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Design of a Minimally Actuated Lower Limb Exoskeleton with Mechanical Joint Coupling

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Journal of Bionic Engineering 2022年第2期19卷 370-389页

作者： Hui Li Hongliu Yu yingwei chen Xinyi Tang Duojin Wang Qiaoling Meng Qing Du Institute of Rehabilitation Engineering and Technology University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Engineering Research Center of Assistive Devices Institute of Rehabilitation Engineering and Technology Shanghai 200093China Key Laboratory of Neural-Functional Information and Rehabilitation Engineering of the Ministry of Civil Affairs Shanghai 200093China Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China Department of Rehabilitation Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China

Powered lower limb exoskeletons have traditionally used four or more powered joints to provide ambulation assistance for individuals with spinal cord *** with numerous powered joints commonly lost some excellent features of passive orthoses and further decreased utility due to added weight and increased control *** work adopts joints coupling mechanism to design a powered exoskeleton to minimize the number of actuated joints and control *** conventional powered exoskeletons,the joint-coupled-powered exoskeleton only has a single motor-actuated joint for each exoskeleton leg in conjunction with a unique knee coupled system to enable their users to walk,sit,and *** two types of joint coupled systems are designed,respectively,hip-knee coupled and knee-ankle *** joint-coupled-powered exoskeleton system allows a single actuator to power the hip motion,and allows activate knee motion through the coupled motions of the hip or *** specifically,when the mechanical coupled system is activated,the knee joint is unlocked,resulting in synchronized hip-knee or ankle-knee flexion and *** coupling mechanism is switched on and off at specific phases of the gait(the stance phase and the swing phase)to generate the desired *** research work proves that minimal actuated robotic systems with joint coupled could achieve safe and natural walking.

关键词： Powered exoskeleton Minimal actuation Joint coupling Single motor-actuated joint

Efficacy and safety of segmental radiofrequency ablation for isolation of the superior vena cava in patients with atrial fibrillation

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China Medical Abstracts(Internal Medicine) 2021年第3期38卷 161-162页

作者： chen yingwei Dept Cardiol 1st Affil HospZhengzhou UnivZhengzhou 450052

Objective To analyze the threedimensional distribution of functional sinus node,right phrenic nerve and superior vena cava(SVC)-right atrial muscle sleeves by three-dimensional electrophysiological technique in patients with atrial fibrillation(AF),and to investigate the efficacy and safety of segmental radiofrequency catheter ablation(RFCA)for isolation of superior vena cava in these patients.

关键词： patients atrial fibrillation

Investigation of a special neutralizing epitope of HEV E2s

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Protein & Cell 2014年第12期5卷 950-953页

作者： Min You Lu Xin Yi Yang Xiao Zhang yingwei chen Hai Yu Shaowei Li Jun Zhang Zhiqiang An Wenxin Luo Ningshao Xia National institute of diagnostics and vaccine development in infectious diseases Xiamen University Xiamen 361105 China Texes Therapeutics Institute The Brown Foundation of Molecular Medicine University of Texas Health Science Center at Houston Houston TX77030 USA Potomac Affinity Proteins 9601 Medical Center Drive Suite #330 Rockville MD 20850 USA

Dear Editor After 14-years of development, the first prophylactic vaccine against the Hepatitis E virus （HEY） has been marketed since 2012 （Wu et al., 2012）o However, the neutralizing epitopes of HEY are not completely defined. E2s, a protruding homodi- mer domain of HEV capsid protein, is responsible for inter- acting with host cells to initiate infection （Li et al., 2009; Li et al., 2005）. It was shown that two monoclonal antibodies （mAb）, 8Cll and 8H3, could neutralize the infectivity of HEV in rhesus, and the two mAbs bind to different neutralizing conformational epitopes on E2s （Zhang et al., 2005）.

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Jackson’s theorem in Q_p spaces

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Science China Mathematics 2010年第2期53卷 367-372页

作者： chen yingwei 1 & REN GuangBin 1, 2, 1 Department of Mathematics, University of Science and Technology of China, Hefei 230026, China 2 Department of Mathematics, University of Aveiro, P-3810-193 Aveiro, Portugal Department of Mathematics University of Science and Technology of China Department of Mathematics University of Aveiro

A Jackson type inequality in Q p spaces is established, i.e., for any f (z) = Σ∞ j=0 ajzj ∈ Qp , 0≤p 1, and k-1 ∈ N,where ω(1/k, f, Q p ) is the modulus of continuity in Q p spaces and C(a) is an absolute const... 详细信息

关键词： Q p space BMOA polynomial approximation

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基于两个导电滑环实现天窗驱动和状态检测

天文研究与技术 2016年第2期13卷 213-218页

作者：陈颖为中国科学院国家天文台北京100012

目前,可旋转天文圆顶仍被大量使用,工作时圆顶可360°旋转,望远镜通过打开的天窗进行观测。国家天文台兴隆观测基地的天窗选用5个导电滑环,但不能检测状态。为了简化天窗的状态检测、驱动系统,并提高其可靠性,利用二极管的单向导通特性... 详细信息

目前,可旋转天文圆顶仍被大量使用,工作时圆顶可360°旋转,望远镜通过打开的天窗进行观测。国家天文台兴隆观测基地的天窗选用5个导电滑环,但不能检测状态。为了简化天窗的状态检测、驱动系统,并提高其可靠性,利用二极管的单向导通特性设计了一种新型天窗状态检测、驱动电路。该电路只需要两个导电滑环和两个限位开关,即可实现天窗的状态检测和驱动控制。当天窗处于限位状态时,二极管构成的限位电路只允许电流单向导通。当天窗处于中间位置时,则可双向导通。该电路已经在85 cm望远镜等多个圆顶的天窗状态检测控制中成功应用。天窗状态检测、控制电路极大简化了测控系统,并可进行故障检测。

关键词：天窗状态检测导电滑环晶闸管场效应管桥路开关

Q_p空间中的de la Vallée Poussin平均

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计算数学 2019年第2期41卷 156-169页

作者：陈英伟王钥河北经贸大学数学与统计学学院石家庄050061

本文研究了单位球上的Q_p空间中的de la Vallée Poussin平均算子,并通过高阶光滑模来建立Jackson逼近定理.此外,我们还得到了Bernstein不等式,K-泛函和光滑模的等价刻画等结果.

关键词： de la Vallée Poussin平均 Q_p空间 Jackson定理 Bernstein不等式

Postablation neutrophil/lymphocyte ratio correlates with arrhythmiarecurrence after catheter ablation of lone atrial fibrillation

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Chinese Medical Journal 2014年第6期127卷 1033-1038页

作者： Xueyuan Guo Sen Zhang Xianliang Yan yingwei chen Ronghui Yu Deyong Long Caihua Sang Xin Du Jianzeng Dong Changsheng Ma Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China. Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China. Email: chshma@***.

Background Neutrophil/lymphocyte ratio(NLR) has been proposed as a novel marker of systemic inflammation and oxidative stress. The objective of this study was to ascertain the relationship between levels of NLR and recurrence of lone atrial fibrillation(AF) after catheter *** A total of 379 lone AF patients who underwent catheter ablation were enrolled in the study. The NLR before and after catheter ablation was determined. Cox regression analyses were used to estimate the relationship between NLR and the recurrence of lone *** After a mean follow-up of(30.5±5.3) months, 124(32.7%) patients had AF recurrences. The patients who developed AF recurrence had a higher postablation NLR(post-NLR) than patients with no recurrence(5.74±1.55 vs. 4.66±1.27, P <0.001). Multivariate Cox regression analysis revealed that post-NLR(hazard ratio(HR) 1.514, 95% confidence interval(CI) 1.364–1.680, P <0.001), left atrium diameter(HR 1.035, 95% CI 1.001–1.071, P=0.04) and body mass index(HR 1.028, 95% CI 1.002–1.054, P=0.03) were independent predictors of AF recurrence. Using a cut-off level of 5.15, post-NLR predicted AF recurrence with a sensitivity of 73% and specificity of 67%.Conclusions Our results indicate that an elevated post-NLR is associated with a high rate of lone AF recurrence. A simple measurement of NLR may help us to identify high-risk patients who need pharmacologic intervention to prevent recurrence.

关键词： atrial fibrillation catheter ablation neutrophil lymphocyte ratio

Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats： a 31p-magnetic resonance spectroscopy study

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Chinese Medical Journal 2014年第5期127卷 937-944页

作者： Sun yingwei Pan Shinong chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong Department of Radiology Shengjing Hospital of China Medical UniversityShenyang Liaoning 110004 China

Background Little is known about the value of 31P-magnetic resonance spectroscopy （31P-MRS） in in vivo assessment of exhaustive exercise-induced injury in skeletal *** aimed to evaluate the value of a 31P-MRS study using the quadriceps femoris after a single bout of acute exhaustive swimming in rats,and the correlation between 31P-MRS and histological *** Sixty male Sprague-Dawley rats were randomly assigned to control,half-exhaustive,and exhaustive exercise groups.31P-MRS of the quadriceps femoris of the right lower limb was performed immediately after swimming exercise to detect Pi,PCr,and β-*** Pi/PCr,Pi/β-ATP,PCr/β-ATP,and PCr/（PCr＋Pi） were calculated and pH *** under the receiver operating characteristic curve （AUCs） were calculated to evaluate the diagnostic potential of 31P-MRS in identifying and distinguishing the three *** staining,electron microscopy and desmin immunostaining after imaging of the muscle were used as a reference *** correlation between 31P-MRS and the mean absorbance （A value） of desmin staining were analyzed with the Pearson correlation *** Pi,PCr,Pi/PCr,and PCr/（PCr＋Pi） showed statistically significant intergroup differences （P＜0.05）.AUCs of Pi,PCr,Pi/PCr,and PCr/（PCr＋Pi） were 0.905,0.848,0.930,and 0.930 for the control and half-exhaustive groups,while sensitivity and specificity were 90％/85％,95％/55％,95％/80％,and 90％/85％,*** AUCs of Pi,PCr,Pi/PCr and PCr/（PCr＋Pi） were 0.995,0.980,1.000,and 1.000 for the control and exhaustive groups,while sensitivity and specificity were 95％/90％,100％/90％,100％/95％,and 100％/95％,*** AUCs of Pi,PCr,Pi/PCr,and PCr/（PCr＋Pi） were 0.735,0.865,0.903,and 0.903 for the half-exhaustive and exhaustive groups,while sensitivity and specificity were 80％/60％,90％/75％,95％/65％,and 95％/70％,*** the half-exhaustive group,some muscle fibers exhibited edema in HE staining,and the unclear Z-discs and the mitochondria with vacuolar degener

关键词： magnetic resonance spectroscopy exhaustive exercise energy metabolism receiver operating characteristic curve

Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

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Curcumin suppresses NLRP3 inflammasome activation and protec...