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Papillary fibroelastoma of aortic valve:a case report and review of the literature

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Journal of Medical Colleges of PLA(China) 2008年第2期23卷 121-125页

作者： Cheng Wei Xiao yingbin zhong Qianjin Department of Cardiovascular Surgery Xinqiao Hospital Third Military Medical University Chongqing 40003 7 China

乳突的 fibroelastoma，一个稀罕主要良性的肿瘤，能通常在心，而是大多数被发现在任何地方包含心脏的阀门。乳突的 fibroelastomas 不引起症状并且通常是偶然的大多数由平淡的 echocardiography 或在尸体发现了。与 echocardiography ... 详细信息

乳突的 fibroelastoma，一个稀罕主要良性的肿瘤，能通常在心，而是大多数被发现在任何地方包含心脏的阀门。乳突的 fibroelastomas 不引起症状并且通常是偶然的大多数由平淡的 echocardiography 或在尸体发现了。与 echocardiography 的来临，然而，越来越多的病人在生活被诊断。自从它为全身的 emboli，击，心肌的梗塞，和突然的心脏的死亡代表一个通过手术可改正的原因，这个条件的早诊断变得很重要。因为， echocardiographic 调查结果应该被组织学证实临床微分诊断包括粘液瘤，植被，血栓症，脂肪瘤，和 pseudopapillary fibroelastoma。我们报导了大动脉的阀门的乳突的 fibroelastoma 的一个案例并且介绍了文学的全面评论。

关键词：乳头状弹力纤维瘤主动脉良性肿瘤病例分析

Anomalous origin of left pulmonary artery branch from the aorta with Fallot's tetralogy:one case report

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Journal of Medical Colleges of PLA(China) 2008年第1期23卷 55-58页

作者： Cheng Wei Xiao yingbin zhong Qianjin Wen Renguo Department of Cardiovascular Surgery Xinqiao Hospital Third Military Medical University Chongqing China

我们报导经常与呼吸窘迫介绍了的一个十岁的男孩的案例后来出生。胸 X 光检查显示出一个扩大右室。Echocardiography 证明 Fallot 的四联剧和左肺的动脉的典型特征不能被设想。然而，心导管插入术透露左肺的动脉在上升主动脉有异常起源... 详细信息

我们报导经常与呼吸窘迫介绍了的一个十岁的男孩的案例后来出生。胸 X 光检查显示出一个扩大右室。Echocardiography 证明 Fallot 的四联剧和左肺的动脉的典型特征不能被设想。然而，心导管插入术透露左肺的动脉在上升主动脉有异常起源。病人经历了缺点的全部的外科的修正。九天以后，他被解除。我们在场发生的文学评论的结果， physiopathological，这稀罕疾病的临床、诊断、外科的特征。

关键词：心脏手术肺动脉病理机制临床分析

Circadian clock protein Period3 contributes to sleep Homeostasis through GABA signaling in zebrafish

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Circadian clock protein Period3 contributes to sleep Homeost...

Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish

中国睡眠研究会第十一届全国学术年会

作者： Zhaomin zhong Xiaona Xu yingbin zhong Han Wang Soochow University

The zebrafish(Danio rerio) has figured prominently as a vertebrate model for studying circadian clocks and sleep. Zebrafish are a strong model for developmental biology research because of their fecundity, larval-stage transparency, short time to hatching and ease in handling;furthermore, they are well characterized in terms of development, neurobiology, and genetics. Moreover, there are many experimental tools not easily applied in mammalian models that can be readily applied to zebrafish. It is known that both the homeostatic process(S) and the circadian process(C) contribute to regulation of sleep homeostasis. While we have a good understanding of circadian regulation, relatively little is known about molecular mechanisms underlying circadian regulation of sleep homeostasis and/or interaction between the circadian clock system and sleep. A variable-number(4 or 5) tandem-repeat polymorphism in the coding region of the clock gene PERIOD3 was shown to confer vulnerability to sleep loss and circadian misalignment through its effects on sleep homeostasis in human beings. While Per3 knockout mice shows little impacts in circadian functions and sleeping behaviors. Here we reported characterization of zebrafish period3(per3) null mutants generated by TALEN method. Locomotor assays showed that per3 mutant fish display 1.1-hour shortened period and approximately 3-hour phase advance compared with wild types fish under constant dark condition, and are nearly 3 hours shortened period under constant light condition;and also bmal1b, per1a, per1b and per2 are down-regulated in per3 mutant fish;Deep sequencing-based transcriptome analysis also showed a lot of circadian genes were altered in per3 mutant fish, indicating that per3 is essential for zebrafish circadian regulation. Cell transfection experiments showed that zebrafish Per3 can regulate the expression of bmal1 b through RRE box. Intriguingly, per3 mutant fish display less sleep time in light dark condition, decreased ar

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Ezh2 promotes clock function and hematopoiesis independent o...

Circadian control of hematopoiesis through the histone methylransferase Ezh2 in zebrafish

2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： yingbin zhong Chengyan Chen Han Wang Center for Circadian Clocks Soochow University School of Biology ＆ Basic Medical Sciences Medical College Soochow University

EZH2 is a subunit of polycomb repressive complex 2（PRC2） that silences gene transcription via H3 K27 me3 and was shown to be essential for mammalian liver circadian regulation and hematopoiesis through gene silencing. Much less, however, is known about how Ezh2 acts in live zebrafish. Here, we show that zebrafish ezh2 is regulated directly by the circadian clock via both E-box and RORE motif, while core circadian clock genes per1 a, per1 b, cry1 aa and cry1 ab are down-regulated in ezh2 null mutant and ezh2 morphant zebrafish, and either knockdown or overexpression of ezh2 alters locomotor rhythms, indicating that Ezh2 is required for zebrafish circadian regulation. In contrast to its canonical silencing function, zebrafish Ezh2 up-regulates these key circadian clock genes independent of histone methyltransferase activity by directly binding to key circadian clock proteins. Similarly, Ezh2 contributes to hematopoiesis by enhancing expression of hematopoietic genes such as cmyb and lck. Together, our findings demonstrate for the first time that Ezh2 acts in both circadian regulation and hematopoiesis independent of silencing PRC2.

关键词： Circadian clocks PRC2 ezh2 hematopoiesis zebrafish

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Circadian control of hematopoiesis through the histone methy...

大豆脲酶诱导碳酸钙固化黄河泥沙水稳定性试验研究

2015年中国中西医结合学会时间生物医学专业委员会学术...

作者： zhong yingbin YE Qiang HUANG Guodong WANG Mingyong WANG Han Center for Circadian Clocks Soochow University School of Biology & Basic Medical Sciences Medical CollegeSoochow University

Circadian rhythms are endogenous oscillations generated by an interlocking positive and negative transcriptional/translational feedback *** in chromatin structure derived from post-translational modifications of histone are required for transcriptional regulation of genes including circadian clock ***2,a polycomb group enzyme that methylates lysine 27 on histone H3,was shown to be essential for mouse liver circadian *** deletion of mouse Ezh2 results in embryonic lethality,whether EZH2 contributes to circadian regulation of other organs remains to be *** we showed that zebrafishezh2 is rhythmically expressed in wild-type larvae under both DD and LD conditions,is up-regulated in the per1 b mutant and show antiphasic expression in the per2 *** assays showed that Bmal1 b binds to the E-box and E’-box and Per2 binds to the RRE on the ezh2 promoter,implicating that the circadian clock directly controls ***,circadian clock genes such as per1 a,per1b,per3,per3,cry1 aa,cry1ab,cry1 baand cry1bbare all down-regulated in homozygous ezh2 mutant zebrafish;zebrafish treated with GSK126(an EZH2 inhibitor) display lengthened period,increased amplitude and phase-delay;and Ezh2 binds to Bmal1b-Clock1 a and enhances the transcription activity of Bmal1b-Clock1a;whereby indicating thatzebrafish Ezh2 contributes to circadian *** ezh2 mutant fish displays defects in circulation and die around 5 dpf,and reduced circulation in this mutant is due to altered primitive and definitive hematopoiesis,as shown byin situ hybridization and ***,rhythmic expression of some hematopoietic markers are disrupted in ezh2 and clock gene zebrafish ***,these results demonstrate thatEzh2 plays important roles in circadian regulation and the circadian clock acts through Ezh2 to contribute to hematopoiesis in zebrafish.

关键词： Ezh2 hematopoesis epigenetic regualtion circadian clocks zebrafish

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水利学报 2024年第1期55卷 71-79页

作者：王钰轲陈浩宋迎宾王振海钟燕辉张蓓郑州大学水利与交通学院河南郑州450001 重大基础设施检测修复技术国家地方联合工程实验室河南郑州450001 地下工程灾变防控省部共建协同创新中心河南郑州450001 黄河水利委员会黄河水利科学研究院河南郑州450003 水利部堤防安全与病害防治工程技术研究中心河南郑州450003

随着国家“交通强国”战略的提出,沿黄工程建设发展迅速,填筑用土需求剧增。黄河泥沙作为填筑材料的可行性已被证实,但其在多雨地区的服役性能需要改善,探索一种生态、高效的泥沙加固方法提高其水稳定性十分关键。本文基于酶诱导碳酸钙... 详细信息

随着国家“交通强国”战略的提出,沿黄工程建设发展迅速,填筑用土需求剧增。黄河泥沙作为填筑材料的可行性已被证实,但其在多雨地区的服役性能需要改善,探索一种生态、高效的泥沙加固方法提高其水稳定性十分关键。本文基于酶诱导碳酸钙沉淀(EICP)技术固化黄河泥沙的方法,分别开展了常规浸水条件和干湿循环条件下固化黄河泥沙的水稳定性试验,研究了浸水后试样的质量损失及强度折损情况,分析了干湿循环对固化后黄河泥沙试样强度软化系数的影响规律。结果表明:采用EICP技术固化的黄河泥沙试样浸水崩解过程相比原状试样更加缓慢;胶结液浓度1.5 mol/L的黄河泥沙试样长期(56 d)浸水后,几乎保持完整,质量损失率仅为6.36%,强度折损率仅为6.21%;10次干湿循环后,不同胶结液浓度处理后的黄河泥沙试样均出现了不同程度的颗粒松散和脱落现象,胶结液浓度1.5 mol/L、灌浆10次的黄河泥沙试样的抗压强度损失仅为9.96%,抗干湿循环能力最强。利用EICP技术可以有效的固化黄河泥沙并提升其水稳定性,这对推进黄河泥沙的资源化利用进程十分重要。

关键词：黄河泥沙 EICP 干湿循环质量损失强度损失软化系数

维普期刊数据库博看期刊

GDF9与BMP15受体基因在异育银鲫卵细胞中的表达

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上海海洋大学学报 2015年第5期24卷 656-661页

作者：陈阿琴刘志伟吕为群杨志刚钟英斌上海海洋大学水产与生命学院上海201306

转化生长因子9(GDF9)与骨形成蛋白15(BMP15)通过受体介导途径,在鱼类卵细胞发育与成熟过程中发挥着重要作用。在GDF9与BMP15信号通路中,GDF9与BMP15的Ⅰ型受体基因分别为TGF-βR1a、TGF-βR1b和BMPR1Ba、BMPR1Bb,两者的Ⅱ型受体基因均为... 详细信息

转化生长因子9(GDF9)与骨形成蛋白15(BMP15)通过受体介导途径,在鱼类卵细胞发育与成熟过程中发挥着重要作用。在GDF9与BMP15信号通路中,GDF9与BMP15的Ⅰ型受体基因分别为TGF-βR1a、TGF-βR1b和BMPR1Ba、BMPR1Bb,两者的Ⅱ型受体基因均为BMPR2a、BMPR2b。本研究以异育银鲫为实验对象,对GDF9和BMP15的各受体基因在卵细胞中的表达模式进行研究。结果显示,在异育银鲫卵细胞发育过程中,TGF-βR1a、BMPR1Ba与BMPR1Bb基因mR NA水平呈先降低后升高的变化趋势,TGF-βR1b基因mR NA水平自Ⅱ期卵细胞开始显著升高,而BMPR2a与BMPR2b mR NA水平则随着卵细胞的发育逐渐降低。同时,TGF-βR1b、BMPR1Bb、BMPR2a及BMPR2b mR NA主要在滤泡细胞中表达,TGF-βR1a与BMPR1Ba mR NA则在卵母细胞与滤泡细胞中均有表达。以上研究提示,GDF9与BMP15可通过与其受体结合,以旁分泌或自分泌参与调控硬骨鱼类卵细胞的发生、发育与成熟。

关键词：异育银鲫受体基因卵细胞

红细胞嘧啶5′-核苷酸酶缺乏致溶血性贫血1例报道并文献复习

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临床血液学杂志 2023年第11期36卷 831-834页

作者：刘媛刘瑞璇庄泽钦曾鹏琳周佳钟应彬杨洪涌杨志文广州中医药大学第一临床医学院广州510405 广州中医药大学第一附属医院血液科昆明市中医医院急诊科昆明650599

红细胞嘧啶5′-核苷酸酶缺乏症(pyrimidine 5′-nucleotide deficiency,P5′ND)是一种罕见的遗传性酶缺陷疾病,目前报道较少。文中病例反复出现溶血性贫血、黄疸、脾脏肿大,经完善红细胞酶学试验最终诊断为P5′ND。笔者结合相关文献复... 详细信息

红细胞嘧啶5′-核苷酸酶缺乏症(pyrimidine 5′-nucleotide deficiency,P5′ND)是一种罕见的遗传性酶缺陷疾病,目前报道较少。文中病例反复出现溶血性贫血、黄疸、脾脏肿大,经完善红细胞酶学试验最终诊断为P5′ND。笔者结合相关文献复习认为,对于慢性非球形溶血性贫血患者,需警惕此类红细胞酶缺陷相关疾病,有条件者可尽量完善二代基因测序筛选致病基因,更好地指导临床实践。现特将其诊疗过程初步整理、总结并报道如下,以期为罕见病的诊治思路提供一定参考价值。

关键词：红细胞嘧啶5′-核苷酸酶缺乏症遗传性红细胞酶缺乏红细胞酶学检查二代基因测序

考虑不同初始状态的黄河泥沙三轴静力剪切特性试验

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工程科学学报 2023年第10期45卷 1782-1794页

作者：王钰轲陈宇源邵景干宋迎宾钟燕辉郑州大学水利科学与工程学院郑州450001 重大基础设施检测修复技术国家地方联合工程实验室郑州450001 水利与交通基础设施安全防护河南省协同创新中心郑州450001 日本九州大学土木与结构工程系福冈819-0385 河南交院工程技术集团有限公司郑州450001 黄河水利委员会黄河水利科学研究院郑州450003

开展了一系列静态三轴剪切试验,研究了不同初始条件(围压、密实度)以及不同试验条件(剪切速率、排水条件)对黄河泥沙静力强度以及变形特性的影响,得到了黄河泥沙的应力应变曲线发展规律,以及应力路径、抗剪强度包线、应力比曲线和不同... 详细信息

开展了一系列静态三轴剪切试验,研究了不同初始条件(围压、密实度)以及不同试验条件(剪切速率、排水条件)对黄河泥沙静力强度以及变形特性的影响,得到了黄河泥沙的应力应变曲线发展规律,以及应力路径、抗剪强度包线、应力比曲线和不同特征状态下的内摩擦角分布、初始剪切模量以及极限偏应力等指标.结果表明:黄河泥沙的抗剪强度对围压、密实度以及排水条件更为敏感,具体而言,峰值强度、临界强度均随着围压与密实度的提高而增大,不排水条件下的抗剪强度大于排水条件;不排水条件下孔压的发展与排水条件下的剪胀特性具有对照关系,但孔压较剪胀特性发展得更为迅速,并且得到黄河泥沙的特征状态内摩擦角分布区间介于22.6°到38.1°之间.本研究可以为黄河泥沙在路基工程中的资源化利用提供数据和理论参考.

关键词：黄河泥沙三轴试验强度变形特征状态