检索结果-南通市图书馆

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu Yan-Ping guo Yan-Mei Lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

Effects of Malnutrition on Child Survival in China As Estimated by PROFILES

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2003年第2期16卷 187-193页

作者： JAYROSS CHUN-MINGCHEN WUHE GANGFU YU-YINGWANG ZHEN-yingfu MING-XIACHEN TheAcademyforEducationalDevelopment WashingtonDCUSA ChineseCenterforDiseaseControlandPrevention Beijing100050China

To estimate the benefits of reductions in underweight and Vitamin A deficiency for child survival in China that might be expected as a result of lowering the prevalence of these conditions. Methods Profiles, a process of nutrition policy analysis was used to quantify the functional consequences of malnutrition in terms of child survival. Results Underweight The actual reduction in underweight between 1992 and 2001 (from 15.7% to the current 10.1 %) resulted in saving of 176 000 child lives. As estimated, without improvements, 612 000 children will die due to underweight between 2001 and 2010, 281 000 (46%) of them living in western provinces. Reducing underweight prevalence from 10.1% to 8% could overall save 62 000 lives. The reduction of underweight prevalence in the west alone might save 56 000 lives. Vitamin A in China as a whole, vitamin A deficiency accounts, as estimated, for 7.5% of deaths of children 6-59 months old, representing 206 000 deaths over the past ten years. Halving the prevalence over the period would save 49 000 child lives. The higher prevalence and higher mortality rates in western provinces mean that even with only 28% of the Chinese population, over half of child deaths there are related to vitamin A.

关键词： PROFILES Malnutrition Vitamin A Underweight

Inhibitory effects of berberine on ion channels of rat hepatocytes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2004年第19期10卷 2842-2845页

作者： FangWang Hong-YiZhou GangZhao Li-yingfu LanCheng Jian-guoChen Wei-XingYao DepartmentofPharmacology TongjiMedicalCollegeofHuazhongUniversityofScienceandTechnologyWuhan430030HubeiProvinceChina PancreaticSurgeryCenter UnionHospitalTongjiMedicalCollegeofHuazhongUniversityofScienceandTechnologyWuhan430022HubeiProvinceChina

AIM: To examine the effects of berberine, an isoquinoline alkaloid with a long history used as a tonic remedy for liver and heart, on ion channels of isolated rat ***: Tight-seal whole-cell patch-clamp techniques were performed to investigate the effects of berberine on the delayed outward potassium currents (Ik), inward rectifier potassium currents (Ik1) and Ca^2+ release-activated Ca^+ currents (ICRAC) in enzymatically isolated rat ***: Berbenne 1-300 μmol/L reduced/K in a concentration-dependent manner with EC50 of 38.86=1=5.37 μmol/L and nH of 0.82±0.05 (n = 8). When the bath solution was changed to tetraethylammonium (TEA) 8 retool/L,IK was *** 30 μmol/L reduced/K at all examined membranepote ntials, especially at potentials positive to +60 mV (n = 8,P<0.05 or P<0.01 vs control). Berberine had mild inhibitory effects on IK1 in rat hepatocytes. Berberine 1-300 μmol/L also inhibited ICRAC in a concentration-dependent fashion. The fitting parameters were EC50 = 47.20±10.86 μmol/L,nH= 0.71±0.09 (n = 8). The peak value of/CRAC in the I-Vrelationship was decreased by berberine 30 μmol/L at potentialnegative to -80 mV (n = 8, P<0.05 vscontrol). But the reverse potential of/CRAC occurred at voltage 0 mV in all ***: Berberine has inhibitory effects on potassium and calcium currents in isolated rat hepatocytes, which may be involved in hepatoprotection.

关键词：抑制作用黄连素离子通路老鼠肝细胞钾离子

Electrophysiological effects of anthopleurin-Q on rat hepatocytes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2004年第1期10卷 96-99页

作者： Hong-YiZhou FangWang Ke-QiangZhang LanCheng JiZhou Li-yingfu Wei-XingYao DepartmentofPharmacology TongjiMedicalCollegeofHuazhongUniversityofScienceandTechnologyWuhan430030HubeiProvinceChina DepartmentofInfectiousDiseases JianghanOilFieldCentralHospitalQianjiang433124HubeiProvinceChina

AIM: To study the effects of AP-Q on CCl4-induced acute liver injury, delayed outward potassium current (Iκ), inward rectifier potassium current (Iκ1) and calcium release-activated calcium current (ICRAC) in isolated rat hepatocytes. METHODS: A single dose of CCl4 (10 μg/mL, ip) was injected to induce acute liver injury in rats. Serum aminotransferase activities were determined. Whole cell patch-clamp techniques were used to investigate the effects of AP-Q on delayed outward potassium current (Iκ), inward rectifier potassium current (IKI) and calcium release-activated calcium current (ICRAC). RESULTS: AP-Q (3.5 and 7 μg/kg) pretreatment significantly reduced ALT and AST activities. AP-Q 0.1-100 nM produced a concentration-dependent increase of Iκ with EC50 value of 5.55±1.8 nM (n=6). AP-Q 30 nM shifted the I-V curve of Iκ leftward and upward. CCl4 4 mM decreased Iκ current 28.6±0.5% at 140 mV. After exposure to CCl4 for 5 rain, AP-Q 30 nM attenuated the decrease of Iκ induced by CCl4 close to normal amplitude. AP-Q 0.01-100 nM had no significant effect on either inward or outward components of Iκ1 at any membrane potential examined. AP-Q 0.1-100 nM had no significant influence on the peak amplitude of ICRAC, either,and did not affect the shape of its current voltage curve. CONCLUSION: AP-Q has a protective effect on CCl4-induced liver injury, probably through selectively increased Iκ in hepatocytes.

关键词：海葵素-Q 肝实质细胞电生理学动物实验肝功能生物化学

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

在线全文

学校读者我要写书评

暂无评论

习近平文化思想的创新性理论

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 7-15,F0002页

作者：张国祚湖南大学中国文化软实力研究中心湖南大学马克思主义学院湖南长沙410012

习近平文化思想是对马克思主义经典作家文化理论的继承、丰富和发展,是对中华优秀传统文化的创造性转化和创新性发展,是中国化时代化的马克思主义文化理论的最新成果,使马克思主义文化理论达到新高度。习近平文化思想的新成果、新高度... 详细信息

习近平文化思想是对马克思主义经典作家文化理论的继承、丰富和发展,是对中华优秀传统文化的创造性转化和创新性发展,是中国化时代化的马克思主义文化理论的最新成果,使马克思主义文化理论达到新高度。习近平文化思想的新成果、新高度充满理论创新性。文本认为,应从关于宣传思想文化工作战略定位的新概括,关于开辟马克思主义中国化时代化新境界必须遵循的原理,关于理论武装工作要在“真”与“化”上下功夫,关于明确意识形态建设的新重点,关于社会主义核心价值观的新阐发,关于文化自信的深刻阐发,关于文化建设必须遵循的原则,关于中华优秀传统文化的时代价值及其赓续的深刻阐发,关于提出构建中国特色哲学社会科学系统思想,关于新闻舆论工作意义、成效的重要论述,关于旗帜鲜明开展文艺批评的新论述,关于办好思政课的系统论述,关于精神文明建设的新坐标,关于人类文明互鉴的新倡议,关于网络文化建设的系统论述等方面理解习近平文化思想的理论创新。

关键词：习近平文化思想马克思主义中国化时代化文化自信创新性价值意蕴

超临界循环流化床锅炉深度调峰时水冷壁流动不稳定特性计算分析

在线全文

学校读者我要写书评

暂无评论

西安交通大学学报 2025年第1期59卷 68-77,92页

作者：李维腾郭泽瑞韩磊杨冬西安交通大学动力工程多相流国家重点实验室西安710049

针对深度调峰时超临界循环流化床锅炉水冷壁管道内的汽液两相流动不稳定问题,提出了一种适用于不同工况的频域法数学模型。通过对质量、能量、动量方程进行小扰动线性化后经拉普拉斯变换得到了用于描述管道内汽液流体流动稳定性的传递函... 详细信息

针对深度调峰时超临界循环流化床锅炉水冷壁管道内的汽液两相流动不稳定问题,提出了一种适用于不同工况的频域法数学模型。通过对质量、能量、动量方程进行小扰动线性化后经拉普拉斯变换得到了用于描述管道内汽液流体流动稳定性的传递函数,通过图解奈奎斯特图的方法判断管内工质流动的稳定性。然后,通过该模型计算了某350 MW超临界循环流化床锅炉水冷壁管段的不稳定边界并研究了不同参数对流动不稳定特性的影响。计算结果表明:所选回路在20%和50%锅炉最大连续蒸发量负荷发生流动不稳定时,热负荷分别为76.09 kW·m-2和113.52 kW·m-2,水冷壁管道流动稳定且安全;入口过冷度对临界热流密度的影响呈非单值性;增大质量流速使流体的进口和出口密度差减小,有利于流动的稳定;增大入口节流系数,可以抑制入口处流量的脉动,有利于流动的稳定;在不同的工况条件下,改变管段倾斜角度会对流动稳定性产生不同的影响。

关键词：深度调峰流动不稳定性频域法超临界循环流化床锅炉

同方期刊数据库

Horizontal well spacing optimization and gas injection simulation for the ultra-low-permeability Yongjin reservoir

在线全文

学校读者我要写书评

暂无评论

Energy Geoscience 2024年第1期5卷 196-203页

作者： Yao Zhang Chengyuan Lv Zengmin Lun Shuxia Zhao yingfu He Ran Gao SINOPEC Exploration and Production Research Institute BeijingChina

Optimal spacing for vertical wells can be effectively predicted with several published methods,but methods suitable for assessing the proper horizontal well spacing are *** work proposes a method for calculating the optimal horizontal well spacing for an ultra-low permeability reservoir e the Yongjin reservoir in the Juggar Basin,northwestern *** result shows that a spacing of 640m is the most economical for the development of the *** better develop the reservoir,simulation approaches are used and a new model is built based on the calculated well *** the reservoir has an ultralow permeability,gas injection is regarded as the preferred enhanced oil recovery(EOR)*** of different gases including carbon dioxide,methane,nitrogen and mixed gas are *** results show that carbon dioxide injection is the most efficient and economical for the development of the ***,if the reservoir produces enough methane,reinjecting methane is even better than injecting carbon dioxide.

关键词： Ultra-low-permeability reservoir Well spacing optimization Numerical simulation Gas injection EOR

Optimal Reordering Trace Files for Improving Software Testing Suitcase

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2021年第4期67卷 1225-1239页

作者： yingfu Cai Sultan Noman Qasem Harish Garg Hamïd Parvïn Kim-Hung Pho Zulkefli Mansor School of Measurement and Communication Harbin University of Science&TechnologyHarbinChina Computer Science Department College of Computer and Information SciencesAl Imam Mohammad Ibn Saud Islamic University(IMSIU)RiyadhSaudi Arabia Department of Computer Science Faculty of Applied ScienceTaiz UniversityTaizYemen School of Mathematics Thapar Institute of Engineering and TechnologyDeemed UniversityPatiala147004India Institute of Research and Development Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam Department of Computer Science Nourabad Mamasani BranchIslamic Azad UniversityMamasaniIran Fractional Calculus Optimization and Algebra Research GroupFaculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh CityVietnam Fakulti Teknologi dan Sains Maklumat Universiti Kebangsan MalaysiaUKM BangiSelangor43600Malaysia

An invariant can be described as an essential relationship between program *** invariants are very useful in software checking and *** tools that are used to detect invariants are invariant *** are two types of invariant detectors:dynamic invariant detectors and static invariant *** software is an available computer program that implements a special case of a dynamic invariant detection *** proposes a dynamic invariant detection algorithm based on several runs of the tested program;then,it gathers the values of its variables,and finally,it detects relationships between the variables based on a simple statistical *** method has some *** of its biggest drawbacks is its overwhelming time *** is observed that the runtime for the Daikon invariant detection tool is dependent on the ordering of traces in the trace file.A mechanism is proposed in order to reduce differences in adjacent trace *** is done by applying some special techniques of mutation/crossover in genetic algorithm(GA).An experiment is run to assess the benefits of this *** findings reveal that the runtime of the proposed dynamic invariant detection algorithm is superior to the main approach with respect to these improvements.

关键词： Dynamic invariant detection software testing genetic algorithm