be enhanced. The results of theoretical models and actual data demonstrate that the method is effective for pre-drilling prediction using VSP data.

关键词： zero-offset VSP impedance inversion non-linear iterative inversion damping factor pre-conditioned conjugate gradient method

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Exosome-loaded biomaterials for tendon/ligament repair

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Biomaterials Translational 2024年第2期5卷 129-143页

作者： Haohan Wang Yonglin Guo Yiwen Jiang yingyu Ge Hanyi Wang Dingyi Shi Guoyang Zhang Jinzhong Zhao Yuhao Kang Liren Wang Shanghai Jiao Tong University School of Medicine ShanghaiChina Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Materials Science and Engineering East China University of Science and TechnologyShanghaiChina

Exosomes,a specialised type of extracellular vesicle,have attracted significant attention in the realm of tendon/ligament repair as a potential biologic therapeutic *** the competence of key substances responsible for the delivery function was gradually elucidated,series of shortcomings exemplified by the limited stability still need to be ***,how to take maximum advantage of the biological characteristics of exosomes is of great ***,the comprehensive exploration and application of biomedical engineering has improved the availability of exosomes and revealed the future direction of exosomes combined with *** review delves into the present application of biomaterials such as nanomaterials,hydrogels,and electrospun scaffolds,serving as the carriers of exosomes in tendon/ligament *** pinpointing and exploring their strengths and limitations,it offers valuable insights,paving the way the future direction of biomaterials in the application of exosomes in tendon/ligament repair in this field.

关键词： biomaterials electrospinning exosomes hydrogel microspheres hydrogels nanoparticles

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Review Integration of smartphone technology and artificial intelligence for advanced ophthalmic care:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 120-127页

作者： Kai Jin yingyu Li Hongkang Wu Yih Chung Tham Victor Koh Yitian Zhao Ryo Kawasaki Andrzej Grzybowski Juan Ye Eye Center The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhouChina Centre for Innovation and Precision Eye Health National University of SingaporeSingapore Department of Ophthalmology National University of SingaporeSingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Ophthalmology and Visual Science Academic Clinical Program Duke-NUS Medical SchoolSingapore Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Ningbo Eye Hospital NingboChina Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Division of Public Health Department of Social MedicineGraduate School of MedicineOsaka UniversityOsakaJapan Artificial Intelligence Center for Medical Research and Application Osaka University HospitalOsakaJapan Institute for Research in Ophthalmology Foundation for Ophthalmology DevelopmentPoznanPoland

Background:The convergence of smartphone technology and artificial intelligence(AI)has revolutionized the landscape of ophthalmic care,offering unprecedented opportunities for diagnosis,monitoring,and management of ocular ***,there is a lack of systematic studies on discussing the integration of smart-phone and AI in this *** text:This review includes 52 studies,and explores the integration of smartphones and AI in ophthalmology,delineating its collective impact on screening methodologies,disease detection,telemedicine initiatives,and patient *** collective findings from the curated studies indicate promising performance of the smartphone-based AI screening for various ocular diseases which encompass major retinal diseases,glaucoma,cataract,visual impairment in children and ocular surface ***,the utilization of smartphone-based imaging modalities,coupled with AI algorithms,is able to provide timely,efficient and cost-effective screening for ocular *** modality can also facilitate patient self-monitoring,remote patient monitoring and enhancing accessibility to eye care services,particularly in underserved *** involving data pri-vacy,algorithm validation,regulatory frameworks and issues of trust are still need to be ***,evaluation on real-world implementation is imperative as well,and real-world prospective studies are currently ***:Smartphone ocular imaging merged with AI enables earlier,precise diagnoses,personalized treat-ments,and enhanced service accessibility in eye *** is crucial to navigate ethical and data security challenges while responsibly leveraging these innovations,promising a potential revolution in care access and global eye health equity.

关键词： Artificial intelligence Smartphone imaging Ophthalmology Telemedicine Ocular disease management

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Measurement of water holdup in oil-in-water emulsions in wellbores using microwave resonance sensor

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Applied Geophysics 2021年第2期18卷 185-197,273页

作者： Jin-Ningde Liu-Dongyang Bai-Landi Ren-yingyu School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China

In this study,we propose a new method for water holdup measurement of oil-in-water emulsions with a microwave resonance sensor(MRS).The angle and length of the electrode plate are optimized by HFSS simulation *** a vector network analyzer(VNA),a static calibration experiment is conducted,and the resonant frequency distribution of oil-in-water emulsions is analyzed within an 80%–100%water holdup *** addition,we observe and analyze the micron-sized oil bubble structure in the emulsifi ed state with an optical *** this basis,a dynamic experiment of oil-in-water emulsions with high water cut and low velocity in a vertical upward pipe is conducted.S_(21) response curves of the MRS are obtained by the VNA under diff erent working conditions in real ***,we analyze the relationship between the resonant frequency and water *** results show that the MRS has an average resolution of 0.096%water cut for high water cut oil-in-water emulsions within the frequency range of 2.2–2.8 GHz.

关键词： oil-in-water emulsions water holdup measurement high water cut microwave resonance sensor

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Elasticity soltion of rupture model of shallow earthquake

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Global Geology 2008年第4期11卷 242-245页

作者： Li YU Zhaohua YANG yingyu JIN Li ZHANG Construction Engineering College Jilin University Changchun 130026 China

Based on the theory of elastic mechanics,and using the typical rupture model of shallow earthquake,the authors considered the shallow earthquake as a plane mechanical problem,which was constructed the corresponding mechanical *** the stress components' formulas of the semi-infinite model acted by the finite even shearing force,the main stress is *** is clear that the sector on the right of the center section is squeezed zone,where the maximum principal stress points at the "source of stress",and that on the left is tensile zone,where the minimum principal stress points to the "source of stress".

关键词： shallow earthquake rupture mechanical model principal stress

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神界的山门:南印度瞿布罗研究

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宗教学研究 2022年第4期 265-270页

作者：李瀛昱四川大学道教与宗教文化研究所

南印度独创的瞿布罗是神庙多重院落格局形成的关键,后期高耸的瞿布罗更是打破旧有“圣室最高峰”的修筑理念。瞿布罗神山道场的宗教象征是对圣室屋顶象征寓意的承接和取代,呈现出象征转移的事实。相比修缮圣室,筑起高大、厚重的瞿布罗... 详细信息

南印度独创的瞿布罗是神庙多重院落格局形成的关键,后期高耸的瞿布罗更是打破旧有“圣室最高峰”的修筑理念。瞿布罗神山道场的宗教象征是对圣室屋顶象征寓意的承接和取代,呈现出象征转移的事实。相比修缮圣室,筑起高大、厚重的瞿布罗是诸多君主宣告王国实力的更优选择,其最终演进为“神王合一”的双重文化符号。瞿布罗投射出的秩序感是南印度社会文化的表征与重要的宗教隐喻,有着极强的印度教特性。伴随虔诚运动的进程,瞿布罗看似是神性空间对世俗的让渡,实际上却通过宗教场域的不断扩张与对俗事之地的层层渗透,使神庙在印度教社会中的角色更加稳固。

关键词：瞿布罗印度教双重象征过渡空间

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Really interesting new gene finger protein 121(RNF121) is anovel Golgi-localized membrane protein that regulates apoptosis

Really interesting new gene finger protein 121(RNF121) is an...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Yuanbo Zhao Dubeiqi Hong Dalong Ma yingyu Chen Key Laboratory of Medical Immunology Ministry of Health Peking University Health Science Center Peking University Center for Human Disease Genomics Peking University

Really interesting new gene(RING)finger protein is a large protein family in the *** have very important functions in physiological activities and cancer *** biological functions of many RING finger proteins remain *** thisstudy,we describe the biological activity of a novel,human Golgi-localized RING fingerprotein 121(RNF121),the function of which is,thus far,*** RNF121 proteincontains five conserved TM domains and that the RING finger domain faces the *** endoplasmic reticulum-localized RNF121 in Caenorhabditis elegans,human RNF121was ***121 predominantly localized to the Golgi apparatus in ***121 mRNA is expressed in a variety of normal human ***121 knockdown inhibited cell growth and induced apoptosis,which was accompaniedby caspase-3 activation and the inactivation of poly(adenosine diphosphate-ribose)polymerase.Z-VAD-FMK,a pan-caspases inhibitor,inhibited the RNF121knockdown–*** of wild-type RNF121 decreased RNF121 knockdown-inducedapoptosis but the RING domain mutants of RNF121did not have this *** theRING-domain mutated(RNF121 C229A C259A)or truncated RNF121(RNF121 1-225)couldn’t alleviate the cell death induced by knockdown of ***121 C229A C259Aand RNF121 1-225 also showed no anti-apoptosis effect when *** indicatesthat the RING domain is required for RNF121-regulated ***,RNF121 knockdown enhanced etoposide-induced *** RNF121has anti-apoptosis effect in cancer cells,and sheds new light to the relation betweenRNF121 and *** finger proteins have been proved to play crucial roles in *** is possible that RNF121 regulates apoptosis through targeting apoptosis-related molecules for *** is also possible that RNF121 regulates apoptosisthrough regulation of Golgi-related transport *** study instigates further investigation to the exact mechanism that RNF121 regula

关键词： RING finger protein 121 RNF121 apoptosis RING domain Golgi apparatus

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A case study investigating the efects of emergency vaccination with Brucella abortus A19 vaccine on a dairy farm undergoing an abortion outbreak in China

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Animal Diseases 2022年第4期2卷 246-257页

作者： Yu Wang Yan Wang Qingjie Peng Zhijie Xiang yingyu Chen Guiqiang Wang Xijuan Wu Aizhen Guo Ian D.Robertson State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070China College of Veterinary Medicine Huazhong Agricultural UniversityWuhanChina Hubei International Scientifc and Technological Cooperation Base of Veterinary Epidemiology Huazhong Agricultural UniversityWuhanChina China-Australia Joint Research and Training Centre for Veterinary Epidemiology Huazhong Agricultural UniversityWuhanChina Technology Centre of Bio-Agricultural Angel Yeast CoLtdYichangChina Hubei Hongshan Laboratory Huazhong Agricultural UniversityWuhanChina Hubei Dairy Herd Improvement Center WuhanChina School of Veterinary Medicine Murdoch UniversityPerthWAAustralia

Brucellosis is an important zoonosis that results in substantial economic losses to the livestock industry through abortions and reduced milk *** study investigated an abortion outbreak in a dairy herd and then explored the efects of emergency vaccination with Brucella abortus A19 vaccine on the incidence of abortion and milk yield.A full dose of vaccine(6×10^(10)—12×10^(10)colony forming units,Cfu)was administered subcutaneously to calves and non-pregnant heifers,and a reduced dose(6×10^(8)—12×10^(8)Cfu)to adult cows and pregnant replacement *** Bengal Test was used to screen Brucella infection status and then positive samples were tested with a *** that tested positive for both tests were considered positive to Brucella *** animal-level seroprevalence of brucellosis was 23.1%(95%CI:17.0,30.2),and the attributable fraction of abortions in seropositive animals was 89.1%(95%CI:64.3,96.7).The odds of seropositivity were signifcantly higher in cows that aborted compared to cows that calved normally(OR=21.4,95%CI:4.4,168.4).Cows in sheds A2 and C1 were 10.2(95%CI:1.4,128.0)and 17.0(95%CI:2.8,190.3)times more likely to be seropositive than cows in shed *** were not detectable in most heifers 12 months *** efectiveness of the vaccine in preventing abortions was estimated to be 56.8%(95%CI:15.8,77.8)for the entire herd,but increased to 86.7%(95%CI:4.4,98.1)when only primiparous heifers were ***,a signifcant increase in the average herd 305-day milk yield one-year after vaccination was also observed relative to that in the previous three *** is concluded that emergency vaccination of a dairy herd undergoing an abortion outbreak with the A19 vaccine efectively reduced the incidence of abortion and indirectly increased milk yield one-year after vaccination.

关键词： Brucellosis Outbreak investigation Emergency vaccination Brucella abortus A19 vaccine Abortion 305-day milk yield

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