检索结果-南通市图书馆

Targeting protein phosphatases for the treatment of inflammation-related diseases:From signaling to therapy

Signal Transduction and Targeted Therapy 2022年第7期7卷 2157-2180页

作者： Jie Pan Lisha zhou Chenyang zhang Qiang Xu Yang Sun State Key Laboratory of Pharmaceutical Biotechnology Chemistry and Biomedicine Innovation Center(ChemBIC)Department of Biotechnology and Pharmaceutical SciencesSchool of Life ScienceNanjing University163 Xianlin AvenueNanjing 210023China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University209 Tongshan RoadXuzhou 221004 JiangsuChina

Inflammation is the common pathological basis of autoimmune diseases,metabolic diseases,malignant tumors,and other major chronic *** plays an important role in tissue *** one hand,inflammation can sense changes in the tissue environment,induce imbalance of tissue homeostasis,and cause tissue *** the other hand,inflammation can also initiate tissue damage repair and maintain normal tissue function by resolving injury and restoring *** opposing functions emphasize the significance of accurate regulation of inflammatory homeostasis to ameliorate inflammation-related *** mechanisms involve protein phosphorylation modifications by kinases and phosphatases,which have a crucial role in inflammatory *** mechanisms by which many kinases resolve inflammation have been well reviewed,whereas a systematic summary of the functions of protein phosphatases in regulating inflammatory homeostasis is *** molecular knowledge of protein phosphatases,and especially the unique biochemical traits of each family member,will be of critical importance for developing drugs that target ***,we provide a comprehensive summary of the structure,the“double-edged sword”function,and the extensive signaling pathways of all protein phosphatases in inflammation-related diseases,as well as their potential inhibitors or activators that can be used in therapeutic interventions in preclinical or clinical *** provide an integrated perspective on the current understanding of all the protein phosphatases associated with inflammationrelated diseases,with the aim of facilitating the development of drugs that target protein phosphatases for the treatment of inflammation-related diseases.

关键词： inflammation homeostasis diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical simulation of inlet placement on sewage characteristics in the rounded square aquaculture tank with single inlet

引用

Journal of Oceanology and Limnology 2024年第4期42卷 1359-1382页

作者： Xiaozhong REN Yixuan HU Yinxin zhou Shupeng DU Wei SUN Hangfei LIU Chenxu ZHAO ying LIU Key Laboratory of Environment Controlled Aquaculture(Dalian Ocean University)Ministry of Education Dalian 116023China College of Marine Science and Environment Dalian Ocean UniversityDalian 116023China College of Ocean and Civil Engineering Dalian Ocean UniversityDalian 116023China Zhejiang University Hangzhou 310058China

To improve the self-cleaning ability of aquaculture tank and the efficiency of circulating water,physical and numerical experiments were conducted on the influence of inlet structure on sewage discharge in a rounded square aquaculture tank with a single *** on the physical model of the tank,analysis of how inlet structure adjustment affects sewage discharge efficiency and flow field characteristics was conducted to provide suitable flow field conditions for sinkable solid particle *** addition,an internal flow field simulation was conducted using the RNG k-εturbulence model in hydraulic drive *** a solid-fluid multiphase model was created to investigate how the inlet structure affects sewage collection in the rounded square aquaculture tank with single inlet and *** finding revealed that the impact of inlet structure is considerably affecting sewage *** conditions of C/B=0.07-0.11(the ratio of horizontal distance between the center of the inlet pipe and the tank wall(C)to length of the tank(B))andα=25°(αis the angle between the direction of the jet and the tangential direction of the arc angle)resulted in optimal sewage collection,which is similar to the flow field experiment in the rounded square aquaculture tank with single inlet and *** excellent correlation was revealed between sewage collection and fluid circulation stability in the aquaculture *** present study provided a reference for design and optimization of circulating aquaculture tanks in aquaculture industry.

关键词： rounded square aquaculture tank sewage collection characteristic inlet structure computational fluid dynamic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiscale simulations of growth-dominated Sb2Te phase-change material for non-volatile photonic applications

引用

npj Computational Materials 2023年第1期9卷 928-936页

作者： Xu-Dong Wang Wen zhou Hangming zhang Shehzad Ahmed Tiankuo Huang Riccardo Mazzarello En Ma Wei zhang Center for Alloy Innovation and Design(CAID) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Department of Physics Sapienza University of RomeRome 00185Italy

Chalcogenide phase-change materials(PCMs)are widely applied in electronic and photonic applications,such as non-volatile memory and neuro-inspired *** Sb2Te alloys are now gaining increasing attention for on-chip photonic applications,due to their growth-driven crystallization ***,it remains unknown whether Sb2Te also forms a metastable crystalline phase upon nanoseconds crystallization in devices,similar to the case of nucleation-driven Ge-Sb-Te ***,we carry out ab initio simulations to understand the changes in optical properties of amorphous Sb2Te upon crystallization and post *** the continuous transformation process,changes in the dielectric function are highly wavelength-dependent from the visible-light range towards the telecommunication *** finite-difference time-domain simulations based on the ab initio input reveal key differences in device output for color display and photonic memory applications upon tellurium *** work serves as an example of how multiscale simulations of materials can guide practical photonic phase-change applications.

关键词： transformation crystallization phase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rapid Recognition of Isomers of Monochlorobiphenyls at Trace Levels by Surface-Enhanced Raman Scattering Using Ag Nanorods as a Substrate

引用

Nano Research 2010年第6期3卷 423-428页

作者： Qin zhou Ye Yang Jie Ni Zhengcao Li Zhengjun zhang Advanced Materials Laboratory Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Isomers and homologues of organic pollutants are hard to distinguish-especially in trace amounts-due to the similarities in their physical and chemical properties. We report here that by identifying the Raman characteristics of isomers of monochlorobiphenyls, these compounds can be recognized, even at trace levels, by using the surface-enhance Raman scattering method with silver nanorods as a substrate. When dissolved in acetone, 2-, 3-, and 4-chlorobiphenyls were detected at a concentration of 10^(-8) mol/L, at which their characteristic Raman peaks were visible. This study may provide a fast, simple, and sensitive method for the detection and recognition of organic pollutants such as polychlorinated biphenyls.

关键词： Recognition isomer chlorobiphenyl trace levels SERS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Beyond hypoxia: Occurrence and characteristics of black blooms due to the decomposition of the submerged plant Potamogeton crispus in a shallow lake

引用

Journal of Environmental Sciences 2014年第2期26卷 281-288页

作者： Qiushi Shen Qilin zhou Jingge Shang Shiguang Shao Lei zhang Chengxin Fan State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences University of Chinese Academy of Sciences College of Hydrology and Water Resource Hohai University

Organic matter-induced black blooms （hypoxia and an offensive odor） are a serious ecosystem disasters that have occurred in some large eutrophic shallow lakes in China. In this study, we investigated two separate black blooms that were induced by Potamogeton crispus in Lake Taihu, China. The main physical and chemical characteristics, including color- and odor-related substances, of the black blooms were analyzed. The black blooms were characterized by low dissolved oxygen concentration （close to 0 mg/L）, low oxidation-reduction potential, and relatively low pH of overlying water. Notably higher Fe^2＋ and ∑S2- were found in the black-bloom waters than in waters not affected by black blooms. The black color of the water may be attributable to the high concentration of these elements, as black FeS was considered to be the main substance causing the black color of blooms in freshwater lakes. Volatile organic sulfur compounds, including dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide, were very abundant in the black-bloom waters. The massive anoxic degradation of dead Potamogeton crispus plants released dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide, which were the main odor-causing compounds in the black blooms. The black blooms also induced an increase in ammonium nitrogen and soluble reactive phosphorus levels in the overlying waters. This extreme phenomenon not only heavily influenced the original lake ecosystem but also greatly changed the cycling of Fe, S, and nutrients in the water column.

关键词： Black bloom hypoxia submerged plant volatile organic sulfur compounds lake

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Orchid diversity in China:Recent discoveries

引用

Plant Diversity 2021年第5期43卷 341-342页

作者： Zhihua zhou Ronghong Shi Yu zhang Xiaohua Jin Department of Wildlife Conservation National Forestry and Grassland AdministrationNo.18HepingliDongjieBeijing100714China Beijing Botanical Garden Beijing Laboratory of Urban and Rural Ecological EnvironmentXiangshanBeijing100039China Institute of Botany Chinese Academy of SciencesNanxincun20XiangshanBeijing100093China

Orchidaceae are among the largest plant families of angiosperms,with approximately 750 genera and 28,500 species around the world(Chase et al.,2015).The orchids have been considered a flagship of conservation biology(zhang et al.,2015;Fay,2018;Liu et al.,2020),and all species have been included in CITES(Convention on International Trade in Endangered Species of Wild Fauna and Flora)Appendix I or *** the last two decades,there has been major progress in the classification of *** updated classification with five subfamilies and 22 tribes(including three new tribes)has been proposed(Chase et al.,2015).Generic classifications in Collabieae,Epidendreae,Malaxideae,Neottieae,Orchideae,Podochileae and Vandeae have been discussed(Xiang et al.,2012a,2012b,2013,2014;Jin et al.,2014;Kocyan and Schuiteman,2014;Zhai et al.,2014;Tang et al.,2015;Raskoti et al.,2016;Simo-Droissart et al.,2018;Yan Peng et al.,2018).The generic delimitation of Orchidaceae in China has been discussed(Jin et al.,2015).

关键词： Flora Species chi

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimizing luminescence sensitivity and moisture stability of porous coordination frameworks by varying ligand side groups

引用

Science China Chemistry 2019年第3期62卷 341-346页

作者： Jia-Wen Ye Xu-Yu Li Hao-Long zhou Jie-Peng zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University

Hydrophobic ethyl, butyl or hexyl groups were introduced into the dicarboxylate ligand in the fluorescent porous coordination framework [Zn_2(fda)_2(bpy)](LMOF-202, H_2fda=9H-fluorene-2,7-dicarboxylic acid, bpy=4,4′-bipyridine) for improving water stability and tuning oxygen sensitivity. The long hexyl groups gave satisfactory water stability but its oxygen sensitivity is low(70.8% fluorescence quenched at 1 bar O_2(1 bar=105 Pa)). In contrast, the shorter side groups gave high oxygen sensitivity(93.9% fluorescence quenched at 1 bar O_2) and low water stability. The derivation of the Stern-Volmer curves of the O_2 luminescence quenching data from the linear form can be used for detecting trace impurities in the luminescent framework, being much more sensitive than conventional methods such as powder X-ray diffraction. Mixing the ethyl and hexyl groups in the solid-solution manner brought high oxygen sensitivity(96.4% fluorescence quenched at 1 bar O_2) and high water stability simultaneously in the same coordination framework.

关键词： metal-organic framework water stability oxygen fluorescence sensor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of PCA and HCA to the Structure-activity Relationship(SAR) Study of Fluoroquinolones

引用

Chinese Journal of Structural Chemistry 2006年第11期25卷 1351-1358页

作者： LI Xiao-Hong zhang Rui-zhou CHENG Xin-Lu YANG Xiang-Dong Institute of Atom and Molecular Physics Sichuan University Chengdu 610065 China Xinxiang Teacher＇s College Xinxiang 453000 China

Density functional theory （DFT） was used to calculate a set of molecular descri ptors （properties） for 14 fluoroquinolones with *** activity. Principal component analysis （PCA） and hierarchical cluster analysis （HCA） were employed in order to reduce dimensionality and investigate which subset of variables should be more effective for classifying fluoroquinolones according to their *** activity degree. The PCA shows that the variables of ELUMO, AEHL, μ, Q2, Q3, Q5, Q6, QB, LogP, MR and MP are responsible for the separation between compounds with higher and lower *** activities. The HCA results are similar to those obtained with PCA. By using the chemometric results, 4 synthetic compounds were analyzed through PCA and HCA, and 2 of them are proposed as active molecules against ***, which is consistent with the results of clinic experiments. The methodologies of PCA and HCA provide a reliable rule for classifying new fluoroquinolones with *** activity.

关键词： structure-activity relationship DFT PCA HCA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Control on Gradient Adhesive Loading of Porous Laminate:Effects on Multiple Performance of Composites with Bamboo Bundle and Sliver

引用

Journal of Renewable Materials 2021年第9期9卷 1555-1570页

作者： Jianchao Deng Haiying zhou Fuming Chen Shuangbao zhang Ge Wang Beijing Key Laboratory of Wood Science&Engineering College of Material Science&TechnologyBeijing Forestry UniversityBeijing100083China Key Laboratory of National Forestry and Grassland Administration/Beijing for Bamboo&Rattan Science and Technology International Center for Bamboo and RattanBeijing100102China

Elementary units“bamboo bundle”and“bamboo sliver”were processed and cross-linked as“bamboo-bundle veneer(BBV)”and“bamboo-sliver veneer(BSV)”for preparation of laminated *** concept of“high-content-adhesive surface treatment”was raised to improve boards’performance,rather than increasing adhesive absorption of every layer’s porous *** is,some BBVs experienced an extra“dipping&drying”to absorb more resin(named“HBBV”).The effect of the amount of knitting threads was also discussed for influencing BBV’s *** indicated that light transmittance of BBVs decreased as the amount of threads added from 3 to 8,while mechanical stiffness *** two skin layers of HBBVs symmetrically was helpful to enhance 24-hour underwater and 28-hour“boil-dry-boil”dimensional stability for boards with BSVs as core,while more than two pairs of HBBVs were needed to improve 28-hour“boil-dry-boil”dimensional stability of boards with BBVs as *** symmetrical surface layers of BBVs/HBBVs provided BSV-boards/BBV-boards with greater bending resistance,while such“surface treatment”would not raise shearing strength of BSV-boards upon 28-hour“boil-dry-boil”***,the data obtained from drop-hammer impact test indicated that more than two pair of surface BBVs or HBBVs were required for significant improvement in anti-impact property.

关键词： Bamboo bundle bamboo sliver laminated composites adhesive loading surface treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Advances in Superhydrophobic and Antibacterial Cellulose‑Based Fibers and Fabrics:Bio‑inspiration,Strategies,and Applications

引用

Advanced Fiber Materials 2023年第5期5卷 1555-1591页

作者： Hua zhou Qingshuo Li Zhong zhang Xungai Wang Haitao Niu College of Textiles and Clothing Qingdao UniversityQingdao 266071China Collaborative Innovation Center for Eco‑Textiles of Shandong Province and the Ministry of Education Collaborative Qingdao UniversityQingdao 266071China JC STEM Lab of Sustainable Fibers and Textiles School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Cellulose-based fabrics are ubiquitous in our daily *** are the preferred choice for bedding materials,active sportswear,and next-to-skin ***,the hydrophilic and polysaccharide characteristics of cellulose materials make them vulnerable to bacterial attack and pathogen *** design of antibacterial cellulose fabrics has been a long-term and on-going *** strategies based on the construction of surface micro-/nanostructure,chemical modification,and the application of antibacterial agents have been extensively investigated by many research groups *** review systematically discusses recent research on super-hydrophobic and antibacterial cellulose fabrics,focusing on morphology construction and surface ***,natural surfaces showing liquid-repellent and antibacterial properties are introduced and the mechanisms behind are ***,the strategies for fabricating super-hydrophobic cellulose fabrics are summarized,and the contribution of the liquid-repellent function to reducing the adhesion of live bacteria and removing dead bacteria is *** studies on cellulose fabrics functionalized with super-hydrophobic and antibacterial properties are discussed in detail,and their potential applications are also ***,the challenges in achieving super-hydrophobic antibacterial cellulose fabrics are discussed,and the future research direction in this area is proposed.

关键词： Cellulose fiber Super-hydrophobic Antibacterial Fabrication strategies Applications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：