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An Intelligent Framework for Resilience Recovery of FANETs with Spatio-Temporal Aggregation and Multi-Head Attention Mechanism

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Computers, Materials & Continua 2024年第5期79卷 2375-2398页

作者： Zhijun Guo Yun Sun YingWang Chaoqi Fu Jilong Zhong Air Traffic Control and Navigation College Air Force Engineering UniversityXi’an710000China Institute of Systems Engineering Academy of Military ScienceBeijing100101China Equipment Management and UAV Engineering College Air Force Engineering UniversityXi’an710038China Defense Innovation Institute Academy of Military ScienceBeijing100071China

Due to the time-varying topology and possible disturbances in a conflict environment,it is still challenging to maintain the mission performance of flying Ad hoc networks(FANET),which limits the application of Unmanned Aerial Vehicle(UAV)swarms in harsh environments.This paper proposes an intelligent framework to quickly recover the cooperative coveragemission by aggregating the historical spatio-temporal network with the attention mechanism.The mission resilience metric is introduced in conjunction with connectivity and coverage status information to simplify the optimization model.A spatio-temporal node pooling method is proposed to ensure all node location features can be updated after destruction by capturing the temporal network structure.Combined with the corresponding Laplacian matrix as the hyperparameter,a recovery algorithm based on the multi-head attention graph network is designed to achieve rapid recovery.Simulation results showed that the proposed framework can facilitate rapid recovery of the connectivity and coverage more effectively compared to the existing studies.The results demonstrate that the average connectivity and coverage results is improved by 17.92%and 16.96%,respectively compared with the state-of-the-art model.Furthermore,by the ablation study,the contributions of each different improvement are compared.The proposed model can be used to support resilient network design for real-time mission execution.

关键词： Resilience cooperative mission FANET spatio-temporal node pooling multi-head attention graph network

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Blood Oxygenation Level-dependent Magnetic Resonance Imaging of Breast Cancer： Correlation with Carbonic Anhydrase IX and Vascular Endothelial Growth Factor

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Chinese Medical Journal 2017年第1期130卷 71-76页

作者： YingWang Min Liu Mu-Lan Jin Department of Pathology Beijing Chaoyang Hospital of Capital Medical University Beijing 100020 China Department of Radiology China-Japan Friendship Hospital Beijing 100029 China

Background： Blood oxygenation level-dependent magnetic resonance imaging （BOLD-MRI） is a functional MRI technique which involves using the paramagnetic properties of deoxyhemoglobin to image the local tissue oxygen concentration. The purpose of this study was to investigate whether BOLD-MRI could evaluate hypoxia and angiogenesis of breast invasive ductal carcinoma （IDC）. Methods： Ninety-eight female patients with IDC were retrospectively included in this research. All patients underwent breast BOLD-MRI at 3.0 T before surgery. R2＊ values of BOLD-MR1 were measured. The expression of carbonic anhydrase IX （CA IX） and vascular endothelial growth factor （VEGF） was analyzed by immunohistochemistry. Spearman＇s correlation analysis was used to correlate R2＊ value with CA IX and VEGF levels. Results： Heterogeneous intensity on BOLD-MRI images was the main finding of IDCs. The mean R2＊ value was 52.8 ± 18.6 Hz. The R2＊ values in patients with axillary lymph node metastasis were significantly higher than the R2＊ values in patients without axillary lymph node metastasis （t = 2.882, P = 0.005）. R2＊ values increased with CA IX level and positively correlated with the level of CA 1X （r = 0.616, P 〈 0.001）; however, R2＊ value had no significantly correlation with the level of VEGF （r = 0.110, P = 0.281）. Conclusion： B OLD-MRI could noninvasively evaluate chronic hypoxia of IDC, but not angiogenesis.

关键词： Angiogenesis Blood Oxygenation Level-dependent Magnetic Resonance Imaging Carbonic Anhydrase IX Hypoxia Invasive Ductal Carcinoma Vascular Endothelial Growth Factor

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Long-term nitrogen and phosphorus removal,shifts of functional bacteria and fate of resistance genes in bioretention systems under sulfamethoxazole stress

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Journal of Environmental Sciences 2023年第4期126卷 1-16页

作者： Yan Xu Danyi Zhang Qingju Xue Chibin Bu Yajun Wang Benchi Zhang YingWang Qingdong Qin Department of Municipal Engineering School of Civil EngineeringSoutheast UniversityNanjing 210096China Nanjing Institute of Geography&Limnology Chinese Academy of Sciences(NIGLAS)Nanjing 210008China Department of Gastroenterology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210096China School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Environmental Systems Engineering University of ReginaSK S4S0A2Canada

To understand the long-term performance of bioretention systems under sulfamethoxazole (SMX) stress, an unplanted bioretention system (BRS) and two modified BRSs with coconut-shell activated carbon (CAC) and CAC/zero-valent-iron (Fe^(0)) granules (CAC-BRS and Fe/CAC-BRS) were established. Both CAC-BRS and Fe/CAC-BRS significantly outperformed BRS in removing total nitrogen (TN)(CAC-BRS:82.48%;Fe/CAC-BRS:78.08%;BRS:47.51%), total phosphorous (TP)(CAC-BRS:79.36%;Fe/CAC-BRS:98.26%;BRS:41.99%),and SMX (CAC-BRS:99.74%, Fe/CAC-BRS:99.80%;BRS:23.05%) under the long-term SMX exposure (0.8 mg/L, 205 days). High-throughput sequencing revealed that the microbial community structures of the three BRSs shifted greatly in upper zones after SMX exposure.Key functional genera, dominantly Nitrospira, Rhodoplanes, Desulfomicrobium, Geobacter,were identified by combining the functional prediction by the FAPROTAX database with the dominant genera. The higher abundance of nitrogen functional genes (nirK, nirS and nos Z) in CAC-BRS and Fe/CAC-BRS might explain the more efficient TN removal in these two systems. Furthermore, the relative abundance of antibiotic-resistant genes (ARGs)sul I and sulII increased in all BRSs along with SMX exposure, suggesting the selection of bacteria containing sul genes. Substrates tended to become reservoirs of sul genes. Also,co-occurrence network analysis revealed distinct potential host genera of ARGs between upper and lower zones. Notably, Fe/CAC-BRS succeeded to reduce the effluent sul genes by1-2 orders of magnitude, followed by CAC-BRS after 205-day exposure. This study demon-strated that substrate modification was crucial to maintain highly efficient nutrients and SMX removals, and ultimately extend the service life of BRSs in treating SMX wastewater.

关键词： Bioretention system Sulfamethoxazole Coconut-shell activated carbon Zero-valent iron

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Specific siRNA Downregulated TLR9 and Altered Cytokine Expression Pattern in Macrophage after CpG DNA Stimulation

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Cellular & Molecular Immunology 2005年第2期2卷 130-135页

作者： BinQiao BaohuaLi XiuliYang HongyongZhang YiweiChu YingWang SidongXiong DepartmentofImmunologyandKeyLaboratoryofMolecularMedicineoftheMinistryofEducation ShanghaiMedicalCollegeofFudanUniversityShanghai200032China Correspondingto：Dr.SidongXiong DepartmentofImmunologyShanghaiMedicalCollegeofFudanUniversity138YixueyuanRoadShanghai200032China.

Bacterial CpG DNA or synthetic oligonucleotides(ODNs)that contain unmethylated CpG motifs(CpG ODN)can directly activate antigen-presenting cells(APCs)to secrete various cytokines through the intraceilular receptor TLR9.Cytokine profiles elicited by the actions of stimulatory CpG DNA on TLR9 expressed APCs are crucial to the subsequent immune responses.To date,cytokine profiles in APCs upon CpG ODN stimulation in vitro are not fully investigated.In the present study,vector-based siRNA was used to downregulate TLR9 expression.Cytokine profiles were observed in murine macrophage cell line RAW264.7 transfected with TLR9-siRNA plasmid upon CpG ODN stimulation.We found that not all the cytokine expressions by the macrophage were decreased while TLR9 was downregulated. IL-12, TNF-α, IFN-γ and IL-1β expressions were significantly decreased,but IL-6, IFN-β and IL-10 expressions were not affected.Interestingly,the level of IFN-α was even increased.This alteration of cytokines produced by TLR9-downregulated APCs upon CpG ODN stimulation might indicate that the role of CpG DNA is more complicated in the pathogenesis and prevention of diseases.Cellular & Molecular Immunology. 2005;2(2):130-135.

关键词： TLR9 RNA interference RAW264.7 CpG DNA

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Characterizing Long-range Correlation Properties in Nucleotide Sequences

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Chinese Chemical Letters 2003年第5期14卷 503-504页

作者： XiaoYanCHEN LunJunBAO JinYuanMO YingWang Departmentofchemistry ZhongshanUniverstiyGuangzhou510275 GuangzhouEntry-ExitInspectionandQuarantineBureau Guangzhou510623

Using continuous wavelet transform as the analytical tool, the fractal characteristic of nucleotide sequences was studied. The fractal dimension of the exon and intron sequences for different species was calculated. We use the Mexican hat wavelet function as the mother wavelet and Hurst exponent to describe the long-range correlation. It is found that the Hurst exponent of intron sequence is larger than that of exon sequence for the same gene.

关键词： Nucleotide sequences long-range correlation wavelet transform.

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毛泽东《论持久战》蕴含的时代观

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党的文献 2022年第3期 37-44页

作者：曹应旺中共中央党史和文献研究院北京100017

“敌退步我进步”和“敌寡助我多助”,是毛泽东在《论持久战》中分析和强调的当时“时代的特点”。毛泽东在《论持久战》中指出,中国正处于“进步时代”,日本已处于“退步时代”。中国处于“进步时代”的主要标志是:“有了共产党”,“... 详细信息

“敌退步我进步”和“敌寡助我多助”,是毛泽东在《论持久战》中分析和强调的当时“时代的特点”。毛泽东在《论持久战》中指出,中国正处于“进步时代”,日本已处于“退步时代”。中国处于“进步时代”的主要标志是:“有了共产党”,“有了已经觉悟或正在觉悟的广大人民”,“有了资产阶级和无产阶级”且“中国已经结成了广大的统一战线,实现了空前的团结”,“有了政治上进步的军队”,“有了数十年革命的传统经验”等。《论持久战》通过对时代因素的分析,富有说服力地向全党全国充分阐述了这样一些道理:日本帝国主义对中国的全面战争必然失败;中国处于“进步时代”最重要的因素在于中国共产党的领导;国民党具有两重性,要力争其向抗战、团结、进步的方向走。《论持久战》蕴含的时代观,从时代、时局、时势的高度,批判了对于抗日战争的各种错误认识,阐明了争取抗战胜利的正确道路,从思想上武装了全党、全军和广大人民,极大地鼓舞和坚定了广大军民争取抗战胜利的信心和决心。

关键词：毛泽东《论持久战》时代观中国共产党

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Precautionary analysis of sprouting potato eyes using hyperspectral imaging technology

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International Journal of Agricultural and Biological Engineering 2018年第2期11卷 153-157页

作者： YingWang Gao Qiwei Li Xiuqin Rao Yibin Ying College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Key Laboratory of Equipment and Informatization in Environment Controlled Agriculture Ministry of AgricultureHangzhou 310058China Faculty of Agricultural and Food Science Zhejiang A&F UniversityHangzhou 311300China

Sprouted potatoes are not allowed for healthy diet.A good knowledge of the sprouting stage of potatoes can help manage the storage conditions and guide market distribution,thus enabling the quality assurance of potatoes on table.This article presented an intelligent method for precautionary analysis of potato eyes based on hyperspectral imaging technique.Potential potato eyes were classified into two categories according to the time gap to the sprouting date,i.***.by-sprouting and pre-sprouting potato eyes,representing eyes about to sprout and eyes that will take a while to sprout.Features used for classification were extracted by two methods,including successive projections algorithm(SPA)and a newly-developed sine fit algorithm(SFA).Then classifiers of fisher discriminant analysis(FDA)and least square support vector machine(LSSVM)were utilized for classification of potential sprouting potato eyes.Results showed that FDA was more effective than LSSVM in classifying pre-sprouting and by-sprouting potato eyes,and SFA performed well in FDA classifier with the recognition accuracy of 95.3%for prediction set.It is concluded that hyperspectral imaging has the potential for predicting the sprouting stages of potato eyes.

关键词： potato tuber potato eyes sprouting stage hyperspectral imaging sine fit algorithm(SFA) quality and safety prediction

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A Rapid and Simple Approach to Preparation of Monoclonal Antibody Based on DNA Immunization

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Cellular & Molecular Immunology 2004年第4期1卷 295-299页

作者： YiNi KeMa JingNi XiujuanZheng YingWang SidongXiong ShanghaiMedicalCollege FudanUniversityShanghai200032.China. DepartmentofImmunology ShanghaiMedicalCollegeofFudanUniversity130DongAnRoadShanghai200032China.

Inoculation with purified specific protein is usually the first step for preparation of monoclonal antibody (mAb). But it is quite difficult to obtain pure proteins especially with natural structures.Here we attempt to replace the protein inoculation with DNA immunization in the preparation of mAb.The eukaryotic expression vectors pcDNA3-PreS2/S and pVAX-PreS2/S encoding the HBV M protein were constructed and prepared for DNA immunization.Female BALB/c mice developed a well antibody response to the target antigen after muscle injection with corresponding plasmids.The mice with effective antibodies induced were used for preparation of mAb.We found the mice immunized with three administrations of pcDNA3-PreS2/S and boosted by intrasplenic injection with the same plasmid could be exploited for preparation of mAb.And positive hybridoma cell 2D3 that can secrete specific mAb was cloned and analyzed.Our studies demonstrate that gene immunization may provide a convenient and efficient way to prepare mAbs.Cellular & Molecular Immunology. 2004;1(4):295-299.

关键词： gene immunization HBV monoclonal antibody intrasplenic immunization

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陈云“百字真言”

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党的文献 2020年第2期 122-127页

作者：曹应旺中共中央党史和文献研究院北京100017

在长期的革命生涯和工作实践中,陈云在哲学、经济、党建等方面提出了许多重要思想。这些思想的精华集中体现在他常讲的九句话、一百个字上,即:"不唯上、不唯书、只唯实,交换、比较、反复";"难者在弄清情况,不在决定政策";"做大事都是从... 详细信息

在长期的革命生涯和工作实践中,陈云在哲学、经济、党建等方面提出了许多重要思想。这些思想的精华集中体现在他常讲的九句话、一百个字上,即:"不唯上、不唯书、只唯实,交换、比较、反复";"难者在弄清情况,不在决定政策";"做大事都是从做小事开始的";"宁可稳当一些,不要冒冒失失";"一要吃饭,二要建设";"七分经济,三分政治";"无农不稳","无粮则乱";"搞经济工作,一定要多方考虑,统筹兼顾";"真正为人民谋福利"。陈云的"百字真言",其思想精髓和方法要旨可以进一步概括为"实""稳""高""本"四个字。深刻体悟陈云的"百字真言",可以对学习、研究和领会他提出的一些重要思想特别是蕴涵其中的思想智慧和领导方法起到一定的引导入门的作用。

关键词：陈云 “百字真言” 领导方法

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Dissolved metal ion removal by online hollow fiber ultrafiltration for enhanced size characterization of metal-containing nanoparticles with single-particle ICP-MS

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Journal of Environmental Sciences 2023年第4期126卷 494-505页

作者： Haowen Jiang YingWang Zhiqiang Tan Ligang Hu Jianbo Shi Guangliang Liu Yongguang Yin Yong Cai Guibin Jiang Laboratory of Environmental Nanotechnology and Health Effect Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry and Biochemistry Florida International UniversityMiami 33199USA School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China

Single particle-inductively coupled plasma mass spectrometry (SP-ICP-MS) is a powerful tool for size-characterization of metal-containing nanoparticles (MCNs) at environmentally relevant concentrations,however,coexisting dissolved metal ions greatly interfere with the accuracy of particle size analysis.The purpose of this study is to develop an online technique that couples hollow fiber ultrafiltration (HFUF) with SP-ICP-MS to improve the accuracy and size detection limit of MCNs by removing metal ions from suspensions of MCNs.Through systematic optimization of conditions including the type and concentration of surfactant and complexing agent,carrier pH,and ion cleaning time,HFUF completely removes metal ions but retains the MCNs in suspension.The optimal conditions include using a mixture of 0.05 vol.%FL-70 and 0.5 mmol/L Na2S2O_(3)(pH=8.0) as the carrier and 4 min as the ion cleaning time.At these conditions,HFUF-SP-ICP-MS accurately determines the sizes of MCNs,and the results agree with the size distribution determined by transmission electron microscopy,even when metal ions also are present in the sample.In addition,reducing the ionic background through HFUF also lowers the particle size detection limit with SP-ICP-MS (e.g.,from 28.3 to 14.2 nm for gold nanoparticles).This size-based ion-removal principle provided by HFUF is suitable for both cations (e.g.,Ag+) and anions (e.g.,AuCl_(4)^(-)) and thus has good versatility compared to ion exchange purification and promising prospects for the removal of salts and macromolecules before single particle analysis.

关键词： Hollow fiber ultrafiltration(HFUF) Single particle-inductively coupled plasma mass spectrometry (SP-ICP-MS) Removal of ions Particle size characterization

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