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Non-spherical symmetry development of underwater shock waves created by laser-induced breakdown

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Journal of Hydrodynamics 2023年第1期35卷 76-82页

作者： ying-xue wang Di-xi Han Jian-hua Liu Qiang Zhong Zhi-feng Yao Ruo-fu Xiao Fu-jun wang College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China China Ship Scientific Research Centre Wuxi214082China Taihu Laboratory of Deepsea Technological Science Wuxi214082China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System China Agricultural UniversityBeijing100083China

As a controllable alternative to cavitation collapse-induced shock waves,numerous cavitation studies on laser-induced breakdown have been carried out in *** the laser focusing region is not spherical,the shock waves caused by laser breakdown also exhibit non-spherical symmetry ***,some researchers have proposed the linear superposition theory based on the far field measurement data to explain this asymmetry,assuming that it is essentially the linear superposition of multiple wave fronts caused by multiple points of laser-induced breakdown that leads to the asymmetric propagation of shock *** this study,measurements of shock wave propagation processes with different breakdown energies are carried out based on a nanosecond resolution photogrammetry system,and the propagation velocities of shock waves in different directions are directly measured using a double exposure technique on a single *** the experiment,the velocity of the shock wave at the beginning of the breakdown was measured up to nearly 4000 m/*** early shock wave front was ellipsoidal,and the propagation velocity in the laser incident direction was generally slower than that in the perpendicular direction,decaying to the speed of sound in water within 1000 ns after the breakdown,and the wave front gradually approached to a *** variability of the shock wave front pressure ratio in the laser propagation direction and the vertical direction implies that the linear superposition theory applicable to the far field is not applicable to the near *** may be more complex mechanism for the near-field shock wave propagation process.

关键词： Underwater shock wave non-spherical symmetry velocity decay linear superposition laser breakdown

Dry eye disease in systemic lupus erythematosus: a cross sectional study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1255-1261页

作者： Sui-Fang Kang ying-xue wang Qi-Chen Zhang Zhi-Lun wang Guo-Ling Chen Department of Ophthalmology the Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Department of Rheumatology the Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina

AIM:To explore ocular surface manifestations of dry eye disease(DED)and its influencing factors in systemic lupus erythematosus(SLE)***:Ophthalmological examinations were conducted in SLE patients(n=43)and controls(n=41),including Ocular Surface Disease Index(OSDI),objective scatter index(OSI),tear meniscus height(TMH),lipid layer thickness(LLT),non-invasive Keratograph tear breakup time(NIKBUT),corneal fluorescein score(CFS),Schirmer I *** was diagnosed according to the Tear Film and Ocular Surface Society Dry Eye Workshop II *** patients were further divided into DED group and non-DED group,the disease activity,clinical manifestations and laboratory investigations were compared between the two *** disease activity was evaluated by Systemic Lupus Erythematosus Disease Activity Index 2000(SLEDAI-2K).Receiver operative characteristic(ROC)curve and multiplefactor binary logistic regression were ***:SLE patients showed higher OSDI[9.1(2.8-15.9)vs 6.3(2.2-7.5),P=0.035],higher OSI[1.67(1.09-2.60)vs 0.96(0.87-1.60),P=0.001],higher CFS[1(0-2)vs 0(0-1),P=0.001],lower LLT[65(42-100)vs 100(79.5-100),P=0.010],and lower NIKBUT[8.03(4.02-9.73)vs 9.67(5.26-12.71),P=0.030]than *** 32.6%of SLE patients had DED,which was higher than 12.2%of healthy *** group showed higher SLEDAI-2K score[9.7±6.1 vs 5.4±3.4,P=0.025],higher anti-cardiolipin antibody(ACL)[8.7(3.5-13.2)vs 3.6(2.0-6.9),P=0.035],and higher proportion of patients with cutaneous eruption[42.9%vs 6.9%,P=0.015]than non-DED *** to multiple-factor binary logistic regression analysis,the SLEDAI-2K score(OR=1.194,P=0.041)and cutaneous eruption(OR=7.094,P=0.045)could be consider as risk factors for DED in SLE *** ROC curve of the combined factors including age,disease duration,SLEDAI-2K score,ACL,and cutaneous eruption was analyzed,with a sensitivity of 0.786,a specificity of 0.793,and an area under curve of ***:Ocular surface affec

关键词： autoimmune disease systemic lupus erythematosus dry eye disease

Clinical analysis of colistin sulfate in the treatment of pneumonia caused by carbapenem-resistant Gram-negative bacteria

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World Journal of Clinical Cases 2024年第13期12卷 2173-2181页

作者： Hai-Chang Xu Yan Cui xue-ying wang Hai-Bo Wu Wei Li Dan wang Na Lin Lin Lin ying-Hui Zhang Department of Intensive Care Medicine The General Hospital of the Northern Theater Command of the People's Liberation Army of ChinaShenyang 110016Liaoning ProvinceChina

BACKGROUND Multidrug-resistant Gram-negative bacteria,exacerbated by excessive use of antimicrobials and immunosuppressants,are a major health *** To study the clinical efficacy and safety of colistin sulfate in the treatment of carbapenem-resistant Gram-negative bacilli-induced pneumonia,and to provide theoretical reference for clinical diagnosis and *** This retrospective analysis involved 54 patients with Gram-negative bacilli pneumonia admitted to intensive care unit of The General Hospital of the Northern Theater Command of the People's Liberation Army of China from August 2020 to June *** bacteriological culture,the patients'airway secretions were collected to confirm the presence of Gram-negative *** patients were divided into the experimental and control groups according to the medication *** research group consisted of 28 patients who received polymyxin sulfate combined with other drugs through intravenous,nebulization,or intravenous combined with nebulization,with a daily dosage of 1.5–3.0 million *** control group consisted of 26 patients who received standard dosages of other antibiotics(including sulbactam sodium for injection,cefoperazone sodium sulbactam for injection,tigecycline,meropenem,or vaborbactam).RESULTS Of the 28 patients included in the research group,26 patients showed improvement,treatment was ineffective for two patients,and one patient died,with the treatment efficacy rate of 92.82%.Of the 26 patients in the control group,18 patients improved,treatment was ineffective for eight patients,and two patients died,with the treatment efficacy rate of 54.9%;significant difference was observed between the two groups(P<0.05).The levels of white blood cell(WBC),procalcitonin(PCT),and C-reactive protein(CRP)in both groups were significantly lower after treatment than before treatment(P<0.05),and the levels of WBC,PCT,and CRP in the research group were significantly lower than those in the control group

关键词： Colistin sulfate Extensively drug-resistant Pneumonia Intravenous combined with nebulization Sepsis Nephrotoxicity Neurotoxicity

Regulating Effects of Novel CpG Chitosan-nanoparticles on Immune Responses of Mice to Porcine Paratyphoid Vaccines

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Biomedical and Environmental Sciences 2006年第4期19卷 315-322页

作者： MAN-LIANG FU SAN-CHENG ying MEI WU HUI LI KAI-YUAN WU YI YANG HUAN ZHANG CHI CHENG ZE-ZHOU wang XIU-ying wang xue-BING LV YI-ZHENG ZHANG RONG GAO Key Lab. for Bio-Resource and Eco-Environment of Education Ministry Life Science College Sichuan University Chengdu 610064 Sichuan China

Objective To study the regulating effects of a novel CpG oligodeoxynuleotide and the synergistic effect of chitosan-nanoparticles （CNP） with CpG on immune responses of mice, which were used to develop a novel immunoadjuvant to boost immune response to conventional vaccines. Methods A novel CpG ODN containing 11 CpG motifs was synthesized and its bioactivities to stimulate the proliferation of lymphocytes of pig in vitro were detected. Then it was entrapped with CNP prepared in our laboratory by the method of ionic cross linkage, and immunized Kunming mice were co-inoculated with paratyphoid vaccine. The peripheral blood was collected weekly from the tail vein of inoculated mice to detect the contents of IgG, IgA, IgM, and specific antibody against salmonella as well as the levels of interleukin-2 （IL2）, IL-4, and IL-6 by SABC-ELISA assay. The numbers of leucocytes, monocytes, granuloytes, and lymphocytes were calculated separately using the routine method. The experimental mice were orally challenged with virulent salmonella 35 days after inoculation. Results This CpG ODN could remarkably provoke the proliferation of lymphocytes of pig in vitro in contrast with the control （P〈0.05）. Compared with those of the control, immunoglobulins, including IgG, IgA, IgM, and specific antibodies to paratyphoid vaccine, increased significantly in sera from the CpG or CpG-CNP-vaccinated mice （P〈0.05）. IL-2, IL-4, and IL-6 increased remarkably in sera from immunized mice （P〈0.05）. The leucocytes, monocytes, granuloytes, and lymphocytes of the mice immunized with CpG or CpG-CNP were also increased in number （P〈0.05）. After the challenge, these immunity values were elevated in the mice vaccinated with CpG or CpG-CNP. The immunized mice all survived, while the control mice fell ill with evident lesions with diffuse hemorrhage in stomach, small intestine, and peritoneum. Conclusions CpG ODN entrapped with CNP is a promising effective immunoadjuvant for vaccination, which promotes humor

关键词： CpG oligonucleotide Mice Immune responses CNP Paratyphoid vaccine

Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

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World Journal of Psychiatry 2024年第4期14卷 523-532页

作者： Jing-Wen Xu Xiao-Bo Guan xue-ying wang Yang Feng Qi Zhang Jun-Juan Zhu Jian-Hua Chen Department of Medicine Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China The Fourth Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Psychotic DisordersShanghai 200030China The First Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China

BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is *** To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS *** This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric *** plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid *** patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were *** Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female *** and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 *** male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total *** Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.

关键词： Antipsychotics Risperidone 9-hydroxyrisperidone Plasma drug concentration monitoring Chronic schizophrenia

A Novel Chitosan CpG Nanoparticle Regulates Cellular and Humoral Immunity of Mice

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Biomedical and Environmental Sciences 2006年第2期19卷 87-95页

作者： KAI-YUAN WU MEI WU MAN-LIANG FU HUI LI YI YANG HUAN ZHANG CHI CHENG ZE-ZHOU wang XIU-ying wang xue-BING Lü DI-GUANG LIU HUA LI RONG GAO Key Labortory for Bio-Resource and Eco-Environment of Education Ministry Life Science College Sichuan University Chengdu 610064 Sichuan China

Objective To develop a safe and novel immunoadjuvant to enhance the immunity and resistance of animals against E. coli infection. Methods An 88-base immunostimulatory oligodeoxynuleotide containing eleven CpG motifs （CpG ODN） was synthesized and amplified by PCR. The chitosan nanoparticle （CNP） was prepared by ion linking method to entrap the CpG ODN that significantly promotes the proliferation of lymphocytes of pig in vitro. Then the CpG- CNP was inoculated into 21-day old Kunming mice, which were orally challenged with virulent K88/K99 E. Coil 35 days after inoculation. Blood was collected from the tail vein of mice on days 0, 7, 14, 21, 28, 35, 42, and 49 after inoculation to detect the changes and content of immunoglobulins, cytokines and immune cells by ELISA, such as IgG, IgA, IgM, IL-2, IL-4, and IL-6. Results The CpG provoked remarkable proliferation of lymphocytes of pig in vitro in comparison with that of control group （P〈0.05）. The inoculation with CpG-CNP significantly raised the content of IgG, IgM, and IgA in the sera of immunized mice （P〈0.05）. The levels of IL-2, 1L-4, and IL-6 in the mice significantly increased in comparison with those in controls （P〈0.05）, so was the number of white blood cells and lymphocytes in immunized mice. The humoral and cellular immunities were significantly enhanced in immunized mice, which resisted the infection of E coli and survived, while the control mice manifested evident symptoms and lesions of infection. Conclusions CpG-CNP can significantly promote cellular and humoral immunity and resistance of mice against E. coli infection, and can be utilized as an effective adjuvant to improve the immunoprotection and resistance of porcine against infectious disease.

关键词： CpG motifs Chitosan nanoparticles Immune responses Mouse E. coli

Magnetic resonance imaging-based pathogenic investigation of patellar instability

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Chinese Medical Journal 2019年第16期132卷 1998-1999页

作者： Yi-Fan Song xue-ying wang ying-Zhen Niu Zhen-Yue Dong Jian-Chao Qi Fei wang Department of Orthopedics The Third Hospital of Hebei Medical UniversityShijiazhuangHebei 050051China Cardiovascular Department The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China.

To the Editor: Compared with the computed tomography, the magnetic resonance imaging (MRI) is a much more sensitive cross-sectional imaging modality for the detection of patellar dislocation-associated capsular, ligam... 详细信息

关键词： Magnetic resonance imaging patellar instability

Observation on the Therapeutic Effect of Acupuncture for Treatment of Acute Waist Sprain

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Journal of Acupuncture and Tuina Science 2003年第2期1卷 56-57页

作者： ZOU Min ZHANG ying-xue wang Ping-xiang WU xue-fei Department of New Medicine Pan County Hospital of TCM Guizhou 553500 China Department of New Medicine Pan County Hospital of TCM Guizhou 553500 China Department of New Medicine Pan County Hospital of TCM Guizhou 553500 China

To compare the clinical effect of needling the Ashi point (4 cm lateral to the lower border of the spinous process of cervical vertebra) plus Yaotongdian on the hand and point injection on the Ashi point with Triamoninde. The curative effect of acupuncture was better than that of point injection. Key Words Sprain, Acute - Psoas Muscles - Acupuncture Therapy Author: ZOU Min (1961-), female, junor consultant doctorTranslator: WU xue-fei

关键词： Sprain, Acute Psoas Muscles Acupuncture Therapy

Initial Study on the Antibacterial Action of Mentha spicata Linn Extract in Vitro

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Agricultural Science & Technology 2010年第11期11卷 47-49页

作者： ZHANG Hong-ying wang xue-bing HAN Wei-li CUI Bao-an Key Laboratory of Animal Food Security in Henan Province College of Animal Husbandry and Veterinary in Henan Agricultural UniversityZhengzhou 450002

[Objective] The research aimed to study the antibacterial action of Mentha spicata Linn extract in vitro.[Method] The cylinder-plate method was used to measure the inhibitory zone size of Mentha spicata Linn *** test-tube double dilution method was used to measure the minimal inhibitory concentration(MIC)of Mentha spicata Linn extract on the four kinds of animal pathogenic bacteria,which could determine the antibacterial effect.[Result] The decoction,alcohol extract and volatile oil of Mentha spicata Linn had the different antibacterial effects on the four kinds of animal pathogenic *** the inhibition effect on the pig staphylococcus was comparatively *** of Mentha spicata Linn decoction I,alcohol extract III,volatile oil V and volatile oil VI were respectively 31.25,62.5,2.32 and 2.31 mg/ml.[Conclusion] The decoction,alcohol extract and volatile oil of Mentha spicata Linn had the certain antibacterial effect in vitro,and the extracts which were gained by the different extraction methods had the different inhibition effects on the experimental bacteria.

关键词： Mentha spicata Linn Extract Minimal inhibitory concentration