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Modeling and simulation of non-linear dynamic process of the induction motor system with fluctuating potential loads

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Science China(Technological Sciences) 2014年第9期57卷 1729-1737页

作者： luo Wei WANG Bo ZHAO HaiSen luo yingli Department of Mathematics Zhejiang University State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power University

The induction motor system with fluctuating potential loads is a non-linear complex electro-mechanical *** beam pumping motors as an example,this paper proposes a multiple factor non-linear mathematical model to study the operating performance of the induction motor *** model consists of non-linear time varying electromagnetic field equations,mechanical wave equations of sucker rods and non-linear coupling equation of reducer and four-bar *** equations are numerically solved by combining time-step finite element method(TS-FEM),finite difference method(FDM),a linear dimension reduction method and the Newton-Raphson *** results,which are validated by experiments,reveal the influence of the fluctuating potential load on magnetic field distributions,stator and rotor currents,the input power and the power *** model and simulation results provide theoretical and technical supports for subsequent researches on model simplification and energy saving technologies.

关键词：非线性数学模型感应电机系统仿真结果动力学过程波动负荷感应电动机系统非线性耦合方程

Nanomedicine-mediated ubiquitination inhibition boosts antitumor immune response via activation of dendritic cells

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Nano Research 2021年第11期14卷 3900-3906页

作者： Jilong Wang Mengwen Huang Senbiao Chen yingli luo Song Shen Xiaojiao Du School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou510006China Institutes for Life Sciences School of MedicineSouth China University of TechnologyGuangzhou510006China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou510006China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou510005China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006China Innovation Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China

Tumor immunotherapy as a promising method for tumor treatment received tremendous attention. However, the problem of low clinical response rate still needs to be solved, especially in the poorly immunogenic tumors. The enhancement of tumor antigens presentation can effectively activate dendritic cells (DCs) and improve the tumor immunotherapy. In this work, TAK-243 as an inhibitor of the ubiquitin activating enzyme (UAE), was fabricated into cationic lipid-assisted nanoparticle (CLANTAK-243). The obtained CLANTAK-243 could act as an effective tumor immunotherapy enhancer to promote the maturation of DCs as well as antigen presentation, which obviously stimulated the T cells activation and proliferation. Such CLANTAK-243 injected intravenously could well trigger immune response to tumor cells in vivo. Importantly, mice treated with CLANTAK-243 could obtain a long immune memory effect to protect themselves from re-challenged tumor cells. Therefore, this work presented an effective immunotherapy strategy for poorly immunogenic tumor.

关键词： drug delivery cancer immunotherapy ubiquitin activating enzyme(UAE) inhibitor antigen presentation dendritic cell(DC)maturation

Towards the performance limit of catenary meta-optics via field-driven optimization

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Opto-Electronic Advances 2024年第5期7卷 38-48页

作者： Siran Chen yingli Ha Fei Zhang Mingbo Pu Hanlin Bao Mingfeng Xu Yinghui Guo Yue Shen Xiaoliang Ma Xiong Li Xiangang luo National Key Laboratory of Optical Field Manipulation Science and Technology Chinese Academy of Sciences State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and ElectronicsChinese Academy of Sciences College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences Research Center on Vector Optical Fields Institute of Optics and ElectronicsChinese Academy of Sciences Department of Electrical and Computer Engineering University of California Los Angeles (UCLA)

Catenary optics enables metasurfaces with higher efficiency and wider bandwidth,and is highly anticipated in the imaging system,super-resolution lithography,and broadband ***,the periodic boundary approximation without considering aperiodic electromagnetic crosstalk poses challenges for catenary optical devices to reach their performance ***,perfect control of both local geometric and propagation phases is realized through field-driven optimization,in which the field distribution is calculated under real boundary *** from other optimization methods requiring a mass of iterations,the proposed design method requires less than ten iterations to get the efficiency close to the optimal *** on the library of shape-optimized catenary structures,centimeter-scale devices can be designed in ten seconds,with the performance improved by ～15%.Furthermore,this method has the ability to extend catenary-like continuous structures to arbitrary polarization,including both linear and elliptical polarizations,which is difficult to achieve with traditional design *** provides a way for the development of catenary optics and serves as a potent tool for constructing high-performance optical devices.

关键词： catenary optics catenary structures field-driven optimization

Performance calculation and improved model research of direct-drive permanent magnet generator based on FEM

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Science China(Technological Sciences) 2012年第8期55卷 2338-2345页

作者： ZHANG Jian LI HeMing luo yingli DOU Na CUI XueShen State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources(North China Electric Power University) Beijing 102206China

In some control strategies of the direct-rive permanent magnet generator(DDPMG),the mathematics model is excessively simplified and some complex nonlinear characteristics,such as core saturation and cross-saturation,are generally *** solve this problem,this paper utilizes the frozen element permeability method to compute the armature self-and mutual-inductance,permanent magnet d-and q-axis flux varying with d-axis and q-axis current,then an improved model is presented in which the core saturation and cross-saturation between d-axis and q-axis are considered *** on this model,the method for computing the performance of the generators is also *** a 1.5-MW DDPMG as an example,the time-stepping finite element method(T-S FEM) is adopted to analyze the performance with no-load and loaded conditions,the results show a good agreement with the ones obtained by the improved *** with the simplified model,it is demonstrated that the presented model has the high efficiency and reliability and can provide a good reference for optimization design of DDPMG and other PM motors.

关键词：永磁发电机数学模型性能计算有限元法交叉饱和永久磁铁负载条件控制策略

Food-Borne Poisoning Accident from Amanitin Toxin in Wild Mushrooms—Xingtai City,Hebei Province,China,2023

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China CDC weekly 2024年第3期6卷 56-59页

作者： Baopu Lv Liang Liu Hao Xiao Qingbing Meng Rui Zhang Yaqing An yingli Jin Yu Ma Hengbo Gao Yongkai Li Qian He Yutao Zhang Changqing Liu Xiaoyan luo Xiaomin Xu Fenshuang Zheng Yingping Tian Hongshun Zhang Dongqi Yao Emergency Department The Second Hospital of Hebei Medical UniversityShijiazhuang CityHebei ProvinceChina National Institute of Occupational Health and Poison Control Chinese Centre for Disease Control and PreventionBeijingChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Emergency Department The Affiliated Hospital of Yunnan UniversityKunming CityYunnan ProvinceChina

What is already known about this topic?Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of *** toxins primarily induce gastrointestinal symptoms initially,which are then followed by potentially life-threatening acute liver *** is added by this report?This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai *** individuals reported consuming wild mushrooms from the same origin,and laboratory tests confirmed the presence ofα-amanitin in their blood *** are the implications for public health practice?This underscores the risk associated with the collection and consumption of amanita toxin-containing mushrooms in *** is important to note that the identification of toxic and non-toxic mushrooms should not solely rely on personal experience or appearance.

关键词： Hebei consuming initially

Research Article Ferric iron coordinated cisplatin prodrug reprograms the immunecold tumor microenvironment through tumor hypoxia relief for enhanced cancer photodynamic-immunotherapy

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Nano Research 2023年第7期16卷 9930-9939页

作者： Yinchu Ma yingli luo Xinfeng Tang Wei Jiang Hongjun Li Jilong Wang Wuxi School of Medicine Jiangnan UniversityWuxi 214122China Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China School of Life Sciences University of Science and Technology of ChinaHefei 230027China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Joint Centre of Translational Medicine Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China

The microenvironment of hypoxia and immune-cold limits the therapeutic outcomes of immune checkpoint blockade(ICB)therapy in solid *** is important and imperative to search new strategies to relieve tumor hypoxia and reverse immunosuppression of cold *** this study,the oxygen(O_(2))self-replenishing nano-enabled coordination platform can be used to induce potent antitumor immune response in cold *** nanoplatform can produce O_(2)by catalyzing hydrogen peroxide(H_(2)O_(2))in tumor site effectively,showing excellent photodynamic therapy(PDT)***,it can further trigger immunogenic cell death(ICD),enhance T cell infiltration,reverse immunosuppression,and reprogram the immune-cold tumor *** vitro and in vivo results demonstrate that the nanoplatform has potential for eradicating tumors and long-term immunological memory *** nanoplatform opens up a strategy for reprograming the immunosuppressive microenvironment in cold tumors.

关键词： immunogenic cell death immune response reprograming cold tumor microenvironment long-term immunological memory effect

用于平滑处理的卷积运算及其在有限元磁场分析后处理中的应用

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电工技术学报 2009年第4期24卷 1-5,29页

作者：罗炜李志强罗应立浙江大学理学院杭州310027 华北电力大学电气与电子工程学院北京102206

在用一阶三角元计算磁场所得到的结果中,相邻单元磁通密度通常不等,所得到的是分片恒定的磁通密度及磁导率。为了计算电磁力在铁心中以及在不同介质交界面上的分布,需要对磁场能量或磁导率求导数,为此,本文采用卷积方法得到平滑分布的... 详细信息

在用一阶三角元计算磁场所得到的结果中,相邻单元磁通密度通常不等,所得到的是分片恒定的磁通密度及磁导率。为了计算电磁力在铁心中以及在不同介质交界面上的分布,需要对磁场能量或磁导率求导数,为此,本文采用卷积方法得到平滑分布的磁通密度及磁导率。首先推导进行平滑化处理的卷积运算基本公式,然后对比采用不同的核函数进行卷积运算所得到的结果,并给出求取平滑化处理核函数的一般方法;作为卷积方法的一个应用,得到考虑饱和时计算铁心内部电磁力密度的公式。

关键词：卷积电磁力有限元光滑处理

Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs

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Nano Research 2018年第10期11卷 5716-5734页

作者： Wei Jiang Jilong Wang Jinbin Yang Zhiwei He Zhenhui Hou yingli luo Li Wang Jing Liu Houbing Zhang Yangyang Zhao Guoqing Zhang Fang Huang Xuechang Zhou Lifeng Yan Xianzhu Yang Yucai Wang Jun Wang Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei230027 China The CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences and Medical Center University of Science and Technology of China Hefei 23002 7 China School of Chemistry and Environmental Engineering Shenzhen University Shenzhen 518060 China School of Earth and Space Sciences University of Science and Technology of China Hefei230027 China Institutes for Life Sciences School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006 China

Hierarchical targeting strategy can combat the sequential drug delivery barriers by changing their properties with response to tumor stimuli. Among these strategies, much less attention has been paid to address the issues of rapid tumor clearance and insufficient cellular translocation. In this work, we demonstrate that a transactivator of transcription （TAT）-presenting nanomedicine （DATAT-NP/Pt）, apart from improving tumor accumulation and cellular uptake, can simultaneously enhance tumor retention and promote nuclear translocation of encapsulated platinum prodrugs, and thus improve therapeutic efficacy. Specifically, a protecting 2,3-dimethylmaleic anhydride （DA） corona on the nanomedicine prevented the TAT peptide from serum. DATAT-NP/Pt efficiently accumulated at the tumor site through the enhanced permeability and retention （EPR） effect, followed by acid-triggered TAT presenting within the tumor acidic microenvironment （pH ~ 6.8）. The exposed TAT peptide augmented tumor retention and nuclear translocation of DATAT-NP/Pt. We used a tumor-on-a-chip microfluidic system to real-time mimic and analyze tumor accumulation and retention at physiological flow conditions and revealed that surface absorption of nanomedicines on tumors was critical in determining their tumor retention and clearance. Furthermore, the TAT peptide rapidly translocated the DATAT-NP/Pt into the perinuclear region, allowing for higher nuclear platinum concentrations and increased Pt-DNA adduct formation in nuclei, which consequently reversed cisplatin resistance. Our work presents a new strategy to overcome path- ophysiological barriers of tumor clearance and insufficient cellular translocation and provides new insights for the design of cancer nanomedicines.

关键词： acidic tumor microenvironment cancer therapy cellular nucleus translocation ligand presenting nanomedicines tumor retention acidic tumormicroenvironment cancer therapy cellular nucleustranslocation ligand presentingnanomedicines tumor retention

Research of the Synchronous Detection for TWACS

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Research of the Synchronous Detection for TWACS