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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao Deng Shenghua ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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三种不同能量平台治疗良性前列腺增生的疗效比较

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国际医药卫生导报 2023年第20期29卷 2919-2923页

作者：叶应林阮永同陈举锋许北勋潘杰敖达文吴远顺阳江市中医医院泌尿外科阳江529500

目的通过钬激光、绿激光、双极等离子治疗良性前列腺增生的对比分析,探讨绿激光前列腺剜除的安全性及临床疗效。方法采用前瞻性方法,选取2019年10月至2021年12月期间在阳江市中医医院接受住院治疗的90例良性前列腺增生患者,年龄范围64~9... 详细信息

目的通过钬激光、绿激光、双极等离子治疗良性前列腺增生的对比分析,探讨绿激光前列腺剜除的安全性及临床疗效。方法采用前瞻性方法,选取2019年10月至2021年12月期间在阳江市中医医院接受住院治疗的90例良性前列腺增生患者,年龄范围64~90岁,平均78岁。按治疗方法不同分为经尿道绿激光前列腺剜除术组、经尿道钬激光前列腺剜除术组与经尿道等离子前列腺剜除术组,各30例。手术前后检测血红蛋白、最大尿流率、残余尿、国际前列腺症状评分、生活质量评分,记录术后不良反应、留置尿管时间、住院时间及近期并发症发生情况。采用χ^(2)检验、t检验进行统计分析。结果经尿道绿激光前列腺剜除术组手术时间、术中血红蛋白下降、术后留置尿管时间、膀胱持续灌洗时间及住院天数分别为(50.5±14.3)min、(6.0±4.9)g/L、(80.1±17.5)h、0、(7.6±1.3)d,经尿道钬激光前列腺剜除术组分别为(72.3±16.9)min、(10.5±4.5)g/L、(87.1±18.5)h、(20.0±4.6)h、(8.1±1.2)d,经尿道等离子前列腺剜除术组分别为(66.5±14.3)min、(7.7±3.4)g/L、(84.3±17.4)h、(17.0±4.3)h、(7.4±1.0)d,经尿道绿光前列腺剜除术患者上述项目均明显优于其他两组,差异均有统计学意义(均P0.05)。结论经尿道进行绿激光前列腺剜除术具有疗效确切、出血少、恢复快的特点,可作为前列腺增生外科治疗的首选术式。

关键词：前列腺增生钬激光绿激光组织粉碎器快速舒适康复

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Six-fold swelling expansion microscopy assisted cell painting for high-content phenotypic screening

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Optoelectronics Letters 2025年

作者： Junfang XIE Yipeng DONG Jin WANG Zhichao DENG Jianguo TIAN Qing ye Key Laboratory of Weak-Light Nonlinear Photonics， Ministry of Education， School of Physics and TEDA Applied Physics， Nankai University

Imaging-based phenotypic screening uses cellular phenotypes to describe the drug performance， which generally focuses on single cellular feature， lacking of a comprehensive characterization. Here， we propose a high content phenotypic screening method based on expansion microscopy (ExM) assisted Cell Painting， which enables multi-channel imaging with approximately 50 nm resolution. As a demonstration， we applied this method to a phenotypic screening involving five drugs. The morphological attributes of three subcellular structures were summarized to consist a “fingerprint” describing the drug effect. The proposed method can provide comprehensive and detailed clues for drug evaluation， enriching the content of phenotypic screening.

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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[Current advances in the analysis of free RNA modified nucleosides by high performance liquid chromatography-tandem mass spectrometry]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 3-12页

作者： Lyu-ye Zhang Wei-Bing Zhang Hai-Lin Wang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 China. State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China 3. University of Chinese Academy of Sciences Beijing 100049 China. University of Chinese Academy of Sciences Beijing 100049 China.

Post-transcriptional ribonucleic acid (RNA) modifications play crucial roles in regulating gene expression, with both eukaryotic and prokaryotic RNA exhibiting more than 170 distinct and ubiquitous modifications. RNA turnover generates numerous free nucleosides, including unmodified nucleosides and a variety of modified ones. Unlike unmodified nucleosides, modified nucleosides are not further degraded or used in the salvage-synthesis pathway owing to a lack of specific enzymes, which leads to the cytosolic accumulation or cellular efflux of modified nucleosides. These modified nucleosides can act as signaling molecules that regulate downstream pathways once transported to the extracellular space; alternatively, they are metabolized in the bloodstream and excreted in urine. Metabolized modified nucleosides are altered by cellular stress responses and mediate abnormal physiological states. Changes in the urinary and blood levels of modified nucleosides associated with cancer can serve as biomarkers for disease. Therefore, identifying and accurately quantifying nucleosides is vital for understanding RNA degradation and associated patterns of nucleoside metabolism. Such analyses are helpful when studying the biological functions and potential clinical applications of modified nucleosides. In this regard, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) offers significant advantages in terms of sensitivity, selectivity, and efficiency, and has been widely used to analyze DNA and RNA nucleosides/nucleotides and their analogues. Multiple MS detection patterns and quantification methods have been established to detect nucleosides in biological samples, including cultured cells, urine, blood, and tissue samples. However, the development of an accurate HPLC-MS/MS method faces several challenges. Firstly, the presence of a complex biological matrix that contains macromolecules, small molecules, and salts can interfere with analysis. Salts and co-elu

关键词： RNA modifications high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) metabolite analysis methylated nucleosides

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超微经皮肾镜碎石术后联合中药排石治疗肾结石30例

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国际医药卫生导报 2023年第13期29卷 1841-1844页

作者：梁健峰许北勋许锦蜂潘杰陈举锋吴远顺敖达文叶应林阮永同阳江市中医医院泌尿外科阳江529500

目的观察超微经皮肾镜碎石术后联合中药排石治疗肾结石(结石<2 cm)的临床疗效。方法本研究为随机对照试验。选取2020年10月至2021年12月阳江市中医医院泌尿外科行超微经皮肾镜碎石术的肾结石患者60例为研究对象,按照随机编号方法分为两... 详细信息

目的观察超微经皮肾镜碎石术后联合中药排石治疗肾结石(结石<2 cm)的临床疗效。方法本研究为随机对照试验。选取2020年10月至2021年12月阳江市中医医院泌尿外科行超微经皮肾镜碎石术的肾结石患者60例为研究对象,按照随机编号方法分为两组,各30例。治疗组男12例、女18例,平均年龄37.43岁,在微创手术基础上结合中药排石治疗;对照组男15例、女15例,平均年龄46.20岁,临床未给予中药排石治疗。对比两组患者术后结石治愈率。采用χ^(2)检验。结果60例患者手术均顺利完成。治疗组结石治愈率为96.7%(29/30),高于对照组的83.3%(25/30),差异有统计学意义(P<0.05)。结论微创手术结合中药排石治疗肾结石微创、高效,且并发症较少,减少对患者机体的损伤。

关键词：肾结石超微经皮肾镜碎石术中药排石

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生物材料异物反应的调控策略

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中国组织工程研究 2025年第16期29卷 3513-3520页

作者：叶超刘晓红海军军医大学附属长海医院心血管外科上海市200433

背景:生物材料植入体内后引发的异物反应会导致其被纤维组织包裹,阻碍植入物与宿主组织的相互作用,损害植入物的功能,进而缩短其寿命。目的:重点讨论生物材料异物反应的调控策略进展,包括基于生物材料表面改性、药物递送和仿生表面修饰... 详细信息

背景:生物材料植入体内后引发的异物反应会导致其被纤维组织包裹,阻碍植入物与宿主组织的相互作用,损害植入物的功能,进而缩短其寿命。目的:重点讨论生物材料异物反应的调控策略进展,包括基于生物材料表面改性、药物递送和仿生表面修饰的策略,同时探讨了这些方法的优势和局限性。方法:应用计算机在PubMed、Wiley、EBSCOhost、ScienceDirect和Elsevier数据库检索2000年1月至2024年3月期间的相关文献,以“biological materials,foreign body reaction,fibrosis,macrophage,myofibroblasts,inflammation,regulation,tissue repair”为检索词,最终纳入69篇文献进行分析。结果与结论:通过调整生物材料的表面特性(例如尺寸、形状、粗糙度、表面电荷、亲水性以及机械刚度等)能够减轻其对免疫系统的刺激,进而降低发生异物反应的风险;通过可控量的药物刺激产生持久的化学反应,结合使用可控降解的载体材料,可以减轻异物反应;生物材料仿生表面修饰(如两性离子涂层、蛋白质分子涂层等生物活性分子涂层)在短期能有效减轻异物反应。由于植入物和组织再生的免疫反应具有复杂性,在设计和制造植入物时也应考虑异物反应和组织再生之间的整体平衡。

关键词：生物材料异物反应纤维化巨噬细胞肌成纤维细胞炎症调控组织修复

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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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原料药生产中溶剂杂质控制及溯源研究进展

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中国药业 2025年第1期34卷 128-128,I0001-I0006页

作者：陈烨南通大学药学院江苏南通226001

目的提升原料药中杂质的控制水平。方法分析溶剂引入杂质的主要途径,并基于溶剂的反应活性特点分析原料药生产过程中常用溶剂(醇、酰胺、腈、酮、酯、卤代烃、醚、芳烃类溶剂)和溶剂中杂质参与化学反应引入的杂质及其机理。结果与结论... 详细信息

目的提升原料药中杂质的控制水平。方法分析溶剂引入杂质的主要途径,并基于溶剂的反应活性特点分析原料药生产过程中常用溶剂(醇、酰胺、腈、酮、酯、卤代烃、醚、芳烃类溶剂)和溶剂中杂质参与化学反应引入的杂质及其机理。结果与结论常见溶剂直接引入的杂质易被识别和清除,但由溶剂或溶剂中杂质参与化学反应而间接引入的新杂质隐蔽性较强,易出现在原料药中,且易被忽略。建议原料药生产企业在工艺开发初期选择合适的反应溶剂,从源头上控制由溶剂间接引入的杂质。

关键词：原料药溶剂杂质引入化学反应

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