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Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet-rich plasma(PRP)

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Animal Models and Experimental Medicine 2024年第2期7卷 106-113页

作者： Qian Zhang Yanan Wang Cheng Ran yingmei Zhou Zigang Zhao Tianhua Xu Hongwei Hou Yuan Lu Beijing Life Science Academy BeijingChina Department of Pathology Affiliated Hospital of Hebei UniversityBaodingChina Department of Otolaryngology Affiliated Hospital of Hebei UniversityBaodingChina Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenChina Department of Dermatology Hainan Hospital of PLA General HospitalSanyaChina Department of Chemical Engineering Tsinghua UniversityBeijingChina

Background:Androgenic alopecia(AGA)is the most common type of hair loss in men,and there are many studies on the treatment of hair loss by platelet-rich plasma(PRP).The human scalp contains a huge microbiome,but its role in the process of hair loss remains unclear,and the relationship between PRP and the microbiome needs further ***,the purpose of this study was to investigate the effect of PRP treatment on scalp microbiota ***:We performed PRP treatment on 14 patients with AGA,observed their clinical efficacy,and collected scalp swab samples before and after *** scalp microflora of AGA patients before and after treatment was characterized by amplifying the V3-V4 region of the 16 s RNA gene and sequencing for bacterial ***:The results showed that PRP was effective in the treatment of AGA patients,and the hair growth increased *** results of relative abundance analysis of microbiota showed that after treatment,g_Cutibacterium increased and g_Staphylococcus decreased,which played a stable role in scalp *** addition,g_Lawsonella decreased,indicating that the scalp oil production decreased after ***:The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.

关键词： androgenic alopecia microbiome platelet-rich plasma scalp

In situ autophagy regulation in synergy with phototherapy for breast cancer treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2317-2332页

作者： Huijuan Zhang Xiangyang Xuan Yaping Wang Zijun Qi Kexuan Cao yingmei Tian Chaoqun Wang Junbiao Chang Zhenzhong Zhang Lin Hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China School of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Autophagy is an important factor in reducing the efficacy of tumor phototherapy(including PTT and PDT).Accurate regulation of autophagy in tumor cells is a new strategy to improve the anti-tumor efficiency of PTT/*** project intended to construct a tumor-activated autophagy regulator to efficiently block PTT/PDT-induced autophagy and realize synergistic sensitization to tumor *** achieve this goal,we first synthesized TRANSFERRIN(Tf)biomimetic mineralized nano-tellurium(Tf-Te)as photosensitizer and then used disulfide bond reconstruction technology to induce Tf-Te *** autophagy inhibitor hydroxychloroquine(HCQ)and iron ions carried by Tf were simultaneously loaded to prepare a tumor-responsive drug reservoir Tf-Te/*** entering breast cancer cells through the“self-guidance system”,Tf-Te/HCQ can generate hyperpyrexia and ROS under NIR laser irradiation,to efficiently induce PTT/PDT ***,the disulfide bond broke down in response to GSH,and the nanoparticles disintegrated to release Fe2+and HCQ at fixed *** simultaneously induce lysosomal alkalinization and increased osmotic pressure,effectively inhibit autophagy,and synergistically enhance the therapeutic effect of *** vivo anti-tumor results have proved that the tumor inhibition rate of Tf-Te/HCQ can be as high as 88.6%on 4T1 tumor-bearing *** multifunctional drug delivery system might provide a new alternative for more precise and effective tumor phototherapy.

关键词： Autophagy Tumor phototherapy Synergistic sensitization HCQ TRANSFERRIN Disulfide bond reconstruction GSH Biomimetic mineralized nano-tellurium

Reduced neutralizing antibody production against Omicron XBB.1.5 in people living with HIV

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中华医学杂志(英文版) 2024年第21期137卷 2633页

作者： Zhang Jiaying Yin Jiming Wang Wenjing Gao Juanli Li Tongzeng Mou Danlei Liang Lianchun Meng Qinghua Feng yingmei Department of Infectious Diseases Beijing Youan Hospital Capital Medical University Beijing China Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University Beijing China Department of Medical Oncology Beijing Youan Hospital Capital Medical University Beijing China Department of Science and Development Beijing Youan Hospital Capital Medical University Beijing China

[4] The Institutional Review Board of Capital Medical University approved the study (No. 2021-087).[5] Consistent with this finding, by univariate linear regression analysis, the plasma levels of IL-1RA were positively associated with the fold change in the levels of NAb against the prototype strain between day 0 and day 14 following the third vaccination (r = 0.40, P = 0.03).[...]the sample size is relatively small, and the findings of the study await further confirmation.[...]the CoronaVac booster administration triggered the dramatic elevation of GMTs against the prototype virus in both PLWH and healthy participants.

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Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies

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Chinese Science Bulletin 2009年第21期54卷 3981-3989页

作者： WANG YanFang SHI Lin SONG QuanSheng ZHANG yingmei LOU YaXin ZHENG Yi MA DaLong WANG Ying KE XiaoYan Department of Hematology Peking University Third Hospital Beijing 100191 China Peking University Center for Human Disease Genomics Beijing 100191 China Department of Medical Immunology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China Peking University Medical and Health Analysis Center Peking University Health Science Center Beijing 100191 China

PDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and As2O3 in three hematologic tumor cell lines. In vivo studies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xenograft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemotherapeutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemosensitizer.

关键词： PDCD5 白蛋白血液病恶性重组肿瘤细胞凋亡柔红霉素凋亡相关基因

Potassium channel in peripheral blood lymphocytes of turbot (Scophthalmus maximus)

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Acta Oceanologica Sinica 2010年第1期29卷 116-119页

作者： CHAI yingmei HUANG Xiaohang CONG Bailin LIU Chenlin LIU Shenghao College of Marine Life Sciences Shandong University at Weihai Weihai 264209 China Marine Bioactive Substances Laboratory the First Institute of Oceanography StateOceanic Administration Qingdao 266061 China

In order to provide pertinent evidence of ion channel with immune response in the fish, whole cell patch-clamp technique was employed for potassium ion channel study in turbot （Scophthalmus maximus）. Lymphocytes were isolated by Percoll density gradient centrifugation from peripheral blood samples, and electrophysiological characters of the channel were analyzed. In the recorded cells, activated voltage of the channels was -42.5±3.7 mV and the average peak current was 313.12±28.2 pA. The channel was identified as voltage dependent, the current was outward and it could be inhibited by 10 mmol/dma TEA or 5 mmol/dm^3 4-AP, a specific potassium channel inhibitor, identifying the existence of potassium channel in peripheral lymphocytes of the turbot.

关键词： patch-clamp technique potassium channel turbot peripheral blood lymphocyte

Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways

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Cancer Biology & Medicine 2019年第1期16卷 55-65页

作者： Wenyan Tian Fei Teng Jinping Gao Chao Gao Guoyan Liu Yanfang Zhang Shizhu Yu Wei Zhang yingmei Wang Fengxia Xue Department of Gynecology and Obstetrics Tianjin Medical University General Hospital Tianjin Neurological Institute Tianjin Medical University General Hospital Department of Cancer Biology Comprehensive Cancer Center of Wake Forest Baptist Medical Center

Objective: Despite evidence that estrogens and insulin are involved in the development and progression of many cancers, their synergistic role in endometrial carcinoma(EC) has not been analyzed ***: Here, we investigated how estrogens act synergistically with insulin to promote EC progression. Cell growth in vitro and in vivo, effects of estradiol and insulin on apoptosis and cell cycle distribution, and expression and activation of estrogen receptor(ER), insulin receptor(InsR), and key proteins in the PI3K and MAPK pathways were examined after combined stimulation with estradiol and ***: Compared to EC cells treated with estradiol or insulin alone, those treated with both estradiol and insulin exhibited stronger stimulation. Estradiol significantly induced phosphorylation of InsR-β and IRS-1, whereas insulin significantly induced phosphorylation of ER-α. In addition, treatment with both insulin and estradiol together significantly increased the expression and phosphorylation of Akt, MAPK, and ERK. Notably, InsR-β inhibition had a limited effect on estradiol-dependent proliferation,cell cycle, and apoptosis, whereas ER-α inhibition had a limited insulin-dependent effect, in EC cell lines. Insulin and estradiol individually and synergistically promoted EC xenograft growth in ***: Estrogen and insulin play synergistic roles in EC carcinogenesis and progression by activating InsR-β and ER-α,promoting a crosstalk between them, and thereby resulting in the activation of downstream PI3K/Akt and MAPK/ERK signaling pathways.

关键词： Endometrial cancer(EC) estrogen insulin InsR-β ER-α PI3K/Akt pathway MAPK/ERK pathway

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多视图三角化中特征点噪声尺度的自适应估算

国防科技大学学报 2015年第6期37卷 116-120,134页

作者：魏迎梅康来国防科技大学信息系统与管理学院湖南长沙410073 国防科技大学信息系统工程重点实验室湖南长沙410073

鲁棒性多视图三角化方法通常借助重投影误差经验阈值来剔除图像对应中的错误匹配,该经验阈值的选取直接影响三维重构场景点的数量和精度。在分析图像特征点定位噪声及对极传递几何原理的基础上,建立对极传递过程不确定性的传递模型,提... 详细信息

鲁棒性多视图三角化方法通常借助重投影误差经验阈值来剔除图像对应中的错误匹配,该经验阈值的选取直接影响三维重构场景点的数量和精度。在分析图像特征点定位噪声及对极传递几何原理的基础上,建立对极传递过程不确定性的传递模型,提出一种基于核密度估计的最优噪声尺度估算方法,并将该噪声尺度作为多视图三角化中错误匹配筛选的依据。实验结果表明,该方法可以获得准确的噪声尺度估计,从而有效提升多视图三角化方法的三维重构质量。

关键词：多视图三角化特征点定位高斯噪声核密度估计

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基于单视点调节相机模型的水下图像三维重构

北京航空航天大学学报 2015年第11期41卷 2017-2022页

作者：魏迎梅康来国防科学技术大学信息系统与管理学院长沙410073 国防科学技术大学信息系统工程重点实验室长沙410073

水下图像成像过程中,每个场景点所对应的光线在传播过程中均经过多种折射率不同的介质,因此水下图像会产生折射变形,导致传统基于单视点相机模型的水下图像三维重构方法精度极大降低.在理论分析一个新的单视点调节模型对水下图像折射变... 详细信息

水下图像成像过程中,每个场景点所对应的光线在传播过程中均经过多种折射率不同的介质,因此水下图像会产生折射变形,导致传统基于单视点相机模型的水下图像三维重构方法精度极大降低.在理论分析一个新的单视点调节模型对水下图像折射变形的补偿能力的基础上,提出一种高效、自动的水下图像三维重构及其非线性优化方法.为了验证该方法的性能,利用合成数据和真实图像对其进行测试,并依据重构有效性、重构误差等定量指标考察分析了实验结果.实验结果表明,提出的多视图水下三维重构方法可有效补偿水下场景成像空间变形,进而显著提高传统基于单视点相机模型的水下三维重构质量.

关键词：水下图像三维重构折射变形单视点调节相机模型非线性优化空间变形

Dissecting the role of alternative splicing in the regulation of autophagy: a narrative review

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Journal of Bio-X Research 2020年第3期3卷 104-108页

作者： Zhang Mengjiao Zhang yingmei Department of Cardiology Fudan University Zhongshan HospitalShanghai Institute for Cardiovascular DiseasesShanghaiChina

Alternative splicing plays a pivotal role in the posttranscriptional regulation of gene expression,contributing to the generation of proteome *** is a conserved cellular machinery governing degradation and recycling of long-lived or damaged proteins and ***,there is limited knowledge of the roles of alternative splicing in autophagy,in particular mitochondrial selective autophagy,termed *** evidence suggests autophagy-related proteins(Atg),key molecules in autophagy process,are *** review highlights recent advances in the understanding of mechanisms by which alternative splicing affects the functions of ATG genes including BECN1,ATG5,ATG16L1,and Bim genes,and thus manipulates autophagy levels in various *** review found that the effects of splicing of ATG genes generally result in inhibiting ***,very few of the many autophagy associated proteins have been *** research into the transcriptional and post-transcriptional regulation of splicing factors will be necessary to understand their roles in pathological conditions associated with autophagy and mitophagy.

关键词： alternative splicing ATG gene autophagy mitochondria mitophagy