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在机测量技术在数控加工中的应用

中国高新科技 2024年第10期 80-82页

作者：张映故柳州职业技术学院广西柳州545000

随着制造业的快速发展,对加工精度的要求也有所提高,传统测量方式已无法满足现代制造业的需求。将在机测量技术应用于数控加工中,通过测量设备对加工中的工件进行实时测量,可实时监控加工过程,提高加工精度与产品质量。在设计好硬件与... 详细信息

随着制造业的快速发展,对加工精度的要求也有所提高,传统测量方式已无法满足现代制造业的需求。将在机测量技术应用于数控加工中,通过测量设备对加工中的工件进行实时测量,可实时监控加工过程,提高加工精度与产品质量。在设计好硬件与软件的基础上,在机测量系统的功能才能实现。对在机测量技术要做好误差分析与测量方案的规划,并须进行实验测试。

关键词：在机测量技术数控加工误差分析测量方案

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薄壁零件数控加工质量的提升策略

现代制造技术与装备 2024年第4期60卷 39-41页

作者：张映故柳州职业技术学院柳州545000

薄壁零件在机械制造中的应用越来越广泛,但其加工难度较大。提升薄壁零件的数控加工精度,可以改善零件质量,提高生产率,降低费用,进而推动先进设备制造业的发展。文章分析影响薄壁零件数控加工质量的因素,包括加工工艺、外部荷载、温度... 详细信息

薄壁零件在机械制造中的应用越来越广泛,但其加工难度较大。提升薄壁零件的数控加工精度,可以改善零件质量,提高生产率,降低费用,进而推动先进设备制造业的发展。文章分析影响薄壁零件数控加工质量的因素,包括加工工艺、外部荷载、温度系数及刀具等,并提出提高加工质量的措施,如合理选用刀具、选择合理的切削用量和技术方案、保证尺寸的精度以及适当延长切削时间等。

关键词：薄壁零件数控加工加工精度刀具切削用量

融媒体视域下高校共青团新媒体矩阵传播策略研究

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新闻研究导刊 2024年第13期15卷 84-87页

作者：陈荣宁杨颖姑广东海洋大学广东湛江524000

当前,互联网已成为高校思想政治工作的重中之重。高校共青团作为校园新媒体传播具有重要影响力的组织,是高校整体育人的重要组成部分,要积极应对传媒环境的巨大变革,在融媒体环境下坚持把立德树人作为根本任务,同时尊重规律,从不同层面... 详细信息

当前,互联网已成为高校思想政治工作的重中之重。高校共青团作为校园新媒体传播具有重要影响力的组织,是高校整体育人的重要组成部分,要积极应对传媒环境的巨大变革,在融媒体环境下坚持把立德树人作为根本任务,同时尊重规律,从不同层面满足师生的需求。鉴于此,高校共青团新媒体矩阵提高传播质量和效率变得尤为关键。在此背景下,文章首先阐述融媒体视域下高校共青团新媒体矩阵的传播功能,包括教育功能、传递信息和引导舆情功能、情感认同功能;分析高校共青团新媒体传播面临的困境,包括共青团新媒体矩阵内容同质化、高校共青团相关职能部门技术跟进乏力、复杂的网络环境带来互动交流方面的挑战;进一步剖析融媒体环境下新媒体矩阵带来的传播机遇:传播范围扩大、传播效率提高,提高内容质量、打造优秀品牌,实现精准管理、加强师生互动。在此基础上,文章提出高校共青团新媒体矩阵的传播优化策略:一是提升团队整体素质,紧跟技术更迭;二是传播内容新颖,打造专属品牌;三是跨平台整合与协同传播相结合,实现精准定位与个性化推送;四是完善反馈机制,加强互动交流;五是优化舆情反应机制,快而准地正向引导舆论。

关键词：互联网高校共青团融媒体新媒体矩阵传播

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共价有机框架型固态电解质研究进展

当代化工研究 2024年第3期 21-23页

作者：汪灿王英姑耿亚芸杨志伟李震华东交通大学材料科学与工程学院江西330013 南昌理工学院建筑工程学院江西330044

共价有机框架材料(COFs)因其结构单元多样性、拓扑结构、有序孔道结构等特点在气体吸附、催化、光电等领域得到广泛的应用。近些年来,基于COFs材料的有序孔道和易于功能化修饰的特性,COFs材料在固态电解质领域展现出巨大的潜力。本文主... 详细信息

共价有机框架材料(COFs)因其结构单元多样性、拓扑结构、有序孔道结构等特点在气体吸附、催化、光电等领域得到广泛的应用。近些年来,基于COFs材料的有序孔道和易于功能化修饰的特性,COFs材料在固态电解质领域展现出巨大的潜力。本文主要总结了近十年来COFs型固态电解质的研究进展,包括聚合物链段-COFs型、离子基团-COFs型固态电解质的应用和锂离子传导性能。对COFs型固态电解质设计思路及未来发展方向进行总结与展望,以期为固态电解质材料的发展提供新思路。

关键词：共价有机框架固态电解质锂离子传导

Expression and immunoactivity of chimeric particulate antigens of receptor binding site-core antigen of hepatitis B virus

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World Journal of Gastroenterology 2005年第4期11卷 492-497页

作者： Hai-JieYang MinChen TongCheng Shui-ZhenHe Shao-WeiLi Bao-QuanGuan Zi-HengZhu yinggu JunZhang Ning-ShaoXia TheKeyLaboratoryofMinistryofEducationforCellBiologyandTumorCellEngineering XiamenUniversityXiamen361005FujianProvinceChina

AIM: To improve the immunogenicity of receptor binding site of hepatitis B virus (HBV) on preS1 antigen using HBV core antigen as an immuno-carrier. METHODS: One to 6 tandem copies of HBV preS1 (21-47) fragment were inserted into HBcAg at the sites of aa 78 and 82, and expressed in ***. ELISA, Western blot and animal immunization were used to analyze the antigenicity and immmunogenicity of purified particulate antigens. The ability to capture HBV by antibodies elicited by chimeric particles was detected with immuno-capture PCR. RESULTS: Recombinant antigens CI, CII, CIII carrying 1-3 copies of HBV preSl (21-47) individually could form virus-like particles (VLPs), similar to HBcAg in morphology. But recombinant antigens carrying 4-6 copies of HBV preSl (21-47) were poorly expressed in ***. Chimeric antigens were lacking of immunoreactivity with anti-HBc monoclonal antibodies (McAbs), but still reserved good immunoreactivity with anti-HBe McAbs. CI, CII, CIII could strongly react with anti-preS1 McAb, suggesting that preS1 (21-47) fragment was well exposed on the surface of chimeric VLPs. Three chimeric VLP antigens (CI, CII and CIII) could stimulate mice to produce high-level antibody responses, and their immunogenicity was stronger than non-particulate antigen 21-47*6, containing 6 copies of preS1 (21-47). Mouse antibodies to CI, CII and CIII were able to capture HBV virions in immuno-capture PCR assay in vitro. CONCLUSION: Chimeric particulate antigens of receptor binding site-core antigen of HBV can elicit strong antibody responses to preS1. They have a potential to be developed into prophylactic or therapeutic vaccines against HBV infection.

关键词： Hepatitis B Virus Chimeric particulate antigens preS1 antigen HBcAg

超声引导下改良送鞘术结合ECG在血液病患者PICC置管中的应用

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河北医药 2024年第15期46卷 2336-2338,2342页

作者：黄丽明黄英姑文丽彬赵慧函覃敏莉周雪梅广西医科大学第一附属医院血液内科南宁市530021

目的探讨超声引导下改良送鞘术结合心电图(ECG)在血液病患者PICC置管中的应用。方法选取广西医科大学第一附属医院2021年1月至2023年1月收治的110例血液病患者为研究对象,按照随机数字表法分为对照组(右侧55例,采用塞丁格技术送血管... 详细信息

目的探讨超声引导下改良送鞘术结合心电图(ECG)在血液病患者PICC置管中的应用。方法选取广西医科大学第一附属医院2021年1月至2023年1月收治的110例血液病患者为研究对象,按照随机数字表法分为对照组(右侧55例,采用塞丁格技术送血管鞘进行)和观察组(右侧55例,采用超声引导下改良送鞘术结合ECG进行)。置管7 d后观察2组穿刺点情况、置管情况、换药次数、一次性成功率、穿刺点出血量以及并发症情况。结果观察组穿刺点渗血、异常、机械性静脉炎发生率低于对照组(P0.05)。治疗后,观察组感染、渗液等并发症发生率与对照组比较差异无统计学意义(P>0.05)。结论超声引导下改良送鞘术结合ECG的成功率更高,能够改善穿刺点情况,缩短送鞘完成时间,降低疼痛,值得临床推广。

关键词：超声引导改良送鞘术心电图血液病

Honokiol:A potent chemotherapy candidate for human colorectal carcinoma

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World Journal of Gastroenterology 2004年第23期10卷 3459-3463页

作者： FeiChen TaoWang Yi-FengWu yinggu Xiao-LiXu ShuZheng XunHu CancerInstitute SecondAffiliatedHospitalofZhejiangUniversityHangzhou310009ZhejiangProvinceChina LifeScienceCollege ZhejiangUniversityHangzhou310027ZhejiangProvinceChina

AIM: To investigate the anticancer activity of Honokiol on RKO,a human colorectal carcinoma cell line in vitro and in vivo,and to evaluate its possible use in ***: In vitro anticancer activity of honokiol was demonstrated by its induction of apoptosis in tumor *** analyzed cell proliferation with MTT assay, cell cycle with flow cytosmeter, DNA fragment with electrophoresis on agarose gels. To test the mechanism of honokiol-induced apoptosis, Westem blotting was used to investigate the factors involved in this process. The pharmacokinetics study of honokiol was tested by high phase liquid *** in vivo study, Balb/c nude mice were incubated with RKO cells. Honokiol was injected intraperitoneally every other day into tumor bearing Balb/c nude ***: Our results showed that honokiol induced apoptosis of RKO cells in a time- and dose-dependent manner. At 5-10 ug/mL for 48 h, honokiol induced apoptosis through activating Caspase cascades. Pharmacokinetics study demonstrated that, honokiol could be absorbed quickly by intraperitoneal injection, and maintained in plasma for more than 10 h. In nude mice bearing RKO-incubated tumor, honokiol displayed anticancer activity by inhibiting tumor growth and prolonging the lifespan of tumor bearing ***: With its few toxicity to normal cells and potent anticancer activity in vitroand in vivo, honokiol might be a potential chemotherapy candidate in treating human colorectal carcinoma.

关键词：和厚朴酚化学疗法候补物质结直肠癌肿瘤消化系统

Research on brake pad surface defects detection based on deep learning

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Research on brake pad surface defects detection based on dee...

Selection of a peptide mimicking neutralization epitope of hepatitis E virus with phage peptide display technology

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作者： Tao Zhang Yuting Liu Yaning Yang yinggu Jin School of Electromechanical Engineering Dalian Minzu University School of Information and Communication Engineering Dalian Minzu University

In order to solve the problem of feature extraction of brake pad surface defects in traditional machine learning, an automatic defect detection system based on deep learning is designed. Firstly, the image acquisition system is designed and the brake pad image dataset is constructed. Then, a kind of defect detection method based on convolutional neural network(CNN) is proposed. The dataset is input into the CNN model for training, and the appropriate defect classification model of brake pad is selected for defect detection and classification. In addition, in order to further improve the performance of the detection system, a defect detection method based on full convolution network(FCN) is also proposed. Finally, the two methods mentioned above are tested. The results show that both methods are suitable for the detection of brake pad defects and can realize the recognition and classification of brake pad defects. In comparison, the method based on CNN has higher detection efficiency than the one based on FCN, but the method based on FCN has better recognition accuracy and stronger performance than the one based on CCN.

关键词： Deep learning Defect detection Convolutional Neural Network Full Convolution Network

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World Journal of Gastroenterology 2004年第11期10卷 1583-1588页

作者： yinggu JunZhang Ying-BingWang Shao-WeiLi Hai-JieYang Wen-XinLuo Ning-ShaoXia TheKeyLaboratoryofMinistryofEducationforCellBiologyandTumorCellEngineering XiamenUniversityXiamen361005FujianProvinceChina

AIM: To select the peptide mimicking the neutralization epitope of hepatitis E virus which bound to non-type-specific and conformational monoclonal antibodies (mAbs) 8Cll and 8H3 fromed 7-peptide phage display library, and expressed the peptide recombinant with HBcAg in *** and to observe whether the recombinant HBcAg could still form virus like particle (VLP) and to test the activation of the recombinant polyprotein and chemo-synthesized peptide that was selected by mAb 8H3. METHODS: 8Cll and 8H3 were used to screen for binding peptides through a 7-peptide phage display library. After 4 rounds of panning, monoclonal phages were selected and sequenced. The obtained dominant peptide coding sequences was then synthesized and inserted into amino acid 78 to 83 of hepatitis B core antigen (HBcAg), and then expressed in *** Activity of the recombinant proteins was detected by Western blotting, VLPs of the recombinant polyproteins were tested by transmission electron microscopy and binding activity of the chemo-synthesized peptide was confirmed by BIAcore biosensor. RESULTS: Twenty-one positive monoclonal phages (10 for 8C11, and 11 for 8H3) were selected and the inserted fragments were sequenced. The DNA sequence coding for the obtained dominant peptides 8Cll (N'-His-Pro-Thr-Leu-Leu-Arg-Ile-C, named 8C11A) and 8H3 (N'-Ser-Ile-Leu-Pro- Tyr-Pro-Tyr-C, named 8H3A) were then synthesized and cloned to the HBcAg vector, then expressed in *** The recombinant proteins aggregated into homodimer or polymer on SDS-PAGE, and could bind to mAb 8Cll and 8H3 in Western blotting. At the same time, the recombinant polyprotein could form virus like particles (VLPs), which could be visualized on electron micrograph. The dominant peptide 8H3A selected by mAb 8H3 was further chemosynthesized, and its binding to mAb 8H3 could be detected by BIAcore biosensor. CONCLUSION: These results implicate that conformational neutralizing epitope can be partially modeled by a short peptide, which

关键词：缩氨酸模拟抗原戊型肝炎病毒缩氨酸抗菌素 HEV 基因序列