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中华医学杂志(英文版) 2024年第7期137卷 757-761页

作者： ao yingfang Yan Wenqiang Wu Yue Institute of Sports Medicine of Peking University Beijing 100191 China

Effects of visual restoration on gait performance and kinematics of lower extremities in patients with age-related cataract

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Chinese Medical Journal 2023年第5期136卷 596-603页

作者： Mingxin ao Huijuan Shi Xuemin Li Hongshi Huang yingfang ao Wei Wang Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third HospitalBeijing 100191China Department of Sports Medicine Institute of Sports Medicine of Peking UniversityBeijing Key Laboratory of Sports InjuriesPeking University Third HospitalBeijing 100191China.

Background:Visual inputs are critical for locomotor navigation and sensorimotor integration in the elderly;however,the mechanism needs to be explored intensively.The present study assessed the gait pattern after cataract surgery to investigate the effects of visual restoration on locomotion.Methods:The prospective study recruited 32 patients(70.1±5.2 years)with bilateral age-related cataracts in the Department of Ophthalmology at Peking University Third Hospital from October 2016 to December 2019.The temporal-spatial gait parameters and kinematic parameters were measured by the Footscan system and inertial measurement units.Paired t-test was employed to compare data normally distributed and Wilcoxon rank-sum test for non-normally distributed.Results:After visual restoration,the walking speed increased by 9.3%(1.19±0.40 m/s vs.1.09±0.34 m/s,P=0.008)and exhibited an efficient gait pattern with significant decrease in gait cycle(1.02±0.08 s vs.1.04±0.07 s,P=0.012),stance time(0.66±0.06 s vs.0.68±0.06 s,P=0.045),and single support time(0.36±0.03 s vs.0.37±0.02 s,P=0.011).High amplitude of joint motion was detected in the sagittal plane in the left hip(37.6°±5.3°vs.35.5°±6.2°,P=0.014),left thigh(38.0°±5.2°vs.36.4°±5.8°,P=0.026),left shank(71.9°±5.7°vs.70.1°±5.6°,P=0.031),and right knee(59.1°±4.8°vs.56.4°±4.8°,P=0.001).The motor symmetry of thigh improved from 8.35±5.30%to 6.30±4.73%(P=0.042).Conclusions:The accelerated gait in response to visual restoration is characterized by decreased stance time and increased range of joint motion.Training programs for improving muscle strength of lower extremities might be helpful to facilitate the adaptation to these changes in gait.

关键词： Biomechanical phenomena Cataract Gait Rehabilitation Visual perception

Posterior hip capsular tenderness test improved the sensitivity and positive predictive value of FADIR test in diagnosing femoroacetabular impingement

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Chinese Medical Journal 2022年第20期135卷 2518-2520页

作者： Guanying Gao Cheng Wang Jianquan Wang yingfang ao Yan Xu Institute of Sports Medicine Peking University Third HospitalBeijing 100191China

To the Editor:Many physical examination tests are used to diagnose femoroacetabular impingement(FAI).The sensitivity and specificity of the flexion,abduction,and external rotation(FABER)test and the flexion,adduction,and internal rotation(FADIR)test for FAI diagnosis are quite different.Therefore,based on clinical practice,we proposed the possibility of adding a physical examination test to improve the accuracy of the traditional physical examinations.

关键词： diagnosis specificity rotation

Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes

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Bioactive Materials 2022年第2期7卷 505-514页

作者： Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu yingfang ao Department of Sports Medicine Institute of Sports Medicine of Peking UniversityBeijing Key Laboratory of Sports InjuriesPeking University Third Hospital49 North Garden RoadHaidian DistrictBeijing100191China Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China

Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy.

关键词： Exosomes Silk fibroin Cryo-sponge Sustained drug delivery Enzyme-responsive

前交叉韧带重建术后三种不同药物镇痛早期疗效的对比

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北京大学学报（医学版） 2024年第2期56卷 293-298页

作者：王江静魏顺依敖英芳杨渝平河北省沧州中西医结合医院河北沧州061001 河北省中西医结合骨关节病研究重点实验室(筹) 河北沧州061001 北京大学第三医院运动医学科北京100191

目的:比较去痛片(复方氨基比林、非那西丁片,商品名去痛片)、盐酸曲马多缓释片(商品名:奇曼丁)及盐酸哌替啶(商品名:杜冷丁)在膝关节前交叉韧带自体肌腱单束重建术后早期的止疼效果及安全性。方法:回顾性分析2018年11月至2019年2月,北... 详细信息

目的:比较去痛片(复方氨基比林、非那西丁片,商品名去痛片)、盐酸曲马多缓释片(商品名:奇曼丁)及盐酸哌替啶(商品名:杜冷丁)在膝关节前交叉韧带自体肌腱单束重建术后早期的止疼效果及安全性。方法:回顾性分析2018年11月至2019年2月,北京大学第三医院连续收治的45例由同一组医师施行膝关节镜下前交叉韧带自体肌腱单束重建术患者,术后疼痛情况和使用药物镇痛情况的临床资料。采用随机区组设计,根据前交叉韧带断裂是否合并半月板损伤将患者分为两组,A组为单纯膝关节前交叉韧带重建的患者24例,B组为前交叉韧带断裂合并半月板损伤的患者21例。两组又根据患者实际使用的术后镇痛药物各分为3组,其中,A组口服去痛片4例、口服奇曼丁11例、肌肉注射(简称肌注)杜冷丁联合盐酸异丙嗪(商品名:非那根)9例;B组口服去痛片3例、口服奇曼丁10例、肌注杜冷丁联合非那根8例。术后早期,患者诉疼痛并主动要求镇痛时随机给予去痛片、奇曼丁或杜冷丁联合非那根这三种不同的止痛药物缓解疼痛,采用疼痛视觉模拟评分(visual analogue scale, VAS)评估疼痛缓解情况,并观察不良反应发生情况。结果:患者在性别、年龄、体重指数、住院时间等基本情况上差异无统计学意义(P>0.05)。应用三种止痛药物缓解疼痛的两组患者,在用药前及用药1 h后通过VAS评分判断结果表明,患者疼痛情况明显缓解,用药前后疼痛差异有统计学意义(P0.05)。应用杜冷丁患者易出现恶心、呕吐等副反应,但应用杜冷丁的同时使用非那根可减少副反应。在不良反应方面,仅单纯前交叉韧带重建组中应用奇曼丁组的患者出现恶心1例,其余各组患者均未出现严重的并发症及过敏反应。结论:无论是单纯交叉韧带重建,还是合并半月板成型或缝合的交叉韧带重建,患者应用去痛片、奇曼丁、杜冷丁联合非那根这三种药物均能有效缓解疼痛,其中杜冷丁对疼痛的缓解幅度最大。应用杜冷丁的同时,合用非那根可有效减轻患者的呕吐、恶心等不良反应,增加用药安全性。

关键词：前交叉韧带重建半月板损伤镇痛镇痛药阿片类

SEMG-based fighter pilot muscle fatigue analysis and operation performance research

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Medicine in Novel Technology and Devices 2022年第4期16卷 345-349页

作者： Biyun Zhou Bo Chen Huijuan Shi Lihao Xue yingfang ao Li Ding Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityNo.37 XueYuan RoadHaiDian DistrictBeijing100191China Institute of Sports Medicine Peking University Third HospitalBeijing Key Laboratory of Sports InjuriesBeijing100191China Biomechanics Laboratory College of Human Movement Science Beijing Sport University Beijing100084China

Fatigue has a tremendously adverse impact on pilot performance.This study aims to explore the Biceps Brachii(BB),Rectus Femoris(RF),Flexor Carpi Radialis(FCR),and Tibialis Anterior(TA)activities of fighter pilots in the early and late combat stages,and the target hitting time.A total of 13 volunteers were recruited to conduct simulated combats inside a real fighter cockpit.The surface Electromyography(sEMG)was collected from all volunteers in the initial and final 20s of flight,and the target hitting time during three simulated combats was recorded.The root mean square(RMS)values of right BB and TA were significantly higher than the left side values(p<0.001),while insignificant differences were found in the RMS values between the bilateral RF and FCR.Compared to the early flight period,the median frequency(MF)values of BB and TA were significantly lower during the late flight period,and the RMS values were significantly higher(p<0.047).Contrastively,the RMS values of FCR and RF differed insignificantly during the late flight period.Regarding the target hitting time,a significant difference was noted between task 1 and rask3.Subjects exhibit varying levels of muscle fatigue for different muscle groups before and after the flight.The muscle fatigue levels are asymmetrical on the left and right sides.Muscle fatigue might reduce the pilots'operational ability.This study provides a reference for fighter pilot fatigue protection and treatment.

关键词： Surface electromyography Flight fatigue Operation performance Daubechies wavelet

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雪上运动创伤救治流程专家共识

科学通报 2023年第18期68卷 2388-2400页

作者：无敖英芳中国雪上运动创伤救治流程专家共识制订工作组中国医师协会运动医学医师分会不详

自中国成功申办和举办2022年北京冬季奥林匹克运动会以来,我国参与雪上运动的人群不断增长.由于雪上运动的高速度和高负荷,运动损伤发生率较高,通常表现为涉及多个器官和系统的多发性创伤,需要临床多学科联合协同开展救治.然而,中国目... 详细信息

自中国成功申办和举办2022年北京冬季奥林匹克运动会以来,我国参与雪上运动的人群不断增长.由于雪上运动的高速度和高负荷,运动损伤发生率较高,通常表现为涉及多个器官和系统的多发性创伤,需要临床多学科联合协同开展救治.然而,中国目前还缺乏针对雪上运动创伤救治的规范指导.为了提高医疗救治效率,最终降低残疾率和死亡率,中国医师协会运动医学医师分会邀请领域内相关专家,经过两轮德尔菲投票和共识会议,制定了“雪上运动创伤救治流程专家共识”(以下简称共识).本共识在总结科学证据、临床实践经验、2022年北京冬季奥林匹克运动会医疗服务经验的基础上,结合中国的具体国情,为建立集院前救援、院内急诊救治、院内专科救治于一体的高效救治网络提出了科学建议.共识的第一部分着重于对现场伤者的快速救援和转运,包括定位伤者、评估伤情、稳定伤者和转运伤者等过程的规范化建议和指导,并探讨了航空医疗救援的开展条件和注意事项.院内救治包括根据院前救治团队预警信息及时启动相应院内预警,从而建立起完整的院前-院内预警联动系统.按照预警级别及伤者信息快速有效地组织专科救治团队,包括神经内科、神经外科、骨科、血管外科、普外科、消化内科、运动医学科、手外科、整形外科及精神科等专家进行接诊和抢救,并再次对伤者进行损伤评估,从而为伤者制定科学性、针对性治疗方案.本共识旨在提高中国雪上运动创伤的医疗救治能力,保障中国竞技性和群众性雪上运动的发展,并为“健康中国”建设作出贡献.

关键词：雪上运动运动创伤医疗救治专家共识

The effects of scaffolds microenvironment on cell-targeting bioactivity of BMSC-affinity peptide for in vivo cartilage regeneration

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The effects of scaffolds microenvironment on cell-targeting ...

Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products

中国生物化学与分子生物学会第十一次会员代表大会暨201...

作者： Hongjie Huang Xin Zhang Xiaoqing Hu Jingxian Zhu Chunyan Zhou yingfang ao Institute of Sports Medicine Peking University Third Hospital Department of Biochemistrya nd Molecular Biology Peking University School of Basic Medical Sciences

Background: Affinity peptide is a kind of short chain polypeptides which play importantbiological activity, like drug/cell targeting, cell interaction or chemotaxis. Our previousstudies found that a heptapeptide(E7, EPLQLKM) has a high specific affinity to bone derived-mesenchymal stem cells(BMSCs) without any species specificity. However, the biologicalactivity of biofactor is highly dependent on the platform materials, which providesthe site for biofunctional implementation as well as affecting cellular function by creatingspecific microenvironments for cell growth and differentiation.Methodology/Principal Findings: This study was designed to evaluate the effects of scaffoldsmicroenvironment on BMSCtargeting bioactivity of affinity peptide for cartilage regeneration.A biphasic material platform was constructed with chitosan hydrogel and a demineralizedbone matrix, which showed superior porosity, equilibrium swelling and biodegradationrate. E7 affinity peptide could be covalently coupled to this biomaterial. Comparedwith scrambled peptide containing the same amino acids as E7(but in a different order),E7 conjugated scaffolds significantly improved BMSC-targeting recruitment and homingin vitro and in vivo. In vitro culture study showed that E7 conjugated scaffolds prompteda significant up-regulated BMSC proliferation and chondrogenic differentiation thancontrol scaffolds, based on DNA quantification, cartilagous matrix production and hyaline-cartilage RNA expression. A rabbit knee cartilage defects model was used to determinethe influence of BMSC-targeting recruitment on cartilage repairing, which showed that,six months after implantation, the E7-conjaguted scaffolds significantly improved thequantity and quality of cartilage regeneration than routine surgery or control scaffolds.These results indicated that affinity peptide and an appropriate microenvironment couldfacilitate cell targeting recruitment, proliferation, differentiation and subsequent tissue regeneration.Conclusions/Significance: E7 peptide sequence

关键词： scaffolds microenvironment cell-targeting affinity peptide functionalb iomaterials cartilage regeneration

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Engineering 2020年第11期6卷 1217-1221页

作者： Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao yingfang ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Science 8 Peking Union Medical CollegeBejjing 100730.China National Engineering Research Center of Light Alloys Net Forming&State Key Laboratony of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Notional Engineering Research Center of Mg Materials and Applicarions and School of Materials Science 8r Engineering.Shanghai Jlao Tong University Shanghai 200240China Department of Spine Surgery Beijing Jishuitan HospitalBeijing 100035China Center for Troanslational Medicine Research and Development Institute of Biomedical and Health EngineeringShenzhen Insitute of Advanced Technology.Chinese Academy of SciencesShenzhen 518055China Guangdong Engineering Laboratony of Biomaterials Additive Manufacturing Guangdong 518055China Musculoskeletal Research Laboratory of the Department of Orthopedics 8 Traumatology and Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077.China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Center for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstiuteShenzhen 518057.China Hong Kong Branch of National Precious Metals Material Engineering Research Center Department of Material Science and EngineeringCity Untiversity of Hong KongHong Kong 999077.China Department of Mechanical Engineering ity Untiversity of Hong Kong.Hong Kong 9977 China School of Pharmacy.Shanghai Jiao Tong University Shanghai 200240China China State Instute of Pharmaceutical Industry Shanghai Institute of Pharmaceutical IndustryShonghai 201203China Shanghai Innovation Instinute for Materials Shanghai 200444.China State Key Laboratory of High-Performance Ceramies and Superfine Microstructure Shanghai Institute of CeramicsChinese Acadermy 0f SciencesShanghai 200050Ch

1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.

关键词： composites printing additive

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前交叉韧带重建术后运动生物力学特征

科技导报 2022年第2期40卷 27-35页

作者：代瑞兰敖英芳天津体育学院社会体育与健康科学学院天津301600 北京大学第三医院运动医学科北京大学运动医学研究所运动医学关节伤病北京市重点实验室北京100191

回顾了前交叉韧带重建术(ACLR)后患者膝关节运动学、动力学改变与功能表现,发现ACLR后患者运动生物力学特征改变主要发生在矢状面,只有在合并其他严重损伤时才会出现冠状面与横断面运动学与动力学改变。ACLR后患者还会存在本体感觉与神... 详细信息

回顾了前交叉韧带重建术(ACLR)后患者膝关节运动学、动力学改变与功能表现,发现ACLR后患者运动生物力学特征改变主要发生在矢状面,只有在合并其他严重损伤时才会出现冠状面与横断面运动学与动力学改变。ACLR后患者还会存在本体感觉与神经肌肉控制改变,提示ACLR后患者康复过程中除了常规康复外,还要额外注重其本体感觉与神经肌肉控制训练。

关键词：前交叉韧带重建运动生物力学神经肌肉控制