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Time to Reconsider Routine Timely Anti-epileptic Medication: Raising Hope with a “Smart” Nanoengineered System

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Neuroscience Bulletin 2022年第8期38卷 973-975页

作者： Yingying Tang Jianan Quan Weijie Zhou Haoliang Zhou Department of Pharmacy Women’s HospitalSchool of MedicineZhejiang UniversityHangzhou310000China

Despite the substantial advances achieved in the development of anti-epileptic treatments,pharmacotherapy is still the optimal choice for patients with epilepsy(PWEs)[1].Once diagnosed,PWEs are required by clinicians to take anti-epileptic drugs(AEDs)orally in a continuous manner(usually twice or thrice daily).The majority of patients need months to years to achieve desirable seizure control and meet the criterion of drug withdrawal[2].However,this routine prophylactic medication in a long-term manner concomitantly imposes a heavy economic burden and unwanted side-effects such as drowsiness and ataxia.

关键词： epileptic routine epilepsy

One Small Step for Neurotechnology,One Giant Leap for an In-Depth Understanding of the Brain

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Neuroscience Bulletin 2023年第6期39卷 1034-1036页

作者： Xiaoyun Qiu Minjuan Sun Cenglin Xu Yingying Tang Zhong Chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Department of Pharmacy Women’s HospitalSchool of MedicineZhejiang UniversityHangzhou310000China

Is science mostly driven by ideas or by tools?The answers to the everlasting question remain open.But the advances in techniques undoubtedly push forward scientific research to investigate both more in-breadth and in-... 详细信息

关键词： Leap One doubt

Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants

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General Psychiatry 2022年第2期35卷 109-118页

作者： Wenjun Su Zhixing Li Lihua Xu Jiahui Zeng Yingying Tang Xiaochen tang Yanyan Wei Qian Guo Tianhong Zhang Jijun Wang Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Heaith Center Shanghai Jiao Tong University School of MedicineShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghaiChina

Background Disrupted white matter(WM)microstructure has been commonly identified in youth at clinical high risk(CHR)for psychosis.Several lines of evidence suggest that fatty acids,especially unsaturated fatty acids(UFAs),might play a crucial role in the WM pathology of early onset psychosis.However,evidence linking UFA and WM microstructure in CHR is quite sparse.Aims We investigated the relationship between the plasma UFA level and WM microstructure in CHR participants and healthy controls(HC).Methods Plasma fatty acids were assessed and diffusion tensor imaging(DTI)data were performed with tract-based spatial statistics(TBSS)analysis for 66 individuals at CHR for psychosis and 70 HC.Results Both the global and regional diffusion measures showed significant between-group differences,with decreased fractional anisotropy(FA)but increased mean diffusivity(MD)and radial diffusivity(RD)found in the CHR group compared with the HC group.On top of that,we found that in the HC group,plasma arachidic acid showed obvious trend-level associations with higher global FA,lower global MD and lower global RD,which regionally spread over the corpus callosum,right anterior and superior corona radiata,bilateral anterior and posterior limb of the internal capsule,and bilateral superior longitudinal fasciculus.However,there were no associations between global WM measures and any UFA in the CHR group.Conversely,we even found negative associations between arachidic acid levels and regional FA values in the right superior longitudinal fasciculus and right retrolenticular part of the internal capsule in the CHR group.Conclusions Compared with the HC group,CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA,with a neuroprotective effect found in the HC group but not in the CHR group.Such discrepancy could be due to the excessively upregulated UFAs accumulated in the plasma of the CHR group,highlighting the role of balanced plasma-membrane fatty acids homeostasis in WM development.

关键词： unsaturated diffusion linking

Photocatalytic Methane Conversion:Insight into the Mechanism of C(sp^(3))-H Bond Activation

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CCS Chemistry 2023年第1期5卷 30-54页

作者： Yuheng Jiang yingying Fan Siyang Li Zhiyong tang Chinese Academy of Science(CAS)Key Laboratory of Nanosystem and Hierarchy Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190 Center for Advanced Analytical Science School of Chemistry and Chemical EngineeringSchool of Civil EngineeringAnalytical and Testing CenterGuangzhou UniversityGuangzhou 510006 Center for Nanoscale Science and Technology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871 University of Chinese Academy of Sciences Beijing 100049

Mild and direct conversion of methane into high value-added products is a desired goal for chemistry,energy,and environment.The active species generated in the photocatalytic reaction system under mild conditions activate the inert C-H bond in methane and promote methane conversion.This review focuses on the developed mechanisms for C(sp^(3))-H bond activation in photocatalytic methane conversion,including radical and active site mechanisms.Particular emphasis is placed on the detailed summary of mechanism,characterization method,and corresponding application in photocatalytic methane conversion.We also discuss the challenges and prospects for future direction on C(sp^(3))-H bond activation mechanism in photocatalytic methane conversion.This review aims to promote the development of photocatalytic methane conversion and provides guidance for the design of high-efficiency photocatalysts.

关键词： photocatalysis methane C-H bonds radical active site

Loss Analysis of Magnetic Gear with Slotted in Magnetic Modulation Ring

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CES Transactions on Electrical Machines and Systems 2023年第1期7卷 110-117页

作者： Can Tan Wei Liu yingying Rao Weizhao tang Libing Jing the College of Electrical Engineering and New Energy China Three Gorges UniversityYichang443002China

In order to improve the operation efficiency of coaxial magnetic gear(CMG),in this paper,a CMG model with slotted in magnetic modulation ring is proposed.In this model,the permanent magnets(PMs)of internal and external rotors are distributed in Halbach array,the inner rotor PMs are equally divided into 3 small pieces,and the outer rotor PMs are equally divided into 2 small pieces.At the same time,the static magnetic modulation ring iron blocks are slotted,each iron block has 3 slots,the width of the slot is 0.4°,and the depth of the single side slot is 1mm.Finally,a two-dimensional model is established,and the eddy current loss and iron loss of the model are optimized,compared with the conventional CMG model,it is found that the changed pattern can increase the internal and external output torque by 4%and 4.12%,respectively.The eddy current loss is reduced by 66.57%,and the iron loss is reduced by 8.9%,which significantly improve the operation efficiency of the CMG.

关键词： Coaxial magnetic gear Electromagnetic torque Halbach array Loss Slotting

Uncovering potential distinctive acoustic features of healing music

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General Psychiatry 2023年第6期36卷 463-471页

作者： Yue Ding Jiaqi Jing Qihui Guo Jiajia Zhou Xinyao Cheng Xiaoya Chen Lihui Wang Yingying Tang Qing Fan Shanghai Mental Health Center Shanghai Jiao Tong UniversitySchool of MedicineShanghaiChina Mental Health Branch China Hospital Development InstituteShanghai Jiao Tong UniversityShanghaiChina Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina

S Background Music therapy is a promising complementary intervention for addressing various mental health conditions.Despite evidence of the beneficial effects of music,the acoustic features that make music effective in therapeutic contexts remain elusive.Aims This study aimed to identify and validate distinctive acoustic features of healing music.Methods We constructed a healing music dataset(HMD)based on nominations from related professionals and extracted 370 acoustic features.Healing-distinctive acoustic features were identified as those that were(1)independent from genre within the HMD,(2)significantly different from music pieces in a classical music dataset(CMD)and(3)similar to pieces in a five-element music dataset(FEMD).We validated the identified features by comparing jazz pieces in the HMD with a jazz music dataset(JMD).We also examined the emotional properties of the features in a Chinese affective music system(CAMS).Results The HMD comprised 165 pieces.Among all the acoustic features,74.59%shared commonalities across genres,and 26.22%significantly differed between the HMD classical pieces and the CMD.The equivalence test showed that the HMD and FEMD did not differ significantly in 9.46%of the features.The potential healing-distinctive acoustic features were identified as the standard deviation of the roughness,mean and period entropy of the third coefficient of the mel-frequency cepstral coefficients.In a three-dimensional space defined by these features,HMD's jazz pieces could be distinguished from those of the JMD.These three features could significantly predict both subjective valence and arousal ratings in the CAMS.Conclusions The distinctive acoustic features of healing music that have been identified and validated in this study have implications for the development of artificial intelligence models for identifying therapeutic music,particularly in contexts where access to professional expertise may be limited.This study contributes to the growing body of research exploring the potential of digit

关键词： healing potential CAMS

Relationships between selfreflectiveness and clinical symptoms in individuals during pre-morbid and early clinical stages of psychosis

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General Psychiatry 2022年第3期35卷 163-172页

作者： Lihua Xu Huiru Cui Yanyan Wei Zhenying Qian Xiaochen tang Yegang Hu Yingchan Wang Hao Hu Qian Guo Yingying Tang Tianhong Zhang Jijun Wang Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Early Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghaiChina

Background Self-reflectiveness,one dimension of cognitive insight,plays a protective role in an individual’s mental state.Both high and low levels of self-reflectiveness have been reported in patients with schizophrenia and individuals at clinical high risk for the illness.Aims This study aimed to explore the relationship patterns between self-reflectiveness and clinical symptoms in individuals during the pre-morbid and early clinical stages of psychosis.Methods A total of 181 subjects,including individuals with attenuated positive symptoms(APS,n=122)and patients with first-episode psychosis(FEP,n=59),completed the Beck Cognitive Insight Scale and were evaluated using the Schedule of Assessment of Insight and Positive and Negative Syndrome Scale.All subjects were classified into three groups according to their level of selfreflectiveness:low level(LSR,n=59),medium level(MSR,n=67)and high level(HSR,n=55).Both linear and nonlinear relationships between self-reflectiveness and clinical symptoms were explored.Results More individuals with APS were classified into the MSR group,while more patients with FEP were classified into the LSR group.The LSR group demonstrated less awareness of illness than the MSR and HSR groups,more stereotyped thinking and poorer impulse control but less anxiety than the MSR group,and lower levels of blunted affect and guilt feelings than the HSR group.The MSR group demonstrated lower stereotyped thinking than the HSR group.Compared to the LSR group,the MSR group had increased selfreflectiveness,improved awareness of illness,decreased stereotyped thinking,and better impulse control,but increased feelings of guilt.The HSR group showed increased stereotyped thinking when compared to the MSR group,but the other variables did not change significantly between these two groups.Overall,self-reflectiveness demonstrated an approximately inverse S-shaped relationship with the awareness of illness,a U-shaped relationship with stereotyped thinking and poor impulse control,and an almost linear relationsh

关键词： clinical symptoms morbid

Tablets of paliperidone using compression-coated technology for controlled ascending release

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 143-154页

作者： Yingying Tang Huan Teng Yanan Shi Haibing He Yu Zhang Tian Yin Cuifang Cai Xing tang School of Pharmacy Shenyang Pharmaceutical University

The aim of this work was to prepare ascending release compression-coated(CC) tablets with paliperidone(PAL) using a simple manufacturing technique and short manufacturing process.The release behavior and mechanisms in vitro of the final tablets was investigated and evaluated. The PAL CC tablets were comprised of a core layer of high viscosity hydroxypropyl cellulose(HPC-H) and a coating layer of high viscosity hydroxypropyl methylcellulose(HPMCK100 M). Several factors such as materials and core tablet compositions were studied for their influence in the formulation procedure. The drug release mechanism was studied using gravimetric analysis. The data could be fitted to the Peppas model. The ascending drug release results were expressed in terms of the slope of the release curve at different time points.Results showed that the formulation could achieve a good ascending drug release when the weight ratio of PAL was 5:1(core:layer). The fraction of HPC and HPMC was 33 %, and the combination of Eudragit RL-PO was 10%. The ascending release mechanism was due to solvent penetration into the PAL CC tablets, and subsequent drug dissolution from the gelatinous HPC and HPMC matrix erosion. The release mechanism was therefore a combination of diffusion and erosion. This work demonstrated that the compression-coated tablets could achieve controlled ascending release over 24 h for the oral administration systems.

关键词： Paliperidone Compression-coated tablet Ascending release Controlled release

Abnormal neural oscillations in clinical high risk for psychosis:a magnetoencephalography method study

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General Psychiatry 2022年第2期35卷 148-153页

作者： Yegang Hu Jun Wu Yujiao Cao Xiaochen tang Guisen Wu Qian Guo Lihua Xu Zhenying Qian Yanyan Wei Yingying Tang Chunbo Li Tianhong Zhang Jijun Wang Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina

Background Neural oscillations directly reflect the rhythmic changes of brain activities during the resting state or while performing specific tasks.Abnormal neural oscillations have been discovered in patients with schizophrenia.However,there is limited evidence available on abnormal spontaneous neural oscillations in clinical high risk for psychosis(CHR-P).The brain signals recorded by the magnetoencephalography(MEG)technique are not to be disrupted by the skull and scalp.Methods In this study,we applied the MEG technique to record the resting-state neural activities in CHR-P.This was followed by a detailed MEG analysis method including three steps:(1)preprocessing,which was band-pass filtering based on the 0.5-60Hz frequency range,removal of 50Hz power frequency interference,and removal of electrocardiography(ECG)and electrooculography(EOG)artefacts by independent component analysis;(2)time-frequency analysis,a multitaper time-frequency transformation based on the Hanning window,and(3)source localisation.an exact low-resolution brain electromagnetic tomography.The method was verified by comparing aparticipant with CHR-P with a healthy control during the MEG recordings with an eyes-closed resting state.Results Experimental results show that the neural oscillations in CHR-P were significantly abnormal in the theta frequency band(4-7Hz)and the delta frequency band(1-3Hz).Also,relevant brain regions were located in the left occipital lobe and left temporo-occipital junction for the theta band and in the right dorsolateral prefrontal lobe and near orbitofrontal gyrus for the delta band.Conclusions Abnormal neural oscillations based on specific frequency bands and corresponding brain sources may become biomarkers for high-risk groups.Further work will validate these characteristics in CHR-P cohorts.

关键词： steps bands exact