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Brain structure underlying the empathizing–systemizing difference in children with autism spectrum disorder

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World Journal of Pediatrics 2023年第8期19卷 782-792页

作者： Ning Pan Li-zi Lin Xin Wang Lei Shi Xiao-Yu Xu Yu-ying jin Si Tan Xiao-jing Song jin jing Xiu-Hong Li Department of Maternal and Child Health School of Public HealthSun Yat-Sen UniversityNo.74 Zhongshan Road 2Yuexiu DistrictGuangzhou510080China Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhou510080China Key Laboratory of Brain Cognition and Education ScienceMinistry of EducationGuangzhouChina Institute for Brain Research and Rehabilitation and Guangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou510631China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research College of PharmacyJinan UniversityGuangzhou510632China Chinese Institute for Brain Research Beijing102206China

Background Behavioral research has shown that children with autism spectrum disorder(ASD)have a higher empathizing–systemizing difference(D score)than normal ***,there is no research about the neuroanatomical mechanisms of the empathizing–systemizing difference in children with *** Participants comprised 41 children with ASD and 39 typically developing(TD)children aged 6‒12 ***–systemizing difference was estimated using the D score from the Chinese version of Children’s Empathy Quotient and Systemizing *** quantified brain morphometry,including global and regional brain volumes and surface-based cortical measures(cortical thickness,surface area,and gyrification)via structural magnetic resonance *** We found that the D score was significantly negatively associated with amygdala gray matter volume[β=−0.16;95%confidence interval(CI):−0.30,−0.02;P value=0.030]in children with *** was a significantly negative association between D score and gyrification in the left lateral occipital cortex(LOC)in children with ASD(B=−0.10;SE=0.03;cluster-wise P value=0.006)and a significantly positive association between D score and gyrification in the right fusiform in TD children(B=0.10;SE=0.03;cluster-wise P value=0.022).Moderation analyses demonstrated significant interactions between D score and diagnosed group in amygdala gray matter volume(β=0.19;95%CI 0.04,0.35;P value=0.013)and left LOC gyrification(β=0.11;95%CI 0.05,0.17;P value=0.001)but not in right fusiform gyrification(β=0.08;95%CI−0.02,0.17;P value=0.105).Conclusions Neuroanatomical variation in amygdala volume and gyrification of LOC could be potential biomarkers for the empathizing–systemizing difference in children with ASD but not in TD ***-scale neuroimaging studies are necessary to test the replicability of our findings.

关键词： Autism spectrum disorder Empathy Structural magnetic resonance imaging Systemizing

Design of an energetic particle radiation diagnostic spectroscopy system based on national core chips and Qt on Linux in EAST

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Nuclear Science and Techniques 2021年第7期32卷 11-21页

作者： ying-ying Zheng zi-Han Zhang Qiang Li Hong-Rui Cao Yong-Qiang Zhang jin-Long Zhao Qi-Ping Yuan Bing-Jia Xiao Ling-Ling Yan Jian-Qiu Zhu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Hefei University of Technology Hefei 230009China

Energetic particle radiation diagnoses mainly detect the particles(such as neutrons,gamma rays,hard X-rays,and escaping electrons)that are radiated in the discharge process of the experimental advanced superconducting tokamak device to characterize the operating state of the plasma in real *** upgrading of these diagnoses requires new instruments based on national(here,“national”means developed and produced by a Chinese company)core chips and open-source software with advanced digitization,a high sampling rate,and a high time *** new spectroscopy system designed in this study adopts the national field-programmable gate array(FPGA)and an analog-to-digital converter as the core chip,and it is developed using Qt on *** communication between the FPGA and embedded controller occurs via a high-speed peripheral component interconnect eXtension for instrument express protocol with a direct memory access *** this basis,the time resolution of the system is improved from 2 to 1 ms,the maximum channel address is increased to 4096,and the sampling rate is increased from 10 to 80 *** experiments of the spectroscopy system with 152Eu and 137Cs sources demonstrate that the best energy resolution is 0.27%and the measurement error is less than±0.5 keV.

关键词： Spectroscopy system National chip Qt Energetic particle radiation Experimental advanced superconducting tokamak

Efficiency of collective myosin Ⅱ motors studied with an elastic coupling power-stroke ratchet model

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Chinese Physics B 2018年第12期27卷 559-562页

作者： zi-Qing Wang jin-Fang Li ying-Ge Xie Guo-Dong Wang Yao-Gen Shu College of Science Northwest A & F University CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences (CAS)

We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin Ⅱ in muscle. Our theoretical results are in good agreement with the experimental data. Our study not only reveals that the maximum efficiency depends on elasticity and is independent of transition rates but also indicates that the parameters fitted to fast muscle are different from those fitted to a slow one. The latter may imply that the structure of the fast muscle is different from that of the slow one. The main reason that our model succeeds is that velocity in this model is an independent variable.

关键词： efficiency of collective non-processive motors ratchet model power-stroke elasticity

Synthesis of Poly(isosorbide carbonate) via Melt Polycondensation Catalyzed by Ca/SBA-15 Solid Base

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Chinese Journal of Polymer Science 2018年第9期36卷 1027-1035页

作者： Xiao-Long Shen zi-Qing Wang Qing-Yin Wang Shao-ying Liu Gong-ying Wang Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China University of Chinese Academy of Sciences Beijing 100049 China Changzhou Institute of Chemistry Changzhou 213164 China

Ca/SBA-15 solid bases with different Ca/Si atomic ratios were prepared by a one-pot route and employed as catalysts for the production of poly（isosorbide carbonate）（PIC） from diphenyl carbonate and isosorbide via a transesterification polymerization process. The relationship between physicochemical properties and catalytic performance for Ca/SBA-15 in this melt process was investigated by means of various characterization techniques. It was found that basic site amount and strength were responsible for this transesterification process; the weak and medium basic sites inclined to promote polycondensation reaction. It was worth noting that strong basic sites could favor the decomposition of the resultant P/C, resulting in the decrease of weight-average molecular weight （Mw） and yield, and the sample with Ca/Si atomic ratio of 0.4 exhibited the best catalytic performance, giving PIC with Mw of 4.88 × 10^4 g/mol and Tg of 169 ℃ at the optimal conditions. This excellent activity can be ascribed to the presence of rich basic sites and specific basic strength on the surface of 0.4Ca/SBA-15.

关键词： Ca/SBA-15 Poly(isosorbide carbonate) Diphenyl carbonate Transesterification Basic sites

Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet’s disease: A case report and review of literature

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World Journal of Clinical Cases 2019年第20期7卷 3377-3383页

作者： Juan Luo ying-Han Jiang zi Lei ying-Lei Miao Department of Gastroenterology the First Affiliated Hospital of Kunming Medical UniversityInstitute of Digestive DiseaseKunming 650000Yunnan ProvinceChina Department of Pathology the First People’s Hospital of Yunnan ProvinceKunming 650000Yunnan ProvinceChina Department of Pathology the First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Anaplastic large cell lymphoma(ALCL)is a CD30-positive T cell lymphoma,a rare type of non-Hodgkin *** current World Health Organization classification system divides ALCLs into anaplastic lymphoma kinase(ALK)-positive and ALK-negative *** rarely presents in the gastrointestinal *** SUMMARY A 54-year-old male was admitted to the department of gastroenterology for abdominal *** presented with lower abdominal pain,diarrhea and recurrent oral and penile *** was misdiagnosed with Behcet's disease and treated with *** after one month,he was hospitalized in another hospital for *** time,the lesion on the penis was biopsied for histological *** final pathological diagnosis was ALCL,*** patient was treated with cyclophosphamide,doxorubicin,vincristine,prednisolone ***,he died within one *** Gastrointestinal ALCL needs to be considered in the differential diagnosis to avoid delaying *** biopsy is the most important for early diagnosis and treatment.

关键词： Anaplastic large cell lymphoma Anaplastic lymphoma kinase Behcet's disease Colon ulcer Penis ulcer Case report

RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201

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mLife 2024年第1期3卷 74-86页

作者： Ya-Wen He zi-jing jin ying Cui Kai Song Bo Chen Lian Zhou State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSJTU-NLBP Joint R&D Centre for Biopesticides and BiofertilizersSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Zhiyuan Innovative Research Centre Student Innovation CentreZhiyuan CollegeShanghai Jiao Tong UniversityShanghaiChina

Pseudomonas aeruginosa is a ubiquitous and metabolically versatile microorganism naturally found in soil and *** is also an opportunistic pathogen in plants,insects,animals,and *** response to increasing cell density,*** uses two acylhomoserine lactone(AHL)quorum-sensing(QS)signals(i.e.,N-3-oxo-dodecanoyl homoserine lactone[3-oxo-C12-HSL]and Nbutanoyl-homoserine lactone[C4-HsL]),which regulate the expression of hundreds of ***,how the biosynthesis of these two QS signals is coordinated remains *** studied the regulation of these two QS signals in the rhizosphere strain ***1201 sequentially produced 3-oxo-C12-HSL and C4-HSL at the early and late growth stages,*** highest 3-oxo-C12-HSL-dependent elastase activity was observed at the early stage,while the highest C4-HSL-dependent rhamnolipid production was observed at the late *** atypical regulator RsaL played a pivotal role in coordinating 3-oxo-C12-HSL and C4-HSL biosynthesis and QS-associated *** repressed las/transcription by binding the-10 and-35 boxes of the lasl *** contrast,RsaL activated rhll transcription by binding the region encoding the 5'-untranslated region of the rhll ***,RsaL repressed its own expression by binding a nucleotide motif located in the-35 box of the rsaL ***,RsaL acts as a molecular switch that coordinates the sequential biosynthesis of AHL QS signals and differential virulence in ***,C4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal(PQS)QS signaling ***,we propose a new model of the QS regulatory network in PA1201,in which RsaL represents a superior player acting at the top of the hierarchy.

关键词： N-3-oxo-dodecanoyl homoserine lactone N-butanoyl-homoserine lactone Pseudomonas aeruginosa quorum sensing RsaL

The Hedgehog signalling pathway in bone formation

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International Journal of Oral Science 2015年第2期7卷 73-79页

作者： jing Yang Philipp Andre Ling Ye ying-zi Yang State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan University Genetic Disease Research National Human Genome Research InstituteNational Institutes of Health Harvard School of Dental Medicine

The Hedgehog（Hh） signalling pathway plays many important roles in development,homeostasis and *** critical function of Hh signalling in bone formation has been identified in the past two ***,we review the evolutionariiy conserved Hh signalling mechanisms with an emphasis on the functions of the Hh signalling pathway in bone development,homeostasis and *** the early stages of embryonic limb development,Sonic Hedgehog（Shh） acts as a major morphogen in patterning the limb *** Hedgehog（Ihh） has an essential function in endochondral ossification and induces osteoblast differentiation in the *** signalling is also involved intramembrane *** between Hh and Wnt signalling regulate cartilage development,endochondral bone formation and synovial joint *** also plays an important role in bone homeostasis,and reducing Hh signalling protects against age-related bone *** of Hh signalling regulation leads to multiple bone diseases,such as progressive osseous ***,understanding the signalling mechanisms and functions of Hh signalling in bone development,homeostasis and diseases will provide important insights into bone disease prevention,diagnoses and therapeutics.

关键词： ossification homeostasis cartilage embryonic conserved progressive regulate osteoclast osteoblast catenin

Evolution of nC_(16)H_(34)-water-mineral systems in thermal capsules and geological implications for deeply-buried hydrocarbon reservoirs

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Geoscience Frontiers 2022年第2期13卷 139-158页

作者： Guang-Hui Yuan zi-Hao jin ying-Chang Cao Ke-Yu Liu Jon Gluyas Yan-Zhong Wang Ke-Lai Xi Key Laboratory of Deep Oil and Gas School of GeosciencesChina University of PetroleumQingdao 266580China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyNo.62Fuzhou South RoadQingdao 266071China Department of Earth Sciences Durham UniversityDurham DH13LEUK

Organic-inorganic interactions between hydrocarbons and most minerals in deeply buried reservoirs remain *** this study,gold capsules and fused silica capillary capsules(FSCCs)with different com-binations of nC_(16)H_(34),water(distilled water,CaCl_(2) water)and minerals(quartz,feldspar,calcite,kaolinite,smectite,and illite)were heated at 340℃ for 3-10 d,to investigate the evolution and reaction pathways of the organic-inorganic interactions in different hot *** heating,minerals exhibited little alteration in the anhydrous *** alterations,how-ever,occurred obviously in the hydrous *** inorganic components affected nC_(16)H_(34) degra-dation ***,water promoted the free-radical thermal-cracking reaction and step oxidation reaction but suppressed the free-radical cross-linking *** impact of CaCl_(2) water on the nC_(16)H_(34) degradation was weaker than the distilled water as high Ca^(2+)concentration suppressed the formation of free *** presence of different waters also affects the impact of different minerals on nC_(16)H_(34) degradation,via its impact on mineral *** the anhydrous nC_(16)H_(34)-mineral systems,calcite and clays catalyzed generation of low-molecular-weight(LMW)alkanes,particularly the ***,feldspar,and calcite catalyzed generation of high-molecular-weight(HMW)alkanes and PAHs,whereas clays catalyzed the generation of LMW alkanes and mono-bicyclic aromatic hydrocarbons(M-BAHs).In the hydrous nC_(16)H_(34)-distilled water-mineral systems,all minerals but quartz promoted nC_(16)H_(34) degra-dation to generate more LMW alkanes,less HMW alkanes and *** the nC_(16)H_(34)-CaCl_(2) water-mineral systems,the promotion impact of minerals was weaker than that in the systems with distilled *** study demonstrated the generation of different hydrocarbons with different fluorescence colors in the different nC_(16)H_(34)-water-mineral systems after heating for t

关键词： nC_(16)H_(34)-water-mineral systems Organic-inorganic interactions Hydrocarbon degradation Mineral alteration Deeply buried hot reservoirs

Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone

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Chinese Physics B 2020年第9期29卷 589-596页

作者： ying Li Guang-Kun Zhang zi-Gen Song College of Information Technology Shanghai Ocean UniversityShanghai 201306China

The circadian clock is a self-sustained biological oscillator which can be entrained by environmental *** cyanobacteria circadian clock is the simplest one,which is composed of the proteins KaiA,KaiB and *** phosphorylation/dephosphorylation state of KaiC exhibits a circadian *** and KaiB activate KaiC phosphorylation and dephosphorylation *** competing with KaiA for the same binding site on KaiB affects the phosphorylation state of *** is a signaling molecule for entraining the cyanobacterial circadian clock which is oxidized at the onset of darkness and reduced at the onset of light,reflecting the environmental light-dark *** and CikA can sense external signals by detecting the oxidation state of ***,the entrainment mechanism is far from *** develop an enhanced mathematical model including oxidized quinone sensed by KaiA and CikA,with which we present a detailed study on the entrainment of the cyanobacteria circadian clock induced by quinone *** find that KaiA and CikA sensing oxidized quinone pulse are related to phase advance and delay,*** time of oxidized quinone pulse addition plays a key role in the phase *** combination of KaiA and CikA is beneficial to the generation of entrainment,and the increase of signal intensity reduces the entrainment *** study provides a theoretical reference for biological research and helps us understand the dynamical mechanisms of cyanobacteria circadian clock.

关键词： mathematical model entrainment cyanobacterial circadian clock phase response curve