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Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

National Science Review 2023年第2期10卷 107-122页

作者： Jun-Ma Yu Rui Hu Yu Mao yingju tai Sen Qun Zhi Zhang Danyang Chen Yan Jin Department of Anesthesiology The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei) Department of Anesthesiology The First Affiliated Hospital of Anhui Medical University Department of Biophysics and Neurobiology Division of Life Sciences and Medicine University of Science and Technology of China Stroke Center and Department of Neurology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China

Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is inadequate.In addition,the neural circuit and molecular mechanisms subserving chronic pain remain largely uncharacterized.Herein we identified enhanced activity of a glutamatergic neuronal circuit that encompasses projections from the ventral posterolateral nucleus(VPLGlu) to the glutamatergic neurons of the hindlimb primary somatosensory cortex(S1HLGlu),driving allodynia in mouse models of chronic pain.Optogenetic inhibition of this VPLGlu→S1HLGlucircuit reversed allodynia,whereas the enhancement of its activity provoked hyperalgesia in control mice.In addition,we found that the expression and function of the HCN2(hyperpolarization-activated cyclic nucleotide-gated channel 2) were increased in VPLGluneurons under conditions of chronic pain.Using in vivo calcium imaging,we demonstrated that downregulation of HCN2 channels in the VPLGluneurons abrogated the rise in S1HLGluneuronal activity while alleviating allodynia in mice with chronic pain.With these data,we propose that dysfunction in HCN2 channels in the VPLGlu→S1HLGluthalamocortical circuit and their upregulation occupy essential roles in the development of chronic pain.

关键词： chronic pain HCN2 channels neural circuit in vivo recordings

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Reliability ensemble averaging reduces surface wind speed projection uncertainties in the 21st century over China

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Advances in Climate Change Research 2024年第2期15卷 222-229页

作者： Zheng-tai ZHANG Chang-Ai XU Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Accurate prediction of future surface wind speed(SWS)changes is the basis of scientific planning for wind turbines.Most studies have projected SWS changes in the 21st century over China on the basis of the multi-model ensemble(MME)of the 6th Coupled Model Intercomparison Project(CMIP6).However,the simulation capability for SWS varies greatly in CMIP6 multi-models,so the MME results still have large uncertainties.In this study,we used the reliability ensemble averaging(REA)method to assign each model different weights according to their performances in simulating historical SWS changes and project the SWS under different shared socioeconomic pathways(SSPs)in 2015-2099.The results indicate that REA considerably improves the SWS simulation capacity of CMIP6,eliminating the overestimation of SWS by the MME and increasing the simulation capacity of spatial distribution.The spatial correlations with observations increased from 0.56 for the MME to 0.85 for REA.Generally,REA could eliminate the overestimation of the SWS by 33%in 2015-2099.Except for southeastern China,the SWS generally decreases over China in the near term(2020-2049)and later term(2070-2099),particularly under high-emission scenarios.The SWS reduction projected by REA is twice as high as that by the MME in the near term,reaching-4%to-3%.REA predicts a larger area of increased SWS in the later term,which expands from southeastern China to eastern China.This study helps to reduce the projected SWS uncertainties.

关键词： Surface wind speed Uncertainty Multi-model ensemble Reliability ensemble averaging CMIP6

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Underdetermined direction of arrival estimation with nonuniform linear motion sampling based on a small unmanned aerial vehicle platform

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Defence Technology（防务技术） 2024年第3期33卷 352-363页

作者： Xinwei Wang Xiaopeng Yan tai An Qile Chen Dingkun Huang Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China

Uniform linear array(ULA)radars are widely used in the collision-avoidance radar systems of small unmanned aerial vehicles(UAVs).In practice,a ULA's multi-target direction of arrival(DOA)estimation performance suffers from significant performance degradation owing to the limited number of physical elements.To improve the underdetermined DOA estimation performance of a ULA radar mounted on a small UAV platform,we propose a nonuniform linear motion sampling underdetermined DOA estimation method.Using the motion of the UAV platform,the echo signal is sampled at different positions.Then,according to the concept of difference co-array,a virtual ULA with multiple array elements and a large aperture is synthesized to increase the degrees of freedom(DOFs).Through position analysis of the original and motion arrays,we propose a nonuniform linear motion sampling method based on ULA for determining the optimal DOFs.Under the condition of no increase in the aperture of the physical array,the proposed method obtains a high DOF with fewer sampling runs and greatly improves the underdetermined DOA estimation performance of ULA.The results of numerical simulations conducted herein verify the superior performance of the proposed method.

关键词： Unmanned aerial vehicle(UAV) Uniform linear array(ULA) Direction of arrival(DOA) Difference co-array Nonuniform linear motion sampling method

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Automatic modulation recognition of radio fuzes using a DR2D-based adaptive denoising method and textural feature extraction

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Defence Technology（防务技术） 2024年第4期34卷 328-338页

作者： Yangtian Liu Xiaopeng Yan Qiang Liu tai An Jian Dai Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

The identification of intercepted radio fuze modulation types is a prerequisite for decision-making in interference systems.However,the electromagnetic environment of modern battlefields is complex,and the signal-to-noise ratio(SNR)of such environments is usually low,which makes it difficult to implement accurate recognition of radio fuzes.To solve the above problem,a radio fuze automatic modulation recognition(AMR)method for low-SNR environments is proposed.First,an adaptive denoising algorithm based on data rearrangement and the two-dimensional(2D)fast Fourier transform(FFT)(DR2D)is used to reduce the noise of the intercepted radio fuze intermediate frequency(IF)signal.Then,the textural features of the denoised IF signal rearranged data matrix are extracted from the statistical indicator vectors of gray-level cooccurrence matrices(GLCMs),and support vector machines(SVMs)are used for classification.The DR2D-based adaptive denoising algorithm achieves an average correlation coefficient of more than 0.76 for ten fuze types under SNRs of-10 d B and above,which is higher than that of other typical algorithms.The trained SVM classification model achieves an average recognition accuracy of more than 96%on seven modulation types and recognition accuracies of more than 94%on each modulation type under SNRs of-12 d B and above,which represents a good AMR performance of radio fuzes under low SNRs.

关键词： Automatic modulation recognition Adaptive denoising Data rearrangement and the 2D FFT(DR2D) Radio fuze

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Enhancement of heavy metals desorption from the soil by eddy deep leaching in hydrocyclone

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Journal of Environmental Sciences 2024年第1期135卷 242-251页

作者： Ning Wang Hao Lu Bo Liu tai Xiong Jianping Li Hualin Wang Qiang Yang School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China National Engineering Laboratory for High Concentration Refractory Organic Wastewater Treatment Technology East China University of Science and TechnologyShanghai 200237China

An eddy deep leaching technology was developed in this paper to address the challenge of treating heavy metal contaminants in industrial mining areas.The desorption effect of As,Cd,Sb and Pb was investigated utilizing chemical leaching and physical eddy techniques.It was found that the heavy metals concentration increased with decreasing particle size.The highest proportion of Cd in the form distribution of soil was in the bound to iron and manganese oxides,while the maximum proportion of As,Sb and Pb were in the residual.The optimal solid-liquid ratio of the hydrocyclone was 1:20,and the corresponding separation efficiency and flow rate were 84.7%and 1.76 m^(3)/hr,respectively.The grade efficiency of soil particle separation increases with particle size and exceeds 99%for particles above 1,000μm.Leaching experiments have revealed that oxalic acid(OA)and a combination of oxalic acid and EDTA(OAPE)were more efficient than citric acid(CA)and a combination of citric acid and EDTA(CAPE)for the desorption of heavy metals,respectively.The comparison of OAPE and eddy leaching found that the latter improved the desorption efficiency by 9.4%,7.5%,7.2%and 7.8%for As,Cd,Sb and Pb compared to the former,respectively.The results demonstrated that the eddy leaching technique could further enhance the desorption efficiency of heavy metals.It is expected to provide technical support for soil remediation with reduced usage of leaching agents.

关键词： Heavy metals Soil remediation Oxalic acid Eddy leaching Hydrocyclone

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Mental retardation,seizures and language delay caused by new SETD1B mutations:Three case reports

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World Journal of Clinical Cases 2024年第2期12卷 383-391页

作者： Le Ding Li-Wan Wei tai-Song Li Jing Chen Department of Neurology Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Chigene(Beijing)Translational Medical Research Center Co.Ltd.Beijing 101111China

BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B gene.Three individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were analyzed.This article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment approach.Among the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had epilepsy.Antiepileptic treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat delayed.Whole exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(p.Arg1825trp),c.4120C>T(p.Gln1374*,593),c.14_15insC(p.His5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language delay.Although the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of life.Furthermore,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.

关键词： Neurodevelopmental disorder Seizure SETD1B gene Whole-exome sequencing New mutation Case report

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Low-Carbon Dispatching for Virtual Power Plant with Aggregated Distributed Energy Storage Considering Spatiotemporal Distribution of Cleanness Value

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 346-358页

作者： Hongchao Gao tai Jin Guanxiong Wang Qixin Chen Chongqing Kang Jingkai Zhu State Key Laboratory of Power System Operation and Control Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Sichuan Energy Internet Research Institute Tsinghua University Chengdu 200016China Power Dispatching and Control Center of Shanghai Municipal Electric Power Company Shanghai 200122China IEEE

The scale of distributed energy resources is increasing,but imperfect business models and value transmission mechanisms lead to low utilization ratio and poor responsiveness.To address this issue,the concept of cleanness value of distributed energy storage(DES)is proposed,and the spatiotemporal distribution mechanism is discussed from the perspectives of electrical energy and cleanness.Based on this,an evaluation system for the environmental benefits of DES is constructed to balance the interests between the aggregator and the power system operator.Then,an optimal low-carbon dispatching for a virtual power plant(VPP)with aggregated DES is constructed,where-in energy value and cleanness value are both considered.To achieve the goal,a green attribute labeling method is used to establish a correlation constraint between the nodal carbon potential of the distribution network(DN)and DES behavior,but as a cost,it brings multiple nonlinear relationships.Subsequently,a solution method based on the convex envelope(CE)linear re-construction method is proposed for the multivariate nonlinear programming problem,thereby improving solution efficiency and feasibility.Finally,the simulation verification based on the IEEE 33-bus DN is conducted.The simulation results show that the multidimensional value recognition of DES motivates the willingness of resource users to respond.Meanwhile,resolving the impact of DES on the nodal carbon potential can effectively alleviate overcompensation of the cleanness value.

关键词： Distributed energy storage virtual power plant(VPP) spatiotemporal distribution low-carbon dispatching

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A mite parasitoid,Pyemotes zhonghuajia,negatively impacts the fitness traits and immune response of the fall armyworm,Spodoptera frugiperda

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Journal of Integrative Agriculture 2024年第1期23卷 205-216页

作者： Yanfei Song tai’an Tian Yichai Chen Keshi Zhang Maofa Yang Jianfeng Liu Institute of Entomology Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous RegionGuizhou University/Scientific Observing and Experiment Station of Crop Pests in GuiyangMinistry of Agriculture and Rural AffairsGuiyang 550025China Administration of Guizhou Fanjingshan National Nature Reserve Jiangkou 554400China Centre for Biodiversity and Biosecurity School of Biological SciencesThe University of AucklandAuckland 1072New Zealand College of Tobacco Science Guizhou UniversityGuiyang 550025China

Parasitoids are key regulators in ecological communities and widely used as agents in biocontrol programmes.The fall armyworm,Spodoptera frugiperda,recently invaded multiple continents and caused substantial economic losses in agriculture.Pyemotes zhonghuajia,a newly identified mite parasitoid,has shown potential for controlling various agricultural insect pests.Therefore,this study tested the performance of P.zhonghuajia in parasitising S.frugiperda.We also investigated the sublethal effects of parasitism by P.zhonghuajia on host fitness traits,transgenerational impacts,and cellular and humoral immunity.Our result showed that the fifth-instar larvae of S.frugiperda parasitised by 40 P.zhonghuajia were all dead(i.e.,a lethal effect),while parasitism by 5 or 10 P.zhonghuajia was considered sublethal since many S.frugiperda survived to adulthood and produced offspring after mating.The sublethal influences from parasitism by P.zhonghuajia resulted in reduced pupal weight,adult emergence rate and fecundity,but increased developmental time and longevity.Parasitism at both lethal(40 mites)and sublethal(10 mites)levels impaired the cellular and humoral immunity of S.frugiperda.This study presents the first empirical evidence that mite parasitoids can negatively influence host immunity.Moreover,it provides insights into the biocontrol potential of mite parasitoids and their interactions with hosts.

关键词： Pyemotes zhonghuajia Spodoptera frugiperda immunity parasitically-induced influence biocontrol parasitoid

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Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis

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Food Science and Human Wellness 2024年第1期13卷 482-493页

作者： Zhihui Yu Lingyu Fan Fei tai Lixin Zhang Xiaoyu Zhang Yisheng Chen College of Food Science and Engineering Shanxi Agricultural UniversityTaigu 030801China Insitute of Food Nutrition and Safety Shanxi Agricultural UniversityTaiyuan 030031China Shanxi Key Laboratory of Edible Fungi for Loess Plateau Taigu 030801China

In this study,the impacts of egg consumption on mice model of metabolic syndrome(Met S)were comparatively investigated.Mice were divided into five groups(n=8):normal diet group(ND),high-fat diet group(HFD),HFD with whole egg group(WE),HFD with free-yolk egg substitute group(YFES),and HFD with lovastatin group(Lov).Main biochemical indexes and a non-targeted lipidomic analysis were employed to insight the lipid profile changes in serum.It was revealed that WE could significantly improve serum biochemical indexes by reducing body weight,low-density lipoprotein cholesterol(LDL-C)and total cholesterol(TC),while increasing high-density lipoprotein cholesterol.YFES exhibited remarkably better performance in increasing phosphatidylglycerol and phosphatidic acids,while decreasing phosphatidylinositol than WE.A total of 50 differential lipids biomarkers tightly related to glycerophospholipids metabolism were screened out.Carnitine C18:2 and C12:1,SM(d18:0/12:0),and SM(d18:1/14:1)were significantly upregulated in YFES compared to WE.YFES reduced expression of SREBP-1c and Cpt1a,while did not affect the expression of PPAR-α.Sphingomyelin biomarkers were positively related to the TC(|r|>0.6),while PPAR-αwas negatively correlated with triglyceride and LDL-C levels.To sum up,YFES attenuated HFD-induced Met S by improving the serum phospholipids,which account for its modulation of glycerophospholipid metabolism.

关键词： Metabolic syndrome Whole egg Yolk free egg substitute Serum Lipidomics

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Review on research and development of oxy-coal burner for carbon capture

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Science China(Technological Sciences) 2024年第3期67卷 647-672页

作者： GUO JunJun LIU JingZhang ZHANG tai HU Fan LI PengFei LIU ZhaoHui ZHENG ChuGuang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and Technology Wuhan 430074China CCRC King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Beijing 100049China Institute of Energy Research Jiangxi Academy of SciencesNanchang 330096China Carbon Neutrality Research Center of Jiangxi Province Nanchang 330096China Faculty of Engineering China University of Geosciences(Wuhan)Wuhan 430074China National Energy Research and Development Center of Clean and Low Carbon Coal-based Power Generation Technologies Wuhan 430074China

In the past two decades, the oxy-fuel combustion of pulverized coal has been extensively developed, leading to the completion of several large industrial pilot oxy-fuel plants worldwide. Various types of oxy-fuel burners have been designed and tested in largescale pilot plants as key components of oxy-fuel combustion. These burners face major challenges in terms of their flame stability because of their decreasing stream momentum ratio and increasing carbon dioxide concentration. However, it offers flexibility in adjusting the oxygen concentration in each burner stream. This study aims to provide a comprehensive review of the state-of-the-art knowledge on oxy-coal burner design and operation in power plants. First, the combustion characteristics under oxy-fuel conditions are briefly introduced. Subsequently, the principal requirements and fundamental parameters of the oxy-coal burners are discussed. The development process of oxy-fuel burners is also presented. Moreover, a compatible design strategy and scaling-up techniques are described for oxy-coal burners developed by the authors over the past ten years. The performances of oxy-coal burners in three large pilot oxy-fuel plants worldwide are summarized and compared. Finally, concluding remarks are provided and potential research needs are suggested.

关键词： carbon capture oxy-fuel combustion oxy-fuel burner pulverized coal compatible design

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