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Photocatalytic synthesis of small-molecule drugs by porous framework materials

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Chinese Chemical Letters 2024年第3期35卷 52-65页

作者： yingying Zhao Jiangpei Yuan Lei Zhu Yu Fang State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Innovation Institute of Industrial Design and Machine Intelligence Quanzhou-Hunan University Quanzhou 362801China

Small-molecule drugs are widely used in daily life.There are still issues with the current industrial synthesis techniques for small-molecule drugs,such as the use of expensive metal catalysts,convoluted reaction processes,and non-recyclable catalysts.The benefits of photocatalytic organic synthesis over conventional techniques are mild conditions,environmental friendliness,and great selectivity.Porous framework materials can precisely modulate catalytic sites'electronic state and ligand structure to improve photocatalytic performance.In particular,MOFs,COFs and PCCs based photocatalysts have received extensive research interest due to their unique morphology,structural adjustability,high photocatalytic performance,unique recyclability,excellent chemical stability,easy synthesis and low cost.Therefore,a key area for future research is the development of porous framework materials as photocatalysts for the synthesis of small-molecule drugs or drug precursors.

关键词： Small-molecule drug Porous framework materials Photocatalysis

Molecular mechanisms of stress resistance in sorghum: Implications for crop improvement strategies

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Journal of Integrative Agriculture 2024年第3期23卷 741-768页

作者： Hongxiang Zheng yingying Dang Xianmin Diao Na Sui Shandong Provincial Key Laboratory of Plant Stress/College of life Sciences Shandong Normal UniversityJinan 250014China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Abiotic stresses, such as drought, salt, extreme temperatures, and heavy metal pollution, are the main environmental factors that limit crop growth and yield. Sorghum, a C4 grass plant with high photosynthetic efficiency, can grow in adverse environmental conditions due to its excellent stress resistance characteristics. Therefore, unraveling the stress-resistance mechanism of sorghum could provide a theoretical basis for developing and cultivating various stress-resistant crops. This understanding could also help to create a conducive environment for using marginal soil in agriculture and ensuring food security. In this review, we discuss the adaptation mechanisms of sorghum under drought, salinity, temperature, and soil heavy metal stresses, the specific response to stress, the screening of sorghum-resistant germplasm, and the identification and functional analysis of the relevant genes and quantitative trait loci(QTL). In addition, we discuss the application potential of different stress-tolerant sorghum germplasms reported to date and emphasize the feasibility and potential use in developing and promoting highly stress-tolerant sorghum in marginal soil.

关键词： abiotic stress C4 plants QTL sorghum stress resistance yield stability

Rapid report of source parameters of 2023 M6.2 Jishishan,Gansu earthquake sequence

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Earth and Planetary Physics 2024年第2期8卷 436-443页

作者： ZhiGao Yang Jie Liu yingying Zhang Wen Yang XueMei Zhang China Earthquake Networks Center Beijing 100045China

The M6.2 earthquake in Jishishan,Gansu Province,on December 18,2023,caused extraordinary earthquake disasters.It was located in the northern part of the north−south seismic zone,which is a key area for earthquake monitoring in China.The newly built dense strong motion stations in this area provide unprecedented conditions for high-precision earthquake relocation,especially the earthquake focal depth.This paper uses the newly built strong motion and traditional broadband seismic networks to relocate the source locations of the M3.0 and above aftershocks and to invert their focal mechanisms.The horizontal error of earthquake location is estimated to be 0.5−1 km,and the vertical error is 1−2 km.The focal depth range of aftershocks is 9.6−14.6 km,distributed in a 12-km-long strip with SSE direction.Aftershocks in the south are more concentrated horizontally and vertically,while aftershocks in the north are more scattered.The focal mechanisms of the main shock and aftershocks are relatively consistent,and the P-axis orientation is consistent with the regional strain direction.There is a seismic blank area of M3.0 and above,about 3−5 km between the main shock and aftershocks.It is suggested that the energy released by the main shock rupture is concentrated in this area.Based on the earthquake location and focal mechanism of the main shock,it is inferred that the Northern Lajishan fault zone is the seismogenic structure of the main shock,and the main shock did not occur on the main fault,but on a secondary fault.The initial rupture depth and centroid depth of the main shock were 12.8 and 14.0 km,respectively.The source rupture depth may not be the main reason for the severe earthquake disaster.

关键词： Jishishan earthquake earthquake relocation focal mechanism strong motion data

Pulmonary Bacterial Infection and Liver Cirrhosis: Current Status and Treatment

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Infectious Microbes & Diseases 2024年第1期6卷 5-10页

作者： yingying Zhao Song Yang Huichun Xing Center of Liver Diseases Division 3 Beijing Ditan HospitalCapital Medical UniversityBeijingChina

Liver cirrhosis has a higher incidence rate and mortality when complicated with bacterial infections.Concomitant bacterial infections,especially bacterial pneumonia,increase the susceptibility of cirrhotic patients to decompensation,with a higher likelihood of mortality.Bacterial pneu-monia is often overlooked in patients with liver cirrhosis,although it can impact the clinical progress and outcomes.Untimely diagnosis and inappropriate antibiotic treatments are associated with poor prognosis and increased mortality.Current understanding of mechanisms and appropriate antibiotic treatments for cirrhosis-related bacterial pneumonia remain inadequate.Herein,we reviewed the epidemiology,clinical characteristics and treatment of pulmonary bacterial infections in cirrhotic patients to provide suggestions for clinical practice.

关键词： bacterial pneumonia liver cirrhosis epidemiology characteristics treatment

Sustainable production of high-energy-density jet fuel via cycloaddition reactions

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Journal of Energy Chemistry 2024年第8期95卷 712-722页

作者： Yan-Cheng Hu yingying Zhao Ning Li Jing-Pei Cao School of Chemical Engineering and Technology China University of Mining and Technology School of Education Science Jiangsu Normal University CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Developing an energy supply-chain based on renewable biomass holds great potential to build a low carbon society. High-energy-density(HED) jet fuel, featuring unique fused/strained cycloalkanes, is of great significance for volume-limited military aircrafts, as their high density and combustion heat can extend flight duration and increase the payload. Therefore, the exploration of biomass-based routes towards HED fuel has drawn much attention over the past decade. Cycloaddition reaction features rapid construction of various carbocycles in an atom-and step-economical fashion. This elegant strategy has been widely applied in the manufacture of sustainable HED fuel. Here we carefully summarize the progress achieved in this fascinating area and the review is categorized by the cycloaddition patterns including [4+2], [2+2],[4+4], and [2+1] cycloadditions. Besides, the energy densities of the as-prepared biofuels and petroleumbased fuels(conventional Jet-A and advanced JP-10) are also compared. This review will provide important insights into rational design of new HED fuel with different ring-types/sizes and inspire the chemists to turn those literature studies into practical applications in military field.

关键词： Biomass-based chemicals Catalysis Cycloaddition Cycloalkanes High-energy-density fuel

Gluing support τ-tilting modules via symmetric ladders of height 2

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Science China Mathematics 2024年

作者： yingying Zhang Department of Mathematics Huzhou University

Gluing techniques with respect to a recollement have long been studied. Recently, ladders of recollements of abelian categories were introduced as important tools. In this paper, we present explicit constructions of gluing of support τ-tilting modules via symmetric ladders of height two. Moreover, we apply the result to triangular matrix algebras to give a detailed version of the known Jasso’s reduction and study maximal green sequences.

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SARS-CoV-2 infection and the antiviral innate immune response

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Journal of Molecular Cell Biology 2020年第12期12卷 963-967页

作者： Hui Yang yingying lyu Fajian Hou Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchMOE Frontiers Center for Brain ScienceShanghai Medical CollegeFudan UniversityShanghai 200032China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200032China

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)outbreak be-gan in December 2019,causing the illness known as the novel coronavirus disease 2019(COVID-19).The virus spread rapidly worldwide to become a global public health emergency.As of November 15,2020,more than 53 million confirmed cases and over 1 million deaths worldwide have been reported(World Health Organization,2020).

关键词： acute respiratory infection

Olfactory dysfunction and its related molecular mechanisms in Parkinson’s disease

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Neural Regeneration Research 2024年第3期19卷 583-590页

作者： yingying Gu Jiaying Zhang Xinru Zhao Wenyuan Nie Xiaole Xu Mingxuan Liu Xiaoling Zhang College of Pharmacy Nantong UniversityNantongJiangsu ProvinceChina

Changes in olfactory function are considered to be early biomarkers of Parkinson’s disease.Olfactory dysfunction is one of the earliest non-motor features of Parkinson’s disease,appearing in about 90%of patients with early-stage Parkinson’s disease,and can often predate the diagnosis by years.Therefore,olfactory dysfunction should be considered a reliable marker of the disease.However,the mechanisms responsible for olfactory dysfunction are currently unknown.In this article,we clearly explain the pathology and medical definition of olfactory function as a biomarker for early-stage Parkinson’s disease.On the basis of the findings of clinical olfactory function tests and animal model experiments as well as neurotransmitter expression levels,we further characterize the relationship between olfactory dysfunction and neurodegenerative diseases as well as the molecular mechanisms underlying olfactory dysfunction in the pathology of early-stage Parkinson’s disease.The findings highlighted in this review suggest that olfactory dysfunction is an important biomarker for preclinical-stage Parkinson’s disease.Therefore,therapeutic drugs targeting non-motor symptoms such as olfactory dysfunction in the early stage of Parkinson’s disease may prevent or delay dopaminergic neurodegeneration and reduce motor symptoms,highlighting the potential of identifying effective targets for treating Parkinson’s disease by inhibiting the deterioration of olfactory dysfunction.

关键词： biomarker early-stage olfactory disorders olfactory dysfunction Parkinson’s disease

Chiral mesostructured hematite with temperature-independent magnetism due to spin confinement

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Nano Research 2024年第3期17卷 2019-2024页

作者： Baiwen Zhang Jing Ai yingying Duan Te Bai Lu Han Shunai Che School of Physics Science and Engineering Tongji UniversityShanghai 200092China School of Chemistry and Chemical Engineering Tongji UniversityShanghai 200092China Wuxi Vocational College of Science and Technology Wuxi 214028China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Hematite(α-Fe_(2)O_(3))is known to undergo conversion from weak ferromagnetic to antiferromagnetic as the temperature decreases below the Morin temperature(TM=250 K)due to spin moment rotation occurring during the Morin transition(MT).Herein,we endowed hematite with mesostructured chirality to maintain weak ferromagnetism without MT.Chiral mesostructured hematite(CMH)nanoparticles were prepared by a hydrothermal method with glutamic acid(Glu)as the symmetry-breaking agent.The triangular bipyramidal CMH nanoparticles were composed of helically cleaved nanoflakes with twisted crystal lattice.Field-cooled(FC)magnetization measurements showed that the magnetic moments of CMH were stabilized without MT within the temperature range of 10–300 K.Hysteresis loop measurements confirmed the weak ferromagnetism of CMH.The enhanced Dzyaloshinskii–Moriya interaction(DMI)was speculated to be responsible for the temperature-independent weak ferromagnetism,in which the spin configuration would be confined with canted antiferromagnetic coupling due to the mesostructured chirality of CMH.

关键词： hematite chiral mesostructure Dzyaloshinskii–Moriya interaction weak ferromagnetism antiferromagnetic material temperature-independent magnetism