检索结果-南通市图书馆

氮、磷限制对球形棕囊藻不同形态细胞生长和多糖产量的影响

在线全文

学校读者我要写书评

暂无评论

广西科学 2024年第1期31卷 60-70页

作者：傅云飞赖俊翔王英辉韦福佳邢政谢芳李杰广西大学资源环境与材料学院广西南宁530004 广西科学院广西海洋科学院(广西红树林研究中心)广西近海海洋环境重点实验室广西南宁530007 北部湾海洋产业研究院广西防城港538000 广西大学海洋学院广西南宁530004

为探究营养盐胁迫对广西北部湾不同倍性球形棕囊藻(Phaeocystis globosa)细胞生长和多糖产量的影响,本研究采用单因子控制试验,设置4.0∶1.0、24.5∶1.0和64.0∶1.03个氮、磷限制比例,对球形棕囊藻的单倍体和二倍体细胞进行人工海水培养... 详细信息

为探究营养盐胁迫对广西北部湾不同倍性球形棕囊藻(Phaeocystis globosa)细胞生长和多糖产量的影响,本研究采用单因子控制试验,设置4.0∶1.0、24.5∶1.0和64.0∶1.03个氮、磷限制比例,对球形棕囊藻的单倍体和二倍体细胞进行人工海水培养,比较二者的生长变化及各生长期内藻多糖含量和透明胞外聚合颗粒物(Transparent Exopolymer Particles,TEP)的释放差异。结果表明,氮、磷营养对二倍体细胞前期生长的促进作用强于单倍体细胞,二倍体细胞生长率显著高于单倍体细胞(P0.05)。磷限制组的二倍体单细胞EPS、IPS和TEP产量显著高于对照组和氮限制组(P<0.05)。总而言之,营养盐胁迫刺激球形棕囊藻EPS和TEP的产生,球形棕囊藻TEP的产生受营养盐相对存量的影响。二倍体细胞多糖与TEP对磷限制的响应比单倍体细胞更敏感。

关键词：有害藻华球形棕囊藻营养盐胁迫透明胞外聚合颗粒物多糖氮磷

Long non-coding RNA Tug 1 regulates inflammation in microglia and in status epilepticus rats through the NF-κB signaling pathway

在线全文

学校读者我要写书评

暂无评论

Acta Epileptologica 2022年第2期5卷 88-96页

作者： Ming Wang Yangmei xie Yiye Shao yinghui Chen Department of Neurology Huashan HospitalFudan UniversityShang-hai 200040China Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China.

Background:Inflammation plays an important role in the pathogenesis of status epilepticus(SE).The long non-cod-ing RNA(lncRNA)taurine up-regulated gene1(Tug1)plays a well-defned role in inflammatory ***,the molecular mechanism of Tug1 in SE progression remains *** present study,we investigated whether Tug1 is involved in microglial inflammation in SE ***:The SE rat model was established via intraperitoneal injection of lithium chloride ***-binding protein immunoprecipitation(RIP)and RIP sequencing were carried out in rat microglia(RM).Tug1 cloned into the adenovirus was overexpressed in the *** of Tug1 was performed via siRNA *** level of Tug1 and inflammatory factors IL-1βand TNF-αwas examined by real-time polymerase chain reaction(RT-PCR)and western *** levels of p65,P-p65,p-IKBa and IkBa were assessed by western ***:The RIP-seq result showed 14 lncRNAs that bound to the NF-κB p65 protein in *** lncRNA Tug1 directly interacted with *** level of declined Tug1 was decreased in the hippocampus of SE *** ofTug1 reduced the LPS-induced inflammation and M1/M2 polarization of microglia,while knockdown of Tug1 aggravated the inflammatory response in ***,the protein levels of p-p65/p65 and p-IkBa/IkBa were reduced in the Tug1-overexpression microglia and elevated in the Tug1-knockdown ***:These findings indicate that Tug1 modulates the inflammation in microglia through the NF-κB signal pathway,and the Tug1/P65 axis are like to play a signifcant role in the inflammatory processes,providing a valid target for the therapy of SE.

关键词： Inflammation Microglia Status epilepticus lncRNA NF-κB signaling pathway Tug1

安罗替尼联合同步放化疗治疗局部晚期食管鳞状细胞癌的效果观察

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国医学创新 2024年第20期21卷 48-52页

作者：王丽菲张洪菊郑英慧谢华聊城市传染病医院肿瘤科山东聊城252000 聊城市东昌府人民医院耳鼻喉科山东聊城252000

目的:探讨安罗替尼与同步放化疗(CCRT)治疗局部晚期食管鳞状细胞癌的临床效果。方法:回顾性分析2021年6月1日—2022年6月1日于聊城市传染病医院接受治疗的80例局部晚期食管鳞状细胞癌患者的临床资料,根据治疗方案分为对照组(n=38)和观察... 详细信息

目的:探讨安罗替尼与同步放化疗(CCRT)治疗局部晚期食管鳞状细胞癌的临床效果。方法:回顾性分析2021年6月1日—2022年6月1日于聊城市传染病医院接受治疗的80例局部晚期食管鳞状细胞癌患者的临床资料,根据治疗方案分为对照组(n=38)和观察组(n=42)。对照组接受CCRT治疗,观察组接受CCRT和安罗替尼联合治疗。评估两组无进展生存期(PFS)、总生存期(OS)、疾病控制率(DCR)、客观缓解率(ORR)和不良事件(AE)。结果:观察组ORR、DCR分别为69.05%、90.48%,明显高于对照组的47.39%、63.16%,差异均有统计学意义(P0.05);观察组Ⅰ、Ⅱ级高血压发生率明显高于对照组(P<0.05)。结论:安罗替尼联合CCRT治疗局部晚期食管鳞状细胞癌可提高临床疗效,延长患者生存时间。

关键词：安罗替尼同步放化疗食管鳞状细胞癌无进展生存期总生存期

Mg^(2+)//CO_3^(2-)、HCO_3^-、OH^--H_2O体系相平衡研究

在线全文

学校读者我要写书评

暂无评论

河北工业大学学报 2018年第1期47卷 53-58页

作者：赵颖颖史婧祎李丹吴梦凡谢英惠袁俊生河北工业大学海洋科学与工程学院天津300130 海水资源高效利用化工技术教育部工程研究中心天津300130 河北省现代海洋化工协同创新中心天津300130

新型碱源脱钙固碳之后的海水中存在的大量镁离子和碳酸氢根,提取其中的镁离子可以实现海水镁资源利用并将海水进一步软化;分离碳酸氢根使固碳彻底,有利于后续海水资源利用.镁和碳酸氢根的提取需要在碱性条件下进行,因此,本实验将CO_2脱... 详细信息

新型碱源脱钙固碳之后的海水中存在的大量镁离子和碳酸氢根,提取其中的镁离子可以实现海水镁资源利用并将海水进一步软化;分离碳酸氢根使固碳彻底,有利于后续海水资源利用.镁和碳酸氢根的提取需要在碱性条件下进行,因此,本实验将CO_2脱钙之后的海水体系简化为Mg^(2+)//CO_3^(2-)、HCO_3-、OH^--H_2O体系.并利用等温溶解平衡法,研究该体系在10℃条件下的相平衡,探索体系的析盐规律.液相组成通过溶液滴定法获得,由X射线衍射分析技术测出固相物质组成得出,并利用origin9.0软件绘制出四元体系相图.相图中得到1个三相共饱点,固相物组成是MgCO_3·3H_2O、Mg(OH)_2和Mg_5(CO_3)4(OH)_2·8H_2O;3条共饱和曲线分别为MgCO_3·3H_2O、Mg(OH)_2的共饱线,Mg_5(CO_3)4(OH)_2·8H_2O、Mg(OH)_2的共饱线,Mg_5(CO_3)4(OH)_2·8H_2O、MgCO_3·3H_2O的共饱线;2个明显的结晶区,MgCO_3·3H_2O结晶区和Mg(OH)_2结晶区,1个Mg_5(CO_3)4(OH)_2·8H_2O的部分结晶区.以上实验数据可为盐化工生产及结晶分离提纯提供参考依据.

关键词：平衡热力学四元体系水盐体系溶解度

Effect of background parabolic current on characteristics and energetics of internal solitary waves by numerical simulation

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2016年第1期35卷 1-10页

作者： Lü Haibin xie Jieshuo YAO Yuan XU Jiexin CHEN Zhiwu HE yinghui CAI Shuqun State Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China School of Geodesy & Geomatics Engineering Huaihai Institute of Technology Lianyungang 222005 China University of Chinese Academy of Sciences Beijing 100049 China Qinhuangdao Marine Environmental Monitoring Central Station State Oceanic Administration Qinhuangdao 066002 China

Based on modifications of the observed background parabolic current in upper layer of the northeastern South China Sea （SCS）, the effects of eight kinds of background currents on the characteristics and energy conversion of internal solitary waves （ISWs） are investigated by an Internal Gravity Wave （IGW） model. It is found that, although the background current has little effect on the number of the generated ISWs, it reduces the resulted phase speed of ISW. When the background parabolic current appears with its lower boundary near or above the main thermocline, the ISW amplitude and the depth of the isopycnal undergoing maximum displacement increase; when the background parabolic current curvature is reduced, the ISW amplitude and the ratio of baroclinic to barotropic energy reduce, whilst the phase speed of ISW, the baroclinic energy, and the ratio of baroclinic kinetic energy （KE） to available potential energy （APE） increase; when the lower boundary of background parabolic current extends down to the seabed and the background current curvature is reduced, the ISW amplitude and phase speed decrease, whilst the barotropic kinetic energy, the baroclinic energy and the ratio of KE to APE increase. At a whole depth, when the lower background current curvature is reduced and the upper current curvature is increased, the ISW amplitude, and phase speed, the ratio of baroclinic to barotropic energy, the baroclinic energy, and the ratio of KE to APE all increase.

关键词： internal solitary waves background current baroclinic energy South China Sea

Oceanic internal solitary waves at the Indonesian submarine wreckage site

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2022年第3期41卷 109-113页

作者： Yankun Gong Jieshuo xie Jiexin Xu Zhiwu Chen yinghui He Shuqun Cai State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Institution of South China Sea Ecology and Environmental Engineering Chinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China

On 21 April 2021 local time(20 April UTC),the Indonesian Navy submarine(KRI Nanggala-402)sank near the Lombok Strait,~100 km north of the Bali Island(see magenta star in Fig.1a),with 53 crew members *** the basis of M... 详细信息

关键词： submarine Island Strait

Facile construction of honeycomb-shaped porous carbon electrode materials using recyclable sodium chloride template for efficient lithium storage

在线全文

学校读者我要写书评

暂无评论

中国科学：技术科学英文版 2020年第10期63卷 2123-2130页

作者： FANG ShiQing HE HaoXuan YU yinghui LI Xiao xie WeiCheng LI Wei JIN LuQiao YANG ZhenYu CAI JianXin School of Resources Environmental&Chemical Engineering Nanchang UniversityNanchang 330031China College of Chemistry Nanchang UniversityNanchang 330031China

Carbon materials are the preferred anode materials for Li-ion ***,we propose an easy and sustainable strategy to prepare honeycomb-shaped porous carbon(HPC)electrode materials through a process involving simple calcination and subsequent water washing by using polyvinyl-pyrrolidone(PVP)as carbon source and NaCl as pore-forming agent.A controllable cavity size and distribution of the carbon materials can be readily obtained solely by adjusting the NaCl *** showed that the optimized HPC sample had a relatively uniform cavity distribution and a highly porous ***,the special honeycomb-shaped structure was conducive to the electronic conductivity of the electrode materials,provided a short path for Li-ion transport and a wide interface with the electrolyte,and buffered the volume change of active *** special honeycomb-shaped structure was also maintained well after long cycles,which improved electrode *** used as anode materials for Li-ion batteries(LIBs),the sample demonstrated excellent cycling stability and rate performance,with a high specific capacity of 230 mA hg^-1 and a reversible capacity of 197 mA hg^-1,after 1200 cycles at 2 ***,we introduced a simple strategy for the potential mass production of porous carbon materials for LIBs.

关键词： lithium-ion batteries polyvinyl-pyrrolidone sodium chloride honeycomb-shaped porous carbon materials

Evaluation of P-glycoprotein-targeting circulating microRNAs as peripheral biomarkers for medically intractable epilepsy

在线全文

学校读者我要写书评

暂无评论

Acta Epileptologica 2023年第1期6卷 14-24页

作者： Yangmei xie Yiye Shao Xue Gong Ming Wang yinghui Chen Department of Neurology Huashan HospitalFudan UniversityNational Center for Neurological Disorders12 Wulumuqi RoadShanghai 200040China Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200940China Community Health Service Center of Xinqiao Town Songjiang DistrictShanghai 201612China

Background Early diagnosis of medically intractable epilepsy is challenging in clinical work.P-glycoprotein(P-gp)is one of the most important multidrug efux transporters,which has been demonstrated to contribute to the drug resistance of intractable *** present study was aimed to explore the diagnostic value of microRNAs(miRNAs)targeting P-gp for medically intractable *** Thirty-six patients with intractable epilepsy and 36 epilepsy patients responsive to anti-epilepsy drugs,who visited Jinshan Hospital of Fudan University from September 2014 to September 2016,were enrolled in this *** information of the patients was obtained by retrospectively reviewing medical *** with diferential serum expression between the two groups of patients were detected by microarray ***,miRNAs that were confrmed to regulate P-gp in vitro by western blot were selected for further *** the validation phase,reverse transcription quantitative PCR(RT-qPCR)was conducted to confrm the diferential expression of the candidate miRNAs in the epilepsy *** operating characteristic(ROC)curve analysis was carried out to evaluate the diagnostic value of the miRNAs for intractable *** Three miRNAs including miR-6514-3p,miR-6076-5p,and miR-6855-3p were identifed to be candidate miRNAs by microarray *** results of western blotting validated that miR-146a-5p and miR-138-5p could regulate P-gp expression in vitro,so they were included in the candidate miRNAs for further *** the validation phase,the results of RT-qPCR indicated that compared with drug-responsive patients,the patients with intractable epilepsy showed decreased level of miR-138-5p and increased level of *** results of ROC curve analysis indicated that miR-138-5p(AUC=0.877)and miR-146a-5p(AUC=0.866)had high diagnostic value for intractable *** addition,the miR-panel composed of miR-138-5p and miR-146a-5p showed higher di

关键词： Intractable epilepsy Drug resistance P-glycoprotein Circulating miRNAs Biomarker

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

前列腺增生的CO2激光气化治疗

激光 1982年第12期 794-795页

作者：李纪寿杜振强何应辉谢佛龙李瑞霞陈锦河广东省肇庆地区激光协作组

前列腺增生症又称前列腺肥大,是一种病程久、进展缓慢的疾病,好发于50岁以上的男性老人,其发病机制是该腺体的良性增生肥大,造成对尿道的机械压迫,直至尿路完全梗阻。其典型临床症状是排尿障碍。目前采用保守疗法,难以获得理想效果,且... 详细信息

前列腺增生症又称前列腺肥大,是一种病程久、进展缓慢的疾病,好发于50岁以上的男性老人,其发病机制是该腺体的良性增生肥大,造成对尿道的机械压迫,直至尿路完全梗阻。其典型临床症状是排尿障碍。目前采用保守疗法,难以获得理想效果,且复发率亦较高。而手术切除前列腺虽疗效确切,但难度大,要求高,术中失血多,且有一定的死亡率。由于病例选择严格,致使一些年老体弱或有心、肺、肾等合并症的患者,被迫采用膀胱造痿术。

关键词：前列腺 CO2 患者男生殖器二氧化碳激光气化增生组织