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Design and mechanism insight on SiC quantum dots sensitized inverse opal TiO_(2) with superior photocatalytic activities under sunlight

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Frontiers of Chemical Science and Engineering 2023年第12期17卷 1913-1924页

作者： yingchao he Qiong Sun Likun Sun Zhixing Gan Liyan Yu Lifeng Dong College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Center for Future Optoelectronic Functional Materials School of Computer and Electronic InformationNanjing Normal UniversityNanjing 210023China Department of Physics Hamline UniversitySt.PaulMN 55104USA

The combination of SiC quantum dots sensitized inverse opal TiO_(2) photocatalyst is designed in this work and then applied in wastewater purification under simulated sunlight.From various spectroscopic techniques,it is found that electrons transfer directionally from SiC quantum dots to inverse opal TiO_(2),and the energy difference between their conduction/valence bands can reduce the recombination rate of photogenerated carriers and provide a pathway with low interfacial resistance for charge transfer inside the composite.As a result,a typical type-II mechanism is proved to dominate the photoinduced charge transfer process.Meanwhile,the composite achieves excellent photocatalytic performances(the highest apparent kinetic constant of 0.037 min^(-1)),which is 6.2 times(0.006 min^(-1))and 2.1 times(0.018 min^(-1))of the bare inverse opal TiO_(2) and commercial P25 photocatalysts.Therefore,the stability and non-toxicity of SiC quantum dots sensitized inverse opal TiO_(2) composite enables it with great potential in practical photocatalytic applications.

关键词： inverse opal TiO_(2) silicon carbide quantum dots quantum dot sensitized photocatalyst type-II charge transfer route

Current situation and prospect for the diagnosis and treatment of pediatric critical rare diseases in China

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儿科学研究(英文) 2024年第1期8卷 66-71页

作者： Liu yingchao Qian Suyun Pediatric Intensive Care Unit Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China

The onset of critical rare diseases (RDs) in children is rapid and dangerous, accompanied by a high mortality rate, which brings a heavy burden to both families and society. Multiple malformations, neuromuscular diseases, metabolic diseases, and heart diseases are the most common types of RDs in children of China, often manifesting with multiple organ dysfunction. At present, the diagnosis and treatment of critical RDs in children face challenges such as prolonged diagnosis time, a high misdiagnosis rate, limited treatment modalities, and a significant disease burden. However, with the progress in genetic testing technology, the establishment of multidisciplinary diagnosis and treatment platforms, and the implementation of relevant RD policies in China, children with critical RDs will received enhanced medical services, experience improved prognoses, and reintegrate into social life.

关键词： Children Critical Current situation Prospect Rare diseases

GNN Representation Learning and Multi-Objective Variable Neighborhood Search Algorithm for Wind Farm Layout Optimization

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Energy Engineering 2024年第4期121卷 1049-1065页

作者： yingchao Li JianbinWang HaibinWang China Electric Power Research Institute State Grid Inner Mongolia Eastern Electric Power Co.Ltd.Hohhot010010China School of Software Nanjing University of Information Science and TechnologyNanjing210044China

With the increasing demand for electrical services,wind farm layout optimization has been one of the biggest challenges that we have to deal with.Despite the promising performance of the heuristic algorithm on the route network design problem,the expressive capability and search performance of the algorithm on multi-objective problems remain unexplored.In this paper,the wind farm layout optimization problem is defined.Then,a multi-objective algorithm based on Graph Neural Network(GNN)and Variable Neighborhood Search(VNS)algorithm is proposed.GNN provides the basis representations for the following search algorithm so that the expressiveness and search accuracy of the algorithm can be improved.The multi-objective VNS algorithm is put forward by combining it with the multi-objective optimization algorithm to solve the problem with multiple objectives.The proposed algorithm is applied to the 18-node simulation example to evaluate the feasibility and practicality of the developed optimization strategy.The experiment on the simulation example shows that the proposed algorithm yields a reduction of 6.1% in Point of Common Coupling(PCC)over the current state-of-the-art algorithm,which means that the proposed algorithm designs a layout that improves the quality of the power supply by 6.1%at the same cost.The ablation experiments show that the proposed algorithm improves the power quality by more than 8.6% and 7.8% compared to both the original VNS algorithm and the multi-objective VNS algorithm.

关键词： GNN representation learning variable neighborhood search multi-objective optimization wind farm layout point of common coupling

Coupling metal-organic frameworks and wood-based carbon for water remediation

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Nano Research 2024年第6期17卷 5661-5669页

作者： Akhter Zia Manish Neupane Aidan McGlone Rui he Ruikun Xin Yifeng Liu Qiangu Yan Jinwu Wang Ling Li Zhiyong Cai Pei Dong yingchao Yang Department of Mechanical Engineering University of MaineOronoME 04469USA Department of Mechanical and Aerospace Engineering University of MissouriColumbiaMO 65211USA Department of Mechanical Engineering George Mason UniversityFairfaxVA 22030USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Department of Materials Science and NanoEngineering Rice UniversityHoustonTX 77005USA Forest Products Laboratory USDAMadisonWI 53726USA School of Forestry Resources University of MaineOronoME 04469USA

Fresh and clean water is highly demanded throughout the world.To effectively address the need,nanomaterials enabled nanotechnology has been explored as a means of more efficient,reliable,and environmentally friendly approach towards water treatment practices.One concern in adopting nanomaterials is how to retrieve them from water body to avoid secondary contamination.In this work,the earth abundant and sustainable wood,e.g.,basswood,was selected and carbonized into porous carbon as host skeleton,and metal-organic frameworks(MOFs),e.g.,MOF-199 with extremely high surface area,were grown throughout all channels in the porous basswood carbon.Targeting the traditional organic pollutant,methyl orange(MO),the combination of MOFs and basswood carbon(MOFs@carbon)demonstrates a remarkable adsorption capacity,which is 243%and 454%higher than basswood carbon and MOF-199,respectively.Such an outstanding adsorption performance originates from that the positively charged carbon pulls MO molecules close to carbon surface,leading to a high MO molecule concentration,and then the concentration gradient drives the MO molecules to be stored inside MOFs,functioning like pockets.These findings highlight the potential application of coupled MOFs and biomass carbon in addressing water remediation.

关键词： metal-organic framework(MOF)-199 basswood carbon MOFs@carbon methyl orange

LncRNA NKILA inhibits HBV replication by repressing NF-κB signalling activation

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Virologica Sinica 2024年第1期39卷 44-55页

作者： Xi Zhang Yuanyuan Li Chen Huan Yubao Hou Rujia Liu Hongyun Shi Peng Zhang Baisong Zheng yingchao Wang Hong Wang Wenyan Zhang Institute of Virology and AIDS Research The First Hospital of Jilin UniversityChangchun130012China Department of Ophthalmology The First Hospital of Jilin UniversityChangchun130012China hepatobiliary Pancreatic Surgery The First Hospital of Jilin UniversityChangchun130012China

hepatitis B virus(HBV)infection results in liver cirrhosis and hepatocellular carcinoma(HCC).HBx/nuclear factor(NF)-κB pathway plays a role in HBV replication.However,whether NF-κB-interacting long noncoding RNA(NKILA),a suppressor of NF-κB activation,regulates HBV replication remains largely unknown.In this study,gain-and-loss experiments showed that NKILA inhibited HBV replication by inhibiting NF-κB activity.In turn,HBV infection down-regulated NKILA expression.In addition,expression levels of NKILA were lower in the peripheral blood-derived monocytes(PBMCs)of HBV-positive patients than in healthy individuals,which were correlated with HBV viral loads.And a negative correlation between NKILA expression level and HBV viral loads was observed in blood serum from HBV-positive patients.Lower levels of endogenous NKILA were also observed in hepG2 cells expressing a 1.3-fold HBV genome,HBV-infected hepG2-NTCP cells,stable HBV-producing hepG2.2.15 and hepAD38 cells,compared to those HBV-negative cells.Furthermore,HBx was required for NKILA-mediated inhibition on HBV replication.NKILA decreased HBx-induced NF-κB activation by interrupting the interaction between HBx and p65,whereas NKILA mutants lack of essential domains for NF-κB inhibition,lost the ability to inhibit HBV replication.Together,our data demonstrate that NKILA may serve as a suppressor of HBV replication via NF-κB signalling.

关键词： LncRNA NF-κB-interacting longnoncoding RNA(NKILA) NF-ĸB signalling ChronichepatitisBvirus(HBV) Viral replication HBx

火灾调查工作中直接证据与间接证据的合理应用

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今日消防 2023年第1期8卷 100-102,105页

作者：何颖超宁夏回族自治区石嘴山市大武口区消防救援大队宁夏石嘴山753000

火灾是一种危害巨大的灾害,各级消防救援部门在火灾事故发生后应当第一时间组织开展必要的灭火行动,同时应做好火灾调查工作,及时搜集与火灾有关的证据,以便第一时间准确确定引发火灾的真正原因。通常情况下,证据有直接证据与间接证据之... 详细信息

火灾是一种危害巨大的灾害,各级消防救援部门在火灾事故发生后应当第一时间组织开展必要的灭火行动,同时应做好火灾调查工作,及时搜集与火灾有关的证据,以便第一时间准确确定引发火灾的真正原因。通常情况下,证据有直接证据与间接证据之分,两者之间存在很大区别,在火灾调查中需要将两者进行有机结合后才能构成较为完整的证据体系,使火灾事故的实际诱发原因得到有效证实。通过对直接证据与间接证据的相关概念及特点进行介绍,具体分析两者在火灾调查过程中的应用,确保直接证据与间接证据能够相互配合、相互印证,为火灾事故的精准认定提供真实、可靠的调查信息。

关键词：直接证据间接证据火灾事故调查起火原因

A multi-parameter-induced activation of gas therapeutic platform to remarkably amplify photodynamic therapy efficacy

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Science China Chemistry 2024年第7期67卷 2403-2411页

作者： Jie Sun Ziwen Zhang Hongyu Wu Xuemei Dong Chengjun Dong Lixin Sun Zhiqian Guo yingchao Liu Xianfeng Gu Chunchang Zhao Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Shandong Provincial Hospital Affiliated to Shandong First Medical University Shandong First Medical University&Shandong Academy of Medical ScienceJinan 250021China

Gas therapy(GT)combined with photodynamic therapy(PDT)is an effective strategy to compensate for the PDT limitation caused by the hypoxic tumor microenvironment,which can greatly improve PDT efficacy.The uncontrolled leakage of gas molecules during delivery seriously hinders its practical biological application.herein,we report a multifunction nanomedicine that enables precise gas therapy(including carbon monoxide(CO)release and H_(2)S depletion)using a multi-parameter-induced activation gas release strategy,enlarging the PDT efficacy.This nanomedicine uses a disulfide bond to covalently link a photosensitizer with the CO donor 3-hydroxyflavone(3-HF).The disulfide bond can be specifically consumed in H_(2)S-rich tumor areas,releasing the CO donor(3-HF),and also depleting H_(2)S.More importantly,the photo-controlled production of^(1)O_(2)can induce 3-HF precise release of CO in the tumor location.Such H_(2)S,light,and^(1)O_(2)multi-parameter-induced activation of gas release strategy ensures the accuracy of GT to amplify PDT efficiency.As expected,in vitro and in vivo investigations show that GT makes up for the PDT limitation,exhibiting the highest tumor therapeutic effect.This multi-parameter-activated design strategy provides a new way to improve the precision and efficacy of multimodal synergistic therapy of tumors.

关键词： gas therapy precision gas release hydrogen sulfide depletion photodynamic therapy multimodal synergistic therapy

Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye

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Chinese Chemical Letters 2024年第4期35卷 310-315页

作者： Songtao Cai Liuying Wu Yuan Li Soham Samanta Jinying Wang Bing Liu Feihu Wu Kaitao Lai yingchao Liu Junle Qu Zhigang Yang Center for Biomedical Photonics&Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

The photothermal therapy(PTT) has come across as a promising noninvasive therapeutic strategy for tumor treatment. However, low photothermal conversion efficiency(PCE) and hydrophobicity may impede the therapeutic efficacy of organic photothermal agents and an efficient PTT-agent must overcome these two major challenges. In this work, we developed a new strategy to promote higher PCE wherein the intermolecular hydrogen-bonding interaction between the single dye molecule and water facilitated the transformation of the absorbed energy into the heat. A hydrophilic squaraine dye(SCy1) with the second near-infrared region(NIR-II) absorption and extremely low emission were designed to exhibit much higher PCE than that of the analogues of pentamethine-dyes(PCy1, PCy2). The presence of the ‘–O-' at middle of squaric cycle enabled the intermolecular H-bonding formation between the SCy1 and water to promote the energy dissipation channel. Moreover, the introduction of long-chain phenylsulfonate groups helped in to improve the water solubility apart from serving as an additional means of further enhancing PCE through fluorescence quenching. Therefore, SCy1 with a squaraine backbone and long-chain sulfonate moieties revealed outstanding photothermal stability and anti-aggregation activity apart from showing exceptionally high PCE(74%) in water. SCy1 demonstrated excellent therapeutic efficacy when applied in the PTT treatment of tumor-bearing mice under a laser irradiation of 915 nm.

关键词： Squaraine-based cyanine Hydrogen bonds High PCE Anti-aggregation Photothermal therapy

超声测量视神经鞘直径联合闪光视觉诱发电位监测颅脑损伤患者颅内压的临床价值

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临床超声医学杂志 2023年第8期25卷 645-649页

作者：贾松吴萍何英超牛苗苗河北省保定市第二中心医院重症医学科 072750 河北省保定市第二中心医院新生儿科 072750

目的应用超声测量颅脑损伤患者视神经鞘直径(ONSD),探讨其联合闪光视觉诱发电位(FVEP)在颅脑损伤患者颅内压监测中的临床价值。方法选取我院重症医学科收治的100例颅脑损伤患者,其中仅采用FVEP指导临床治疗者43例(对照组),FVEP联合ONS... 详细信息

目的应用超声测量颅脑损伤患者视神经鞘直径(ONSD),探讨其联合闪光视觉诱发电位(FVEP)在颅脑损伤患者颅内压监测中的临床价值。方法选取我院重症医学科收治的100例颅脑损伤患者,其中仅采用FVEP指导临床治疗者43例(对照组),FVEP联合ONSD指导临床治疗者57例(联合组),比较两组中颅内压升高者ONSD、颅内压的差异;分析ONSD、颅内压与颅内压升高的相关性。比较两组甘露醇使用时间及总量、急性肾损伤例数、住院费用、抗菌药物使用强度、住院时间、机械通气时间。结果对照组与联合组中出现颅内压升高者分别为29例和22例,两组颅内压升高者颅内压比较差异无统计学意义;联合组和对照组中颅内压升高者ONSD均显著高于颅内压正常者,差异均有统计学意义(均P<0.05)。相关性分析显示,联合组ONSD、颅内压与颅内压升高均呈正相关(r=0.739、0.981,均P<0.05);且ONSD与颅内压呈正相关(r=0.752,P<0.05)。联合组甘露醇使用时间、住院时间、机械通气时间均短于对照组,甘露醇使用总量、急性肾损伤占比、住院费用、抗菌药物使用强度均少于对照组,差异均有统计学意义(均P<0.05)。结论 ONSD联合FVEP在颅脑损伤患者颅内压监测中具有重要意义,可用于指导临床用药。

关键词：超声检查视神经鞘直径闪光视觉诱发电位颅脑损伤颅内压