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高阶段大结构崩落采矿法采场破坏规律研究

矿业研究与开发 2017年第8期37卷 109-112页

作者：黄敏周爱民黄英华吴亚斌吕冠颖长沙矿山研究院有限责任公司湖南长沙410012 金属矿山安全技术国家重点实验室湖南长沙410012 国家金属采矿工程技术研究中心湖南长沙410012

根据矿山工程概况及采场宏观破坏现象,通过数值模拟计算、现状地压调查及现场原岩应力测试等工作,对大结构崩落采矿过程中采场破坏规律进行深入研究,研究结果表明,高阶段大结构崩落采矿法采场破坏主要由拉伸应力、工程地质条件、应力集... 详细信息

根据矿山工程概况及采场宏观破坏现象,通过数值模拟计算、现状地压调查及现场原岩应力测试等工作,对大结构崩落采矿过程中采场破坏规律进行深入研究,研究结果表明,高阶段大结构崩落采矿法采场破坏主要由拉伸应力、工程地质条件、应力集中现象、高应力静压场及采矿动压现象引起。通过分析采场的破坏规律,矿山可以采取针对性技术措施,从而保障井下安全生产及改善矿山整体经济效益。

关键词：无底柱分段崩落采矿法 3D-σ 数值模拟采场破坏规律

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高校网络党建的实践与探索

科教文汇 2013年第7期 165-165,169页

作者：郈兵徐迎华吕波赵国朋大连理工大学电信学部辽宁大连116024

随着信息技术的迅速发展,互联网作为一个开发和使用信息资源的全球性网络,其影响日益广泛,并且在我们的学习工作生活中发挥着越来越重要的作用。面对网络信息时代的巨大冲击与挑战,高校应该充分利用计算机网络的强大功能,及时开辟高校... 详细信息

随着信息技术的迅速发展,互联网作为一个开发和使用信息资源的全球性网络,其影响日益广泛,并且在我们的学习工作生活中发挥着越来越重要的作用。面对网络信息时代的巨大冲击与挑战,高校应该充分利用计算机网络的强大功能,及时开辟高校网络党建的新平台,做到党建的有效性和针对性,确保高校党建的重要阵地。如何发挥互联网络在大学生党建工作中的积极的作用,是高校党组织当前加强与开展大学生党建工作实践中所面临着的一个新的课题。

关键词：高校网络党建实践

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植物中lncRNAs的研究进展

西北植物学报 2018年第3期38卷 582-588页

作者：王艳芳苏婉玉张琳曹绍玉吕霞张应华许俊强云南农业大学园林园艺学院昆明650201 云南农业大学资源与环境学院昆明650201 云南农业大学云南省滇台特色农业产业化工程研究中心昆明650201

随着高通量测序技术的飞速发展,越来越多的lncRNAs在植物中被发现,并具有生物学功能。lncRNAs是长度大于200个核苷酸且不具备编码蛋白质功能的一类RNA分子。目前lncRNAs在动物中的功能、作用机制等方面的研究较深入,lncRNAs不仅在表观... 详细信息

随着高通量测序技术的飞速发展,越来越多的lncRNAs在植物中被发现,并具有生物学功能。lncRNAs是长度大于200个核苷酸且不具备编码蛋白质功能的一类RNA分子。目前lncRNAs在动物中的功能、作用机制等方面的研究较深入,lncRNAs不仅在表观遗传水平、转录水平、转录后水平上调控基因的表达,也参与诸多生命过程调控如基因组印迹、染色体重塑、转录激活等。在植物中虽有关于lncRNAs的研究,但由于缺乏有效的技术方法而相对滞后。该文就近几年来国内外关于植物lncRNAs的来源、结构特征、分类、功能等方面的研究进展进行综述,为进一步理解和研究植物中lncRNAs的功能和分子机制提供参考。

关键词： lncRNA 来源结构特征分类植物

Second-trimester maternal body composition,dietary intakes and risk of gestational diabetes mellitus in Chinese women

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Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

第十四届全国临床营养学术会议

作者： Qing XU Zhiying GAO Lu WANG Qian ZHANG Yue TENG Xia ZHAO Sheng GE Hongjiang JING Yongtao YANG Xiaojun LIU Chunjian lv Lun MAO Xiaoming YU yinghua LIU Aijing KONG Xueyan YANG Zhao LIU Yong ZHANG Jin WANG Xinsheng ZHANG Rongxin ZHANG Jing LI Changyong XUE Department of Nutrition Chinese PLA General Hospital Department of Gynaecology and Obstetrics Chinese PLA General Hospital Department of Nutrition Beijing Hospital Department of Nutrition Beijing Tongren Hospital Department of Nutrition Haidian District Health Center for Women and Children Department of Nutrition Jishuitan Hospital Department of Nutrition Sixth People's Hospital Shanghai Department of Nutrition Chinese Air Force General Hospital Department of Nutrition People's Hospital of Sichuan Province Department of Nutrition Bethune International Peace Hospital Department of Nutrition No.304 PLA Hospital

Objectives:To investigate the relationships among second-trimester maternal body composition,dietary intakes and the risk of gestational diabetes mellitus(GDM).Research design and methods:This was a prospective cohort study of subjects enrolled in Chinese pregnant women were free of recognized *** subjects were the 154 women who developed GDM(classified by the International Association of Diabetes and Pregnancy Study Groups criterion at 24-28 weeks of gestation),control subjects were the 981 women who do not developed GDM in the *** bioelectrical impedance analysis were used to detect the body composition and a dietary survey(24-hour dietary recall on 3 consecutive days) was used to evaluate the intake of energy,protein,fat,carbohydrate and dietary fibers in the subjects at21-24 weeks of gestation,*** regression analysis was used to explore the relationships among maternal body composition,dietary intakes and the risk of ***:Maternal age,pregravidic weight and BMI were associated with an increased risk of *** with the lowest quartile of body weight(BW) in 21-24 weeks of gestation,the risk of GDM increased with rising quartile(P<0.01) after adjustment for maternal age,pregravidic weight and *** results were also be found in fat mass(FM),body fat percentage(BFP),extracellular water(ECW),BMI,dietary intakes of energy,protein,fat and *** contrast,compared with the lowest quartile of fat free mass(FFM),the risk of GDM decreased with rising quartile(P<0.01),and as same as lean body mass(LBM) and intracellular water(ICW).Conclusions:Our study shows that the high level of BW,BMI,FM,FBP and ECW,and the dietary intakes of energy,protein,fat and carbohydrates at the second-trimester pregnancy increased the risks of *** high level of FFM,LBM and ICW decreased the risks of GDM.

关键词： gestational diabetes mellitus body composition dietary intakes

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Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun Lu Xiaorong Dong Hong Jian Jianhua Chen Gongyan Chen Yuping Sun yinghua Ji ZipingWang Jianhua Shi Junguo Lu Shaoshui Chen Dongqing lv Guojun Zhang Chunling Liu Juan Li Xinmin Yu Zhong Lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa Jie Hu Nong Yang Xiangdong Zhou XiaohongWu Chengping Hu Zhihong Zhang You Lu Yanping Hu Liyan Jiang Qiming wang Renhua Guo Jianying Zhou Baolan Li Chunhong Hu Wancheng Tong Helong Zhang LinMa Yuan Chen Zhijun Jie Yu Yao Longzhen Zhang JieWeng Weidong Li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili Sun HongyingWei JiaweiWei Zheyu Zhang QiongWu Department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Oncology Jinan Central HospitalJinanShandongP.R.China Department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China Department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China Department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China Department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China Department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China Department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China Department of Oncology Shandong Cancer HospitalJinanShandongP.R.China Department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China Department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China Department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,*** risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

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离子液体及其在石油化工中的应用

广东化工 2007年第9期34卷 24-27页

作者：郭红霞芮玉兰梁英华吕敬德河北理工大学化工与生物技术学院河北唐山063009

离子液体即在室温或接近室温下呈液态的、完全由离子构成的物质,作为环境友好和"可设计性"溶剂正在引起越来越多的重视。它具有熔点低、蒸气压小、酸性可调及良好的溶解度、粘度和密度等特点。本文综述了离子液体的组成、分类、性质、... 详细信息

离子液体即在室温或接近室温下呈液态的、完全由离子构成的物质,作为环境友好和"可设计性"溶剂正在引起越来越多的重视。它具有熔点低、蒸气压小、酸性可调及良好的溶解度、粘度和密度等特点。本文综述了离子液体的组成、分类、性质、制备和纯化,详细说明了其在石油化工中的应用,如在烷基化、氢化、脱硫等反应中的应用。

关键词：离子液体性质制备纯化石油化工

The association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus during second-trimester in Chinese women

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The association of maternal body composition and dietary int...

第十二届全国营养科学大会

作者： Xu Qing Gao Zhiying Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hongjiang Yang Yongtao Liu Xiaojun lv Chunjian Mao Lun Yu Xiaoming Liu yinghua Kong Aijing Yang Xueyan Liu Zhao Zhang Yong Wang Jin Zhang Xinsheng Zhang Rongxin Li Jing Xue Changyong Lu Yanping Department of Nutrition Chinese PLA General Hospital Department of Gynaecology and Obstetrics Chinese PLA General Hospital Department of Nutrition Beijing Hospital Department of Nutrition Beijing Tongren Hospital Department of Nutrition Haidian District Health Center for Women and Children Department of Nutrition Jishuitan Hospital

Objectives To investigate the association of second-trimester maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM).Methods In this prospective cohort study,Chinese pregnant ...

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铆钉电触头接触温升与接触电阻特性研究

电器与能效管理技术 2015年第4期 7-11,26页

作者：任万滨支宏旭付颖华吕超翟国富哈尔滨工业大学军用电器研究所黑龙江哈尔滨150001 桂林航天电子有限公司广西桂林541002 哈尔滨工业大学电气工程及自动化学院黑龙江哈尔滨150001

铆钉触头材料的接触温升与接触电阻直接关系到电气连接的可靠性。通过设计触头材料电接触试验系统,实现了球-平面电接触对接触温升与接触电阻的测量方法,从而研究了接触压力和电流对于稳定温升和热时间常数的影响。为获得接触斑点的发... 详细信息

铆钉触头材料的接触温升与接触电阻直接关系到电气连接的可靠性。通过设计触头材料电接触试验系统,实现了球-平面电接触对接触温升与接触电阻的测量方法,从而研究了接触压力和电流对于稳定温升和热时间常数的影响。为获得接触斑点的发热状态,应用COMSOL Multiphysics有限元软件建立了包含触头对、触头夹具及热电偶的多物理场耦合仿真分析模型,根据试验环境确定了仿真边界条件,进而分析了膜电阻、接触压力和电流对于斑点稳定温升的影响。

关键词：电接触电触头接触温升接触电阻有限元仿真

黄连解毒汤对阿尔茨海默病小鼠闭锁小带蛋白表达的影响

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智慧健康 2022年第11期8卷 190-192,196页

作者：吕翰林张英华樊丽周建文李洋齐齐哈尔医学院附属第一医院黑龙江齐齐哈尔161041 齐齐哈尔医学院精神卫生学院黑龙江齐齐哈尔161006 齐齐哈尔医学院医药科学研究院黑龙江齐齐哈尔161006

目的通过观察黄连解毒汤(huanglian jiedutang,HLJDT)对APP/PS1双转基因小鼠闭锁小带蛋白(ZO-1)表达的影响,探究其对阿尔茨海默病的保护机制。方法将APP/PS1双转基因小鼠随机分为6组:模型组、多奈哌齐组(2 mg·kg^(-1)·d^(-1))、黄连... 详细信息

目的通过观察黄连解毒汤(huanglian jiedutang,HLJDT)对APP/PS1双转基因小鼠闭锁小带蛋白(ZO-1)表达的影响,探究其对阿尔茨海默病的保护机制。方法将APP/PS1双转基因小鼠随机分为6组:模型组、多奈哌齐组(2 mg·kg^(-1)·d^(-1))、黄连解毒汤低、中、高剂量(1.5、3、6)g·kg^(-1)·d^(-1),C57BL/6小鼠为正常组,每组8只。采用Morris水迷宫检测小鼠学习记忆能力,采用Western blot实验对小鼠海马区β-淀粉样蛋白(Aβ)和ZO-1蛋白进行检测,采用实时荧光定量PCR技术对海马区Aβ和ZO-1 mRNA表达进行检测。结果与正常组比较,模型组小鼠的穿越平台次数明显减少(P<0.05),目标象限游程明显减少(P<0.05),Aβ蛋白表达明显增加(P<0.05),ZO-1蛋白表达明显减少(P<0.05),AβmRNA表达明显增加(P<0.05),ZO^(-1) mRNA表达明显减少;与模型组比较,多奈哌齐组和HLJDT高剂量组小鼠穿越平台次数明显增加(P<0.05),目标象限游程明显增加(P<0.05),Aβ蛋白表达明显减少(P<0.05),ZO-1蛋白表达明显增加(P<0.05),AβmRNA表达明显减少(P<0.05),ZO-1 mRNA表达明显增加。结论HLJDT改善小鼠学习记忆能力和对神经保护作用,可能是通过降低Aβ表达,升高ZO^(-1)表达实现的。

关键词：黄连解毒汤 β-淀粉样蛋白(Aβ) 闭锁小带蛋白(ZO-1)