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Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy

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Journal of Molecular Cell Biology 2023年第9期15卷 25-39页

作者： yingmei Zhang Rongjun Zou Miyesaier Abudureyimu Qiong Liu Jipeng Ma Haixia Xu Wei Yu Jian Yang Jianguo Jia Sanli Qian Haichang Wang Yang Yang Xin Wang Xiaoping Fan Jun Ren Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan Hospital Fudan UniversityShanghai 710032China National Clinical Research Center for Interventional Medicine Shanghai 200032China Department of Cardiovascular Surgery Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510405China Cardiovascular Department Shanghai Xuhui Central HospitalFudan UniversityShanghai 200031China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of Life Sciences and MedicineNorthwest UniversityXi’an 710069China Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases Xi’an No.3 HospitalThe Affiliated Hospital of Northwest UniversitySchool of Life Sciences and MedicineNorthwest UniversityXi’an 710069China Department of Cardiovascular Surgery Xĳing HospitalAir Force Medical UniversityXi’an 710032China Department of Cardiology Affiliated Hospital of Nantong UniversityNantong 226001China School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Xi’an International Medical Center Hospital Affiliated to Northwest University Xi’an 710077China Division of Cardiovascular Sciences Faculty of BiologyMedicine and HealthThe University of ManchesterManchester M139GBUK

Mitochondrial aldehyde dehydrogenase(ALDH2)offers proven cardiovascular benefit,although its impact on diabetes remains *** study examined the effects of ALDH2 overexpression and knockout on diabetic cardiomyopathy and the mechanism involved with a focus on mitochondrial *** challenged with streptozotocin(STZ,200 mg/kg,via intraperitoneal injection)exhibited pathological alterations,including reduced respiratory exchange ratio,dampened fractional shortening and ejection fraction,increased left ventricular end-systolic and diastolic diameters,cardiac remodeling,cardiomyocyte contractile anomalies,intracellular Ca2+defects,myocardial ultrastructural injury,oxidative stress,apoptosis,and mitochondrial damage,which were overtly attenuated or accentuated by ALDH2 overexpression or knockout,*** patients also exhibited reduced plasma ALDH2 activity,cardiac remodeling,and diastolic *** addition,STZ challenge altered expression levels of mitochondrial proteins(PGC-1αand UCP2)and Ca2+regulatory proteins(SERCA,Na+–Ca2+exchanger,and phospholamban),dampened autophagy and mitophagy(LC3B ratio,TOM20,Parkin,FUNDC1,and BNIP3),disrupted phosphorylation of Akt,GSK3β,and Foxo3a,and elevated PTEN phosphorylation,most of which were reversed or worsened by ALDH2 overexpression or knockout,***,the novel ALDH2 activator torezolid,as well as the classical ALDH2 activator Alda-1,protected against STZ-or high glucose-induced in vivo or in vitro cardiac anomalies,which was nullified by inhibition of Akt,GSK3β,Parkin,or mitochondrial *** data discerned a vital role for ALDH2 in diabetic cardiomyopathy possibly through regulation of Akt and GSK3βactivation,Parkin mitophagy,and mitochondrial function.

关键词： ALDH2 diabetes mitophagy cardiac contraction GSK3β mitochondrial function

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First principles study of the electronic structure and photovoltaic properties ofβ-CuGaO2 with MBJ+U approach

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Journal of Semiconductors 2020年第10期41卷 21-24页

作者： Guoping Luo yingmei Bian Ruifeng Wu Guoxia Lai Xiangfu Xu Weiwei Zhang Xingyuan Chen Department of Applied Physics School of ScienceGuangdong University of Petrochemical TechnologyMaoming 525000China School of Materials Science and Engineering Chang’an UniversityXi’an 710064China

Based on the density functional theory,the energy band and electronic structure ofβ-CuGaO2 are calculated by the modified Becke-Johnson plus an on-site Coulomb U(MBJ+U)approach in this *** calculated results show that the band gap value ofβ-CuGaO2 obtained by the MBJ+U approach is close to the experimental *** calculated results of electronic structure indicate that the main properties of the material are determined by the bond between Cu-3 d and O-2p energy levels near the valence band ofβ-CuGaO2,while a weak anti-bond combination is formed mainly by the O-2p energy level and Ga-4 s energy level near the bottom of the conduction band ofβ-***β-CuGaO2 thin film is predicted to hold excellent photovoltaic performance by analysis of the spectroscopic limited maximum efficiency(SLME)*** the same time,the calculated maximum photoelectric conversion efficiency of the ideal CuGaO2 solar cell is 32.4%.Relevant conclusions can expandβ-CuGaO2 photovoltaic applications.

关键词： first principles β-CuGaO2 electronic structure photovoltaic properties

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试析土耳其社会阶层变迁及其与政治发展的关系

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中国软科学 2023年第S1期 39-49页

作者：姜英梅中国社会科学院西亚非洲研究所北京100101

研究分析土耳其社会各阶层变迁与在政治发展中的作用.研究认为,土耳其共和国成立近100年来,随着所有制结构和生产关系的不断变化,土耳其士农工商等主要社会阶层分化日益明显,阶层结构发生了重大变化,对土耳其政治参与、政党政治以及政... 详细信息

研究分析土耳其社会各阶层变迁与在政治发展中的作用.研究认为,土耳其共和国成立近100年来,随着所有制结构和生产关系的不断变化,土耳其士农工商等主要社会阶层分化日益明显,阶层结构发生了重大变化,对土耳其政治参与、政党政治以及政治发展带来巨大影响.与此同时,土耳其伊斯兰教传统、发达的政党政治产生了独特的政教关系和军政关系;库尔德人问题时至今日仍未解决,成为土耳其政治发展的离心力之一.土耳其社会阶层变迁实质上体现了政治和社会发展进程中中心和边缘力量的较量,健康的社会分层状况和运行机制才有利于政治稳定和社会良性发展.

关键词：社会阶层政治发展政教关系军政关系

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Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells

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Cellular & Molecular Immunology 2010年第4期7卷 279-287页

作者： Xiaohui Zhu Lina Wu Li Zhang Peng Hao Shuai Zhang Jing Huang Jie Zheng Yinan Liu Wenjun Li yingmei Zhang Chunyan Zhou Youhui Zhang C Cameron Yin Xiaoyan Qiu Peking University Center for Human Disease Genomics BeijingChina Department of Biochemistry School of Basic Medical SciencePeking UniversityBeijingChina Department of Immunology Cancer InstituteChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Hematopathology University of Texas M.D.Anderson Cancer CenterHoustonTXUSA These authors contributed equally to this work

The restriction of immunoglobulin(Ig)expression to B lymphocytes is well ***,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal *** aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene *** results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell ***,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and *** octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene *** importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer *** results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells.

关键词： Ig gene transcription Oct-1 promoter transcription regulation VH4-59

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Construction of a targeting adenoviral vector carrying AFP promoter for expressing EGFP gene in AFP-producing hepatocarcinoma cell

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World Journal of Gastroenterology 2004年第2期10卷 186-189页

作者： Yu-JunShi Jian-PingGong Chang-AnLiu Xu-HongLi yingmei CanMi Yan-YingHuo DepartmentofGeneralSurgery theSecondCollegeofClinicalMedicineandtheSecondAffiliatedHospitalofChongqingUniversityofMedicalSciencesChongqing400010China DepartmentofPathoiogy BasicMedicalCollegeChongqingUniversityofMedicalSciencesChongqing400016China InstituteforRadiology MilitaryAcademyofMedicalSciencesBeijing100850China

AIM:To construct a recombinant adenoviral vector carrying AFP promoter and EGFP gene for specific expression of EGFP gene in AFP producing hepatocellular carcinoma (HCC) HepG2 ***: Based on the Adeno-X^TM expression system, the human immediate early cytomegalovirus promoter (PCMV IE)was removed from the plasmid, pshuttle,and replaced by a 0.3 kb (α-fetoprotein (AFP) promoter that was synthesized by polymerase chain reaction (PCR).The enhanced green fluorescent protein (EGFP) gene was inserted into the multiclone site (MCS),and then the recombinant adenovirus vector carrying the 0.3kb AFP promoter and EGFP gene was *** of a normal liver cell line (LO2),a hepatocarcinoma cell line (HepG2) and a cervical cancer cell line (HeLa) were transfected with the *** blot and fluorescence microscopy were used to detect the expression of the EGFP gene at mRNA or protein level in three different cell ***:The 0.3kb AFP promoter was synthesized through PCR from the human *** AFP promoter and EGFP gene were directly inserted into the plasmid pshuttle as confirmed by restriction digestion and DNA *** blot showed that EGFP gene was markedly transcribed in HepG2 cells,but only slightly in LO2 and HeLa *** addition,strong green fluorescence was observed in HepG2 cells under a fluorescence microscopy,but fluorescence was very weak in LO2 and HeLa ***:Under control of the 0.3kb human AFP promoter, the recombinant adenovirus vector carrying EGFP gene can be specially expressed in AFP-producing HepG2 cells,Therefore,this adenovirus system can be used as a novel,potent and specific tool for gene-targeting therapy for the AFP positive primary hepatocellular carcinoma,

关键词：肝细胞癌聚合酶链反应 AFP EGFP基因基因序列重组肾病毒受体

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SUPER EDGE-CONNECTIVITY OF DE BRUIJN AND KAUTZ UNDIRECTED GRAPHS

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Applied Mathematics(A Journal of Chinese Universities) 2004年第4期19卷 449-454页

作者： XuJunming Fanyingmei Dept.ofMath. Univ.ofScienceandTechologyofChinaHefei230026China. Dept.ofMath. GuangxiUniv.Nanning53004China.

The super edge-connectivity of a graph is an important parameter to measure fault-tolerance of interconnection *** note shows that the Kautz undirected graph is super edge-connected,and provides a short proof of Lü a... 详细信息

关键词： super edge-connctivity de Bruijn graphs Kautz graphs.

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游戏治疗的内涵及其对智力障碍儿童心理发展的意义

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中国特殊教育 2006年第10期 36-39页

作者：毛颖梅北京联合大学特殊教育学院北京100075

游戏治疗是帮助儿童解决心理问题的有效方法,了解游戏治疗产生发展及其内涵对特殊教育领域开展游戏治疗的实践和研究有重要意义。游戏治疗对智力障碍儿童的心理发展也必然发挥重要作用。

关键词：游戏游戏治疗儿童智力障碍心理发展

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烟道气驱油过程中N80钢的腐蚀规律实验研究

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油气地质与采收率 2018年第5期25卷 122-126页

作者：周迎梅中国石油大学(华东)胜利学院山东东营257601

随着注烟道气驱油技术应用的增多,烟道气对油井管柱的腐蚀问题日益突出。利用烟道气腐蚀测试装置模拟高温高压条件进行N80钢腐蚀实验,通过X射线衍射仪、扫描电子显微镜和能谱分析仪,分析腐蚀产物的成分和微观形貌,并研究温度、压力、流... 详细信息

随着注烟道气驱油技术应用的增多,烟道气对油井管柱的腐蚀问题日益突出。利用烟道气腐蚀测试装置模拟高温高压条件进行N80钢腐蚀实验,通过X射线衍射仪、扫描电子显微镜和能谱分析仪,分析腐蚀产物的成分和微观形貌,并研究温度、压力、流速、O_2和SO_2含量等对N80钢腐蚀速率的影响。结果表明:在模拟高温高压烟道气动态腐蚀环境下,随着时间的延长,腐蚀速率快速下降,72 h后趋于平缓;N80钢腐蚀产物成分主要为FeCO_3,Fe_3O_4和Fe_2O_3,腐蚀产物覆盖不完整,形态呈环形,排列无序。温度小于60℃时随着温度升高腐蚀速率变大,60℃时达到最大值,随后开始减小;压力增大,溶液中的碳酸浓度升高,腐蚀速率增大;流速和O_2体积分数增加,腐蚀速率增加;随着SO_2含量的增加,腐蚀速率呈先下降后增大的趋势。

关键词：烟道气驱油 N80钢腐蚀产物腐蚀规律

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Water transfer characteristics during methane hydrate formation and dissociation processes inside saturated sand

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Journal of Natural Gas Chemistry 2010年第1期19卷 71-76页

作者： Peng Zhang, Qingbai Wu, Yibin Pu, Guanli Jiang, Jing Zhan, yingmei Wang State Key Laboratory, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China [a] State Key Laboratory Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 Gansu China

Gas hydrates formation and dissociation processes inside porous media are always accompanied by water transfer behavior, which is similar to the water behavior of ice freezing and thawing processes. These processes have been studied by many researchers, but all the studies are so far on the water transfer characteristics outside porous media and the water transfer characteristics inside porous media have been little known. In this study, in order to study the water transfer characteristics inside porous media during methane hydrate formation and dissociation processes, a novel apparatus with three pF-meter sensors which can detect water content changes inside porous media was applied. It was experimentally observed that methane hydrate formation processes were accompanied by water transfer from bottom to top inside porous media, however, the water behavior during hydrate dissociation processes was abnormal, for which more studies are needed to find out the real reason in our future work.

关键词： methane hydrate formation and dissociation processes: water transfer inside porous media saturated

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Experimental Study of 103Pd Stent Affecting Dynamic Equilibrium Between Proliferation and Apoptosis of Vascular Smooth Muscle Cells

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South China Journal of Cardiology 2006年第2期7卷 69-72页

作者： Liu yingmei Fu Yuewu Wei Yulin Wu Wei Departme nt of Cardiology The Second Affiliated Hospital Sun Y at-sen University Guangzhou 510120 China Guangdong Provincial TCM Hospital Guangzhou 510120 China

Objectives By observing γ radioactive 103Pd stent affecting the proliferation and apoptosis of vascular smooth muscle cells （VSMCs） to explore the mechanism of radioactive stent preventing in-stent restenosis. Methods Fifty male New Zealand rabbits were randomized into stent group and 103Pd stent group. Control group was set up. The materials were harvested on 3, 7, 14, 28, 56 days after operation and the following investigations were carried out, including pathomorphology, immunohistochemistry, apoptosis （TUNEL） and in situs hybridization studies. Results ①The severity of the stenosis in 103Pd stent group was less than that of stent group. It was the most obvious on 56th day （P 〈 0.01）. ②The expression of PCNA of 103Pd stent group was lower than that of stent group on 3 to 28 days. It was the most obvious on 7th day, 16.35%±0.79% vs 24.36%±0.55% （P〈 0.01）. ②TUNEL method showed that the 103Pd stent group had much more apoptosis of VSMCs than that of stent group. The highest rate of apoptosis appeared on day 7, 14.72%±0.53% vs 12.42%±1.13% （P〈0.01）. ④ By calculating the ratio of PCNA/apoptosis （P：A）, a much lower ratio was seen in 103Pd-stent group than that of stent group at 3 to 28 days. There was significant statistic difference between two groups （P〈0.05）. ⑤For bcl-2/bax ratio, the result in 103Pd-stent group was lower than that of stent group at 3 to 28 days. It had significant statistic difference （P〈0.05）. Conclusions γ radioactive stent can inhibit the proliferation and accelerate apoptosis of injured media VSMCs. Also it can decrease the ratio of proliferation to apoptosis and relieve the severity of restenosis.

关键词： Radioisotope Stent Proliferation Apoptosis

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