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Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults

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Neuroscience Bulletin 2014年第2期30卷 172-184页

作者： Jing Yu Tao Su Ting Zhou yingge he Jing Lu Juan Li Rongqiao he Center on Ageing Psychology Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Faculty of Psychology Southwest University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences The University of Chinese Academy of Sciences

Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography （n = 604）, and general cognitive abilities were measured using the Montreal Cognitive Assessment （MoCA）. Demographic characteristics, in terms of age, gender, residential region, and education were taken into consideration. We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features： higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impairedthe processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment.

关键词： uric formaldehyde the MontrealCognitive Assessment education learning livingregion

Autofluorescence of MDA-modified proteins as an in vitro and in vivo probe in oxidative stress analysis

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Protein & Cell 2014年第6期5卷 484-487页

作者： Qiang, Min Xu, Yajie Lu, Yang he, yingge Han, Chanshuai Liu, Ying he, Rongqiao Chinese Acad Sci Inst Biophys State Key Lab Brain & Cognit Sci Beijing 100101 Peoples R China Chinese Acad Sci Inst Psychol Key Lab Mental Hlth Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Malondialdehyde （MDA） is regarded as a biomarker for oxidative stress （Del Rio et al., 2005; Stancliffe et al., 2011 ）, and is generated in the oxidative degradation process of polyunsaturated lipids （Stancliffe et al., 2011）. This compound, a reactive electrophile species, contains two aldehyde groups and exhibits cytotoxic effects. As a product of lipid peroxidation, MDA was found to accumulate during many pathophysiological processes （Miller et al., 2011 ）,

关键词： Bovine Serum Albumin Coomassie Brilliant Blue Staining Bovine Serum Albumin Sample Oxidative Stress Analysis Oxidative Degradation Process

Correlation and Pathway Analysis of the Carbon,Nitrogen,and Phosphorus in Soil-Microorganism-Plant with Main Quality Components of Tea(Camellia sinensis)

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 487-502页

作者： Chun Mao Ji he Xuefeng Wen Yangzhou Xiang Jihong Feng yingge Shu College of Agriculture Guizhou UniversityGuiyangChina School of Geography and Resources Guizhou Education UniversityGuiyangChina

The contents of carbon(C),nitrogen(N),and phosphorus(P)in soil-microorganisms-plant signiﬁcantly affect tea quality by altering the main quality components of tea,such as tea polyphenols,amino acids,and ***,few studies have quantiﬁed the effects of these factors on the main quality components of *** study aimed to explore the interactions of C,N,and P in soil-microorganisms-plants and the effects of these factors on the main quality components of tea by using the path analysis *** results indicated that(1)The contents of C,N,and P in soil,microorganisms,and tea plants were highly correlated and collinear,and showed signiﬁcant correlations with the main quality components of tea.(2)Optimal regression equations were established to esti-mate tea polyphenol,amino acid,catechin,caffeine,and water extract content based on C,N,and P contents in soil,microorganisms,and tea plants(R^(2)=0.923,0.726,0.954,0.848,and 0.883,respectively).(3)Pathway analysis showed that microbial biomass phosphorus(MBP),root phosphorus,branch nitrogen,and microbial biomass carbon(MBC)were the largest direct impact factors on tea polyphenol,catechin,water extracts,amino acid,and caffeine content,*** carbon,root phosphorus,and leaf nitrogen were the largest indirect impact factors on tea polyphenol,catechin,and water extract content,*** carbon indirectly affected tea polyphenol content mainly by altering MBP *** phosphorus indirectly affected catechin content mainly by altering soil organic carbon *** nitrogen indirectly affected water extract content mainly by altering branch nitrogen *** research results provide the scientiﬁc basis for reasonable fertilization in tea gardens and tea quality improvement.

关键词： Soil-microorganisms-plant system carbon nitrogen phosphorus tea quality path analysis

MEA-PRA分光光度法测定大气中的SO_2

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天然气工业 1989年第3期9卷 78-82页

作者：贺英阁四川石油管理局天然气研究所

本文提出的MEA-PRA分光光度法适用于油气勘探开发企业内的大气污染例行监测,尤其是SO_2污染较产重的天然气净化厂和热电厂及类似企业。1986年被石油部门推荐为油气田环境监测试行分析方法,该法不仅克服目前国内外已沿用多年的TCM法的两... 详细信息

本文提出的MEA-PRA分光光度法适用于油气勘探开发企业内的大气污染例行监测,尤其是SO_2污染较产重的天然气净化厂和热电厂及类似企业。1986年被石油部门推荐为油气田环境监测试行分析方法,该法不仅克服目前国内外已沿用多年的TCM法的两大缺点,并保持了TCM法灵敏度高,选择性好,简便易行等优点。

关键词：分光光度法大气监测 SO2

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矿工习惯性违章行为风险态势评估

中国安全科学学报 2020年第12期30卷 62-69页

作者：贺莹鸽连民杰江松苏梦哲西安建筑科技大学管理学院陕西西安710055 中钢矿业开发有限公司北京100080

为减少由矿工习惯性违章行为引发的安全事故,考虑到这种行为具有随机性与不确定性,通过模糊层次分析法(FAHP)与信息熵(IE)理论相结合的方法,确定评价指标的客观权重;将风险级别划分为由低到高5个等级,采用五元联系数构建矿工习惯性违章... 详细信息

为减少由矿工习惯性违章行为引发的安全事故,考虑到这种行为具有随机性与不确定性,通过模糊层次分析法(FAHP)与信息熵(IE)理论相结合的方法,确定评价指标的客观权重;将风险级别划分为由低到高5个等级,采用五元联系数构建矿工习惯性违章行为风险态势评估模型;以陕西省某煤矿为例,探讨矿工习惯性违章行为风险变化趋势。结果表明:组织管理和作业环境是矿工习惯性违章行为发生的重要原因,矿工习惯性违章行为风险是波动变化的,资源管理不当、组织文化宣传不足、浮游煤尘多、工作倦怠等指标的集对势较小,风险程度较高,应予以重视。

关键词：矿工习惯性违章行为风险态势模糊层次分析法(FAHP) 信息熵(IE) 五元联系数

超浸润性可逆切换的超双疏复合海绵材料的制备及油水分离应用

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复合材料学报 2021年第3期38卷 854-862页

作者：何影格陈媛媛刘维仪张延宗四川农业大学环境学院成都611130 四川省农村环境技术保护工程技术中心成都611130

通过简单的溶胶-凝胶法制备了全氟癸基三甲氧基硅烷(PFDMS)-正癸酸(DA)-TiO_(2)溶液,经浸泡后得到PFDMS-DA-TiO_(2)超双疏海绵。PFDMS-DA-TiO_(2)超双疏海绵在质量分数为25wt%~28wt%的氨气诱导下,表面浸润性由超双疏切换为超亲水-空气... 详细信息

通过简单的溶胶-凝胶法制备了全氟癸基三甲氧基硅烷(PFDMS)-正癸酸(DA)-TiO_(2)溶液,经浸泡后得到PFDMS-DA-TiO_(2)超双疏海绵。PFDMS-DA-TiO_(2)超双疏海绵在质量分数为25wt%~28wt%的氨气诱导下,表面浸润性由超双疏切换为超亲水-空气中超疏油。利用FTIR和SEM对改性前后PFDMS-DA-TiO_(2)海绵表面进行表征,分析其化学组成和表面形貌,研究了DA的体积比对PFDMS-DA-TiO_(2)超双疏海绵表面浸润性可逆切换效果的影响,并对其耐盐性、耐磨性及油水分离性能进行了测试。结果表明:DA的最佳体积比为5.8%,其油水分离效率与通量分别可达99.6%、4 775 L/(m^(2)·h)。PFDMS-DA-TiO_(2)超双疏海绵经磨损实验及在质量分数为3.5wt%的NaCl溶液中浸泡12 h后,均保持优异的超双疏性能,表现出较高的耐磨性和耐盐性。经氨气诱导,其表面浸润性在超双疏与超亲水-空气中超疏油之间可逆切换20次后,两种润湿性能仍能各自保持稳定,可用于实际工业中高效可控地分离油水混合物。

关键词：聚氨酯海绵超亲水-空气中超疏油超双疏氨气诱导油水分离

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两种铸造缺陷在精加工后的补救方法

现代制造技术与装备 2016年第6期52卷 117-118页

作者：和颍歌河南省许昌电气职业学院(许昌技师学院) 许昌461000

机械产品中,有相当大比重的箱体类和机座类零件采用铸造毛坯。这类零件的外形和内腔结构复杂,不规则,加工时精度要求高。此类铸件多为单件、小批量生产,受生产条件、工艺流程等多方面因素的影响,气孔、夹砂、裂纹等铸造缺陷多有发生。同... 详细信息

机械产品中,有相当大比重的箱体类和机座类零件采用铸造毛坯。这类零件的外形和内腔结构复杂,不规则,加工时精度要求高。此类铸件多为单件、小批量生产,受生产条件、工艺流程等多方面因素的影响,气孔、夹砂、裂纹等铸造缺陷多有发生。同时,缺陷的位置又比较深,许多缺陷不能及时发现而流入精加工工序,严重影响零件质量。因此,本文主要介绍两种铸造缺陷在精加工阶段采取的挽救措施,以有效提高产品质量,保证生产进度,降低生产成本。

关键词：精加工铸造缺陷小孔修复单一裂纹

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内蒙古草原灌丛化对土壤真菌群落的影响

应用与环境生物学报 2024年第2期30卷 271-280页

作者：刘莺歌李欢欢于世永李贺江苏师范大学地理测绘与城乡规划学院徐州221116

草原灌丛化在全球干旱半干旱地区生态系统中普遍发生,并对草地生态系统的养分循环和植被组成产生显著影响;真菌群落作为土壤养分积累与转化、植物体生长与繁殖的关键调控因子,如何响应草原灌丛化目前尚不明确.以内蒙古地区典型的灌丛化... 详细信息

草原灌丛化在全球干旱半干旱地区生态系统中普遍发生,并对草地生态系统的养分循环和植被组成产生显著影响;真菌群落作为土壤养分积累与转化、植物体生长与繁殖的关键调控因子,如何响应草原灌丛化目前尚不明确.以内蒙古地区典型的灌丛化草原为研究对象,选取与其配对的纯草原作为对照,采用高通量测序技术分析草原灌丛化对土壤真菌群落结构和功能的影响.所有已鉴别的土壤真菌隶属4门、10纲、18目、28科、29属,土壤真菌Sobs指数、Shannon指数、Ace指数和Chao1指数在0-10 cm和10-20 cm两个土壤深度下均为灌丛化草原>纯草原;土壤真菌群落组成有明显差异,例如镰刀菌属(Fusarium,+19.51%)、粗糙孔菌属(Trechispora,+16.20%)等真菌属在灌丛化草原中的相对丰度上升,而未分类子囊菌属(unclassified_p__Ascomycota,-19.30%)、角担菌属(Ceratobasidium,-13.20%)等真菌属的相对丰度下降,灌丛化草原土壤真菌群落和纯草原土壤真菌群落之间的差异显著大于其各自群落内部的差异(P<0.05);土壤真菌功能也发生变化,腐生营养和病理营养功能增加,其中木质腐生真菌增幅最大;另外还发现,土壤pH、有机碳、全氮和全磷是影响草原土壤真菌群落结构的主导因子.本研究表明草原灌丛化会显著影响内蒙古地区草原的土壤真菌群落的结构和功能.(图5表2参61)

关键词：草原灌丛化土壤真菌群落结构环境因子功能预测

抗凝与其联合介入方法治疗重症颅内静脉血栓形成

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中国介入影像与治疗学 2024年第5期21卷 276-280页

作者：徐振何浩许莺歌闫磊张松朱明吴垠垠水少锋郑州大学第一附属医院介入科河南郑州450052

目的对比单纯抗凝与其联合介入方法治疗重症颅内静脉血栓形成(CVT)的效果。方法根据治疗方法将65例重症CVT患者纳入抗凝组(n=32)或联合组(n=33),比较组间入院、出院时改良Rankin量表(mRS)评分、患者预后、血管再通率,以及随访期间并发... 详细信息

目的对比单纯抗凝与其联合介入方法治疗重症颅内静脉血栓形成(CVT)的效果。方法根据治疗方法将65例重症CVT患者纳入抗凝组(n=32)或联合组(n=33),比较组间入院、出院时改良Rankin量表(mRS)评分、患者预后、血管再通率,以及随访期间并发症发生率。结果组间入院时mRS评分差异无统计学意义(P>0.05);联合组出院时mRS评分低于抗凝组(P0.05)。结论对于重症CVT患者,相比单纯抗凝,以抗凝联合介入方法进行治疗可明显减轻症状、改善预后。

关键词：脑静脉颅内血栓形成溶栓疗法血栓切除术