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The benign mimickers of prostatic acinar adenocarcinoma

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Chinese Journal of Cancer Research 2016年第1期28卷 72-79页

作者： Yuqiao Xu yingmei wang Ru Zhou Haiyang Li Hong Cheng Zhe wang Jing Zhang Department of Pathology State Key Laboratory of Tumor Biology Xijing Hospital The Fourth Military Medical University Cadet Brigade The Fourth Military Medical University

As the most frequent malignant histological subtype in prostatic cancer, prostatic acinar adenocarcinoma （PAA） has a series of benign mimickers including prostatic or non-prostatic lesions and normal structures, which may lead to an erroneous diagnosis and inappropriate treatment. It is very important to be aware of the existence of these mimickers and to recognize their histological features. The differential diagnosis should be based on a comprehensive evaluation of clinical history, histological structure, cytological morphology and the results of immunohistochemistry （IHC） straining, rather than on single criteria （e.g., the presence of prominent nueleoli or basal cell layer）.

关键词： Prostatic acinar adenocarcinoma （PAA） differential diagnosis immunohistochemistry

Ovarian cancer presenting with hypercalcemia:two cases with similar manifestations but different mechanisms

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Cancer Biology & Medicine 2018年第2期15卷 182-187页

作者： Xuegong Ma yingmei wang Xuhong Zhang Mengting Dong Wen Yang Fengxia Xue Department of Gynecology and Obstetrics Tianjin Medical University General Hospital

Hypercalcemia presenting in ovarian cancer is uncommon in the clinic.Here,two cases of ovarian epithelial carcinoma that presented with severe hypercalcemia were reported,with a review of the literature.The laboratory findings and stepwise clinical investigations of these two cases differed,indicating distinct underlying causes of hypercalcemia.In case one,the serum levels and immunostaining for parathyroid hormone-related protein(PTHr P)verified humoral hypercalcemia of malignancy(HHM).In case two,the high level of parathyroid hormone(PTH)and the scintigraphy scan showing parathyroid gland adenoma confirmed primary hyperparathyroidism-induced hypercalcemia.Both patients received optimal cytoreductive operation and adjuvant chemotherapy but showed different outcomes respectively.This article focused on differential diagnosis of ovarian cancerassociated hypercalcemia,by stepwise imaging and laboratory investigation,and the appropriate therapy should be considered based on the different etiologies.

关键词：癌症卵巢案例类似机制调查结果甲状旁腺大小写

The update of prostatic ductal adenocarcinoma

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Chinese Journal of Cancer Research 2016年第1期28卷 50-57页

作者： Tantan Liu yingmei wang Ru Zhou Haiyang Li Hong Cheng Jing Zhang State Key Laboratory of Tumor Biology Department of Pathology Xijing Hospital Cadet Brigade The Fourth Military Medical University

Since initially described in 1967, prostatic ductal adenocarcinoma （PDA） has engendered a series of controversies on its origin, histological features, and biological behavior. Owing to the improvement of molecular biological technique, there are some updated findings on the characteristics of PDA. In the current review, we will mainly analyze its origin, clinical manifestations, morphological features, differential diagnosis, immunophenotype and molecular genetics, with the purpose of enhancing recognition of this tumor and making a correct diagnosis and treatment choice.

关键词： Prostatic cancer ductal adenocarcinoma elinieopathology differential diagnosis

Effect of rapidly depressurizing and rising temperature on methane hydrate dissociation

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Journal of Natural Gas Chemistry 2012年第1期21卷 91-97页

作者： Qingbai Wu yingmei wang Jing Zhan State Key Laboratory of Frozen Soil Engineering Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of ScienceLanzhou 730000GansuChina

Two methods, rapidly depressurizing to 0.1 MPa at a constant temperature and rising temperature under equilibrium P , T conditions, were used to study the dissociation of pure CH 4 hydrate formed below the ice point. At a constant temperature with rapidly depressurizing to 0.1 MPa, CH 4 hydrate dissociated rapidly at initial dissociation and then the dissociation rate gradually decreased. However, the dissociation of CH 4 hydrate at temperatures of 261 to 266 K was much faster than that at temperatures of 269 to 272 K, indicating its anomalous preservation. Under an equilibrium P , T conditions, rising temperature had extensively controlling impact on dissociation of CH 4 hydrate at equilibrium pressures of 2.31, 2.16 and 1.96 MPa. In this study, we report the effect of pressure on CH 4 hydrate dissociation, especially the effect of equilibrium pressure on dissociation at various melting temperatures. And we find that the ice particles size of CH 4 hydrate formed may dominant the CH 4 hydrate dissociation. Dissociation of CH 4 hydrate formed from ice particles of smaller than 250 μm may not have an anomalous preservation below the ice point, while particles larger than 250 μm may have more extensive anomalous preservation.

关键词： dissociation of CH4 hydrate method of rapid depressurization method of rising temperature

Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers

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Cancer Biology & Medicine 2019年第3期16卷 462-474页

作者： Jiali Hu Ke Li Zhanghuan Li Chao Gao Fei Guo yingmei wang Fengxia Xue Department of Gynecology and Obstetrics Tianjin Medical University General Hospital

Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers.

关键词： Sex-determining region Y box-containing gene gynecological cancer regulator biomarker clinical feature progression

基于2004—2017年中国肿瘤登记年报数据的我国子宫内膜癌发病和死亡分析

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中华医学杂志 2024年第10期104卷 721-728页

作者：闫晔王颖梅王寅丹茅文鑫田文艳薛凤霞天津医科大学总医院妇产科天津市女性生殖健康与优生重点实验室天津300052

目的基于2004—2017年中国肿瘤登记年报数据分析我国子宫内膜癌(EC)发病和死亡情况。方法提取中国肿瘤登记年报2004—2017年中EC的发病率及死亡率数据,按照地区(全国、城市、农村,东、中、西部)和年龄别的发病率、死亡率、发病例数、死... 详细信息

目的基于2004—2017年中国肿瘤登记年报数据分析我国子宫内膜癌(EC)发病和死亡情况。方法提取中国肿瘤登记年报2004—2017年中EC的发病率及死亡率数据,按照地区(全国、城市、农村,东、中、西部)和年龄别的发病率、死亡率、发病例数、死亡例数,及分地区的人口学数据分别进行提取计算,估计全国的EC的发病及死亡情况。使用2000年全国人口普查的标准人口年龄构成及Segi′s标准人口年龄构成数据计算中国人口标化率(中标率)和世界人口标化率(世标率)。使用Join Point回归计算发病率的年度变化百分比,Cochran-Armitage趋势检验分析变化趋势。结果2004—2017年,我国肿瘤登记报告地区覆盖女性人口数由35571657名增长至215201995名,覆盖地区总人口数量占全国总人口数量的比例由5.53%提升至31.39%,EC粗发病率由6.20/10万增长至10.06/10万,粗发病率随时间增加呈上升趋势(P_(趋势)<0.001);调整年龄后,发病率的中标率由2004年的5.75/10万增长至2017年的6.79/10万,世标率由2004年的5.60/10万增长至2017年的6.56/10万,均呈逐年上升趋势(均P_(趋势)<0.001)。2017年城市与农村地区粗发病率分别为10.89/10万、9.25/10万,调整年龄后,发病率的中标率分别为7.14/10万、6.43/10万;世标发病率东部地区高于中部及西部地区(7.16/10万、6.44/10万、5.60/10万);发病率农村地区增长较城市地区年度变化百分比(APC)更为显著(3.2%比0.7%,P<0.001)。年龄别发病率随年龄增长而升高,50~54岁年龄组达高峰(25.70/10万)。40岁以下年龄组粗发病率农村地区增长幅度高于城市地区(69.84%比-7.09%)。2004—2017年间子宫内膜肿瘤标化死亡率呈下降趋势,中标率由1.83/10万下降至1.47/10万,世标率由1.81/10万下降至1.46/10万。年龄别死亡率随年龄增长而增高,≥85岁年龄组达高峰(13.16/10万)。结论近年来我国EC发病率整体呈上升趋势,特别是在农村地区40岁以下年轻女性EC发病率快速增长。全国EC发病率存在城乡差异及地区差异。部分城市地区EC发病率已居我国女性生殖系统恶性肿瘤发病率之首。EC标化死亡率呈下降趋势。

关键词：子宫内膜肿瘤发病率死亡率中国肿瘤登记年报流行病学

乳腺鳞状细胞癌临床病理特征及其免疫微环境分析

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中华病理学杂志 2024年第4期53卷 337-343页

作者：梁佳毅王映梅文珠张雯慧高子昭王哲郭双平空军军医大学第一附属医院病理科西安710000

目的探讨乳腺鳞状细胞癌临床病理学特征,分析其免疫微环境肿瘤浸润淋巴细胞(tumor infiltrating lymphocytes,TILs)与预后的关系。方法收集空军军医大学第一附属医院2006年1月至2022年7月诊治的乳腺鳞状细胞癌44例,分析其临床病理学特点... 详细信息

目的探讨乳腺鳞状细胞癌临床病理学特征,分析其免疫微环境肿瘤浸润淋巴细胞(tumor infiltrating lymphocytes,TILs)与预后的关系。方法收集空军军医大学第一附属医院2006年1月至2022年7月诊治的乳腺鳞状细胞癌44例,分析其临床病理学特点,评估TILs、免疫组织化学检测TILs的细胞组成(主要包括B淋巴细胞、T淋巴细胞及浆细胞),并分析和预后的关系。结果44例患者均为女性,均为浸润性癌。8例(8/44,18.2%)为单纯性鳞状细胞癌,36例(36/44,81.8%)为混合性鳞状细胞癌,混合性成分主要为非特殊型浸润性癌和梭形细胞化生性癌(各17例),1例仅合并乳腺导管原位癌成分,1例合并小管癌,鳞状细胞癌的成分占比10%~90%。单纯性鳞状细胞癌常有大的囊腔,囊腔内衬不同异型程度的鳞状上皮,囊腔周围乳腺组织中可见浸润性生长的鳞状细胞癌巢。免疫组织化学染色显示,鳞状细胞癌成分均表达p63和细胞角蛋白5/6,除1例HER21+外,均不表达雌激素受体、孕激素受体和HER2;TRPS1表达率76%;PD-L1表达均0.05)。高TILs组患者预后相比低TILs组较好,单纯性鳞状细胞患者预后相比混合性鳞状细胞癌较好,差异无统计学意义(P>0.05)。结论乳腺鳞状细胞癌分为单纯性鳞状细胞癌和混合性鳞状细胞癌。乳腺单纯性和混合性鳞状细胞癌的大体检查、组织学有差异,应充分取材避免漏诊占比少的肿瘤成分。高TILs组患者预后相比低TILs组较好,但PD-L1表达低,提示不适合免疫治疗。乳腺原发鳞状细胞癌TRPS1表达率较高,可协助与转移性鳞状细胞癌鉴别。

关键词：乳腺肿瘤预后免疫组织化学

Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways

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Cancer Biology & Medicine 2019年第1期16卷 55-65页

作者： Wenyan Tian Fei Teng Jinping Gao Chao Gao Guoyan Liu Yanfang Zhang Shizhu Yu Wei Zhang yingmei wang Fengxia Xue Department of Gynecology and Obstetrics Tianjin Medical University General Hospital Tianjin Neurological Institute Tianjin Medical University General Hospital Department of Cancer Biology Comprehensive Cancer Center of Wake Forest Baptist Medical Center

Objective: Despite evidence that estrogens and insulin are involved in the development and progression of many cancers, their synergistic role in endometrial carcinoma(EC) has not been analyzed yet.Methods: Here, we investigated how estrogens act synergistically with insulin to promote EC progression. Cell growth in vitro and in vivo, effects of estradiol and insulin on apoptosis and cell cycle distribution, and expression and activation of estrogen receptor(ER), insulin receptor(InsR), and key proteins in the PI3K and MAPK pathways were examined after combined stimulation with estradiol and insulin.Results: Compared to EC cells treated with estradiol or insulin alone, those treated with both estradiol and insulin exhibited stronger stimulation. Estradiol significantly induced phosphorylation of InsR-β and IRS-1, whereas insulin significantly induced phosphorylation of ER-α. In addition, treatment with both insulin and estradiol together significantly increased the expression and phosphorylation of Akt, MAPK, and ERK. Notably, InsR-β inhibition had a limited effect on estradiol-dependent proliferation,cell cycle, and apoptosis, whereas ER-α inhibition had a limited insulin-dependent effect, in EC cell lines. Insulin and estradiol individually and synergistically promoted EC xenograft growth in mice.Conclusions: Estrogen and insulin play synergistic roles in EC carcinogenesis and progression by activating InsR-β and ER-α,promoting a crosstalk between them, and thereby resulting in the activation of downstream PI3K/Akt and MAPK/ERK signaling pathways.

关键词： Endometrial cancer(EC) estrogen insulin InsR-β ER-α PI3K/Akt pathway MAPK/ERK pathway

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妊娠晚期子宫血管自然破裂出血1例

中华围产医学杂志 2024年第4期27卷 328-331页

作者：赵晨旭孙艳李廼珺李洁王颖梅天津医科大学总医院妇产科天津300041 天津市女性生殖健康与优生重点实验室天津300041 山东省潍坊市人民医院妇科潍坊261000

本文报告了1例妊娠晚期子宫血管自然破裂出血的病例。患者因妊娠晚期不规律腹痛入院,考虑有活动性腹腔内出血,行开腹探查术+剖宫产术。术中见近子宫下段右侧壁表面2根血管破裂。先行子宫下段剖宫产术娩出一活婴,新生儿生后1、5和10 min ... 详细信息

本文报告了1例妊娠晚期子宫血管自然破裂出血的病例。患者因妊娠晚期不规律腹痛入院,考虑有活动性腹腔内出血,行开腹探查术+剖宫产术。术中见近子宫下段右侧壁表面2根血管破裂。先行子宫下段剖宫产术娩出一活婴,新生儿生后1、5和10 min Apgar评分分别为7、9、9分。新生儿娩出后,缝扎子宫表面破裂血管,探查腹腔未见其他异常,清理盆腹腔未再见活动性出血,腹腔内出血共1600 ml。术后诊断为子宫表面血管破裂出血、腹腔内出血、子宫多发性平滑肌瘤。术后母儿恢复良好。

关键词：子宫出血腹腔积血妊娠末期