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Discovery of a normal-tension glaucoma-suspect rhesus macaque with craniocerebral injury:Hints of elevated translaminar cribrosa pressure difference

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Chinese Medical Journal 2024年第4期137卷 484-486页

作者： Jian wu Qi Zhang Xu Jia yingting Zhu Zhidong Li Shu Tu Ling Zhao Yifan Du Wei Liu Jiaoyan Ren Liangzhi Xu Hanxiang Yu Fagao Luo Wenru Su Ningli Wang Yehong Zhuo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-sen UniversityGuangzhouGuangdong 510060China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China School of Food Sciences and Engineering South China University of TechnologyGuangzhouGuangdong 510641China Guangzhou Huazhen Biosciences GuangzhouGuangdong 510920China

To the Editor:Normal-tension glaucoma(NTG)is a progressive optic neuropathy characterized by irreversible blindness with statistically normal intraocular pressure(IOP)(≤21 mmHg),^([1,2])which makes early-stage diagnosis in the clinical practice *** pathways underlying NTG include vascular dysregulation,toxic metabolite accumulation,and elevated translaminar cribrosa pressure difference(TLCPD).^([3])Although various small animal models have provided evidence of different pathophysiological mechanisms,the complicated clinical phenotype cannot be fully imitated by secondary disease models,and the gap between rodents and humans weakens their translational ***,the pathological changes associated with NTG remain unclear.

关键词： elevated glaucoma diagnosis

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma

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Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and I...

多学科交叉视角下乡土景观肌理分类研究——以四川省南江县龙泉村为例

2016年广东省药师周大会

作者： Wei Chi Fei Li Hongrui Chen Yandong Wang yingting Zhu Xuejiao Yang Jie Zhu Frances wu Hong Ouyang Jian Ge Robert N.Weinreb Kang Zhang Yehong Zhuo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University Department of Ophthalmology and Shiley Eye Center University of California

Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure(IOP) and consequent retinal ganglion cell(RGC) *** closure glaucoma,a common cause of glaucoma in Asia that affects tens of millions of people worldwide,often presents acutely with loss of vision,pain,and high *** when medical and surgical treatment is available,acute angle closure glaucoma can cause permanent and irreversible loss of ***-like receptor 4(TLR4) signaling has been previously implicated in the pathogenesis of IOP-induced RGC death,although the underlying mechanisms are largely *** the present study,we used an acute IOP elevation/glaucoma model to investigate the underlying mechanism of RGC *** found that TLR4 leads to increased caspase-8 expression;this elevation increases IL-1β expression and RGC death via a caspase-1–dependent pathway involving Nod-like receptor family,pyrin domain containing 1(NLRP1)/NLRP3 inflammasomes and a caspase-1–independent *** show that inhibition of caspase-8 activation significantly attenuates RGC death by down-regulating the activation of NLRP1 and NLRP3,thus demonstrating the pivotal role of caspase-8 in the TLR4-mediated activation of *** findings demonstrate collectively a critical role of caspase-8 in transducing TLR4-mediated IL-1β production and RGC death and highlight signal transduction in a caspase-1–dependent NLRP1/NLRP3 inflammasome pathway and a caspase-1–independent pathway in acute *** results provide new insight into the pathogenesis of glaucoma and point to a treatment strategy.

关键词： retinal ischemia reperfusion injury cell apoptosis

来源： cnki会议评论

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城市建筑空间 2023年第9期30卷 86-88页

作者：周盈廷吴有鹏重庆大学建筑城规学院

乡土景观是乡村振兴背景下备受关注的研究领域,乡土景观肌理是乡土景观最具表现力的外在形式,是乡村规划设计的重要依据。目前,学界对乡土景观肌理尚未形成明确的界定范畴和分类标准,研究成果不成系统。梳理国内外乡土景观研究现状,结... 详细信息

乡土景观是乡村振兴背景下备受关注的研究领域,乡土景观肌理是乡土景观最具表现力的外在形式,是乡村规划设计的重要依据。目前,学界对乡土景观肌理尚未形成明确的界定范畴和分类标准,研究成果不成系统。梳理国内外乡土景观研究现状,结合相关实践成果,从多学科视角建立乡土景观肌理的系统性分类框架。

关键词：多学科交叉乡土景观肌理分类

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青稞功能成分与生物活性研究进展

食品工业科技 2021年第5期42卷 357-362,368页

作者：余勤业吴彤罗颖婷李畅白术群沈群薛勇中国农业大学食品科学与营养工程学院北京100083 中粮营养健康研究院有限公司北京102209

青稞是一种营养丰富的禾本科植物,食用历史悠久。除具有较高的营养价值外,现代研究表明,青稞富含β-葡聚糖、多酚等功能因子,具有抗氧化、抗肿瘤、降糖、抗心血管疾病等多种生物活性,在食品、保健及相关行业中具有广阔的应用前景,受到... 详细信息

青稞是一种营养丰富的禾本科植物,食用历史悠久。除具有较高的营养价值外,现代研究表明,青稞富含β-葡聚糖、多酚等功能因子,具有抗氧化、抗肿瘤、降糖、抗心血管疾病等多种生物活性,在食品、保健及相关行业中具有广阔的应用前景,受到了国内外学者的广泛关注。本文总结了青稞已培育的种类和营养品质,以期为青稞的功能与生物活性的研究和开发提供参考和依据。同时重点综述了青稞抗氧化、降血糖、减肥、降血脂、抗动脉粥样硬化、抗血小板凝聚、免疫调节等功能性研究的成果,旨在为功能性食品的开发提供理论依据,继而有助于预防和辅助治疗慢性病。

关键词：青稞功能成分生物活性慢性病

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兜兰新品种‘紫光’

园艺学报 2019年第S2期46卷 2878-2879页

作者：文颖婷郑枫吴坤林房林李琳陈砚曾宋君中国科学院华南植物园华南农业植物分子分析与遗传改良重点实验室广州510650 中国科学院大学北京100049 广州华大锦兰花卉有限公司广州510176 中国科学院华南植物园广东省应用植物学重点实验室广州510650

兜兰新品种‘紫光’是以红旗兜兰(Paphiopedilumcharlesworthii)优良株系‘CZ-1’为母本,‘黑光’兜兰(Paph.‘Blacklight’)优良株系‘BZ-1’为父本通过人工授粉杂交后经单种子播种、组培快繁选育而成。叶黄绿色,叶背紫色。花葶近直立... 详细信息

兜兰新品种‘紫光’是以红旗兜兰(Paphiopedilumcharlesworthii)优良株系‘CZ-1’为母本,‘黑光’兜兰(Paph.‘Blacklight’)优良株系‘BZ-1’为父本通过人工授粉杂交后经单种子播种、组培快繁选育而成。叶黄绿色,叶背紫色。花葶近直立,平均长12.3 cm,深紫色有细密绒毛。花单朵,暗紫红色,平均横径9.4 cm,纵径7.7 cm。中萼片近圆形,两侧略向后翻卷;花瓣匙形,略卷曲,黑紫色;唇瓣盔状,黑紫色。盛花期3月,单朵花寿命40~45 d。

关键词：兜兰杂交单株选择品种

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主动脉弓分支、胸导管变异2例

中华解剖与临床杂志 2024年第6期29卷 416-418页

作者：曾涛吴磊孙国栋符庆琳李莹婷长治医学院第一临床学院临床医学系长治046000 长治医学院第二临床学院临床医学系长治046000 长治医学院人体解剖学教研室长治046000

笔者在解剖2具成年尸体时, 观察到标本主动脉分支之一的头臂干在起点、走行位置存在变异, 胸导管在走行、最终注入点存在变异。尸体标本10%甲醛固定, 来源于长治医学院人体解剖学教研室。标本1为女性, 身高168 cm, 60岁左右, 发育正常;... 详细信息

笔者在解剖2具成年尸体时, 观察到标本主动脉分支之一的头臂干在起点、走行位置存在变异, 胸导管在走行、最终注入点存在变异。尸体标本10%甲醛固定, 来源于长治医学院人体解剖学教研室。标本1为女性, 身高168 cm, 60岁左右, 发育正常;标本2为男性, 身高158 cm, 55岁左右, 发育正常。测量工具为游标卡尺(精确度0.02 mm)。查阅国内外文献, 未见此类变异报道。为积累国人主动脉弓和胸导管变异的解剖学资料, 报道如下。

关键词：遗传变异主动脉弓分支胸导管

中医外治法联合低分子肝素治疗脾肾两虚型复发性流产

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华夏医学 2023年第6期36卷 71-75页

作者：邬丹张劲宜邱颖婷萍乡市妇幼保健院江西萍乡337000

目的:探讨中医外治法联合低分子肝素治疗脾肾两虚型复发性流产的临床效果。方法:选择2021年1月至2022年12月收治的脾肾两虚型复发性流产患者90例,按照随机数字表法分为中医外治法组、低分子肝素组以及中医外治法联合低分子肝素组(联合... 详细信息

目的:探讨中医外治法联合低分子肝素治疗脾肾两虚型复发性流产的临床效果。方法:选择2021年1月至2022年12月收治的脾肾两虚型复发性流产患者90例,按照随机数字表法分为中医外治法组、低分子肝素组以及中医外治法联合低分子肝素组(联合治疗组),每组30例。治疗后,比较3组临床治疗有效率、血清激素水平和中医证候积分。结果:联合治疗组治疗总有效率76.67%高于低分子肝素组的43.33%及中医外治法组的50.00%,差异有统计学意义(P<0.05)。治疗后,3组血清激素水平均升高,联合治疗组高于低分子肝素组及中医外治法组(P<0.05);3组中医证候积分均降低,联合治疗组低于低分子肝素组及中医外治法组(P<0.05)。结论:脾肾两虚型复发性流产患者采用中医外治法联合低分子肝素治疗能提高血清激素水平,改善患者临床症状,提高临床治疗效果。

关键词：复发性流产脾肾两虚型穴位贴敷耳穴埋豆低分子肝素

低分子肝素配合丹参川芎在孕早期子宫动脉阻力异常患者中的临床应用疗效观察

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中国医药指南 2022年第34期20卷 119-121页

作者：邱颖婷宁杉邬丹萍乡市妇幼保健院江西萍乡337000

目的探讨低分子肝素配合丹参川芎在孕早期子宫动脉阻力异常患者中的临床应用疗效。方法选择2020年1月至2022年9月超声提示孕早期子宫动脉阻力异常患者70例为对象,随机数字表法分为两组各35例。两组均给予口服地屈孕酮治疗,对照组采用... 详细信息

目的探讨低分子肝素配合丹参川芎在孕早期子宫动脉阻力异常患者中的临床应用疗效。方法选择2020年1月至2022年9月超声提示孕早期子宫动脉阻力异常患者70例为对象,随机数字表法分为两组各35例。两组均给予口服地屈孕酮治疗,对照组采用低分子肝素治疗,观察组联合丹参川芎治疗,7 d为1个疗程,两组完成1~3个疗程,并完成12周随访,比较两组有效率、激素水平、子宫动脉血流频谱、稽留流产及药物不良反应发生率。结果观察组2个疗程治疗后有效率为94.28%,高于对照组的85.71%(P 0.05);观察组随访12周内稽留流产发生率低于对照组(P <0.05)。结论低分子肝素联合丹参川芎应用于孕早期子宫动脉阻力异常患者,能获得较高的有效率,有助于改善患者激素及子宫动脉血流频谱,能降低稽留流产率,且药物安全性较高。

关键词：低分子肝素丹参川芎孕早期子宫动脉阻力异常激素水平

Effectiveness of a theory-based tailored mHealth physical activity intervention for women undergoing chemotherapy for breast cancer:A quasi-experimental study

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International Journal of Nursing Sciences 2024年第4期11卷 405-413页

作者： Zhaohui Geng Jingting Wang Weibo Lyu Xinyu Li Wenjia Ye Wei Zheng Juan Yang Li Ning Lingzhi Cai Ying Liu yingting Zhang Fulei wu Changrong Yuan School of Nursing Shanghai University of Traditional Chinese MedicineShanghaiChina School of Nursing Navy Medical UniversityShanghaiChina Department of Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Breast Surgery Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Nursing Hangzhou First People’s HospitalHangzhouChina Department of Breast Surgery Hangzhou First People’s HospitalHangzhouChina Department of Nursing Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghaiChina School of Nursing Fudan UniversityShanghaiChina

Objectives:This study aimed to explore the effectiveness of the theory-based tailored mHealth physical activity(PA)intervention among patients with breast cancer undergoing ***:A quasi-experimental study design was adopted.A total of 60 breast cancer patients were selected from two tertiary hospitals in Shanghai and Hangzhou City from September 2019 to August *** to the admission order,30 patients werefirst included in the control group,followed by 30 patients in the intervention group.A smartphone application(app)named“Breast Care”was developed based on social cognitive theory,self-efficacy theory,and the theory of planned *** app integrated various functions,including information browsing,PA monitoring and feedback,symptom reporting,and social *** in the intervention group received three months of personalized online PA guidance in addition to routine *** control group received routine *** and post-intervention investigations after three months were conducted in two groups using the Short Form of International Physical Activity Questionnaire,the Hospital Anxiety and Depression Scale,and the Functional Assessment of Cancer TherapydBreast ***:After three months of intervention,compared to the control group,breast cancer patients in the intervention group showed significant improvements in walking,moderate PA,and overall PA(P<0.05).Compared to the baseline data,breast cancer patients in the intervention group had significant improvements in walking and overall PA after three months(P<0.05),whereas the control group experienced significant declines in walking,moderate PA,and overall PA after three months(P<0.05).There were statistically differences between the two groups in scores for anxiety,overall quality of life,and its dimensions,such as physical well-being,emotional well-being,and additional breast cancer well-being(P<0.05).Conclusions:The theory-based tailored mHealth PA interventio

关键词： Anxiety Breast cancer Chemotherapy Depression Patients Physical activity Telemedicine