检索结果-南通市图书馆

Journal of Analysis and Testing 2024年第3期8卷 327-334页

作者： Yang Bai Shulin Tan yingsong sheng Yueqing Gu Haiping Wu Baicun Li Yunlong Liu Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing210009China National Center for Respiratory Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing100029China Department of Clinical Pharmacy Jinling HospitalState Key Laboratory of Analytical Chemistry for Life Science&Jiangsu Key Laboratory of Molecular MedicineMedical School of Nanjing UniversityNanjing210002China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou510515China

DNA methyltransferase(MTase)activity detection has received increasing attention as a promising biomarker and therapeutic ***,most of these detection methods rely on endonuclease digestion and signal groups ***,we present a novel platform for sensing DNA MTase activity that overcomes these *** approach is both endonuclease-free and label-free,utilizing a combination of a high-affinity streptavidin-methyl-CpG-binding domain(SA-MBD)protein and surface plasmon resonance(SPR)*** SA-MBD protein specifically recognizes a hairpin probe containing methylated CpG sites,which is treated with *** *** recognition event generates a corresponding SPR response *** limit of detection is as low as 0.016 U/mL,owing to the high-affinity of the SA-MBD ***,we have demonstrated the feasibility of our method for *** MTase activity analysis in serum and inhibitor screening,which implies the potential prospects for biomedical research.

关键词： DNA methyltransferase Methyl-CpG-binding protein Surface plasmon resonance Inhibitor screening Biosensing

Robust flutter analysis based on genetic algorithm

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2012年第9期55卷 2474-2481页

作者： GU yingsong ZHANG XinPing YANG ZhiChun Institute of Structural Dynamics and Control Northwestern Polytechnical UniversityXi'an 710072China A VIC Shaanxi Aircraft Industry(Group)Corporation LTD. Hanzhong 723213China

Robust flutter analysis considering model uncertain parameters is very important in theory and engineering *** robust flutter solution based on structured singular value subject to real parametric uncertainties may become difficult because the discontinuity and increasing complexity in real mu *** is crucial to solve the worst-case flutter speed accurately and efficiently for real parametric *** this paper,robust flutter analysis is formulated as a nonlinear programming *** proper nonlinear programming technique and classical flutter analysis method,the worst-case parametric perturbations and the robust flutter solution will be captured by optimization *** the derived nonlinear programming problem,the parametric uncertainties are taken as design variables bounded with perturbed intervals,while the flutter speed is selected as the objective *** model is optimized by the genetic algorithm with promising global optimum *** present approach avoids calculating purely real mu and makes robust flutter analysis a plain *** is illustrated by a special test case that the robust flutter results coincide well with the exhaustive *** is also demonstrated that the present method can solve the match-point robust flutter solution under constant Mach number accurately and *** method is implemented in problem with more uncertain parameters and asymmetric perturbation interval.

关键词： Flutter genetic algorithm robust flutter analysis match-point solution nonmatch-point solution

Hyperspectral Image Super-Resolution Meets Deep Learning:A Survey and Perspective

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2023年第8期10卷 1668-1691页

作者： Xinya Wang Qian Hu yingsong Cheng Jiayi Ma the Electronic Information School Wuhan UniversityWuhan 430072China IEEE

Hyperspectral image super-resolution,which refers to reconstructing the high-resolution hyperspectral image from the input low-resolution observation,aims to improve the spatial resolution of the hyperspectral image,which is beneficial for subsequent *** development of deep learning has promoted significant progress in hyperspectral image super-resolution,and the powerful expression capabilities of deep neural networks make the predicted results more ***,several latest deep learning technologies have made the hyperspectral image super-resolution method ***,a comprehensive review and analysis of the latest deep learning methods from the hyperspectral image super-resolution perspective is *** this end,in this survey,we first introduce the concept of hyperspectral image super-resolution and classify the methods from the perspectives with or without auxiliary ***,we review the learning-based methods in three categories,including single hyperspectral image super-resolution,panchromatic-based hyperspectral image super-resolution,and multispectral-based hyperspectral image ***,we summarize the commonly used hyperspectral dataset,and the evaluations for some representative methods in three categories are performed qualitatively and ***,we briefly introduce several typical applications of hyperspectral image super-resolution,including ground object classification,urban change detection,and ecosystem ***,we provide the conclusion and challenges in existing learning-based methods,looking forward to potential future research directions.

关键词： Deep learning hyperspectral image image fusion image super-resolution survey

Suppressing nonlinear aeroelastic response of laminated composite panels in supersonic airflows using a nonlinear energy sink

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2021年第2期34卷 376-385页

作者： Jian ZHOU Minglong XU Zhichun YANG yingsong GU State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong UniversityXi'an 710049China School of Aeronautics Northwestern Polyteclmical UniversityXi'an 710072China

This paper proposes using a Nonlinear Energy Sink(NES) to suppress the nonlinear aeroelastic response of laminated composite panels in supersonic airflows. Relevant aeroelastic equations are established using Hamilton’s principle and a finite element approach, drawing upon Von Karman’s large deflection theory and first order piston theory. The idea of the NES suppression region is proposed and the effects of NES parameters on the NES suppression region are studied in detail. The results show that the nonlinear aeroelastic responses of the panel can be completely suppressed by the Transient Resonance Capture(TRC);the appropriate NES parameter values can increase the critical dynamic pressure for flutter and suppress the nonlinear aeroelastic response effectively. Increasing the mass ratio of the NES can improve the NES suppression region;the nonlinear stiffness coefficient and damping of the NES within a specific range can suppress the nonlinear aeroelastic response. The most effective installation position for a NES is in a specific region behind the center-line of the panel in the direction of the airflow.

关键词： Aeroelasticity Laminated composite panel Nonlinear dynamics Nonlinear energy sink Panel flutter Passive suppression

Machine learning methods for predicting CO2 solubility in hydrocarbons

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第5期21卷 3340-3349页

作者： Yi Yang Binshan Ju Guangzhong Lü yingsong Huang School of Energy Resources China University of Geosciences(Beijing) Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of Education Key Laboratory of Geological Evaluation and Development Engineering of Unconventional Natural Gas Energy shengli Oilfield Company SINOPEC

The application of carbon dioxide（CO2） in enhanced oil recovery（EOR） has increased significantly, in which CO2solubility in oil is a key parameter in predicting CO2flooding performance. Hydrocarbons are the major constituents of oil, thus the focus of this work lies in investigating the solubility of CO2in hydrocarbons. However, current experimental measurements are time-consuming, and equations of state can be computationally complex. To address these challenges, we developed an artificial intelligence-based model to predict the solubility of CO2in hydrocarbons under varying conditions of temperature, pressure, molecular weight, and density. Using experimental data from previous studies,we trained and predicted the solubility using four machine learning models: support vector regression（SVR）, extreme gradient boosting（XGBoost）, random forest（RF）, and multilayer perceptron（MLP）.Among four models, the XGBoost model has the best predictive performance, with an R2of ***, sensitivity analysis and evaluation of the relative impacts of each input parameter indicate that the prediction of CO2solubility in hydrocarbons is most sensitive to pressure. Furthermore, our trained model was compared with existing models, demonstrating higher accuracy and applicability of our model. The developed machine learning-based model provides a more efficient and accurate approach for predicting CO2solubility in hydrocarbons, which may contribute to the advancement of CO2-related applications in the petroleum industry.

关键词： CO2 solubility Machine learning Support vector regression Extreme gradient boosting Random forest Multi-layer perceptron

Supersonic flutter control and optimization of metamaterial plate

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2021年第11期34卷 15-20页

作者： Wei TIAN Tian ZHAO yingsong GU Zhichun YANG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

A metamaterial plate is designed by embedding a periodic array of local nonlinear resonators for its supersonic flutter *** on the von Karman large deformation theory and supersonic piston aerodynamic theory,the nonlinear aeroelastic equations of the metamaterial plate are obtained by using the Hamilton *** comparisons for aeroelastic behaviors of the metamaterial plate and pure plate show that the proposed metamaterial plate can lead to an enlarged flutter boundary and lower vibration ***,a parametric optimization strategy for local nonlinear resonators is proposed to improve the nonlinear flutter behaviors of the metamaterial plate,and a significant enhancement of passive control performance can be achieved through optimization *** present study demonstrates that the design of the metamaterial plate can provide an effective approach and potential application for nonlinear flutter suppression of supersonic plate.

关键词： Local resonators Metamaterial plate Nonlinear aeroelastic responses Parametric optimization design Supersonic flutter control

Mutation of RET gene in Chinese patients with Hirschsprung's disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2002年第6期8卷 1108-1111页

作者： Ji-ChengLi Shi-PingDing yingsong Min-JuLi Children’sHospital ZhejiangUniversityMedicalCollegeHangzhou310006ZhejiangProvinceChina DepartmentofLymphology DepartmentofHistologyandEmbryologyZhejiangUniversityMedicalCollegeHangzhou310031Zhe

AIM: To investigate the pathogenic mechanism of Hirschsprung's disease (HD) at the molecular level and to elucidate the relationship between RET oncogene and Chinese patients with ***: Exon 13 of RET oncogene from 20 unrelated HD patients was analyzed with polymerase chain reactionsingle strand conformation polymorphism (PCR-SSCP). The positive amplifying products were then sequenced. According to the results of SSCP and DNA sequence, SSCP was done as well for the samples from the family other members of some cases with mutated RET ***: SSCP analysis indicated that mobility abnormality existed in 4 unrelated HD patients. Direct DNA sequence analysis identified a missense mutation, T to G at the nucleotide 18 888 and a frameshift mutation at the nucleotide 18 926 insG. In a HD family, the sicked child and his father were the same heterozygous missense mutation (T to G at nucleotide 18 888).CONCLUSION: Among Chinese HD patients, RET gene mutations may exist in considerable proportion with different patterns. These new discoveries indicate that RET mutations may play an important role in the pathogenesis of unrelated HD in the Chinese population. PCR-SSCP combined with DNA sequence can be used as a tool in the genetic diagnosis of HD.

关键词： RET基因突变中国人巨结肠病分子病理

Thinning and Shrinkage of Laohugou No. 12 Glacier in the Western Qilian Mountains, China, from 1957 to 2007

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2012年第3期9卷 343-350页

作者： ZHANG yingsong LIU Shiyin SHANGGUAN Donghui LI Jing ZHAO Jingdong State Key Laboratory of Cryospheric Science Cold and Arid Regions Environmental and Engineering Research InstituteLanzhou 730000China

Landsat images, real-time kinematic GPS measurements, and topographic maps were used to determine changes in ice elevation, volume, and areal extent of the Laohugou No. 12 glacier (Qilian Mountains, China) between 1957 and 2007. The glacier experienced significant thinning and areal shrinkage in the ablation zone, but slight thickening in part of the accumulation zone. Elevation decreased by 18.6±5.4 m between 1957 and 2007 in the regions covered by the GPS measurements. The total volume loss for the entire glacier was estimated to be 0.218 km3 using a third-order polynomial fit method. The area diminished by 0.28 km2 between 1957 and 1994, 0.26 km2 between 1994 and 2000, and 0.28 km2 between 2000 and 2007, suggesting that the rate of loss in glacial coverage has increased since the mid-1990s. Significant increases in annual mean air temperature may have contributed to shrinkage and thinning of the glacier.

关键词： Glacier RTK-GPS Volume loss QilianMountain

Undersea Buried Pipeline Reconstruction Based on the Level Set and Inverse Multiquadric Regularization Method

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2022年第1期21卷 101-112页

作者： SHANG Wenjing XUE Wei XU Yidong MAKAROV Sergey B LI yingsong College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Advanced Marine Communication and Information Technology Ministry of Industry and Information TechnologyHarbin 150001China Yantai Research Institute and Graduate School of Harbin Engineering University Yantai 264006China Institute of Physics Nanotechnology and TelecommunicationsHigher School of Applied Physics and Space TechnologiesPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251Russia

The electric inversion technique reconstructs the subsurface medium distribution from acquired *** the basis of electric inversion,objects buried under the earth or seabed,such as pipelines and unexploded ordnance,are detected and located in a contactless ***,the process of accurately reconstructing the shape of the target object is challenging because electric inversion is a nonlinear and ill-posed *** this work,we present an inverse multiquadric(IMQ)regularization method based on the level set function for reconstructing buried *** the case of locating underwater objects,the unknown inversion area is split into two parts,the background and the pipeline with known *** geometry of the pipeline is represented based on the level set function for achieving a noiseless inversion *** obtain a binary image,the IMQ is used as the regularization term,which‘pushes’the level set function away from *** also provide an appropriate method to select the bandwidth and regularization parameters for the IMQ regularization term,resulting in reconstructed images with sharp *** simulation results and analysis show that the proposed method performs better than classical inversion methods.

关键词： inverse problems level set function inverse multiquadric regularization method buried pipeline

High-temperature dielectric switch and second harmonic generation integrated in a stimulus responsive material

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第1期32卷 539-542页

作者： yingsong Xue Zhixu Zhang Pingping Shi Wanying Zhang Qiong Ye Dawei Fu Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and Applications of Molecular FerroelectricsSoutheast UniversityNanjing 211189China

Stimulus re s ponsive materials can provide a variety of desirable properties in one equipment unit,such as optoelectronic devices,data communications,actuators,memories,sensors and ***,it remains a large challenge to design such stimulus responsive materials,especially functional materials having both dielectric switch and second harmonic generation(SHG).Here,a new stimuli-responsive switchable material [(CH_(3))_(3)N(CH_(2))_(2)Cl]_(2)]Mn(SCN)_(4)(H_(2)O)_(2)] was discovered as a potential secondharmonic generation(SHG) dielectric *** is worth noting that it has SHG characteristics before and after undergoing reversible high-temperature phase *** this work,we successfully refined the tetramethylammonium cation to obtain a quasi-spherical cation,which is tetramethylchloroethylamine(TMCEM) *** substituting H with a halogen,the increased steric hindrance of the molecular makes energy barrier increased,resulting in the reversible high-temperature phase *** the same time,the interactions of quasi-spherical cations and [Mn(SCN)_(4)(H_(2)O)_(2)]^(2-) anions affect a noncentrosymmetric structure to induce the SHG *** findings provide a new approach to design novel functional switch materials.

关键词： Dielectric switch Second harmonic generation High-temperature Phase transition Stimulus responsive material