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中国组织化学与细胞化学杂志 2017年第1期26卷 36-41,78页

作者：陈泽鑫 lin Chun Huang Jia Zeng Qingxiang lin Jiali lin yingwen Yuan Yanping Cai Bozhi lin Changmin Department of Histology and Embryology Shantou University Medical College Shantou University Medical College Tissue Engineering Laboratory First Affiliated HospitalShantou University Medical College

Objective To investigate the distribution and dynamic changes of both Wnt signaling molecules and CK15 throughoutthe three phases of the follicular cycle,and to explore the relationship between Wnt/β-catenin signaling and CK15 in rat whisker hair follicle(HF)growth *** Hematoxylin-Eosin(HE)and immunofluorescence stains were used to characterize the expression patterns,including sites and levels of some representative proteins of both canonical and non-canonical Wnt signaling molecules,as well as HF epithelial stem cell marker *** The expression patterns of bothβ-catenin and Wnt5a were correlated with that of ***15 was only expressed in *** catagen,β-catenin showed a massive depletion while Wnt5a noticeably *** telogen,high level expression ofβ-catenin and low level of Wnt5a were ***10b and TCF3 were detected during the entire HF growth *** These results suggest that Wnt5a is associated with the transition of anagen-catagen phase,accompanied by broad deletion ofβ-catenin and loss of *** is important for the maintenance of HF activity and is related to the telogenanagen transition.

关键词： Wnt5a β-catenin Wnt10b CK15 TCF3 hair follicle

Prognostic implications of overt congestion in heart failure with preserved ejection fraction and the interaction with spironolactone:Insights from TOPCAT

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Chinese Medical Journal 2024年第10期137卷 1249-1251页

作者： yingwen lin Hengli Zhao Dongtu Hu Jia Huang You Peng Juncong Li Dingli Xu Qingchun Zeng State Key Laboratory of Organ Failure Research Department of CardiologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Clinical Pharmacology Medical Research InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510515China Department of Radiology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

To the Editor:Heart failure with preserved ejection fraction(HFpEF)is a clinical entity characterized by impaired diastolic *** recently,there have been few studies directly evaluating how volume status impacts future cardiac events for patients with *** supporting the application of spironolactone in HFpEF is mainly derived from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist(TOPCAT)*** though primary analysis of the trial reached a neutral result,subgroup and subsequent post hoc analyses have confirmed its efficacy in selected groups of patients,suggesting that identifying the potential subgroups of patients who would benefit from spironolactone treatment is important.[1]Data regarding the impact of congestion status on the efficacy of spironolactone in HFpEF are lacking.

关键词： function. fraction impaired

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荧光余辉的非指数分量及处理

仪器仪表学报 2008年第12期29卷 2581-2586页

作者：贾丹平贾婷苑玮琦林应文沈阳工业大学信息科学与工程学院沈阳110178

发现高精度荧光测温时,荧光寿命与荧光强度有关,表现为激励光源强度、光传输效率、通道放大倍数等影响测量结果,原因在于荧光余辉不是准确的指数变化,它可能导致以荧光余辉指数变化为前提推导的结论要重新考虑其适用范围。论证了实际荧... 详细信息

发现高精度荧光测温时,荧光寿命与荧光强度有关,表现为激励光源强度、光传输效率、通道放大倍数等影响测量结果,原因在于荧光余辉不是准确的指数变化,它可能导致以荧光余辉指数变化为前提推导的结论要重新考虑其适用范围。论证了实际荧光余辉偏离指数的程度与光谱形状的关系。提出了余辉曲线截断归一化法,用来比较不同材料的余辉偏离指数程度的大小。指出多指数拟合法可以减少非指数分量对测量的影响,给出了数值示例。

关键词：荧光数据拟合余辉普罗尼法光纤传感器

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基于光纤测温法的电流互感器

电工技术学报 2008年第10期23卷 47-52页

作者：贾丹平伞宏力苑玮琦林应文沈阳工业大学信息科学与工程学院沈阳110178

提出了电流-温度传感新方案,它在解决光纤电流互感器性能不稳定问题上有突出的理论优势。文中建立了电流-温度传感的数学模型,分析了暂态、稳态特性,给出了光纤电流互感器实验装置及测量结果。理论分析及实验测试表明,只要技术措施得当... 详细信息

提出了电流-温度传感新方案,它在解决光纤电流互感器性能不稳定问题上有突出的理论优势。文中建立了电流-温度传感的数学模型,分析了暂态、稳态特性,给出了光纤电流互感器实验装置及测量结果。理论分析及实验测试表明,只要技术措施得当,采用本传感方案实现全光纤电流互感器是可行的。

关键词：电流互感器光纤荧光温度

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深基坑预应力锚索张拉试验的若干误区

山西建筑 2016年第12期42卷 66-67页

作者：聂磊林颖文云南省设计院集团云南昆明650228

介绍了深基坑预应力锚索张拉试验的基本概念,总结了深基坑预应力锚索基本、验收、蠕变三种张拉试验的要点,阐述了各种张拉试验中存在的若干误区,从而保证深基坑试验的准确性。

关键词：深基坑预应力锚索张拉试验误区

Pretrained Models and Evaluation Data for the Khmer Language

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Tsinghua Science and Technology 2022年第4期27卷 709-718页

作者： Shengyi Jiang Sihui Fu Nankai lin yingwen Fu School of Information Science and Technology Guangdong University of Foreign StudiesGuangzhou 510000China Guangzhou Key Laboratory of Multilingual Intelligent Processing Guangdong University of Foreign StudiesGuangzhou 510000China

Trained on a large corpus,pretrained models(PTMs)can capture different levels of concepts in context and hence generate universal language representations,which greatly benefit downstream natural language processing(NLP)*** recent years,PTMs have been widely used in most NLP applications,especially for high-resource languages,such as English and ***,scarce resources have discouraged the progress of PTMs for low-resource ***-based PTMs for the Khmer language are presented in this work for the first *** evaluate our models on two downstream tasks:Part-of-speech tagging and news *** dataset for the latter task is *** demonstrate the effectiveness of the Khmer *** addition,we find that the current Khmer word segmentation technology does not aid performance *** aim to release our models and datasets to the community in hopes of facilitating the future development of Khmer NLP applications.

关键词： pretrained models Khmer language word segmentation part-of-speech(POS)tagging news categorization

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数字图像技术在古建筑裂缝监测中的应用

河南科学 2008年第2期26卷 212-214页

作者：奥村运明林颖文李宁孙亚军郑州大学环境与水利学院郑州450002

古建筑的保护已到了刻不容缓的时期.要保护古建筑就必须对建筑物进行检测观察,建立古建筑档案.传统的方法仍存在着经济性差,检测周期长,劳动强度大等缺点.提出了基于数字摄影和图像分析技术的墙体开裂变形图像测量方法,建立了相应的图... 详细信息

古建筑的保护已到了刻不容缓的时期.要保护古建筑就必须对建筑物进行检测观察,建立古建筑档案.传统的方法仍存在着经济性差,检测周期长,劳动强度大等缺点.提出了基于数字摄影和图像分析技术的墙体开裂变形图像测量方法,建立了相应的图像处理系统.并以平遥古城为例,应用该方法对墙体裂缝进行观测.经检验,数码图像经过处理后得到的裂缝宽度与现场测量结果一致.研究结果表明,利用数字图像技术可以正确地测出墙体裂缝宽度,具有廉价、快速、安全、无接触、无量程限制、多点同时测量以及可视化的特点.

关键词：数字图像技术古建筑裂缝监测数字摄影

临床及科研综合考评方案在口腔医学生实习考核中的应用

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中华口腔医学研究杂志（电子版） 2020年第4期14卷 252-256页

作者：赵怡鸣林正梅阎英刘洋靖雯谢君林颖文洪筠中山大学附属口腔医院光华口腔医学院广东省口腔医学重点实验室广州510055

目的探讨临床及科研综合考评方案在口腔医学专业本科生实习考核中的应用效果。方法以中山大学光华口腔医学院2008、2013级本科生为对象,在2008级学生中实施传统实习考核方案,在2013级学生中实施综合考评方案。实习结束后对带教老师和学... 详细信息

目的探讨临床及科研综合考评方案在口腔医学专业本科生实习考核中的应用效果。方法以中山大学光华口腔医学院2008、2013级本科生为对象,在2008级学生中实施传统实习考核方案,在2013级学生中实施综合考评方案。实习结束后对带教老师和学生进行问卷调查,评价两种方案的应用效果。使用SPSS 20.0软件进行统计学分析。两独立样本采用t检验,以P0.05),2013级学生科研能力相关的4项自我评分均高于2008级学生(P<0.05)。另外,超过85%的带教老师对综合考评方案感到满意,认为其更有利于学生临床和科研能力的培养。结论综合考评方案维持了本科生的临床能力并提高了其科研能力。

关键词：口腔医学生教育,医学,本科临床实习考核

Comparison of Antibacterial Activities of Six Bacillus amyloliquefaciens Strains

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Journal of Clinical and Nursing Research 2024年第9期8卷 261-272页

作者： Jiedan Liao yingwen Chen Yuchao lin Junxiang Wei Hongyu Gao Yuchen Liu Wanjun Gu Zhiheng Xie Shuzhen Zhou College of Animal Science and Technology Foshan UniversityFoshan 528225Guangdong ProvinceChina Foshan City Nanhai Eastern Along Pharmaceutical Co. LtdFoshan 528234Guangdong ProvinceChina

In this study, six bacterial strains were isolated from the sediment, probiotic fermentation products, and lake sediments, they were identified as Bacillus amyloliquefaciens using genetic evolution analysis, which were named B3, B4, B5, XD3, YF6, and YF8. The comparison of the antibacterial activity, hemolytic activity, and antibiotic sensitivity of six Bacillus amyloliquefaciens strains laid a foundation for the development and application of antimicrobial peptide products. A surface activity assay was used to determine the production of biosurfactants in six Bacillus amyloliquefaciens strains. With Staphylococcus aureus and Escherichia coli as indicator bacteria, their antibacterial activity was determined using the agar diffusion method;the same diffusion method was used to determine the antibiotic susceptibility of Bacillus amyloliquefaciens. The results showed that the six Bacillus amyloliquefaciens strains had obvious biosurface activity, and the bacteria inhibited Staphylococcus aureus and Escherichia coli, from strong to weak: YF8, XD3, B3, B4, YF6, and B5. Strain YF8 had the best broad-spectrum bacteriostatic effect, followed by strain XD3. All Bacillus amyloliquefaciens strains were susceptible to 16 common drugs, except for Bacillus amyloliquefaciens strain YF8, which was intermediate to neomycin. The study shows that Bacillus amyloliquefaciens and secondary metabolites have the ability to produce a variety of active peptides, exert a certain inhibitory effect on common pathogens, and have the potential to develop as animal probiotics.

关键词： Bacillus amyloliquefaciens Identification Biosurface activity Antibacterial activity Drug sensitivity test

Identification and Antibacterial Activity Study of a Terrestrial Strain of Brevibacterium aureus 431

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Journal of Clinical and Nursing Research 2024年第10期8卷 231-242页

作者： Jiedan Liao Junxiang Wei yingwen Chen Yuchao lin Hongyu Gao Yuchen Liu Danmin Zheng Guangwen Lai Weiquan Liang Wanjun Gu Shuzhen Zhou School of Animal Science and Technology Foshan UniversityFoshan 528225Guangdong ProvinceChina Foshan City Nanhai Eastern Along Pharmaceutical Co. LtdFoshan 528234Guangdong ProvinceChina

This study isolated and purified strain 431 from an animal probiotic *** staining and microscopic examination,colony morphology analysis,biochemical reaction tests,and 16S rDNA sequence alignment,the strain was identified and named Brevibacterium aureus *** study focused on the production of biosurfactants by strain 431,and antibacterial activity tests were conducted on the strain and its secondary *** results showed that strain 431 exhibited no resistance to 10 commonly used drugs,and its concentrated secondary metabolites were highly sensitive to the indicator bacterium Escherichia *** administration of strain 431 to BALB/c mice resulted in normal mental state,diet,and bowel movements,with no signs of illness or death,indicating that strain 431 is highly safe and non-pathogenic to *** study suggests that Brevibacterium aureus 431 has significant research value as a new source of actinomycetes and that its secondary metabolites have potential application value in the development of antibacterial drugs.

关键词： Brevibacterium aureus 431 Isolation and identification Genetic evolution analysis Antibacterial activity Drug susceptibility test Safety test