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Genes & Diseases 2024年第4期11卷 138-140页

作者： Lei Xiong Miaomiao Lan Chang Liu Lei Li yingying yu Tongtong Wang Fan Liu Kun Wang Jin Liu Qingyong Meng State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100094China

Osteoporosis(OP)is an aging-associated condition that significantly affects the quality of life in aging humans and has few treatment options.As an important marker,recombinant immunoglobulin superfamily containing leucinerich repeat(ISLR)could be used as a gene therapy for OP.We herein used alkaline phosphatase(ALP)and alizarin red S(ARS)staining to evaluate osteogenic differentiation potential.

关键词： Immunoglobulin alkaline herein

Photocatalytic synthesis of small-molecule drugs by porous framework materials

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Chinese Chemical Letters 2024年第3期35卷 52-65页

作者： yingying Zhao Jiangpei yuan Lei Zhu yu Fang State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Innovation Institute of Industrial Design and Machine Intelligence Quanzhou-Hunan University Quanzhou 362801China

Small-molecule drugs are widely used in daily life.There are still issues with the current industrial synthesis techniques for small-molecule drugs,such as the use of expensive metal catalysts,convoluted reaction processes,and non-recyclable catalysts.The benefits of photocatalytic organic synthesis over conventional techniques are mild conditions,environmental friendliness,and great selectivity.Porous framework materials can precisely modulate catalytic sites'electronic state and ligand structure to improve photocatalytic performance.In particular,MOFs,COFs and PCCs based photocatalysts have received extensive research interest due to their unique morphology,structural adjustability,high photocatalytic performance,unique recyclability,excellent chemical stability,easy synthesis and low cost.Therefore,a key area for future research is the development of porous framework materials as photocatalysts for the synthesis of small-molecule drugs or drug precursors.

关键词： Small-molecule drug Porous framework materials Photocatalysis

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Immune checkpoint inhibitors break whose heart? Perspectives from cardio-immuno-oncology

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Genes & Diseases 2024年第2期11卷 807-818页

作者： yingying He Hui yu Shuang Dai Miao He Ling Ma Zihan Xu Feng Luo Li Wang Oncology Department Deyang People's HospitalDeyangSichuan 618000China Department of Medical Oncology Lung Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610000China Cardiovascular Department Mianyang Central HospitalMianyangSichuan 621000China Department of Rheumatology and Immunology Deyang People's HospitalDeyangSichuan 618000China

Immune checkpoint inhibitors (ICIs) are monoclonal antibody antagonists,which can block cytotoxic T lymphocyte antigen-4 (CTLA-4),programmed death-1/ligand-1 (PD-1/PD-L1) pathways,and other molecules exploited by tumor cells to evade T cell-mediated immune response.ICIs have transformed the treatment landscape for various cancers due to their amazing efficacy.Many anti-tumor therapies,including targeted therapy,radiotherapy,and chemotherapy,combine ICIs to make the treatment more effective.However,the off-target immune activation caused by ICIs may lead to a broad spectrum of immune-related adverse events (irAEs) affecting multiple organ systems.Among irAEs,cardiotoxicity induced by ICIs,uncommon but fatal,has greatly offset survival benefits from ICIs,which is heartbreaking for both patients and clinicians.Consequently,such cardiotoxicity requires special vigilance,and it has become a common challenge both for patients and clinicians.This article reviewed the clinical manifestations and influence of cardiotoxicity from the view of patients and clinicians,elaborated on the underlying mechanisms in conjunction with animal studies,and then attempted to propose management strategies from a cardio-immuno-oncology multidisciplinary perspective.

关键词： Cancer management Cardio-immuno-oncology multidisciplinary Cardiotoxicity Immune checkpoint inhibitors Immune tolerance

Development of Spectral Features for Monitoring Rice Bacterial Leaf Blight Disease Using Broad-Band Remote Sensing Systems

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 745-762页

作者： Jingcheng Zhang Xingjian Zhou Dong Shen Qimeng yu Lin yuan yingying Dong College of Artificial Intelligence Hangzhou Dianzi UniversityHangzhou310018China School of Information Engineering Zhejiang University of Water Resources and Electric PowerHangzhou310018China Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing100094China

As an important rice disease, rice bacterial leaf blight (RBLB, caused by the bacterium Xanthomonas oryzae pv.oryzae), has become widespread in east China in recent years. Significant losses in rice yield occurred as a result ofthe disease’s epidemic, making it imperative to monitor RBLB at a large scale. With the development of remotesensing technology, the broad-band sensors equipped with red-edge channels over multiple spatial resolutionsoffer numerous available data for large-scale monitoring of rice diseases. However, RBLB is characterized by rapiddispersal under suitable conditions, making it difficult to track the disease at a regional scale with a single sensorin practice. Therefore, it is necessary to identify or construct features that are effective across different sensors formonitoring RBLB. To achieve this goal, the spectral response of RBLB was first analyzed based on the canopyhyperspectral data. Using the relative spectral response (RSR) functions of four representative satellite or UAVsensors (i.e., Sentinel-2, GF-6, Planet, and Rededge-M) and the hyperspectral data, the corresponding broad-bandspectral data was simulated. According to a thorough band combination and sensitivity analysis, two novel spectralindices for monitoring RBLB that can be effective across multiple sensors (i.e., RBBRI and RBBDI) weredeveloped. An optimal feature set that includes the two novel indices and a classical vegetation index was formed.The capability of such a feature set in monitoring RBLB was assessed via FLDA and SVM algorithms. The resultdemonstrated that both constructed novel indices exhibited high sensitivity to the disease across multiple sensors.Meanwhile, the feature set yielded an overall accuracy above 90% for all sensors, which indicates its cross-sensorgenerality in monitoring RBLB. The outcome of this research permits disease monitoring with different remotesensing data over a large scale.

关键词： Rice bacterial leaf blight analysis of spectral response multispectral data simulation vegetation indices cross-sensor disease monitoring

A review of integrated surface-subsurface numerical hydrological models

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Science China Earth Sciences 2024年第5期67卷 1459-1479页

作者： Lele SHU Hao CHEN Xianhong MENG Yan CHANG Litang HU Wenke WANG Longcang SHU Xuan yu Christopher DUFFY yingying YAO Donghai ZHENG Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Water Sciences Beijing Normal UniversityBeijing 100038China School of Water and Environment Chang’an UniversityXi’an 710064China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Department of Civil and Environmental Engineering Pennsylvania State UniversityState CollegePA 16801USA Department of Earth and Environmental Science School of Human Settlements and Civil EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

Hydrological modeling,leveraging mathematical formulations to represent the hydrological cycle,is a pivotal tool in representing the spatiotemporal dynamics and distribution patterns inherent in hydrology.These models serve a dual purpose:they validate theoretical robustness and applicability via observational data and project future trends,thereby bridging the understanding and prediction of natural processes.In rapid advancements in computational methodologies and the continuous evolution of observational and experimental techniques,the development of numerical hydrological models based on physicallybased surface-subsurface process coupling have accelerated.Anchored in micro-scale conservation principles and physical equations,these models employ numerical techniques to integrate surface and subsurface hydrodynamics,thus replicating the macro-scale hydrological responses of watersheds.Numerical hydrological models have emerged as a leading and predominant trend in hydrological modeling due to their explicit representation of physical processes,heightened by their spatiotemporal resolution and reliance on interdisciplinary integration.This article focuses on the theoretical foundation of surface-subsurface numerical hydrological models.It includes a comparative and analytical discussion of leading numerical hydrological models,encompassing model architecture,numerical solution strategies,spatial representation,and coupling algorithms.Additionally,this paper contrasts these models with traditional hydrological models,thereby delineating the relative merits,drawbacks,and future directions of numerical hydrological modeling.

关键词： Numerical Hydrological Models Surface-Subsurface Process Coupling Numerical Methods Hydrological Modeling

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Nanomedicine sheds new light on cancer immunotherapy

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Medical Review 2023年第2期3卷 188-192页

作者： yingying yu Liangzhu Feng Zhuang Liu Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhouJiangsu ProvinceChina Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow University199 Ren’ai RoadSuzhou 215123Jiangsu ProvinceChina

Cancer immunotherapy comprising of immune checkpoint blockade(ICB)therapy,immune cell therapies,cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers.However,their overall clinical objective response rates,particularly against most solid tumors,are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens,limited tumor infiltration of effector immune cells,acquired tumor immunosuppression and some other factors.In recent years,various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms,presenting new promises in many published studies.This perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy.

关键词： cancer immunotherapy in situ cancer vaccine nanomedicine nanovaccine tumor microenvironment

Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics

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Protein & Cell 2024年第5期15卷 364-384页

作者： Huifen Lu Ying Jing Chen Zhang Shuai Ma Weiqi Zhang Daoyuan Huang Bin Zhang yuesheng Zuo yingying Qin Guang-Hui Liu Yang yu Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration CASBeijing 100101China China National Center for Bioinformation Beijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking UniversityThird HospitalBeijing 100191China Clinical Stem Cell Research Center Peking UniversityThird HospitalBeijing 100191China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education National Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthJinan 250012China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Biomarker Consortium Beijing 100101China

The ovary is indispensable for female reproduction,and its age-dependent functional decline is the primary cause of infertility.However,the molecular basis of ovarian aging in higher vertebrates remains poorly understood.Herein,we apply spatiotemporal transcriptomics to benchmark architecture organization as well as cellular and molecular determinants in young primate ovaries and compare these to aged primate ovaries.From a global view,somatic cells within the non-follicle region undergo more pronounced transcriptional fluctuation relative to those in the follicle region,likely constituting a hostile microenvironment that facilitates ovarian aging.Further,we uncovered that inflammation,the senescent-associated secretory phenotype,senescence,and fibrosis are the likely primary contributors to ovarian aging(PCOA).Of note,we identified spatial co-localization between a PCOA-featured spot and an unappreciated MT2(Metallothionein 2)highly expressing spot(MT2^(high))characterized by high levels of inflammation,potentially serving as an aging hotspot in the primate ovary.Moreover,with advanced age,a subpopulation of MT2^(high)accumulates,likely disseminating and amplifying the senescent signal outward.Our study establishes the first primate spatiotemporal transcriptomic atlas,advancing our understanding of mechanistic determinants underpinning primate ovarian aging and unraveling potential biomarkers and therapeutic targets for aging and age-associated human ovarian disorders.

关键词： spatial transcriptome primate ovary aging senescence inflammation

Research on organized method and regulatory mechanism of Cell cultured meat based on modified silk

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Food Science and Human Wellness 2024年

作者： Feng Yang Haijuan Hu yingying Li Shilei Li Wenting Liu yu Qi Shouwei Wang China Meat Research Center Beijing Institute of Food Science

Cell cultured meat has been extensively studied as an environmentally friendly， energy-saving and more effective technology. However， there are many technical bottlenecks， especially the regulatory mechanism and manufacturing method of in vitro myogenesis. Based on an edible modified silk protein scaffold， with 3D culturing， in situ differentiated and transcriptome analysis， this study describes novel scaffolds and fabrication methods for cell cultured meat. The results showed that the effective space and utilization efficiency for cell culture of the scaffold is 26-1000 that of the traditional culture dish; it could form a tissue-like structure. Transcriptomics revealed the regulatory pathways and key factors of different cycles. It clarifies that the multi-cycle process of myoblast myogenesis in vitro is different from the single feedback regulation in vivo. More importantly， a novel scaffold-based cell cultured meat manufacturing method was developed， further develop a new tissue culture solution that is different from existing cell culture meat production.For manufacturing processes， it provides a new cell culture meat technology system， provides a theoretical basis for the regulation of cell proliferation and muscle growth， and lays the technical foundation for in situ tissue culture of cell cultured meat in vitro.

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Fast Zn^(2+)mobility enabled by sucrose modified Zn^(2+)solvation structure for dendrite-free aqueous zinc battery

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Nano Research 2023年第3期16卷 3839-3846页

作者： yufang Cao Xiaohui Tang Linge Li Haifeng Tu yuzhen Hu yingying yu Shuang Cheng Hongzhen Lin Liwen Zhang Jiangtao Di Yongyi Zhang Meinan Liu School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Division of Nanomaterials and Jiangxi Key Lab of Carbonene Materials Jiangxi Institute of NanotechnologyNanchang 330200China

Aqueous zinc battery has been regarded as one of the most promising energy storage systems due to its low cost and environmental benignity.However,the safety concern on Zn anodes caused by uncontrolled Zn dendrite growth in aqueous electrolyte hinders their application.Herein,sucrose with multi-hydroxyl groups has been introduced into aqueous electrolyte to modify Zn^(2+)solvation environment and create a protection layer on Zn anode,thus effectively retarding the growth of zinc dendrites.Atomistic simulations and experiments confirm that sucrose molecules can enter into the solvation sheath of Zn^(2+),and the as-formed unique solvation structure enhances the mobility of Zn^(2+).Such fast Zn^(2+)kinetics in sucrose-modified electrolyte can successfully suppress the dendrite growth.With this sucrose-modified aqueous electrolyte,Zn/Zn symmetric cells present more stable cycle performance than those using pure aqueous electrolyte;Zn/C cells also deliver an impressive higher energy density of 129.7 Wh·kg^(−1)and improved stability,suggesting a great potential application of sucrose-modified electrolytes for future Zn batteries.

关键词： solvation structure Zn^(2+)mobility dendrite suppression sucrose

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GTN细观损伤模型的发展与应用综述

机械工程学报 2024年第2期60卷 62-80页

作者：陈鑫杨立飞于雪龚颖颖吉林大学汽车仿真与控制国家重点实验室长春130022 大众汽车(安徽)有限公司合肥230601

细观损伤力学分析广泛应用于韧性金属损伤、断裂、成形极限预测等领域。Gurson-Tvergaard-Needleman(GTN)损伤模型是细观损伤力学领域最为重要的经典模型之一。该模型将材料的细观孔洞演化过程与宏观力学行为相结合,描述材料在外部载荷... 详细信息

细观损伤力学分析广泛应用于韧性金属损伤、断裂、成形极限预测等领域。Gurson-Tvergaard-Needleman(GTN)损伤模型是细观损伤力学领域最为重要的经典模型之一。该模型将材料的细观孔洞演化过程与宏观力学行为相结合,描述材料在外部载荷作用下的细观损伤机理及宏观损伤失效行为。大量试验研究表明,在剪切载荷为主的应力状态下,材料内部孔洞体积分数并没有明显增加,但依然会发生失效。由于传统GTN模型只考虑孔洞体积分数变化对金属材料损伤行为的影响,使得GTN模型并不适合中、低应力三轴度下的损伤及断裂预测,因此多位学者都对原始GTN模型进行了修正。概述细观损伤力学和GTN模型的发展历程,并分析GTN模型的几种典型修正方法及其适用范围和优劣势,总结GTN模型参数标定方法。将GTN细观模型在工业领域中的应用分类整理,展望GTN模型的发展趋势,可为今后GTN模型的研究与应用提供参考。

关键词：细观损伤 GTN模型损伤力学塑性成形剪切修正

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