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Optimising multi-vent module-based adaptive ventilation using a novel parameter for improved indoor air quality and health protection

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Building Simulation 2024年第1期17卷 113-130页

作者： Haotian Zhang Xiaoxiao Ding Weirong Zhang Weijia Zhang yingli xuan Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Department ofArchitecture TokyoPolytechnic UniversityTokyoJapan

As infectious respiratory diseases are highly transmissible through the air,researchers have improved traditional total volume air distribution systems to reduce infection risk.Multi-vent module-based adaptive ventilation(MAV)is a novel ventilation type that facilitates the switching of inlets and outlets to suit different indoor scenarios without changing ductwork layout.However,little research has evaluated MAV module sizing and air velocity selection,both related to MAV system efficiency in removing contaminants and the corresponding level of protection for occupants in the ventilated room.Therefore,the module-source offset ratio(MSOR)is proposed,based on the MAV module size and its distance from an infected occupant,to inform selection of optimal MAV module parameters.Computational fluid dynamics simulations illustrated contaminant distribution in a two-person MAV equipped office.Discrete phase particles modelled respiratory contaminants from the infected occupant,and contaminant concentration distributions were compared under four MAV air distribution layouts,three air velocities,and three module sizes considered using the MsOR.Results indicate that lower air velocities favour rising contaminant levels,provided the ventilation rate is met.Optimal contaminant discharge can be achieved when the line of outlets is located directly above the infected occupant.Using this parameter to guide MAV system design,85.7% of contaminants may be rendered harmless to the human body within 120 s using the default air vent layout.A more appropriate supply air velocity and air vent layout increases this value to 91.4%.These results are expected to inform the deployment of MAV systems to reduce airborne infection risk.

关键词： multi-vent module-based adaptive ventilation computational fluid dynamics indoor air quality infection control

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Effective improvement of a local thermal environment using multi-vent module-based adaptive ventilation

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Building Simulation 2023年第7期16卷 1115-1134页

作者： Weijia Zhang Weirong Zhang Haotian Zhang yingli xuan Xuebiao Liu Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Department of Architecture Tokyo Polytechnic UniversityTokyoJapan China Railway Construction Group Corporation Limited BeijingChina

Indoor thermal comfort is essential as it improves living standards.Activity scenarios of personnel are in the process of a dynamic change.In most interior spaces with fixed working stations,people directly blown by cold air have a poor thermal experience.Therefore,to meet the differentiated environmental demands,one challenge is to explore novel ventilation strategies to satisfy the changing environmental needs.An adaptive strategy,multi-vent module-based adaptive ventilation(MAV),was designed to increase the adjustability of air distribution and better adapt to variable demands.A classroom was chosen as a representative model with multiple scenarios during its use.Simulations were conducted to verify the three-level control effect of MAV on improving the thermal environment.The results revealed that different vent solutions create different airflow patterns and thermal environments,which can be matched to the scenarios.The scale for ventilation efficiency No.4,which measured the influence scope of supply air,was used to evaluate the zoning division control in MAV.The space under the charge of a concerned MAV module showed a higher SVE4 than that at other zones.This implied that the zoning division can be effectively implemented.Thermal comfort measured using the air diffusion performance index,predicted mean vote,and draught rate showed that the application of MAV is better than that of the fixed MV mode,and the discomfort experienced when exposed to cold air can be avoided.It is believed that these results will help extend the research of adaptive ventilation strategies.

关键词： adaptive ventilation local thermal environment thermal comfort CFD dynamic airflow

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Association between sex hormone-binding globulin and kidney function in men: results from the SPECT-China study

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Chinese Medical Journal 2022年第17期135卷 2083-2088页

作者： Haojie Zhang Chi Chen xuan Zhang Yuying Wang Heng Wan Yi Chen Wen Zhang Fangzhen Xia yingli Lu Ningjian Wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Pharmacy The 305th Hospital of PLABejing 100017China

Background::The association between sex hormone-binding globulin(SHBG)and renal function has rarely been reported in men.We aimed to investigate the above association in a community-based Chinese population.Methods::A total of 5027 men were included from the survey on prevalence for metabolic diseases and risk factors,which is a population-based study conducted from 2014 to 2016 in Eastern China.The estimated glomerular filtration rate(eGFR)was calculated according to the chronic kidney disease Epidemiology Collaboration equation.Low eGFR was defined as eGFR<60 mL·min-1·1.73 m-2.Results::After adjusting for age,smoking,metabolic factors,and testosterone,through increasing quartiles of SHBG,a significantly positive association between SHBG quartiles and eGFR was detected in men(Q1 vs.Q4,β-2.53,95%confidence interval-3.89,-1.17,Ptrend<0.001).Compared with the highest quartile of SHBG,SHBG in the lowest quartile was associated with 96%higher odds of low eGFR(odds ratio 1.96,95%confidence interval 1.10,3.48)in the model after full adjustment.According to the stratified analyses,the associations between a 1-standard deviation increase in serum SHBG and the prevalence of low eGFR were significant in men aged≥60 years old,waist circumference<90 cm,diabetes(no),hypertension(yes),dyslipidemia(no),and nonalcoholic fatty liver disease(no).Conclusions::Lower serum SHBG levels were significantly associated with lower eGFR and a higher prevalence of low eGFR in Chinese men independent of demographics,lifestyle,metabolic-related risk factors,and testosterone.Large prospective cohort and basic mechanistic studies are warranted in the future.

关键词： Estimated glomerular filtration rate Sex hormone-binding globulin Testosterone

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维持性血液透析患者血清β-catenin水平与腹主动脉钙化的关系

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肾脏病与透析肾移植杂志 2024年第2期33卷 121-126页

作者：丁婷婷和瑞斌谢伟珍秦丽轩应利姜娜袁江姿上海交通大学医学院附属仁济医院宝山分院肾内科上海200444 上海交通大学医学院附属仁济医院肾内科

目的:探讨维持性血液透析(MHD)患者血清β-catenin水平与腹主动脉钙化(AAC)的关系。方法:选取上海交通大学医学院附属仁济医院宝山分院MHD患者70例,使用腹部侧位平片检测AAC情况,根据CORD研究分组方法,将患者分为无或轻度钙化组、中度... 详细信息

目的:探讨维持性血液透析(MHD)患者血清β-catenin水平与腹主动脉钙化(AAC)的关系。方法:选取上海交通大学医学院附属仁济医院宝山分院MHD患者70例,使用腹部侧位平片检测AAC情况,根据CORD研究分组方法,将患者分为无或轻度钙化组、中度钙化组和重度钙化组。采用ELISA法检测患者血清β-catenin水平,观察MHD患者血清β-catenin水平与AAC评分(AACS)及人口学特性和生化指标的关系。结果:本组MHD患者AAC发生率为70%。腹主动脉重度钙化组血清β-catenin水平显著高于中度钙化组、无或轻度钙化组(P<0.05);中度钙化组血清β-catenin水平亦高于无或轻度钙化组(P<0.05)。相关性分析结果显示,MHD患者血清β-catenin水平与AACS、透析龄、甲状旁腺激素、血磷成正相关。Logistic回归分析结果显示,β-catenin水平升高、高体质量指数及高C反应蛋白水平是MHD患者发生AAC的独立危险因素(P<0.05),而血清白蛋白水平升高则属于保护因素(P<0.05)。血清β-catenin预测AAC的曲线下面积(AUC)为0.864(95%CI 0.766~0.961,P=0.000),约登指数为0.693,对应血清β-catenin水平值为211.63 pg/ml,其预测AAC的灵敏度为91.70%,特异度为77.60%。结论:MHD患者血清β-catenin升高可能与AAC相关。

关键词：维持性血液透析 β-catenin 腹主动脉钙化

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The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis

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Journal of Integrative Plant Biology 2022年第12期64卷 2385-2395页

作者： Xuelin Zhou Mengwei Wei Wenfeng Nie Yue Xi Li Peng Qijie Zheng Kai Tang Viswanathan Satheesh Yuhua Wang Jinyan Luo xuan Du Rui Liu Zhenlin Yang Honggui La yingli Zhong Yu Yang Jian-Kang Zhu Jiamu Du Mingguang Lei Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China Department of Horticulture College of Horticulture and Plant ProtectionYangzhou UniversityYangzhou 225009China Department of Horticulture&Landscape Architecture Purdue UniversityWest LafayetteIdiana47906USA Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes Institute of Plant and Food ScienceSchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China College of Bioscience and Biotechnology Hunan Agricultural UniversityChangsha 410128China

DNA methylation,a conserved epigenetic mark,is critical for tuning temporal and spatial gene expression.The Arabidopsis thaliana DNA glycosylase/lyase REPRESSOR OF SILENCING 1(ROS1)initiates active DNA demethylation and is required to prevent DNA hypermethylation at thousands of genomic loci.However,how ROS1 is recruited to specific loci is not well understood.Here,we report the discovery of Arabidopsis AGENET Domain Containing Protein 3(AGDP3)as a cellular factor that is required to prevent gene silencing and DNA hypermethylation.AGDP3 binds to H3K9me2 marks in its target DNA via its AGD12 cassette.Analysis of the crystal structure of the AGD12 cassette of AGDP3 in complex with an H3K9me2 peptide revealed that dimethylated H3 K9 and unmodified H3 K4 are specifically anchored into two different surface pockets.A histidine residue located in the methyllysine binding aromatic cage provides AGDP3 with pH-dependent H3K9me2 binding capacity.Our results uncover a molecular mechanism for the regulation of DNA demethylation by the gene silencing mark H3K9me2.

关键词： AGDP3 DNA demethylation epigenetics H3K9me2 ROS1

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Polymorphism of the 86th amino acid in CX26 protein and hereditary deafness

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Journal of Otology 2016年第2期11卷 84-87页

作者： Xi Shi Shiwei Qiu Fendong Yan Lizhang Shi Yili xuan Wei Zhuang yingli Bei Hanli Yao Na Yuan Mingyang Shi Yuehua Qiao Institute of Audiology and Balance Science Xuzhou Medical University Department of OtolaryngologydHead & Neck Surgery Institute of Otolaryngology of PLA Chinese PLA General Hospital Clinical Hearing Center Affiliated Hospital of Xuzhou Medical University

Objective:To investigate the membrane localization function of the CX26 protein when its 86th amino acid is Thr, Ser or Arg, and its relations to deafness. Methods:CX26-GFP protein with either Thr, Ser or Arg as the 86th amino acid was expressed in mouse SGN cells via the GFP fusion type lenti-virus expression system. The membrane localization of the fusion protein was observed under a fluorescence microscope. Results:The mutated protein of CX26 T86S was localized to cell membrane and form gap conjunction structures, showing no difference to the wild type CX26 protein (with Thr as the 86th amino acid). However, the gap conjunction structure disappeared when the mutation was CX26 T86A. Conclusion:These results indicate that the CX26 T86R mutation may be a cause of hearing loss, but CX26 T86S as a non-pathogenic poly-morphism mutation does not affect functions of the CX26 protein. The results are in accordance with the results of clinical screening.

关键词： Heredity deafness CX26 SGN

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低渗致密砂岩储层充注模拟实验及含气性变化规律——以鄂尔多斯盆地苏里格气藏为例

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中国矿业大学学报 2017年第6期46卷 1323-1331,1339页

作者：徐轩胡勇邵龙义王继平陈颖莉焦春艳中国矿业大学地球科学与测绘工程学院北京100083 中国石油勘探开发研究院廊坊院区河北廊坊065007 长庆油田苏里格研究中心陕西西安710018 中国石油西南油气田分公司研究院四川成都610041

低渗致密气藏复杂的储层特征和充注机理是导致其气藏压力与含气性与常规砂岩迥异的关键因素.选取苏里格气藏42块岩心,开展气藏充注模拟实验,实验中考虑温度影响,逐级增加充注动力,模拟储层低速缓慢充注过程.系统研究了储层物性、充注动... 详细信息

低渗致密气藏复杂的储层特征和充注机理是导致其气藏压力与含气性与常规砂岩迥异的关键因素.选取苏里格气藏42块岩心,开展气藏充注模拟实验,实验中考虑温度影响,逐级增加充注动力,模拟储层低速缓慢充注过程.系统研究了储层物性、充注动力、充注温度3个关键因素对充注成藏的影响,分析了充注过程中气、水产出机理,提出了含气性与储层物性、充注动力为正相关的对数函数关系.研究结果表明:1)低渗致密储层存在充注门限压力,渗透率0.10mD和0.01mD的储层,充注门限压力达2.0 MPa和10.0 MPa.开始进气后,源储压力存在平衡过程,储层越致密,门限压力越高,平衡过程越慢,最终平衡压力越高.2)门限压力和平衡压力是储层含气性变化的拐点,将充注过程划分为3个不同阶段:临界进气阶段,快速增长阶段和平缓增长阶段.不同阶段含气性上升速度和幅度不同,孔隙出水部位不同.3)相同储层及充注动力时,提高充注温度,含气性可上升5%~10%.

关键词：砂岩储层充注机理充注物理模拟源储压力含气性苏里格气藏

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基于网络药理学探讨黄芪甲苷治疗非酒精性脂肪性肝病的作用机制

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现代医药卫生 2023年第14期39卷 2372-2378页

作者：刘应莉刘璇王艳荣张其良张秋瓒天津市第四中心医院/南开大学附属第四中心医院消化内科天津300140 天津市第四中心医院/南开大学附属第四中心医院药理科天津300140

目的基于网络药理学方法探讨黄芪甲苷(AS-Ⅳ)治疗非酒精性脂肪性肝病(NAFLD)的潜在作用机制。方法通过PharmMapper、Swiss-Target-Prediction、HERBs、TCMSP、ETCM数据库建库以来至2022年6月预测AS-Ⅳ的潜在作用靶标,搜索GeneCards、OMI... 详细信息

目的基于网络药理学方法探讨黄芪甲苷(AS-Ⅳ)治疗非酒精性脂肪性肝病(NAFLD)的潜在作用机制。方法通过PharmMapper、Swiss-Target-Prediction、HERBs、TCMSP、ETCM数据库建库以来至2022年6月预测AS-Ⅳ的潜在作用靶标,搜索GeneCards、OMIM数据库中NAFLD的疾病靶标,利用Cytoscape软件获得AS-Ⅳ治疗NAFLD潜在作用靶标,利用String绘制靶标蛋白质互作网络图,并进行基因本体功能注释分析及京都基因与基因组百科全书信号传导通路的富集分析。结果AS-Ⅳ可能作用于蛋白激酶B丝氨酸/苏氨酸激酶1、血管内皮生长因子A、表皮生长因子受体、一氧化氮合酶3、雌激素受体1、半胱天冬酶3、哺乳动物雷帕霉素蛋白、过氧化物酶体增殖物激活受体γ等32个靶点,进一步调节环磷酸鸟苷-蛋白激酶G、哺乳动物雷帕霉素蛋白、胰岛素抵抗、腺苷酸活化蛋白激酶、丝裂原活化蛋白激酶、磷酸肌醇-3激酶-蛋白激酶B等多个信号通路,发挥负性细胞死亡调节、细胞信号传导、正向分子功能调节、氧化应激反应抑制等多种生物学功能,抑制NAFLD发病过程中的炎性反应、氧化应激和胰岛素抵抗等机制。结论AS-Ⅳ可通过多靶点、多通路对NAFLD发挥作用,可能是NAFLD潜在的治疗药物。

关键词：黄芪甲苷非酒精性脂肪性肝病网络药理学作用机制多靶点治疗

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基于CMONOC建立和评估中国大陆地壳运动速度场模型

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大地测量与地球动力学 2017年第7期37卷 704-708,714页

作者：于亮朱璇陈永祥张英利谢方西安测绘信息技术总站西安市西影路36号710054 地理信息工程国家重点实验室西安市雁塔路1号710054 国家测绘地理信息局大地测量数据处理中心西安市友谊东路334号710054

针对现有速度场模型采用数据少、现势性不强的问题,详细论述了速度场模型建立的数据获取与处理方法,利用中国大陆地壳运动监测网络中260个连续运行基准站2011~2015年的连续观测数据,采用GAMIT/GLOBK与GMT软件,获得高精度的定位及速度成... 详细信息

针对现有速度场模型采用数据少、现势性不强的问题,详细论述了速度场模型建立的数据获取与处理方法,利用中国大陆地壳运动监测网络中260个连续运行基准站2011~2015年的连续观测数据,采用GAMIT/GLOBK与GMT软件,获得高精度的定位及速度成果,并基于上述速度成果采用克里金插值法构建了中国大陆地壳运动速度场1°×1°格网模型。最后利用IERS公布的中国区域7个IGS站实测速度以及全国范围内均匀分布的陆态网络区域站实测速度,对模型内插结果进行检核,验证了模型的现势性、精确性和可靠性。

关键词： 2000国家大地坐标系速度场中国地壳运动监测网络 GAMIT/GLOBK

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孟津矿穿层抽采孔漏气原因分析及封孔工艺改进

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河南工程学院学报（自然科学版） 2020年第4期32卷 26-29页

作者：宣德全黄应利河南大有能源股份有限公司河南义马472300 河南工程学院电气信息工程学院河南郑州451191

针对孟津煤矿底板巷穿层抽采钻孔漏气问题进行研究分析,发现所用的“两堵一注”封孔技术存在封孔连管漏气接口多、爆破阀可靠性差等缺陷。在此基础上对封孔工艺进行了改进,将原2 m/根的丝接式封孔管改为整根PE通管,并通过增设一趟注浆... 详细信息

针对孟津煤矿底板巷穿层抽采钻孔漏气问题进行研究分析,发现所用的“两堵一注”封孔技术存在封孔连管漏气接口多、爆破阀可靠性差等缺陷。在此基础上对封孔工艺进行了改进,将原2 m/根的丝接式封孔管改为整根PE通管,并通过增设一趟注浆管去掉爆破阀。现场应用实验结果表明:改进后的封孔新工艺有效减少了穿层抽采钻孔漏气,提高了抽采浓度和抽采效果,对煤矿的瓦斯抽采与瓦斯事故防治具有重要的借鉴意义。

关键词：封孔漏气瓦斯浓度爆破阀通管

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