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Pulmonary Bacterial Infection and Liver Cirrhosis: Current Status and Treatment

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Infectious Microbes & Diseases 2024年第1期6卷 5-10页

作者： yingying zhao Song Yang Huichun Xing Center of Liver Diseases Division 3 Beijing Ditan HospitalCapital Medical UniversityBeijingChina

Liver cirrhosis has a higher incidence rate and mortality when complicated with bacterial infections.Concomitant bacterial infections,especially bacterial pneumonia,increase the susceptibility of cirrhotic patients to decompensation,with a higher likelihood of mortality.Bacterial pneu-monia is often overlooked in patients with liver cirrhosis,although it can impact the clinical progress and outcomes.Untimely diagnosis and inappropriate antibiotic treatments are associated with poor prognosis and increased mortality.Current understanding of mechanisms and appropriate antibiotic treatments for cirrhosis-related bacterial pneumonia remain inadequate.Herein,we reviewed the epidemiology,clinical characteristics and treatment of pulmonary bacterial infections in cirrhotic patients to provide suggestions for clinical practice.

关键词： bacterial pneumonia liver cirrhosis epidemiology characteristics treatment

Sustainable production of high-energy-density jet fuel via cycloaddition reactions

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Journal of Energy Chemistry 2024年第8期95卷 712-722页

作者： Yan-Cheng Hu yingying zhao Ning Li Jing-Pei Cao School of Chemical Engineering and Technology China University of Mining and Technology School of Education Science Jiangsu Normal University CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Developing an energy supply-chain based on renewable biomass holds great potential to build a low carbon society. High-energy-density(HED) jet fuel, featuring unique fused/strained cycloalkanes, is of great significance for volume-limited military aircrafts, as their high density and combustion heat can extend flight duration and increase the payload. Therefore, the exploration of biomass-based routes towards HED fuel has drawn much attention over the past decade. Cycloaddition reaction features rapid construction of various carbocycles in an atom-and step-economical fashion. This elegant strategy has been widely applied in the manufacture of sustainable HED fuel. Here we carefully summarize the progress achieved in this fascinating area and the review is categorized by the cycloaddition patterns including [4+2], [2+2],[4+4], and [2+1] cycloadditions. Besides, the energy densities of the as-prepared biofuels and petroleumbased fuels(conventional Jet-A and advanced JP-10) are also compared. This review will provide important insights into rational design of new HED fuel with different ring-types/sizes and inspire the chemists to turn those literature studies into practical applications in military field.

关键词： Biomass-based chemicals Catalysis Cycloaddition Cycloalkanes High-energy-density fuel

Bipolar membrane electrodialysis integrated with in-situ CO_(2)absorption for simulated seawater concentrate utilization,carbon storage and production of sodium carbonate

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Journal of Environmental Sciences 2024年第8期142卷 21-32页

作者： Jingtao Bi Tianyi Chen Yue Xie Ruochen Shen Bin Li Mengmeng Sun Xiaofu Guo yingying zhao School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300401China Engineering Research Center of Seawater Utilization Technology of Ministry of Education School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300401China Hebei Collaborative Innovation Center of Modern Marine Chemical Technology Tianjin 300401China Tianjin Key Laboratory of Chemical Process Safety Tianjin 300130China Shandong Technology Innovation Center of Seawater and Brine Efficient Utilization Weifang 262737China

In the context of carbon capture,utilization,and storage,the high-value utilization of carbon storage presents a significant challenge.To address this challenge,this study employed the bipolar membrane electrodialysis integrated with carbon utilization technology to prepare Na_(2)CO_(3)products using simulated seawater concentrate,achieving simultaneous saline wastewater utilization,carbon storage and high-value production of Na_(2)CO_(3).The effects of various factors,including concentration of simulated seawater concentrate,current density,CO_(2)aeration rate,and circulating flow rate of alkali chamber,on the quality of Na_(2)CO_(3)product,carbon sequestration rate,and energy consumption were investigated.Under the optimal condition,the CO_(3)^(2-)concentration in the alkaline chamber reached a maximum of 0.817 mol/L with 98 mol%purity.The resulting carbon fixation rate was 70.50%,with energy consumption for carbon sequestration and product production of 5.7 k Whr/m^(3)CO_(2)and1237.8 k Whr/ton Na_(2)CO_(3),respectively.This coupling design provides a triple-win outcome promoting waste reduction and efficient utilization of resources.

关键词： Bipolar membrane electrodialysis(BMED) Carbon capture Utilization and storage(CCUS) Seawater concentrate Sodium carbonate

Paleontology Knowledge Graph for Data-Driven Discovery

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Journal of Earth Science 2024年第3期35卷 1024-1034页

作者： Yiying Deng Sicun Song Junxuan Fan Mao Luo Le Yao Shaochun Dong Yukun Shi Linna Zhang Yue Wang Haipeng Xu Huiqing Xu yingying zhao zhaohui Pan Zhangshuai Hou Xiaoming Li Boheng Shen Xinran Chen Shuhan Zhang Xuejin Wu Lida Xing Qingqing Liang Enze Wang School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Centre for Research and Education on Biological Evolution and Environment Nanjing UniversityNanjing 210023China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China School of the Earth Sciences and Resources China University of GeosciencesBeijing 100083China

A knowledge graph(KG)is a knowledge base that integrates and represents data based on a graph-structured data model or topology.Geoscientists have made efforts to construct geosciencerelated KGs to overcome semantic heterogeneity and facilitate knowledge representation,data integration,and text analysis.However,there is currently no comprehensive paleontology KG or data-driven discovery based on it.In this study,we constructed a two-layer model to represent the ordinal hierarchical structure of the paleontology KG following a top-down construction process.An ontology containing 19365 concepts has been defined up to 2023.On this basis,we derived the synonymy list based on the paleontology KG and designed corresponding online functions in the OneStratigraphy database to showcase the use of the KG in paleontological research.

关键词： paleontology knowledge graph ontology synonymy list OneStratigraphy big data ge-ology.

Numerical simulation of vibrational response characteristics of railway subgrades with insulation boards

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Research in Cold and Arid Regions 2022年第1期14卷 23-31页

作者： ZiYu Wang XianZhang Ling yingying zhao Feng Zhang LiHui Tian School of Marine Science and Technology Hainan Tropical Ocean UniversitySanyaHainan 572022China School of Civil Engineering Harbin Institute of TechnologyHarbinHeilongjiang 150090China School of Civil Engineering Southeast UniversityNanjingJiangsu 211189China School of Mining Engineering Heilongjiang University of Science and TechnologyHarbinHeilongjiang 150022China

This study presents a numerical method based on the surface temperature data and the ground temperature increase in Daqing for predicting temperature field distribution in the Binzhou Railway subgrade and analyzing the temporal and spatial distribution of freeze−thaw status of railway subgrade.The calibrated numerical method is applied to simulate the temperature field distribution and roadbed vibrational response of the railway subgrade with a thermal insulation layer at different seasons.The results show the following:(1)The thermal insulation layer can remarkably increase the soil temperature below it and maximum frost depth in the subgrade.(2)Thermal insulation can effectively reduce the subgrade vibration and protect it from frost damage.(3)Given that the strength requirements are met,the insulation layer should be buried as shallow as possible to effectively reduce the subgrade vibration response.The research findings provide theoretical support for the frost damage prevention of railway subgrades in seasonally frozen regions.

关键词： seasonally frozen regions railway subgrade insulation layer vibrational response frost depth

Hydrogenase as the basis for green hydrogen production and utilization

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Journal of Energy Chemistry 2023年第10期85卷 348-362,I0011页

作者： Haishuo Ji Lei Wan Yanxin Gao Ping Du Wenjin Li Hang Luo Jiarui Ning yingying zhao Huangwei Wang Lixin Zhang Liyun Zhang State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300350China Max Planck Institute for Chemical Energy Conversion Stiftstrasse 34-3645470 Mülheim an der RuhrGermany State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300350China State Key Laboratory of Bioreactor Engineering and School of BiotechnologyEast China University of Science and Technology(ECUST)Shanghai 200237China

Hydrogenase is a paradigm of highly efficient biocatalyst for H_(2) production and utilization evolved in nature. A dilemma is that despite the high activity and efficiency expected for hydrogenases as promising catalysts for the hydrogen economy, the poor oxygen tolerance and low yield of hydrogenases largely hinder their practical application. In these years, the enigmas surrounding hydrogenases regarding their structures, oxygen tolerance, mechanisms for catalysis, redox intermediates, and proton-coupled electron transfer schemes have been gradually elucidated;the schemes, which can well couple hydrogenases with other highly efficient(in)organic and biological catalysts to build novel reactors and drive valuable reactions, make it possible for hydrogenases to find their niches. To see how scientists put efforts to tackle this issue and design novel reactors in the fields where hydrogenases play crucial roles, in this review,recent advances were summarized, including different strategies for protecting enzyme molecules from oxygen, enzyme-based assembling systems for H_(2) evolution in the photoelectronic catalysis, enzymatic biofuel cells for H_(2) utilization and storage and the efficient electricity-hydrogen-carbohydrate cycle for high-purity hydrogen and biofuel automobiles. Limitations and future perspectives of hydrogenasebased applications in H_(2) production and utilization with great impact are discussed. In addition, this review also provides a new perspective on the use of biohydrogen in healthcare beyond energy.

关键词： Hydrogenase Biological H_(2)energy Oxygen tolerance Artificial photosynthesis Biofuel cells

A comprehensive review on mechanism of natural products against Staphylococcus aureus

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Journal of Future Foods 2022年第1期2卷 25-33页

作者： yingying zhao Jinfeng Wei Changqin Li Adel F.Ahmed Zhenhua Liu Changyang Ma National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Henan Kaifeng College of Science Technology and Communication(Minsheng College Henan University)Kaifeng 475004China Functional Food Engineering Technology Research Center of Henan Province Kaifeng 475004China Medicinal and Aromatic Plants Researches Department Horticulture Research InstituteAgricultural Research CenterCairo 11435Egypt Joint International Research Laboratory of Food&Medicine Resource Function of Henan Province Henan UniversityKaifeng 475004China

The abuse of antibiotics seriously threatens the therapeutic effect.Natural products from plants,antimicrobial peptides and micro-organisms have antibacterial activity against Staphylococcus aureus.The mechanism of natural products reported in recent years on S.aureus includes six types,which are the acting on bacterial cell wall,cytomembrane,metabolic pathway,protein,nucleic acid,biofilm and quorum sensing system to achieve antibacterial effect.This article summarized the mechanism of natural products reported in recent years on S.aureus.It is found that the natural products acting on cell wall or cell wall synthesis pathway key enzymes are relatively safe and highly selective.It has the prospect of developing into medicine and provides the clue to investigate and utilize natural products in antibacterial activity.

关键词： Natural products Staphylococcus aureus Antibacterial mechanism Enzymes Cell wall

Immunosuppression Induced by Brain-Specific HDAC6 Knockdown Improves Aging Performance in Drosophila melanogaster

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Phenomics 2022年第3期2卷 194-200页

作者： yingying zhao Hongwen Xuan Chao Shen Peiyi Liu Jing-Dong J.Han Wei Yu State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China CAS Key Laboratory of Computational Biology Shanghai Institutes for Biological SciencesCAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthChinese Academy of Sciences320 Yue Yang RoadShanghai 200031China Peking-Tsinghua Center for Life Sciences Center for Quantitative Biology(CQB)Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China

HDAC6 is involved in several biological processes related to aging-associated diseases.However,it was unknown whether HDAC6 could directly regulate lifespan and healthspan.We found that HDAC6 knockdown induced transcriptome changes to attenuate the aging changes in the Drosophila head,particularly on the inflammation and innate immunity-related genes.Whole-body knockdown of HDAC6 extended lifespan in the fly,furthermore brain-specific knockdown of HDAC6 extended both lifespan and healthspan in the fly.Our results established HDAC6 as a lifespan regulator and provided a potential anti-aging target.

关键词： HDAC6 Aging Drosophila Inflammation Innate immunity Motor neuron

Vascular protection and regenerative effects of intranasal DL-3-N butylphthalide treatment after ischaemic stroke in mice

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Stroke & Vascular Neurology 2021年第1期6卷 74-79页

作者： Mengyao Qu Jingjie zhao yingying zhao Jinmei Sun Liping Liu Ling Wei Yongbo Zhang Neurology Capital Medical University Affiliated Beijing Friendship HospitalBeijingChina Anesthesiology Emory University School of MedicineAtlantaGeorgiaUSA Chinese Traditional Medicine Capital Medical University Affiliated Beijing Friendship HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Neurology Tiantan Clinical Trial and Research Center for StrokeBeijingChina

Objective To investigate the effects of DL-3-N butylphthalide(NBP)via intranasal delivery after ischaemic stroke in mice.Methods C57BL/6 mice were divided into three groups:sham,stroke with vehicle and stroke with NBP treatment.Ischaemic stroke was induced by permanent ligation of right middle cerebral artery with 7 min common carotid artery occlusion.NBP(100 mg/kg)or vehicle was intranasally administered at 1 hour after stroke and repeated once a day until sacrifice.Bromodeoxyuridine(BrdU)(50 mg/kg/day)was given from the third day until sacrifice.Sensorimotor function was tested during 1-21 days after stroke.Local cerebral blood flow in the ischaemic and peri-infarct regions was measured using laser Doppler flowmetry before,during and 3 days after ischaemia.Expressions of vascular endothelial growth factor(VEGF)and endothelial nitric oxide synthase as well as regenerative marker BrdU in the peri-infarct region were analysed by western blotting and immunohistochemical methods.Results Compared with the vehicle group,NBP treatment significantly increased the VEGF expression in the poststroke brain.Stroke mice that received NBP showed significantly less vascular damage after stroke and more new neurons and blood vessels in the peri-infarct region at 21 days after stroke.In the adhesive removal test,the sensorimotor function of stroke mice treated with NBP performed significantly better at 1,3 and 7 days after stroke compared with vehicle controls.Conclusion Daily intranasal NBP treatment provides protective and neurogenic/angiogenic effects in the poststroke brain,accompanied with functional improvements after a focal ischaemic stroke in mice.

关键词： nasal protective treatment