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粤语语音合成系统语料库设计研究

计算机工程 2005年第14期31卷 59-61页

作者：徐英莹张培仁中国科学技术大学自动化系合肥230027

介绍了语料库设计的原理和过程,并结合粤语语音合成系统语料库实现,提出了“语境矢量”的独特设计和“语境总量”的概念,给出了语境总量的计算方法。最后介绍了Greedy算法,并给出了文本语料搜索的具体流程。

关键词：语音合成语料库语境矢量语境总量

Bleomycin-induced Death following ABVD Chemotherapy for Hodgkin's Disease with Pulmonary Tuberculosis

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Bleomycin-induced Death following ABVD Chemotherapy for Hodg...

Chiral transfer amidst one-dimensional linear polymers and twodimensional network covalent organic frameworks:Striking a fine balance between helicity and crystallinity

中华医学会临床药学分会2014年全国学术会议

作者：王怀冲 YANG Wei xu Xiaofeng xu yingying ZHANG xuejin Department of Clinic Pharmacy Integrated Chinese and Western Medicine Hospital of Zhejiang Province Department of Oncology and Hematology Integrated Chinese and Western Medicine Hospital of Zhejiang Province

Hodgkin’s disease(HD)has been long described in association with ***(doxorubicin,bleomycin,vinblastine,and dacarbazine)chemotherapy is regarded as standard of care for these ***(BLM)in ABVD regimen has a low therapeu...

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Nano Research 2024年第6期17卷 5726-5734页

作者： Xinlin Zha Mengjuan Zuo Guilin xu Zhong Yan Haining You Yi Xiong Ying Liu yingying Li Liyan Yang Ke Liu Mufang Li Tao Zhao Dong Wang College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China Key Laboratory of Textile Fiber and Products Ministry of EducationWuhan Textile UniversityWuhan 430200China

The current landscape of chiral covalent organic frameworks(COFs)predominantly centered on constructing asymmetric molecular-scale chirality,often introducing an inherent contradiction to the COF symmetry and limiting ***,we overcome these challenges by achieving chiral transfer between one-dimensional(1D)imine linear polymers(LPs)and two-dimensional(2D)networkβ-ketoenamine COFs composed of achiral *** successfully synthesize several 1D imine LPs with mesoscopic helical chirality,comprising achiral C2-symmetric terephthalaldehyde and diamine linkers in a chiral supramolecular transcription *** the irreversible tautomerism mechanism within the linker replacement approach,terephthalaldehyde(TPA)units in these helical 1D LPs are substituted with C3-symmetric 1,3,5-triformylphloroglucinol(TP),yielding the corresponding 2D networkβ-ketoenamine *** and helicity of the resultantβ-ketoenamine COFs intimately hinge on reaction conditions,including the aldehyde stoichiometry of Tp and TPA,as well as the quantity and concentration of the catalyst *** optimized conditions,the nucleation and growth were precisely governed,achieving a harmonious equilibrium of crystallinity and helicity within the generated 2D networkβ-ketoenamine COFs,even with covalent bond rupture,recombination,and topological transition(from[C2+C2]to[C3+C2]).Impressively,the ground state chirality inherent to helical 1D LPs seamlessly transfers to helical 2D networkβ-ketoenamine *** study not only offers new perspectives on the development of chiral functional COFs,but also provides fresh insights into the precise control of COFs'microscopic morphology.

关键词： chiral covalent organic frameworks chiral transfer dimensional transformation helicity

Germylene-Fe complexes caused by heterometallic coupling and investigation into the 3d-4p bonding

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Chinese Chemical Letters 2024年第3期35卷 304-307页

作者： yingying Qin Yongmei Kang Lei Zhang Jianping Sun Zhijing Zhang Jialei xu Fanlong Zeng Anyang Li Wenyuan Wang Weiqun Shi Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710127China Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Shaanxi Coal and Chemical Industry Xi'an 710054China

The interpretation of heterometallic bonding nature is a basic work of inorganic *** means of intermetallic substitution of germylene anions with iron halide complexes CpFe(CO)_(2)I andβ-diketiminato Fe^Ⅱchloride,the ferrogermylene complexes 3a,3b and 4a were synthesized and structurally *** structural and IR characterizations show the presence of the Ge←Feπbackbonding in molecules 3a,3b and *** computational works on frontier molecular orbitals and their comparison of energy states confirmed thatσdonation andπbackbonding are both weak in these molecules,despite three complexes have longer Ge-Fe bonds,whose strength decreases slightly with the degressive electron density around Fe environment in a sequence from 3a,3b to 4a.

关键词： Metallic bonding Germylene Iron Crystal structure σbond πbackbond

Development of SSR markers from ESTs of gramineous species and their chromosome location on wheat

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Progress in Natural Science:Materials International 2008年第12期18卷 1485-1490页

作者： Linzhi Li~1 Junjun Wang Ying Guo Fangshan Jiang Yunfeng xu yingying Wang Haitao Pan Guanzhu Han Ruijun Li Sishen Li National Key Laboratory of Crop Biology,College of Agronomy,Shandong Agricultural University,Tai’an 271018,China National Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Tai’an 271018 China

A total of 407,663 expressed sequence tags (ESTs) of wheat,barley,maize,rice,and sorghum,obtained from GenBank/dbEST,were used to search for simple sequence repeats (SSRs).A total of 10,253 EST-SSRs,which accounted for 2.52% of all the ESTs,were iden- *** Primer Premier 5.0,1367 EST-SSR primer pairs were designed,of which 715 with high quality were *** 715 primer pairs were tested on wheat,rice,maize,cotton,and soybean under the same PCR conditions,and the effective primer pairs in the five crops were 500 (69.93%),383 (53.57%),452 (63.22%),357 (49.93%),and 388 (56.27%),*** indicated a high transfer- ability of EST-SSR markers between far-ranging *** addition,139 EST-SSR primer pairs with 240 loci were localized on all the 21 wheat chromosomes by using Chinese Spring nulli-tetrasomic lines of wheat.

关键词： EST-SSR Wheat Maize Rice Barley Sorghum Cotton Soybean

基于AVMS模型的学科交叉可视化研究——以图书情报学为例

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现代情报 2015年第2期35卷 87-92,97页

作者：徐迎迎安徽财经大学管理科学与工程学院安徽蚌埠233030

以中国期刊全文数据库(CNKI)和万方为来源数据库,统计分析了国内图书情报学(Library and Information Science,简称LIS)有关学科交叉研究的文献。基于AVMS(Author-Viewpoint-Method-Subject)模型对检索出图书情报学有关学科交叉研究的6... 详细信息

以中国期刊全文数据库(CNKI)和万方为来源数据库,统计分析了国内图书情报学(Library and Information Science,简称LIS)有关学科交叉研究的文献。基于AVMS(Author-Viewpoint-Method-Subject)模型对检索出图书情报学有关学科交叉研究的60篇文献进行可视化分析,结果表明:图书情报学学科交叉多以引文为研究视角,不乏文献计量(文章、作者和引文)、跨学科发文等创新视角;多以引文分析、社会网络分析、共词分析为研究方法,不乏聚类分析、调查法、SWOT分析法等方法;主题研究集中与图书情报学具体交叉学科研究、学科交叉程度测度和交叉学科的主题研究。

关键词：学科交叉跨学科图书情报学 AVSM模型共词分析

伟大抗疫精神融入医学院校思政课教学的思考——以“中国近现代史纲要”课为例

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中国医学伦理学 2023年第7期36卷 819-823,828页

作者：许莹莹福建医科大学马克思主义学院福建福州3500122

伟大抗疫精神融入“中国近现代史纲要”课教学,是医学院校思政课教育教学改革的重要内容。两者相融合有助于优化“纲要”课的话语体系,强化“纲要”课的政治功能和深化“纲要”课的价值引领。认真研究“纲要”课教学内容,寻找其与伟大... 详细信息

伟大抗疫精神融入“中国近现代史纲要”课教学,是医学院校思政课教育教学改革的重要内容。两者相融合有助于优化“纲要”课的话语体系,强化“纲要”课的政治功能和深化“纲要”课的价值引领。认真研究“纲要”课教学内容,寻找其与伟大抗疫精神的相通相融之处,进而通过立足课堂主阵地,搭建实践大平台和用好网络新媒体等具体路径,将伟大抗疫精神及其彰显的中国共产党坚强领导力、马克思主义立场观点方法、中国特色社会主义制度显著优势以及中国坚实国力等内容“基因式”地嵌入教学过程中,提高“纲要”课实效性,培养具有坚定政治立场和高尚医德素养的新时代医学人才。

关键词：伟大抗疫精神中国近现代史纲要医学院校思政课教学

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2581-2597页

作者： Hongliang Qiu Sihui Huang Yuting Liu Libo Liu Fengming Guo yingying Guo Dan Li Xianfeng Cen Yajie Chen Meng Zhang Yan Che Man xu Qizhu Tang Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan 430060China

Doxorubicin(DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients,but related pharmacotherapeutic measures are relatively *** was recently identified as a major mechanism of DOX-induced ***,a novel ferroptosis inhibitor,is a well-described clinical drug widely ***,its role and pathological mechanism in DOX-induced cardiotoxicity are still *** this study,we demonstrated the effects of idebenone on DOX-induced cardiotoxicity and elucidated its underlying mechanism.A single intraperitoneal injection of DOX(15 mg/kg)was administrated to establish DOX-induced *** results showed that idebenone significantly attenuated DOX-induced cardiac dysfunction due to its ability to regulate acute DOX-induced Fe^(2+)and ROS overload,which resulted in *** and BLI further revealed that idebenone's anti-ferroptosis effect was mediated by ***,idebenone increased FSP1 protein levels but did not affect Fsp1 mRNA levels in the presence of *** could form stable hydrogen bonds with FSP1 protein at K355,which may influence its association with *** results confirmed that idebenone stabilized FSP1 protein levels by inhibiting its ubiquitination *** conclusion,this study demonstrates idebenone attenuated DOX-induced cardiotoxicity by inhibiting ferroptosis via regulation of FSP1,making it a potential clinical drug for patients receiving DOX treatment.

关键词： Idebenone DOX-induced cardiotoxicity Ferroptosis FSP1 Ubiquitination Lipid peroxidation Iron overload Clinical translation

Cordotomy for bilateral cord abductal paralysis

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Chinese Medical Journal 2001年第5期114卷 94-95,111页

作者：汪审清周水洪徐盈盈浙江大学医学院附属第一医院耳鼻咽喉科杭州310003

Objective To investigate the clinical effects of cordotomy on bilateral cord abductal paralysis. Methods With unilateral cordotomy, we treated 4 patients with bilateral cord paralysis whose glottis size was about 2.0 mm to 2.5 mm. They were followed up for over one *** One week after surgery, the tracheotomy tubes of all 4 patients were plugged and no dyspnea occurred during rest and mild action. Their voices were more hoarse than before surgery. After 3 months,the tracheotomy tubes were successfully decannulated, and in the following one year, their respiration was normal and then speech was clear, although their voices were still a little *** We suggest that cordotomy be one option in the treatment of bilateral cord abductal paralysis.

关键词： vocal cord paralysis · surgery · hoarseness