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Study of chemical kinetics on labeling of ^(99m)Tc-N-ethyl-N_2S_2-Memantine

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Nuclear Science and Techniques 2012年第1期23卷 52-56页

作者： CAO Guoxian ZHOU Xingqin liu yingtao KONG Yanyan ZHANG Jiankang Key Laboratory of Nuclear Medicine Ministry of HealthWuxi 214063China Key Laboratory of Molecular Nuclear Medicine of Jiangsu Wuxi 214063China jiangsu Institute of Nuclear Medicine Wuxi 214063China

In this work,a calculation method of chemical kinetics was established for labeling reaction of 99mTc-N-ethyl-N2S2-memantine,a potential NMDA receptor imaging agent prepared in our *** groups of vials (3 vials per group) were added with 0.02 mL (1 mg/mL) N-ethyl-N2S2Memantine,0.08 mL (40 mg/mL) GH,0.05 mL (10 mg/mL) EDTA-2Na,0.035 mL (2 mg/mL) SnF2,0.8 mL phosphate buffer(1mol/L,pH 6.5) and 37 MBq *** vials were incubated at 70℃,80℃,90℃ or 100℃.Samples were taken with capillary from the vials at 2,5,10,20,30,40 and *** yields were determined by *** of reaction n,rate constant k,activation energy Ea and half life t1/2 of labeling reaction were calculated with the kinetics software we *** labeling yields of 99m Tc-N-ethyl-N2S2-memantine at 2,5,10,20,30,40 and 60min were (1) 13.5,15.7,34.0,64.8,81.9,91.4 and 95.4 at 70℃;(2) 13.2,20.5,40.1,70.0,88.2,94.5 and 95.6 at 80℃;(3) 15.6,22.9,43.7,74.3,87.2,93.4 and 96.1 at 90℃;and (4) 20.5,25.8,45.3,81.1,92.2,95.6 and 96.0 at 100℃.The other parameters were;n =1;k=0.053,0.061,0.063 and 0.076 L/min at 70℃,80℃,90℃ and 100℃,respectively;Ea=12.38 kJ/L;t1/2=13.11,11.45,11.05 and 9.07min at 70℃,80℃,90℃ and 100℃,*** mean labeling yield increased with temperature and time,optimized at 100℃ and *** concentration of 99mTc-N-ethyl-N2S2-Memantine was larger than that of Na99mTcO4,so n=*** k increased with reaction,hence the accelerated reaction rate at higher *** labeling reaction was not so difficult because of the low *** t1/2 decreased with increasing reaction temperature,hence the acceleration of labeling reaction.

关键词：化学动力学乙基标签反应速率常数金 NMDA受体 EDTA二钠磷酸盐缓冲液

Regulating microstructures and mechanical properties of Al-Fe-Ni alloys

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Progress in Natural Science:Materials International 2020年第1期30卷 54-62页

作者： Zeyu Bian yingtao liu Shihan Dai Zhe Chen Mingliang Wang Dong Chen Haowei Wang School of Materials Science & Engineering Shanghai Jiao Tong University State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Anhui Aluminium Matrix Composites Engineering Research Centre

Mechanical properties of Al-Fe-Ni eutectic alloys have been investigated based on the nominal mass fraction of eutectic phase,and the added Fe/Ni mass *** X-Ray diffraction,scanning electron microscopy equipped with energy dispersive spectroscopy and transmission electron microscope have been used to identify phase composition,characterize microstructure and crystal structure of Al9FeNi phase,*** results demonstrate that the nominal mass fraction of eutectic phase control the presence of primary *** tensile strength slightly increases,and the ductility deteriorates sharply as the volume fraction of primary phase *** Fe/Ni mass ratio has the profound effect on the microstructures(i.e.,size and shape) of primary *** the Fe/Ni ratio is approaching to 1,the primary phase becomes rod-like shape,which can enhance the ductility of alloys over the flake-like *** increasing cooling rate can effectively reduce the eutectic grains size and primary phase fraction,and further significantly improve mechanical properties of the alloys.

关键词： Al-Fe-Ni eutectic alloys Microstructures Primary phase High-temperature alloys

Poly dimethylsiloxane/carbon nanofiber nanocomposites: fabrication and characterization of electrical and thermal properties

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International Journal of Smart and Nano Materials 2016年第4期7卷 236-247页

作者： Shoieb Chowdhury Mark Olima yingtao liu Mrinal Saha James Bergman Thomas Robison School of Aerospace and Mechanical Engineering University of OklahomaNormanOKUSA NNSA’s National Security Campus operated by Honeywell Kansas CityMOUSA

This article presents the fabrication and characterization of poly dimethylsiloxane/carbon nanofiber(CNF)-based *** silica and carbon nanoparticles have been traditionally used to reinforce mechanical properties in PDMS matrix nanocom-posites,this article focuses on understanding their impacts on electrical and thermal *** adjusting both the silica and CNF concentrations,12 different nanocomposite formulations were studied,and the thermal and electrical properties of these materials were experimentally *** developed nano-composites were prepared using a solvent-assisted method pro-viding uniform dispersion of the CNFs in the polymer *** electron microscopy was employed to determine the dispersion of the CNFs at different length *** thermal properties,such as thermal stability and thermal diffusivity,of the developed nanocomposites were studied using thermogravi-metirc and laser flash ***,the electrical volume conductivity of each type of nanocomposite was tested using the four-probe method to eliminate the effects of contact electrical resistance during *** results showed that both CNFs and silica were able to impact on the overall properties of the synthesized PDMS/CNF *** developed nanocomposites have the potential to be applied to the development of new load sensors in the future.

关键词： Nanocomposites poly dimethylsiloxane carbon nanofiber electrical conductivity thermal stability thermal diffusivity

Radio-ligand receptor binding assav in vitro and animal biodistribution in vivo of ^(99)Tc^m-N-ethyl-N_2S_2-memantine as a potential NMDA receptor imaging agent

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Nuclear Science and Techniques 2010年第3期21卷 171-176页

作者： liu yingtao ZHOU Xingqin CAO Guoxian ZHANG Jiankang QIN Xiaofeng XU Xijie ZOU Meifen Jiangnan University School of Medicine and Pharmaceutics Wuxi 214122 China Key Laboratory of Nuclear Medicine Ministry of Health Jiangsu Institute of Nuclear Medicine Wuxi 214063 China

The pharmacologic characteristics of ^(99)Tc^m-N-ethyl-N_2S_2-memantine,an NMDA receptor imaging agent,was *** was prepared by a one-step reaction from N-ethyl-N_2S_*** affinity and specificity were determined by radio-ligand receptor binding assay(RRA).Biodistribution in vivo in mice was *** results showed that ^(99)Tc^m-N-ethyl-N_2S_2-memantine bound to a single site on NMDA receptor with a K_d of 584.32 nmol/L and a B_(max)of 267.05 nmol/mg.A competitive analysis showed that such specific binding could be inhibited by specific inhibitors of NMDA receptor,such as ketamine and(+)-*** biodistribution exhibited rapid uptake and favorable retention in mice *** major radioactivity was metabolized by the hepatic system.A two-compartment model of C=4.49e^(-0.083t)+ 1.42e^(-0.0016t)was established,and the half life was 8.35 min in *** conclusion,the new radio-ligand ^(99)Tc^m-N-ethyl-N_2S_2-Memantine has a moderate affinity and specific binding to NMDA receptor,and can easily cross the blood-brain barrier(BBB).Therefore,it may be a potential NMDA receptor imaging agent.

关键词： NMDA受体体内分布受体结合无线电显像剂乙基配体特异性结合

Nonlinear Flexural Behavior and Moment Curvature Response of Epoxy Resin Using Digital Image Correlation Technique

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材料科学与工程（中英文版） 2011年第2期5卷 212-219页

作者： Masoud Yekani Fard yingtao liu yingtao liu and Aditi Chattopadhyay Department of Mechanical Engineering School of Engineering of Matter Transport and Energy Arizona State University TempeAZ85287-6106 USA

The effect of local strain and stress distribution in the polymeric material under out of plane loading is of interest in many applications. Flexural testing of the epoxy resins is necessary to evaluate their mechanical behavior. In this paper, the flexural response of epoxy resin Epon E 863 and hardener EPI-CURE 3290 has been investigated in three point bending (3PB) at different strain rates. Beam specimens with rectangular cross sections, different lengths and span to depth ratios were tested at their mid point. Samples had either a quarter deep notch or a groove at their mid points. Strain fields within the beam structure were determined using digital image correlation technique. Load deflection curves at different load speeds were obtained. Limit of proportionality (LOP), modulus of rupture (MOR), initial slope of the load-deflection curve, and slope of load deflection curve after the LOP point were extracted. The nonlinear moment curvature behavior has been obtained. The results show that a digital image correlation can accurately categorize the material response of an epoxy resin for flexural loading. Results clearly display the strain rate effects on the material response.

关键词： Flexure epoxy resin load deflection digital image correlation technique

Flexible Nanopaper Composed of Wood-Derived Nanofibrillated Cellulose and Graphene Building Blocks

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Journal of Renewable Materials 2021年第3期9卷 451-461页

作者： Qing Li Ming Dai Xueren Qian Tian liu Zhenbo liu Yu liu Ming Chen Wang He Suqing Zeng Yu Meng Chenchen Dai Jing Shen yingtao liu Wenshuai Chen Wenbo liu Ping Lu College of Material Science and Engineering Northeast Forestry UniversityHarbin150040China Department of Chemistry and Biochemistry Rowan UniversityGlassboroNJ08028USA

Nanopaper has attracted considerable interest in the fields of films and paper ***,the challenge of integrating the many advantages of nanopaper still ***,we developed a facile strategy to fabricate multifunctional nanocomposite paper(NGCP)composed of wood-derived nanofibrillated cellulose(NFC)and graphene as building *** suspension was consisted of long and entangled NFCs(10–30 nm in width)and their *** NGCP formation,NFC was chemically modified with a silane coupling agent to ensure that it could interact strongly with graphene in *** resulting NGCP samples were flexible and could be bent repeatedly without any structural *** the NGCP samples,the high aspect ratio of NFC made a major contribution to its high mechanical strength,whereas the sheet-like graphene endowed the NGCP with electrical resistance and electrochemical *** mechanical strength of the NGCP samples decreased as their graphene content ***,the electrical resistance and electrochemical activity of the NGCP samples both rose with increasing content of *** NGCPs still kept advantageous mechanical properties even at high temperatures around 300℃ because of the high thermal stability of NFCs and their strong entangled web-like *** view of its sustainable building blocks and multifunctional characteristics,the NGCP developed in this work is promising as low-cost and high-performance nanopaper.

关键词： Nanofibrillated cellulose graphene flexible nanopaper mechanical strength electrical resistance

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二叉树型知识获取与推理技术研究

高技术通讯 2007年第6期17卷 657-660页

作者：刘瀛弢中国农业科学院计划财务局北京100081

通过应用计算机可视化技术、二叉树表达技术、XML数据库技术和推理技术,开发了基于可视化技术的专家知识采集与知识推理系统。其推理机利用了无状态连续推理技术,提高了有害生物知识采集和系统推理的效率。系统具有简单易用的特点,植保... 详细信息

通过应用计算机可视化技术、二叉树表达技术、XML数据库技术和推理技术,开发了基于可视化技术的专家知识采集与知识推理系统。其推理机利用了无状态连续推理技术,提高了有害生物知识采集和系统推理的效率。系统具有简单易用的特点,植保专家可以方便地利用该系统构建有害生物调控知识库。

关键词：有害生物二叉树知识获取非连续无状态推理技术

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基于逻辑控制的双输入运动体感算法研究

系统仿真学报 2021年第1期33卷 91-98页

作者：王辉柳颖涛中国民航大学航空工程学院天津300300

针对飞行模拟器中的双输入经典洗出算法存在感知角速度信号丢失、相位误差、逼真度不足等问题。提出一种逻辑控制洗出算法:依据前庭系统理论改进经典洗出算法高通角速度通道结构,设计逻辑控制器和角位移连续发生器优化高通角速度通道和... 详细信息

针对飞行模拟器中的双输入经典洗出算法存在感知角速度信号丢失、相位误差、逼真度不足等问题。提出一种逻辑控制洗出算法:依据前庭系统理论改进经典洗出算法高通角速度通道结构,设计逻辑控制器和角位移连续发生器优化高通角速度通道和倾斜协调通道中的耦合角速度并稳定跳跃变化的洗出角位移,使改进算法更符合人体感知模型。在Matlab/Simulink中对改进算法进行建模仿真,仿真结果表明:改进洗出算法减小了相位误差和虚假暗示,提高了角速度动感模拟逼真度。

关键词：逻辑控制洗出算法角速度相位误差动感逼真度

供体-锯齿型碳纳米管-受体的非线性光学响应对管径的依赖性

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化学学报 2012年第9期70卷 1131-1134页

作者：刘英涛王鑫刘翔宇冀永强宁夏大学化学化工学院银川750021

用密度泛函B3LYP方法得到一系列不同管径的氨基-硝基双取代纳米管NH2-(n,0)CNT-NO2(n=5～10)的几何结构.用CAM-B3LYP方法计算了体系的第一超极化率(β0).研究表明,β0对管径大小有着极强的依赖性.特别是对偶数纳米管(n=6,8和10),其β0(... 详细信息

用密度泛函B3LYP方法得到一系列不同管径的氨基-硝基双取代纳米管NH2-(n,0)CNT-NO2(n=5～10)的几何结构.用CAM-B3LYP方法计算了体系的第一超极化率(β0).研究表明,β0对管径大小有着极强的依赖性.特别是对偶数纳米管(n=6,8和10),其β0(5.5×103～9.8×104au)是奇数纳米管β0(1.0×103～2.8×103au)的5～35倍.

关键词：碳纳米管非线性光学依赖性