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Coinfection of Streptococcus suis and Nocardia asiatica in the human central nervous system:A case report

World Journal of Clinical Cases 2022年第18期10卷 6283-6288页

作者： ying-ying chen Xin-Hong Xue Department of Neurology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

BACKGROUND Streptococcus suis(***)is an anthropozoonotic pathogen that shows clinical manifestations of meningitis,septicemia,and arthritis in infected *** is another type of anthropozoonotic bacteria,with clinical manifestations of skin,lung,and brain abscesses in infected *** intracranial infections caused by *** or Nocardia have been *** the best of our knowledge,no study has reported a patient with simultaneous intracranial infection by *** and *** SUMMARY A 66-year-old male presented at Liaocheng People’s Hospital(Liaocheng,Shandong Province,China)reporting dizziness with nausea and *** next-generation sequencing(m NGS)was performed on cerebrospinal fluid for examination,and the patient was diagnosed with suppurative meningitis caused by *** *** received anti-infection treatment with penicillin sodium and *** patient’s condition initially improved but then *** m NGS of cerebrospinal fluid revealed both *** and *** examination revealed a brain ***,a mixed infection of *** and Nocardia was detected in the patient’s central nervous *** patient was treated with antibiotics and *** was discharged after his condition *** This case shows that the disease can be recurrent in patients with intracranial infection of a rare *** possibility of mixed infection should also be considered,especially in patients treated with immunosuppressive agents.m NGS of cerebrospinal fluid is a supplement to conventional microbial pathogen identification *** with unknown pathogen diagnosis,early extensive use of antibiotics and infection with rare pathogens can be diagnosed by the combination of conventional methods and m NGS of cerebrospinal fluid.

关键词： Streptococcus suis Nocardia Meningitis Brain abscess Case report

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An Azoester-containing Photoresponsive Linear Liquid Crystal Polymer with Good Mesophase Stability

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Chinese Journal of Polymer Science 2020年第8期38卷 806-813,I0005页

作者： Shu-Qiang Han ying-ying chen Bo Xu Jia Wei Yan-Lei Yu Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200433China

Photoresponsive linear liquid crystal polymers(LLCPs)are attractive because of the excellent stimuli-responsibility and the good *** this study,a new photoresponsive LLCP containing azoester(PC11AE6)with good mesophase stability was synthesized by ringopening metathesis *** introducing photoresponsive azoester mesogenic unit,which has high rigidity and a large lengthdiameter ratio,the resultant polymer possesses a broad mesophase temperature interval(isotropic temperature=180℃).A study on mesophase by 2D-wide angle X-ray diffraction indicated that the mesogens were orientated spontaneously into smectic A phase after *** orientated films and fibres exhibited macroscopic,rapid and reversible deformations under light irradiation as a result of the photoisomerization of azoester as confirmed by UV-Vis absorption *** anticipate that this work provides a strategy for preparing LLCP with a broad mesophase temperature range,which is positive for potential applications.

关键词： Ring-opening metathesis polymerization Liquid crystal polymers Azoester Photodeformation

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Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment

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World Journal of Clinical Cases 2022年第22期10卷 7760-7771页

作者： ying-ying chen Yan Guo Xin-Hong Xue Feng Pang Department of Neurology Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Central Laboratory Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina

BACKGROUND The diagnostic value of metagenomic next-generation sequencing(mNGS)in central nervous system(CNS)infectious diseases after empirical treatment has not been *** To investigate the diagnostic value of mNGS of cerebrospinal fluid(CSF)in the empirically treated CNS infectious *** A total of 262 CSF samples from patients with suspected CNS infections were collected between August 2020 and December *** mNGS and conventional methods were used for *** conventional methods included microbial culture,smear,polymerase chain reaction,*** Among 262 suspected cases,183 cases(69.84%)were diagnosed as CNS infection,including 86 cases of virus infection(47.00%),70 cases of bacterial infection(38.25%)and 27 cases of fungal infection(14.76%).The sensitivity and specificity of mNGS were 65.6%(95%CI:58.2%-72.3%)and 89.6%(95%CI:79.1%-95.3%),*** PPV of mNGS was 94.5%(95%CI:88.6%-97.6%),and the NPV was 48.8%(95%CI:39.7%–57.9%).The pathogen detective sensitivity and accuracy of mNGS were higher than those of conventional methods(Sensitivity:65.6%vs 37.2%;P<0.001;Accuracy:72.0%vs 50%,P<0.001).The results showed that compared with conventional methods,mNGS technology was a more sensitive method for the diagnosis of CNS infection after empirical *** mNGS can be a better method applied in the diagnosis of CNS infection after empirical treatment.

关键词： Metagenomic next-generation sequencing Cerebrospinal fluid Central nervous system infection Pathogenic culture

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New insights into the biological roles of immune cells in neural stem cells in post-traumatic injury of the central nervous system

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Neural Regeneration Research 2023年第9期18卷 1908-1916页

作者： Ning He Xing-Jia Mao Yue-Min Ding Tong Zuo ying-ying chen Lin-Lin Wang Department of Basic Medicine Sciences and Department of Orthopaedics of Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina School of Medicine Hangzhou City UniversityHangzhouZhejiang ProvinceChina University of Chicago College University of ChicagoChicagoILUSA Department of Basic Medicine Sciences and Department of Obstetrics of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Traumatic injuries in the central nervous system,such as traumatic brain injury and spinal cord injury,are associated with tissue inflammation and the infiltration of immune cells,which simultaneously affect the self-renewal and differentiation of neural stem *** r,the tissue repair process instigated by endogenous neural stem cells is incapable of restoring central nervous system injuries without external ***,resident/peripheral immune cells have been demonstrated to exert significant effects on neural stem ***,the resto ration of traumatic injuries in the central nervous system by the immune intervention in neural stem cells represents a potential therapeutic *** this review,we discuss the roles and possible mechanisms of immune cells on the selfrenewal and differentiation of neural stem cells along with the prognosis of central nervous system injuries based on immune ***,we discuss remaining research challenges that need to be considered in the *** elucidation of these challenges will fa cilitate the successful application of neural stem cells in central nervous system injuries.

关键词： B cells central nervous system injury macrophages microglia neural stem cells spinal cord injury T cells traumatic brain injury

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Leaching and mass transfer characteristics of elements from ion-adsorption type rare earth ore

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Rare Metals 2015年第5期34卷 357-365页

作者： Yan-Fei Xiao Zong-Yu Feng Gu-Hua Hu Li Huang Xiao-Wei Huang ying-ying chen Ming-Lai Li National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous Metals Grirem Advanced Materials Co. Ltd. Chalco Guangxi Nonferrous Rare Earth Development Co. Ltd. School of Chemical Engineering China University of PetroleumBeijing

The differences in the leaching and mass transfer characteristics of ion-adsorption type rare earth ore between rare earth and non-rare earth impurities were investigated. It is determined that the leaching kinetics of rare earths （REs）, Mg and Ca could be described by the shrinking-core model. The leaching rate is controlled by inner diffusion and is in the order of Mg 〉 Ca 〉 RE. The apparent activation energy is 8.48, 6.79 and 6.32 kJ·mol^-1, respectively. In leaching system of Al, the leaching efficiency decreases with the increase in temperature because of hydrolysis reactions. The leaching efficiency of aluminum increases firstly and then decreases with the passage of time when the temperature is higher than 35 ℃. Besides, there is a good consistency in leaching characteristics and mass transfer, and the order of the time-to- peak is Mg 〈 Ca 〈 RE 〈 Al. Therefore, rare earth and non-rare earth may be partly separated by expanding the separation coefficient. The research could provide a theoretic basis for the separation of rare earth and non-rare earth impurities. Furthermore, compound leaching with magnesium salt and calcium salt is innovatively proposed to solve the problem of calcium and magnesium nutrient loss in the soil as well as eliminate ammonia-nitrogen emissions from the source.

关键词： impurities Rare earth Leaching Non-rare earth Mass transfer

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Type 1 diabetes mellitus and its oral tolerance therapy

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World Journal of Diabetes 2020年第10期11卷 400-415页

作者： Rui-Feng Mao ying-ying chen Ji Zhang Xin Chang Ye-Fu Wang Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection School of Life ScienceHuaiyin Normal UniversityHuai'an 223300Jiangsu ProvinceChina School of Life Sciences Huaiyin Normal UniversityHuai'an 223300Jiangsu ProvinceChina Department of Ultrasound Medicine Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina College of Life Sciences Wuhan UniversityWuhan 430072Hubei ProvinceChina

As a T cell-mediated autoimmune disease,type 1 diabetes mellitus(T1DM)is marked by insulin defect resulting from the destruction of pancreaticβ-*** understanding of various aspects of T1DM,such as its epidemiology,pathobiology,pathogenesis,clinical manifestations,and complications,has been greatly promoted by valuable research performed during the past ***,these findings have not been translated into an effective *** ideal treatment should safely repair the destroyed immune balance in a longlasting manner,preventing or stopping the destruction ofβ-*** a type of immune hypo-responsiveness to the orally administrated antigen,oral tolerance may be induced by enhancement of regulatory T cells(Tregs)or by anergy/deletion of T cells,depending on the dosage of orally administrated *** as an antigen-specific immunotherapy,oral tolerance therapy for T1DM has been mainly performed using animal models and some clinical trials have been completed or are still *** on the review of the proposed mechanism of the development of T1DM and oral tolerance,we give a current overview of oral tolerance therapy for T1DM conducted in both animal models and clinical trials.

关键词： Type 1 diabetes mellitus Immunotherapy Oral tolerance Regulatory T cells Antigen-specific immunotherapy

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Adolescent alcohol exposure changes RNA modifications in adult brain by mass spectrometry-based comprehensive profiling analysis

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Chinese Chemical Letters 2024年第1期35卷 461-464页

作者： ying-ying chen Zhu Gui Di Hu Meng-Yuan chen Jin-Gang He Si-Yu Yu Yu-Qi Feng Jie Wang Bi-Feng Yuan College of Chemistry and Molecular Sciences Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversitySchool of Public HealthWuhan UniversityWuhan 430071China Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center Zhongnan Hospital of Wuhan UniversityWuhan Research Center for Infectious Diseases and CancerChinese Academy of Medical SciencesWuhan 430071China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430071China Phase I Clinical Trial Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441000China University of Chinese Academy of Sciences Beijing 101408China

Alcohol consumption is one of the leading causes of death *** is a critical period of structural and functional maturation of the *** alcohol use can alter epigenetic ***,little is known on the long-term effects of alcohol consumption during adolescence on RNA epigenetic modifications in ***,we systematically explored the long-term effects of alcohol exposure during adolescence on small RNA modifications in adult rat brain tissues by comprehensive liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS)*** totally detected 26 modifications in small RNA of brain ***,we observed most of these modifications were decreased in brain *** results suggest that alcohol exposure during adolescence may impose a long-lasting impact on RNA modifications in brain *** is the first report that alcohol use during adolescence can alter RNA modifications in adult ***,this study suggests a long-term adverse effects of alcohol consumption on brain from RNA epigenetics angle by comprehensive mass spectrometry analysis.

关键词： Mass spectrometry RNA modification Adolescence Alcohol exposure Brain

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Corneal endothelial cell density and morphology and central corneal thickness in Guangxi Maonan and Han adolescent students of China

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 608-611页

作者： Hao Liang Hui-Yi Zuo Jin-Mao chen Jie Cai Yu-Zhua Qin Yu-Ping Huang ying-ying chen Dong-Yong Tang Shao-Jian Tan Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical University People's Hospital of Huanjiang Maonan Autonomous County

AIM: To investigate the corneal endothelial cell density and morphology and central corneal thickness in the Guangxi Maonan and Han adolescent students of ***: Noncontact specular microscope(Topcon SP3000 P, Tokyo, Japan) was performed in 133 adolescent students of Maonan nationality(M:F 54:79)and 105 adolescent students of Han nationality(M:F 50:55),5 to 20 y of age, who were randomly selected from 3schools in Huanjiang Maonan Autonomous County of Guangxi Zhuang Autonomous Region of *** studied included endothelial cell density,mean cell area, coefficient of variation in cell size,percentage hexagonality and central corneal thickness. RESULTS: Endothelial cell density, mean cell area,coefficient of variation in cell size, percentage hexagonality and central corneal thickness in the study population were(2969.50 ±253.93) cells/mm2,(339.23 ±29.44) μm2,(29.96 ±4.07) %,(64.58 ±9.41) % and(523.71 ±32.82) μm in Maonan and(2998.26 ±262.65) cells/mm2,(336.11±30.07) μm2,(29.89±5.03) %,(64.91±11.64) % and(524.39 ±33.15) μm in Han, respectively. No significant differences were observed in endothelial cell density,mean cell area, coefficient of variation in cell size,percentage hexagonality and central corneal thickness between Maonan and Han(P =0.615, 0.659, 0.528, 0.551,0.999). In Maonan and Han, we found age was negatively correlated with endothelial cell density and percentagehexagonality and positively correlated with mean cell area and coefficient of variation in cell size. Negative correlation was also found between central corneal thickness and age in Han, whereas no correlation was found in Maonan. CONCLUSION: There were no differences between Maonan and Han in corneal endothelial cell density and morphology and central corneal thickness. In these two nationalities, there were statistically significant decrease in endothelial cell density and percentage hexagonality with increasing age and statistically significant increase in cell area and coef

关键词： endothelial cell density morphology central corneal thickness Maonan

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Immune profiles of a COVID-19 adolescent with mild symptoms and anti anti-viral antibody deficiency

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Fundamental Research 2021年第2期1卷 117-123页

作者： Yang-dian Lai ying-ying chen Ji-ping Sun Yun Ling Jie Xu Youqiong Ye Lei Shen Hong-zhou Lu Bing Su ying Wang Shanghai Institute of Immunology Department of Immunology and Microbiologyand the Ministry of Education Key Laboratory of Cell Death and DifferentiationShanghai Jiao Tong University School of MedicineShanghai200025China Department of Infectious Disease Shanghai Public Health Clinical CenterShanghai201052China Department of Infectious Disease Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of MedicineShanghai200011China Key Laboratory of Emergency Prevention Diagnosis and treatment of Respiratory DiseaseShanghai200025China

*** acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has led to the outbreak of COVID-19 syndrome since December 2019,becoming prevalent worldwide afterward[1,2].Unlike severe acute respiratory syndrome(SARS)and Middle East respiratory syndrome(MERS),which cause severe symptoms and high mortality[1],the morbidity from COVID-19 is relatively low,especially in young people[3].In China,the mortality rate was 1023 of 44,672 confirmed cases by the end of Februaryl 1,2020[4].However,there were no cases of death among 416 patients aged 0-9 years,and only 1 in 549 patients aged 10-19 years[4].The exact reasons for this clinical phenomenon remain unclear.

关键词： mortality acute respiratory

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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