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基于虚、痰、瘀、毒理论浅析射血分数保留的心力衰竭炎症状态与中医药干预策略

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天津中医药大学学报 2024年第7期43卷 637-649页

作者：和振杰时晓迟赵英强天津中医药大学天津301617 天津中医药大学第二附属医院天津300250

射血分数保留的心力衰竭(HFpEF)是常见的心力衰竭类型之一,约占全部心力衰竭的50%,具有较高的发病率、再住院率及病死率。HFpEF的发病机制较其他类型的心力衰竭更为复杂,具有高度异质性特点。近年来,关于其细胞分子学发病机制的相关研... 详细信息

射血分数保留的心力衰竭(HFpEF)是常见的心力衰竭类型之一,约占全部心力衰竭的50%,具有较高的发病率、再住院率及病死率。HFpEF的发病机制较其他类型的心力衰竭更为复杂,具有高度异质性特点。近年来,关于其细胞分子学发病机制的相关研究越来越受到重视,大量研究显示HFpEF的发病及疾病进展与炎症密切相关,微血管炎症和内皮细胞炎症是HFpEF的关键分子机制,涉及一氧化氮(NO)-环磷酸鸟苷(cGMP)-蛋白激酶G(PKG)、转化生长因子-β1(TGF-β1)/Smads、血管紧张素Ⅱ(AngⅡ)/TGF-β1/Smad2/3、白细胞介素-33(IL-33)/跨膜型ST2(ST2L)等信号通路。HFpEF合并症通过全身炎症和氧化应激,进而导致冠状动脉微血管内皮炎症驱动心肌功能障碍及重塑。现代研究表明炎症与中医“虚、痰、瘀、毒”理论高度相似,结合HFpEF的致病因素、病理机制及病程不同阶段的临床表现采用中医药干预策略,注重补虚、化痰、祛瘀、解毒等治法的运用,结果显示中医药可以通过改善线粒体功能,调节能量代谢,从而抑制炎症反应,减轻心肌纤维化,逆转心肌肥厚,进而保护心肌细胞,抑制心室重构,延缓HFpEF病理进程,能够减轻患者临床症状,提高生活质量。文章试从虚、痰、瘀、毒理论浅析HFpEF病理变化,以期为临床防治HFpEF提供科学依据。

关键词：射血分数保留的心力衰竭炎症状态中医药

Hierarchical NiCo2O4 microspheres assembled by nanorods with p-type response for detection of triethylamine

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Chinese Chemical Letters 2020年第8期31卷 2077-2082页

作者： Chen Yang Yongshan Xu Lingli Zheng yingqiang zhao Wei Zheng Xianghong Liu Jun Zhang College of Physics Center for Marine Observation and CommunicationsQingdao UniversityQingdao 266071China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJi'nan 250014China

The morphological and structural design provides an efficient protocol to optimize the performance of gas sensing *** this work,a gas sensor with high sensitivity for triethylamine(TEA)detection is developed based on p-type NiCo2 O4 hierarchical *** NiCo2 O4 microspheres,synthesized by a hydrothermal route,have a three-dimensional(3 D)urchin-like structure assembled by nanorod building *** structure-property correlation has been investigated by powder X-ray diffraction,X-ray photoelectron spectroscopy,transmission electron microscope,scanning electron microscope,N2 adsorption-desorption tests and comprehensive gas sensing *** influence of calcination temperature on the morphological structure and sensing performances has been *** reveal that the material annealed at 300℃has a very large specific surface area of 125.27 m2/g,thereby demonstrating the best TEA sensing properties including high response and low limit of detection(145 ppb),good selectivity and *** further increase of the calcination temperature leads to the collapse of the 3 D hierarchical structure with significantly decreased surface area,which is found to decline the sensing *** work indicates the promise of ternary p-type metal oxide nanostructures for application in highly sensitive gas sensors.

关键词： Microstructures NiCo2O4 Metal oxide p-type response Gas sensor

1990-2019年中国心血管疾病流行现状、疾病负担及发病预测分析

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中国全科医学 2024年第2期27卷 233-244,252页

作者：杨继张垚马腾田昕彤赵英强天津中医药大学第一附属医院天津市300381 国家中医针灸临床医学研究中心天津市300381 天津中医药大学天津市301617 天津中医药大学第二附属医院天津市300250

背景心血管疾病是严重危害人类健康的重大慢病,且仍是我国乃至全球一个亟待解决的公共卫生问题。目的探讨1990—2019年中国心血管疾病流行特征和疾病负担情况,预测2020—2050年中国心血管疾病发病情况,为心血管疾病相关防治策略的制订... 详细信息

背景心血管疾病是严重危害人类健康的重大慢病,且仍是我国乃至全球一个亟待解决的公共卫生问题。目的探讨1990—2019年中国心血管疾病流行特征和疾病负担情况,预测2020—2050年中国心血管疾病发病情况,为心血管疾病相关防治策略的制订提供参考。方法检索2019年全球疾病负担研究(GBD 2019)数据库,提取1990—2019年中国及全球心血管疾病负担及危险因素的相关数据并进行分析,使用基于GBD 2019数据库可公开的发病率、患病率、死亡率以及对应的年龄标准化(简称标化)率来量化心血管疾病的疾病流行情况,使用伤残损失寿命年(YLD)、早死损失寿命年(YLL)、伤残调整寿命年(DALY)量化疾病负担情况,构建ARIMA模型预测2020—2050年中国心血管疾病的发病情况。结果1990—2019年中国心血管疾病的发病率、患病率及死亡率呈逐年上升趋势,其中发病率、患病率及死亡率分别增长了93.75%、99.75%、57.39%。女性的标化发病率、标化患病率均高于男性,标化死亡率低于男性(P<0.05)。从2019年数据上看,中国心血管疾病总体发病率随着年龄升高呈上升趋势,在95岁及以上年龄组达到最高值。男性和女性的发病率趋势与总体趋势相似,但略有差异。总体患病率随着年龄升高呈上升趋势,女性高于男性。在45岁以后心血管疾病的死亡率呈现上升趋势,男性的死亡率在各个年龄段均高于女性。1990—2019年男性YLL率、YLD率、DALY率增长了36.99%、102.42%、40.78%,女性增长了2.79%、107.13%、11.50%。从2019年数据来看,中国总人群心血管疾病的YLL率、YLD率、DALY率总体随着年龄的增加呈上升趋势,尚无拐点出现。男性YLL率、DALY率随人口老龄化进展逐渐升高并远高过女性,女性YLD率在55~59岁年龄组后逐渐升高并远高过男性。1990—2019年,全球心血管疾病的标化发病率、标化患病率及标化死亡率呈逐年下降趋势,而中国的标化发病率和标化患病率仍有所增加,标化死亡率虽有所降低,但仍高于全球范围。从全球整体水平上看,中国心血管疾病的标化YLL率、标化DALY率虽同全球一样呈下降趋势,但2000年以后中国心血管疾病的疾病负担高于全球整体水平,且标化YLD率逐年增加。与心血管疾病死亡相关的危险因素主要是吸烟、吸二手烟、饮酒、体力活动少、高空腹血糖、高收缩压、高BMI、高低密度脂蛋白胆固醇以及肾功能不全。从中国及全球相关数据来看,高收缩压(高血压)依然是造成心血管疾病死亡的首要危险因素,且死亡人数逐年增加。高低密度脂蛋白胆固醇(高脂血症)是全球及近年来中国心血管疾病死亡的第二因素。2020—2050年中国心血管疾病标化发病率仍呈上升趋势,预计到2050年心血管疾病的标化发病率将达到663.618/10万。结论1990—2019年我国心血管疾病的发病率、患病率及死亡率呈逐年上升趋势,因心血管疾病导致的疾病负担较重,在未来50年尚无拐点出现,疾病流行及负担情况均高于全球范围。预计到2050年心血管疾病的标化发病率将达到663.618/10万。

关键词：心血管疾病疾病负担伤残调整寿命年危险因素预测

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Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial

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Journal of Traditional Chinese Medicine 2017年第6期37卷 756-766页

作者： Wang Xianliang Hou Yazhu Mao Jingyuan zhao yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli Cardiovascular Department the First Teaching Hospital of Tianjin University of Traditional Chinese Medi-cineTianjin 300193China Cardiovascular Department the SecondTeaching Hospital of Tianjin University of Traditional Chi-nese MedicineTianjin 30015OChina Cardiovascular Department Shanxi TraditionalChinese Medicine InstituteTaiyuan 030012China Cardiovascular Department the Second Teach-ing Hospital of Tianjin Medical UniversityTianjin 300211China Cardiovascular Department the SecondTeaching Hospital of Shanxi University of Traditional Chinese MedicineXianyang 712000China Cardiovascular Department the Integrated Hospitals of TCM and Western Medicine of Shanxi Universityof Traditional Chinese MedicineTaiyuan 030001China Cardiovascular Department Tianjin Beichen Tradi-tional Chinese Medicine HospitalTianjin 300400China Cardiovascular Department Tianjin Nankai Tradi-tional Chinese Medicine HospitalTianjin 300102China Cardiovascular Department Tianjin Tradition-al Chinese Medicine HospitalTianjin 300020China Cardiovascular Department the Eastern Hospitalof Beijing University of Traditional Chinese MedicineBeijing 100078China Evidence-based medicinecenter Tianjin University of Traditional Chinese MedicineTianjin 300193China Statistic Department Tianjin University ofTraditional Chinese MedicineTianjin 300193China Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China Graduate school Tianjin Universi-ty of Traditional Chinese MedicineTianjin 300193China Ruan JishouDepartment of MathematicsNankai Universi-tyTianjin 300071China

OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) ***: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause *** efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse ***: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival *** treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two ***: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients.

关键词： Heart failure Medicine, Chinese tradi-tional Walk test Randomized controlled trail

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钩藤提取物及钩藤碱的药理研究进展

中药新药与临床药理 2021年第6期32卷 899-904页

作者：柳威邓林华赵英强天津中医药大学第二附属医院天津300150 天津中医药大学天津301617

钩藤是一味具有息风定惊、清热平肝功效的中药材。近年来,研究发现钩藤提取物及钩藤主要有效成分钩藤碱具有保护神经、降压、保护心肌、抗癌、抗炎、平喘等多种药理作用,且对多种疾病,包括心脑血管、癌症、哮喘等均具有潜在的治疗作用... 详细信息

钩藤是一味具有息风定惊、清热平肝功效的中药材。近年来,研究发现钩藤提取物及钩藤主要有效成分钩藤碱具有保护神经、降压、保护心肌、抗癌、抗炎、平喘等多种药理作用,且对多种疾病,包括心脑血管、癌症、哮喘等均具有潜在的治疗作用。该文概述了钩藤提取物及钩藤主要有效成分钩藤碱的药理作用研究进展,可为钩藤的临床应用提供依据。

关键词：钩藤提取物钩藤碱药理作用研究进展

高血压病并发脑卒中的影响因素分析及风险预测模型的初步建立——3859例回顾性研究

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中医杂志 2021年第10期62卷 868-873页

作者：杨继张垚张秋月赵英强天津中医药大学天津市300193 天津中医药大学第二附属医院

目的探讨高血压病并发脑卒中的相关危险因素,初步构建高血压病并发脑卒中的风险预测模型。方法以天津市社区卫生服务系统为资料来源,回顾性抽取2018年1月1日至2019年12月31日在天津市北辰区社区卫生服务中心签约建档、资料保存完整、符... 详细信息

目的探讨高血压病并发脑卒中的相关危险因素,初步构建高血压病并发脑卒中的风险预测模型。方法以天津市社区卫生服务系统为资料来源,回顾性抽取2018年1月1日至2019年12月31日在天津市北辰区社区卫生服务中心签约建档、资料保存完整、符合高血压病诊断的患者3859例,按是否并发脑卒中分为脑卒中组412例(10.68%)、非脑卒中组3447例(89.32%)。分别采用单因素及多因素分析方法筛选高血压病并发脑卒中的危险因素,根据筛选结果建立预测模型并通过Hosmer-Lemeshow拟合度检验和受试者工作特征曲线(ROC)对该模型进行评估。结果单因素分析结果显示,白细胞计数、中性粒细胞百分比、淋巴细胞百分比、空腹血糖、总胆红素、血肌酐、血尿素氮、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、年龄、性别、吸烟史、荤素均衡嗜盐、荤食为主嗜盐、素食为主嗜盐、气虚质是高血压病并发脑卒中的可疑影响因素;多因素分析结果显示,总胆固醇、低密度脂蛋白胆固醇、体重指数(BMI)、荤食为主嗜盐是高血压病脑卒中发生的独立影响因素。建立的预测模型为Logit(P)=1.580-0.610×总胆固醇+0.525×低密度脂蛋白胆固醇-0.075×BMI+2.064×荤食为主嗜盐(1="是",0="否"),模型诊断灵敏度为66.20%,特异性为54.70%,一致率为74.76%。结论高血压病并发脑卒中的高危影响因素为总胆固醇、低密度脂蛋白胆固醇、BMI、荤食为主嗜盐,据此建立的风险预测模型与临床诊断吻合良好,可定量评估高血压病患者脑卒中发生风险。

关键词：高血压病脑卒中危险因素风险预测模型

Recycling arsenic-containing bio-leaching residue after thermal treatment in cemented paste backfill:Structure modification,binder properties and environmental assessment

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2136-2147页

作者： Dengfeng zhao Shiyu Zhang Yingliang zhao Department of Mining Engineering Lyuliang UniversityLvliang 033000China School of Civil and Environmental Engineering University of Science and Technology BeijingBeijing 100083China School of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 00852China

The substantial arsenic(As)content present in arsenic-containing bio-leaching residue(ABR)presents noteworthy environ-mental challenges attributable to its inherent instability and susceptibility to *** its elevated calcium sulfate content,ABR exhibits considerable promise for industrial *** study delved into the feasibility of utilizing ABR as a source of sulfates for producing super sulfated cement(SSC),offering an innovative binder for cemented paste backfill(CPB).Thermal treatment at varying temperatures of 150,350,600,and 800℃ was employed to modify ABR’s *** investigation encompassed the examination of phase transformations and alterations in the chemical composition of As within ***,the hydration characteristics of SSC utilizing ABR,with or without thermal treatment,were studied,encompassing reaction kinetics,setting time,strength development,and *** findings revealed that thermal treatment changed the calcium sulfate structure in ABR,consequently impacting the resultant sample ***,calcination at 600℃ demonstrated optimal modification effects on both early and long-term strength *** enhanced performance can be attributed to the augmented formation of reaction products and a densified ***,the thermal treatment elicited modifications in the chemical As fractions within ABR,with limited impact on the As immobilization capacity of the prepared binders.

关键词： cemented paste backfill bio-leaching residue arsenic immobilization binder hydration calcination

Automatic modeling algorithm of stochastic error for inertial sensors

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Control Theory and Technology 2024年第1期22卷 81-91页

作者： Luodi zhao Long zhao School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China Digital Navigation Center Beihang UniversityBeijing100191China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing100191China

This paper proposes an automatic algorithm to determine the properties of stochastic processes and their parameters for inertial error. The proposed approach is based on a recently developed method called the generalized method of wavelet moments (GMWM), whose estimator was proven to be consistent and asymptotically normally distributed. This algorithm is suitable mainly (but not only) for the combination of several stochastic processes, where the model identification and parameter estimation are quite difficult for the traditional methods, such as the Allan variance and the power spectral density analysis. This algorithm further explores the complete stochastic error models and the candidate model ranking criterion to realize automatic model identification and determination. The best model is selected by making the trade-off between the model accuracy and the model complexity. The validation of this approach is verified by practical examples of model selection for MEMS-IMUs (micro-electro-mechanical system inertial measurement units) in varying dynamic conditions.

关键词： GMWM Stochastic process Inertial sensor Sensor calibration Error model Allan variance

Meeting the challenges of invasive alien species

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National Science Review 2024年第3期11卷 296-298页

作者： Weijie zhao NSR news

The Xinjiang Uygur Autonomous Region of China is famous for its tomato production. Abundant sunshine, large day–night temperature difference and the abundant irrigation by snowmelt from the Tianshan Mountains produce...

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