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A coating strategy on titanium implants with enhanced photodynamic therapy and CO-based gas therapy for bacterial killing and inflammation regulation

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Chinese Chemical Letters 2024年第2期35卷 386-395页

作者： Liang Cheng Bingshuai Zhou Manlin Qi Xiaolin Sun Shujun Dong Yue Sun Biao Dong Lin Wang yingwei Yang Department of Oral Implantology Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering School and Hospital of StomatologyJilin UniversityChangchun 130021China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130021China College of Chemistry Jilin UniversityChangchun 130012China

Antimicrobial photodynamic therapy(aPDT)has been considered a noninvasive and effective modality against the bacterial infection of peri‑implantitis,especially the aPDT triggered by near-infrared(NIR)light due to the large penetration depth in ***,the complexity of hypoxia microenvironments and the distance of aPDT sterilization still pose challenges before realizing the aPDT clinical *** to the long lifespan and transmission distance of therapeutic gas molecules,we design a multi-functional gas generator that combines aPDT as well as O_(2) and CO gas release function,which can solve the problem of hypoxia(O_(2))in PDT and the problem of inflammation regulation(CO)in the distal part of peri‑implant inflammation under near-infrared(NIR)*** the composite nanoplatform that spin-coated on the surface of titanium implants,up-conversion nanoparticles(UCNPs)were involved in converting the NIR to visible,which further excites the partially oxidized stannic sulfide(SnS_(2)),realizing the therapeutic gas *** green(ICG)was further integrated to enhance the aPDT performance(Ti-U@SnS_(2)/I).Therefore,reactive oxygen species(ROS),CO,and O_(2) can be controllably administered via a composite nano-platform mediated by a single NIR light(808 nm).This implant surface modification strategy could achieve great self-enhancement antibacterial effectiveness and regulate the lingering questions,such as relieving the anoxic microenvironment and reaching deep infection sites,providing a viable antibiotic-free technique to combat peri‑implantitis.

关键词： Photodynamic therapy Biomaterials Dental implant Reactive oxygen species Carbon monoxide Hybrid nanoplatform

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A model for predicting bubble rise velocity in a pulsed gas solid fluidized bed

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International Journal of Mining Science and Technology 2013年第2期23卷 233-236页

作者： Dong Liang Zhao Yuemin Luo Zhenfu Duan Chenlong Wang yingwei Yang Xuliang Zhang Bo School of Chemical Engineering and Technology China University of Mining & Technology

Bed stability, and especially the bed density distribution, is affected by the behavior of bubbles in a gas solid fluidized bed. Bubble rise velocity in a pulsed gas-solid fluidized bed was studied using photographic and computational fluid dynamics methods. The variation in bubble rise velocity was investigated as a function of the periodic pulsed air flow. A predictive model of bubble rise velocity was derived: ub=ψ(Ut+Up-Umf)+kp(gdb)(1/2). The software of Origin was used to fit the empirical coefficients to give ψ = 0.4807 and kp = 0.1305. Experimental verification of the simulations shows that the regular change in bubble rise velocity is accurately described by the model. The correlation coefficient was 0.9905 for the simulations and 0.9706 for the experiments.

关键词： Pulsed fluidized bed Bubble Rise velocity Prediction model

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华北克拉通丰镇碳酸岩中榴辉岩捕虏体岩石学研究:现今板块体制古元古代开始启动证据

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岩石学报 2021年第2期37卷 391-416页

作者：李韵秀张立飞许成 KYNICKY Jindrich FEI yingwei 北京大学地球与空间科学学院造山带与地壳演化重点实验室北京100871 桂林理工大学地球科学学院桂林541006 孟德尔大学地质与土壤学系布尔诺613004 .布尔诺理工大学中欧理工学院布尔诺616005 .华盛顿卡内基研究院地球与行星实验室华盛顿20015

关于现今板块构造体制何时启动是目前地球科学研究的焦点问题。本文在原报道的古元古代丰镇火成碳酸岩中发现的榴辉岩捕虏体基础上,开展了详细的岩石学研究。该榴辉岩捕虏体分为两种类型:即相对富石榴石的Fz-2和贫石榴石的Fz-16,它们产... 详细信息

关于现今板块构造体制何时启动是目前地球科学研究的焦点问题。本文在原报道的古元古代丰镇火成碳酸岩中发现的榴辉岩捕虏体基础上,开展了详细的岩石学研究。该榴辉岩捕虏体分为两种类型:即相对富石榴石的Fz-2和贫石榴石的Fz-16,它们产于同一地点,且具有相同的矿物成分和结构构造特征。Xu et al.(2018)的研究表明该捕虏体具有1839±26Ma和1766±7Ma的独居石U-Th-Pb年龄且具有大洋辉长岩原岩的全岩成分特征。本文通过进一步的岩相学研究发现该榴辉岩至少经历了两期变质阶段:M1,角闪石/绿帘石-榴辉岩阶段;M2,硬柱石-榴辉岩阶段。具有放射状裂纹包裹特征的柯英石假象在石榴石变斑晶和基质绿辉石中以包体形式出现。以蓝晶石与黝帘石共存为特征的柱状硬柱石假象,也偶尔以包体形式存在于石榴石中。变斑晶石榴石分为富含包体的核部和比较干净的边部。石榴石从中心到边部具有明显的镁铝榴石含量增加和钙铝榴石含量降低的环带特征,通过相平衡模拟和等值线投图得到其温压范围为2.6~3.7GPa和655~670℃,记录了从M1到M2的近等温增压的进变质过程。通过石榴石边部-绿辉石-蓝晶石-石英的地质温压计计算得到温压条件为3.0GPa、734℃。金红石中的锆含量温度计也给出了相似的温度条件,即在2.6~3.7GPa压力时为601~685℃。石榴石边部的柯石英假象和硬柱石假象支持了M2硬柱石-榴辉岩阶段的存在,这表明丰镇古元古代榴辉岩可能是目前发现的世界上最古老的低温超高压变质岩。同时,我们得到该榴辉岩代表的进变质过程中的地温梯度为216±35℃/GPa,证明至少在~1.8Ga以来代表现今板块构造体制的板块冷俯冲作用就开始启动了。

关键词：古元古代板块冷俯冲榴辉岩捕虏体超高压变质作用现今板块构造体制

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IL-17-triggered downregulation of miR-497 results in high HIF-1α expression and consequent IL-1β and IL-6 production by astrocytes in EAE mice

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Cellular & Molecular Immunology 2017年第11期14卷 909-923页

作者： Kai Shan Rongrong Pang Chenhui Zhao Xiaomei Liu Wenxing Gao Jing Zhang Dan Zhao yingwei Wang Wen Qiu Department of Immunology Nanjing Medical UniversityNanjingJiangsu 211166China Department of Medicine First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Pathogen Biology and Immunology and Laboratory of Infection and Immunity Xuzhou Medical UniversityXuzhouJiangsu 221004China Basic Medical Science of Basic Medical College Nanjing Medical UniversityNanjingJiangsu211166China

Interleukin 17(IL-17)is increasingly recognized as a key factor that contributes to the pathogenesis of multiple sclerosis(MS)and its experimental mouse autoimmune encephalomyelitis(EAE)***,the roles and regulatory mechanisms of IL-17-induced pro-inflammatory cytokine production in EAE mice remain largely *** this study,the expression of IL-17,hypoxia inducible factor-1α(HIF-1α),IL-1β,IL-6 and microRNA-497(miR-497),as well as their intrinsic associations,was investigated using EAE model mice and cultured astrocytes exposed to IL-17 in *** observed markedly increased production of IL-17,HIF-1α,IL-1βand IL-6 in the brain tissues of EAE mice,while the expression and secretion of HIF-1α,IL-1βand IL-6 were also significantly increased when cultured primary astrocytes from mice were stimulated with ***,the expression of miR-497 was downregulated both in vivo and in *** in vitro experiments revealed that IL-17 induced the production of IL-1βand IL-6 in astrocytes through the upregulation of HIF-1αas a transcriptional factor,indicating that IL-17-mediated downregulation of miR-497 enhanced HIF-1α***,astrocytespecific knockdown of IL-17RA and HIF-1αor astrocyte-specific overexpression of miR-497 by infection with different lentiviral vectors containing an astrocyte-specific promotor markedly decreased IL-1βand IL-6 production in brain tissues and alleviated the pathological changes and score of EAE ***,these findings indicate that decreased miR-497 expression is responsible for IL-17-triggered high HIF-1αexpression and consequent IL-1βand IL-6 production by astrocytes in EAE mice.

关键词： astrocytes experimental autoimmune encephalomyelitis HIF-1α interleukin-17 miR-497

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In situ doping brushite on zinc manganese oxide toward enhanced water oxidation performance: Mimicry of an oxygen‐evolving complex

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Chinese Journal of Catalysis 2018年第6期39卷 1017-1026页

作者： Miao Jiang Junying Chen yingwei Li State Key Laboratory of Pulp and Paper Engineering School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640GuangdongChina

We report in situ doping of brushite on zinc manganese oxide（ZMO）, fabricated by calcining a Mn（II） oxalate‐impregnated metal‐organic framework. The doping process was conducted in com‐bination with the photocatalytic water oxidation reaction which was catalyzed by ZMO in neutral phosphate‐buffered aqueous solution containing [Ru（bpy）3]^2＋‐Na2S2O8 and calcium（II） triflate salt, exhibiting greatly enhanced water oxidation performance with optimized turnover frequency of 0.18 mmol（O2） mol（Mn）^（–1） s^（–1）. Different analytical techniques indicated that photodeposited calci‐um‐phosphate（CaP） acted as a co‐catalyst to promote the O2 evolution activity of ZMO. This system involved the use of manganese oxide and calcium ion, and the operation was conducted under am‐bient temperature and neutral conditions, thus, it efficiently mimicked the oxygen‐evolving complex in photosystem II.

关键词： Zincmanganese oxide Brushite Metal‐organic frameworks Water oxidation Oxygen‐evolving complex

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Learning to Combine Answer Boundary Detection and Answer Re-ranking for Phrase-Indexed Question Answering

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Chinese Journal of Electronics 2022年第5期31卷 938-948页

作者： WEN Liang SHI Haibo ZHANG Xiaodong SUN Xin WEI Xiaochi WANG Junfeng CHENG Zhicong YIN Dawei WANG Xiaolin LUO yingwei WANG Houfeng Department of Computer Science and Technology Peking University Peng Cheng Laboratory Baidu Inc.

Phrase-indexed question answering(PIQA) seeks to improve the inference speed of question answering(QA) models by enforcing complete independence of the document encoder from the question encoder,and it shows that the constrained model can achieve significant efficiency at the cost of its accuracy. In this paper, we aim to build a model under the PIQA constraint while reducing its accuracy gap with the unconstrained QA models. We propose a novel framework —Ans DR,which consists of an answer boundary detector(Ans D)and an answer candidate ranker(Ans R). More specifically, Ans D is a QA model under the PIQA architecture and it is designed to identify the rough answer boundaries; and Ans R is a lightweight ranking model to finely rerank the potential candidates without losing the efficiency. We perform the extensive experiments on public datasets. The experimental results show that the proposed method achieves the state of the art on the PIQA task.

关键词： text analysis unconstrained QA models Answer Re-ranking rough answer boundaries phrase-indexed question answering indexing lightweight ranking model information retrieval combine answer boundary detection question encoder natural language processing answer boundary detector QA model learning (artificial intelligence) encoding question answering (information retrieval) question answering models constrained model answer candidate ranker

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Story of an Electrician and Plumber　

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China Today 1996年第8期45卷 25-26页

作者： WANG yingwei

ＳｔｏｒｙｏｆａｎＥｌｅｃｔｒｉｃｉａｎａｎｄＰｌｕｍｂｅｒＢｙＷＡＮＧＹＩＮＧＷＥＩＸｕＨｕｆｉｘｅｓａｓｔｒｅｅｔｌｉｇｈｔｆｏｒｃｉｔｉｚｅｎｓ．ＲｅｎＬｏｎｇＸＵＨＵ，４０，ｉｓａｎｅｌｅｃｔｒｉｃｉａｎａｎ... 详细信息

ＳｔｏｒｙｏｆａｎＥｌｅｃｔｒｉｃｉａｎａｎｄＰｌｕｍｂｅｒＢｙＷＡＮＧＹＩＮＧＷＥＩＸｕＨｕｆｉｘｅｓａｓｔｒｅｅｔｌｉｇｈｔｆｏｒｃｉｔｉｚｅｎｓ．ＲｅｎＬｏｎｇＸＵＨＵ，４０，ｉｓａｎｅｌｅｃｔｒｉｃｉａｎａｎｄｐｌｕｍｂｅｒｗｉｔｈｔｈｅＳｈ...

关键词： Story of an Electrician and Plumber

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Preparation and Characterization of Waterborne Polyurethane/Cellulose Nanocrystal Composite Membrane from Recycling Waste Paper

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Journal of Renewable Materials 2020年第6期8卷 631-645页

作者： Xing Zhou Xin Zhang Dong Wang Changqing Fang Wanqing Lei Zhigang Huang Yonghua Song Xinyu He yingwei Huang Faculty of Printing Packaging Engineering and Digital Media TechnologyXi’an University of TechnologyXi’an710048China School of Materials Science and Mechanical Engineering Beijing Technology and Business UniversityBeijing100048China

Cellulose plays a key role in abundant organic natural materials meeting the increasing demand for green and biocompatible *** highly crystalline nanoscale component of cellulose nanocrystals has recently attracted great attention due to the versatile performance as filler or matrix in producing functional *** this work,we prepared the waterborne polyurethane via a prepolymer process,and obtained cellulose and cellulose nanocrystals from waste paper via a facile acid hydrolysis *** that,the cellulose nanocrystals were assembled into film and mixed with polyurethane to prepare flexible polyurethane/cellulose nanocrystals composite membrane with different soaking *** correlation between the bulk structure and applied properties including thermal resistance and mechanical property was investigated by using Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC)and folding *** structure analysis indicates that cellulose nanocrystals prepared from used paper have a quality similar to that of commercial ***,the cellulose nanocrystals have been mixed with polyurethane *** can significantly benefit to the thermal resistance and mechanical property of the cellulose nanocrystals *** polyurethane/cellulose nanocrystals composite membrane present good flexibility and may hold a significantly potential application as visual and flexible material.

关键词： Cellulose waterborne polyurethane membrane recycling

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Size Effects of Atomically Precise Gold Nanoclusters in Catalysis

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Precision Chemistry 2023年第1期1卷 14-28页

作者： Site Li Xiangsha Du Zhongyu Liu yingwei Li Yucai Shao Rongchao Jin Department of Chemistry Carnegie Mellon UniversityPittsburghPennsylvania 15213United States

The emergence of ligand-protected,atomically precise gold nanoclusters(NCs)in recent years has attracted broad interest in catalysis due to their well-defined atomic structures and intriguing ***,the precise formulas of NCs provide an opportunity to study the size effects at the atomic level without complications by the polydispersity in conventional nanoparticles that obscures the relationship between the size/structure and ***,we summarize the catalytic size effects of atomically precise,thioate-protected gold NCs in the range of tens to hundreds of metal *** catalytic reactions include electrochemical catalysis,photocatalysis,and *** the precise sizes and structures,the fundamentals underlying the size effects are analyzed,such as the surface area,electronic properties,and active *** the catalytic reactions,one or more factors may exert catalytic effects simultaneously,hence leading to different catalytic-activity trends with the size change of *** summary of literature work disentangles the underlying fundamental mechanisms and provides insights into the size *** studies will lead to further understanding of the size effects and shed light on the catalytic active sites and ultimately promote catalyst design at the atomic level.

关键词： atomic precision nanoclusters catalysis size effects electronic structure

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Carbon-based nanoarrays embedded with Ce-doped ultrasmall CoP nanoparticles enable efficient electrooxidation of 5-hydroxymethylfurfural coupled with hydrogen production

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Science China Chemistry 2023年

作者： Shangfang Xie Hongchuan Fu Liyu Chen yingwei Li Kui Shen Guangdong Provincial Key Laboratory of Fuel Cell Technology School of Chemistry and Chemical Engineering South China University of Technology

The electrooxidation of 5-hydroxymethylfurfural (HMFOR) not only offers a green route to attain high-value 2,5-furandicarboxylic acid (FDCA) from biomass,but also is considered as a promising approach to replace the kinetically sluggish OER for future hydrogen ***,we report the construction and structural optimization of Ce-doped ultrasmall Co2P nanoparticles (NPs) in carbon-based nanoarrays to boost HER-coupled *** demonstrate that the electronic structure of Co-based electrocatalysts can be positively regulated by Ce doping and the optimized Ce-Co2P-based electrocatalyst only require a low voltage of 1.20 V *** to achieve 10 mA cm-2for HMFOR with an excellent FDCA Faraday efficiency (FEFDCA) of98.5%,which are superior to its Ce-free counterpart (1.29 V ***;FEFDCA=83.9%).When being assembled into a HER-coupled HMFOR system,this bifunctional electrocatalyst can achieve 50 mA cm-2with an ultralow voltage of 1.46 V,which is reduced by 210 m Vas compared with that of its Ce-free counterpart (1.67 V).Quasi-operando experiments and DFTcalculations further reveal the significant roles of Ce doping in promoting the charge transfer between active sites and HMF,and reducing the free energy barrier of intermediate (*HMFCA) *** study provides new insights into the underlying mechanisms of Ce doping into metal phosphides for boosting HER-coupled HMFOR,developing a facile methodology to construct efficient electrocatalysts for energy storage/conversion systems.

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