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Chinese Chemical Letters 2022年第8期33卷 3713-3720页

作者： yingjie gao Ying Han Bingrui Liu Jianfeng Gou Dan Feng Xiuwen Cheng Key Laboratory for Environmental Pollution Prediction and Control College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China College of Chemistry and Environmental Sciences Yili Normal UniversityYining 835000China Key Laboratory of Pollutant Chemistry and Environmental Treatment Yili Normal UniversityYining 835000China

Eggshell-loaded CoFe_(2)O_(4) catalyst was synthesized via a convenient hydrothermal method during our work,then the surface morphology and elemental composition of the composites were systematically investigated.Performance of CoFe_(2)O_(4)/eggshell-activated peroxymonosulfate(PMS)system was evaluated by selecting florfenicol(FF)as the model pollutant,and effects of operating parameters and water matrices on the FF removal efficiency in this system were investigated.In addition,main radicals involved in FF degradation were identified by EPR tests and radical quenching experiments,and possible mechanism was proposed.The reduction of toxicity during FF degradation was confirmed,and in combination with HP-LC tests,it was found that dehalogenation and defluorination were effectively carried out during FF degradation.In addition,the prepared CoFe_(2)O_(4)polyvinylidene fluoride(PVDF)membrane effectively improved the stability of the material and reduced the precipitation of metals.

关键词： CoFe_(2)O_(4)/eggshell Peroxymonosulfate Florfenicol PVDF membrane

Antiviral activity of Jinchai capsule against influenza virus

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Journal of Traditional Chinese Medicine 2013年第2期33卷 200-204页

作者： Juying Zhong Xiaolan Cui Yujing Shi yingjie gao Hongxin Cao Experimental Research Center China Academy of Chinese Medical Sciences Pharmacology laboratory Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Graduate School of China Academy of Chinese Medical sciences

OBJECTIVE:To evaluate the effect on influenza virus of Jinchai,a capsule made of Traditional Chinese Medicine.METHODS:Madin-darby canine kidney(MDCK) cells were infected with the FM1 strain of influenza virus A(subtype H1N1) in vitro.They were used to explore how Jinchai affected cell adsorption,cell membrane fusion,transcription and replication of the influenza virus.Hemagglutinin(HA) protein,intracellular pH,and influenza virus protein acid(PA) polymerase subunit were detected with confocal microscopy and real-time fluorescent quantitative polymerase chain reaction.RESULTS:Jinchai significantly reduced the expression of HA and PA polymerase subunit mRNA in infected MDCK cells.Jinchai also significantly decreased intracellular pH in infected cells.CONCLUSIONS:Jinchai had strong anti-influenza activity against the influenza virus.It weakened the ability of the influenza virus to adsorb to cell wall and fuse with cell membranes in the early infection stage,and inhibited the transcription and replication of the virus.

关键词： A型流感病毒抗病毒活性荧光定量聚合酶链反应胶囊金共聚焦显微镜 MDCK细胞细胞吸附

Degradation of tartrazine by peroxymonosulfate through magnetic Fe_(2)O_(3)/Mn_(2)O_(3) composites activation

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Chinese Chemical Letters 2020年第10期31卷 2730-2736页

作者： Gong Chen Li-Chao Nengzi yingjie gao Guixian Zhu Jianfeng Gou Xiuwen Cheng Key Laboratory of Western China's Environmental Systems(Ministry of Education)and Key Laboratory for Environmental Pollution Prediction and Control Gansu ProvinceCollege of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Academy of Economics and Environmental Sciences Xichang UniversityXichang 615000China

In this study,Fe_(2)O_(3)/Mn_(2)O_(3) composite was synthesized by a facile two-step technique,and several methods were carried out to characterize it.Then,the decomposition experiments of tartrazine(TTZ),a kind of refractory o rganic pollutant,were conducted under various enviro nmental condition to detect the catalyst performance,such as reaction system,the dosage of catalyst,peroxymonosulfate(PMS)concentration,initial pH,different natural water substances.The results exhibited that Fe_(2)O_(3)/Mn_(2)O_(3) composite with the mole rate 2:3 had the best PMS activation performance and the removal efficiency was 97.3%within 30 min.Besides,the optimum degradation conditions of TTZ we re also discussed,that is catalyst dosage(0.6 g/L),PMS concentration(0.8 g/L)and the initial pH 11.In addition,proved by the natural water substances adding experiments,HPO_(4)^(2)-,HCO_(3)^-,NO_(3)^-and NOM(nature organic matter)could slow down the experiments progressing,but Cl^-could boost it.Then inhibitor experiments indicated both the HO^·and SO_(4)^·-played a vital role in the experiments.Reusability and ions leaching experiments as well as the used catalyst physical characte rization images exhibited the excellent stability and cyclicity of the Fe_(2)O_(3)/Mn_(2)O_(3) composite.Finally,based on the XPS(X-ray photoelectro n spectro scopy)and the experiments results,the possible mechanism of TTZ degradation was proposed.This system might provide a novel thought for the decomposition of refractory organic pollutant and had potential in promotion of actual sewage treatment technology.

关键词： Fe_(2)O_(3)/Mn2O3 Peroxymonosulfate Tartrazine Degradation Activation Mechanism

Antidepressant Effect of Shenwei Ningyu Tablets on Rat Chronic Stress Model and Mouse Tail Suspension Model

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Medicinal Plant 2022年第2期13卷 21-25页

作者： Yaxin WANG Shanshan GUO yingjie gao Ya TU Xiaolan CUI Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China School of Acupuncture-moxibustion and Tuina Beijing University of Chinese Medicine Beijing 100029 China

[Objectives]To explore the antidepressant effect of Shenwei Ningyu Tablet,a new antidepressant traditional Chinese medicine,on rat chronic stress depression model and mouse tail suspension models.[Methods]Rat chronic stress model:except for the normal group,the rats in other groups were given corresponding chronic stress,and administered by gavage 1 h before modeling,for a total of 21 d.The changes of each indicator before and after the experiment were observed through the body weight change,the sugar water test,and open field test.The relevant hormone levels were detected by radioimmunoassay.Mouse tail suspension depression model:after continuous administration for 7 d,the activity times was recorded with the mouse automatic recorder,and the mouse immobility time was recorded after tail suspension,to explore the effects of each administration group on the tail suspension immobility time of mice.[Results]Chronic stress depression model:21 d after modeling,compared with the normal group,rats in the model group exhibited significantly reduced body weight,sucrose preference index,and horizontal and vertical movement scores(P<0.05).Compared with the model group,the low-dose Shenwei Ningyu Tablets group had significant differences in the sugar water test,horizontal and vertical movement scores(P<0.05).In addition,all three dose groups of Shenwei Ningyu Tablets could effectively reduce the content of CRF in chronic stress model rats,and the low dose group could significantly reduce the ACTH level in model rats(P<0.05).Mouse tail suspension depression model:the immobility time after tail suspension in each administration group was significantly different from that in the model group(P<0.05).[Conclusions]Shenwei Ningyu Tablets has a certain anti-depression effect on both the rat chronic stress depression model and the mouse tail suspension depression model.

关键词： Depression Rat chronic stress model Mouse tail suspension model Open field experiment Sugar water preference Radioimmunoassay Shenwei Ningyu Tablets

Feedforward loop profile among transcription factor, miRNA and mRNA in influenza A virus-infected mouse lungs

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Medical Data Mining 2019年第4期2卷 150-159,I0001-I0038页

作者： Yanyan Bao Yujing Shi yingjie gao Lirun Zhou Xiaolan Cui Biosafety Laboratory Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing100700China

Purpose:In the present study,we focused on the 46 microRNAs and 719 genes in the microRNA-gene network,reported by us,and aimed to build a research blueprint of feedforward loops and reveal the key TFs in H1N1-infected mouse lung.Method:Based on microRNAs and genes in the microRNA-gene network previously reported by us,we used Jemboss software to find relationships between TFs and microRNAs(or genes),and then built a TF-microRNA-gene network exploiting the interactions between TFs and microRNAs(or genes).Next,we searched the sequences of above genes or microRNAs near the transcription start site(TSS)area,and then used the MatchTM algorithm to predict relevant TFs,and built the TF-Gene-Network.Result:We built a TF-microRNAgene network and exploreed eight key TFs,namely NF-AT1,GKLF,SRY,SOX10,AML1,MZF1,CRX and myogenin,in the network,and then constructed subgraphs of these eight TFs.Simultaneously,we predicted the possible target genes of microRNAs and identified the feedforward regulation relationship of possible TFs,microRNAs and mRNAs.The results showed that all eight factors with a score greater than 100 were TFs,namely NF-AT1,GKLF,SRY,SOX10,AML1,CRX,myogenin and MZF1.We then constructed subtables of the above eight TFs.Conclusion:In this study,TFs including NF-AT1,GKLF,SRY,SOX10,AML1,MZF1,CRX and myogenin showed the highest score(>100)not only in the TF-microRNA-gene network but also in feedforward loops,indicating that these eight TFs play the most important roles in mouse H1N1 influenza virus infection biology.

关键词： H1N1 Influenza A virus Transcription factor MicroRNA Gene

土藤草颗粒对微晶型尿酸钠致家兔急性痛风性关节炎的药效学研究

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中国药物警戒 2024年第3期21卷 263-268页

作者：姚荣妹毛鑫徐英莉高英杰包蕾鲍岩岩孟凤仙崔晓兰中国中医科学院中药研究所北京100700 北京中医药大学东方医院风湿病科北京100700

目的观察土藤草颗粒对微晶型尿酸钠(monosodium urate,MSU)致家兔急性痛风性关节炎模型的药效学作用。方法选用取雄性日本大耳白兔,随机分为正常对照组,模型对照组,阳性药秋水仙碱组(0.18 mg·kg^(-1)),土藤草颗粒高、中、低剂量组分别... 详细信息

目的观察土藤草颗粒对微晶型尿酸钠(monosodium urate,MSU)致家兔急性痛风性关节炎模型的药效学作用。方法选用取雄性日本大耳白兔,随机分为正常对照组,模型对照组,阳性药秋水仙碱组(0.18 mg·kg^(-1)),土藤草颗粒高、中、低剂量组分别为600、300、150 mg·kg^(-1)。通过家兔左后肢膝关节腔内注入MSU的方式建立急性痛风性关节炎模型,给药5天后收集关节液,检测关节腔积液中的白细胞数,测定关节液中炎症细胞因子白介素-6(interleukin-6,IL-6)、白介素-8(interleukin-8,IL-8)、肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)、白介素-1β(interleukin-1β,IL-1β)、前列腺素E2(prostaglandin E2,PGE2)含量;采血检测血尿酸值,给药前后血清中尿素(urea,UREA)、胆固醇(cholesterol,CHO)、血肌酐(serum creatinine,Cre)、血糖(glucose,GLU)及甘油三酯(triglyceride,TG)含量。结果土藤草颗粒高、中、低剂量组给药5 d后关节腔内白细胞数均有所下降,中剂量组与模型对照组比较有显著性差异(P<0.01);高、中剂量组有降低血尿酸的趋势;土藤草颗粒对家兔血清中UREA、CHO、Cre、GLU及TG含量均无影响;与模型对照组比较,土藤草颗粒高、中、低剂量组IL-6、IL-8、TNF-α及PGE2含量均明显降低,其中高、中、低剂量组的IL-6、TNF-α含量,高、中剂量组IL-8含量及中剂量组PGE2含量与之比较有显著性差异(P<0.01);土藤草颗粒高、中、低剂量组可以一定程度上降低关节液中IL-1β含量。结论土藤草颗粒对MSU致急性关节炎家兔模型有明显的治疗作用,可以减少动物关节腔内白细胞数量、抑制炎症细胞因子的表达,降低血清中尿酸含量。

关键词：土藤草颗粒微晶型尿酸钠急性痛风性关节炎药效学大耳白兔白介素-6 白介素-8 肿瘤坏死因子

Pharmacodynamics Study in vitro and in vivo of Zijin Huadu Suppository Treating Cervicitis

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Medicinal Plant 2017年第4期8卷 40-47页

作者： Shanshan GUO yingjie gao Lei BAO Yahong JIN Yanying LI Xiaolan CUI Wei XIAO Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing Increase Pharmaceutical Institute Co.Ltd. Jiangsu Kanion Pharmaceutical Co. Ltd.

[Objectives] To observe the pharmaceutical effect of Zijin Huadu suppository on treatment of cervicitis induced by virus,bacteria and phenol in vivo and in vitro,and provide experimental basis for evaluating its therapeutic effects for cervicitis. [Methods]Real-time RT-PCR and CPE methods were used to observe the inhibition of Zijin Huadu suppository on virus,and turbidimetry was used to observe bacteriostatic action; HE pathological section was used to observe cervicitis of rat,and enzyme-linked immunosorbent assay was used to detect virus' s expression in cervical tissue.[Results]In cervicitis rat model infected by HPV16,Zijin Huadu suppositories at the doses of 1. 2,0. 6 and0. 3 g/( kg·d) had significant inhibitory effect on HPV16 expression in cervical tissues,and the doses of 1. 2 and 0. 6 g/( kg·d) had significantly inhibitory effect on pathological changes of cervical tissues. In cervicities rat models infected mixedly by Escherichia coli,Neisseria gonorrhoeae and Staphylococcus aureus,Zijin Huadu suppositories at the doses of 1. 2 and 0. 6 g/( kg·d) had significant inhibitory effect on pathological changes of cervical tissues. In cervicitis rat models induced by chemical substances,Zijin Huadu suppositories at the dose of1. 2 g/( kg·d) had significant inhibitory effect on vagina and cervix lesions in rats. In vitro,Zijin Huadu suppository showed obvious inhibitory effects on HSV-2,HPV16,Staphylococcus aureus,Staphylococcus albus,Staphylococcus epidermidis,group B Streptococcus,E. coli,Pseudomonas aeruginosa,Proteusbacillus vulgaris,Neisseria gonorrhoeae and Candida albicans.[Conclusions] Zijin Huadu suppository has obvious inhibitory effect in vitro on viruses and bacteria,and could obviously improve the phenol-induced cervicitis.

关键词： Zijin Huadu suppository Cervicitis HPV16 Bacteria mixed infection Phenol mucilage

Motion Planning Based Coordinated Control for Hydraulic Excavators

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Chinese Journal of Mechanical Engineering 2009年第1期22卷 97-101页

作者： gao yingjie JIN Yanchao ZHANG Qin Hebei Province Key Laboratory of Fluid Power Transmission and Control Yanshan University Qinhuangdao 066004 China Eaton Hydraulics Systems （Jining） Co. Ltd Jining 272023 China Department of Agricultural and Biological Engineering University of Illinois at Urbana-Champaign Urbana-Champaign IL 61801 USA

Hydraulic excavator is one type of the most widely applied construction equipment for various applications mainly because of its versatility and mobility. Among the tasks performed by a hydraulic excavator, repeatable level digging or flat surface finishing may take a large percentage. Using automated functions to perform such repeatable and tedious jobs will not only greatly increase the overall productivity but more importantly also improve the operation safety. For the purpose of investigating the technology without loss of generality, this research is conducted to create a coordinate control method for the boom, arm and bucket cylinders on a hydraulic excavator to perform accurate and effective works. On the basis of the kinematic analysis of the excavator linkage system, the tip trajectory of the end-effector can be determined in terms of three hydraulic cylinders coordinated motion with a visualized method. The coordination of those hydraulic cylinders is realized by controlling three electro-hydraulic proportional valves coordinately. Therefore, the complex control algorithm of a hydraulic excavator can be simplified into coordinated motion control of three individual systems. This coordinate control algorithm was validated on a wheeled hydraulic excavator, and the validation results indicated that this developed control method could satisfactorily accomplish the auto-digging function for level digging or flat surface finishing.

关键词： hydraulic excavator motion planning coordinated control

高校公共体育课程“体育+劳育”融合教学资源开发路径研究

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山东农业工程学院学报 2024年第4期41卷 124-128页

作者：赵健徐铭鑫刘翰林刘佳奇闫鹏旭张瑞营高英杰山东农业工程学院山东济南250100

随着社会的发展和教育改革的推进,体育和劳动教育的重要性日益凸显。在高校公共体育课程教学中,传统的体育教学资源已不能满足学生发展的需要,劳育和体育的教学资源有着诸多共通之处,“体育+劳育”融合教学资源的开发可以满足二者共同... 详细信息

随着社会的发展和教育改革的推进,体育和劳动教育的重要性日益凸显。在高校公共体育课程教学中,传统的体育教学资源已不能满足学生发展的需要,劳育和体育的教学资源有着诸多共通之处,“体育+劳育”融合教学资源的开发可以满足二者共同培养学生的需要。体育与劳动教育融合教学资源开发是实现教育资源优化配置、提升教学质量和效果、促进学生的全面发展的重要途径。同时,也为其他领域的教育改革提供了借鉴和参考。

关键词：高校公共体育课程 “体育+劳育” 教学资源开发

Unsplit complex frequency shifted perfectly matched layer for second-order wave equation using auxiliary differential equations

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Unsplit complex frequency shifted perfectly matched layer fo...