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World Journal of Gastroenterology 2018年第24期24卷 2640-2646页

作者： Xiang-Fei Meng ying-wei pan Zhan-Bo Wang wei-Dong Duan Department of Hepatobiliary Surgery Chinese PLA General Hospital Department of Pathology Chinese PLA General Hospital

Primary hepatic neuroendocrine tumor(PHNET) is an extremely rare liver tumor. Patients often have no clinical symptoms or have only non-specific symptoms, such as abdominal pain and abdominal mass. The clinical manifestations, disease development, treatment methods, and treatment outcomes of PHNET vary greatly among cases. Here we report a case of PHNET with a confirmed 26-year survival before surgery. The patient was a 56-year-old female. A large right hepatic mass was detected when the patient was 30 years old. The tumor could not be removed during exploratory laparotomy, and constriction of the right hepatic artery and biopsy were conducted. Pathological results indicated a diagnosis of benign tumor, but a confirmed diagnosis was not reached. Twenty-six years after the patient had been living with the tumor, she sought treatment again because of tumor progression. After systematic evaluation of the resectability, the tumor was resected. Based on the examination results of the gastrointestinal tract and lungs, intraoperative examination results, pathological findings, and long-term follow-up results, the diagnosis of PHNET was confirmed. This case represents the longest reported survival time for a PHNET patient before removal of the tumor.

关键词： Primary hepatic neuroendocrine tumor Surgery Pathology Radiology Surgical plan Follow up

Time-Delay Signature of Chaotic Vertical-Cavity Surface-Emitting Lasers with Polarization-Rotated Optical Feedback

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Chinese Physics Letters 2011年第1期28卷 98-101页

作者： XIANG Shui-ying pan wei YAN Lian-Shan LUO Bin ZOU Xi-Hua JIANG Ning WEN Kun-Hua Center for Information Photonics and Communications Southwest Jiaotong University Chengdu 610031

To quantitatively evaluate the time-delay （TD） signatures of chaotic signals generated by vertical-cavity surface- emitting lasers （VCSELs） with polarization-rotated optical feedback （PROF）, we propose four cases of resolution coefficients R based on correlation functions. The resolution coefficient characteristics for the x-polarization （XP） mode, g-polarization （YP） mode and the total output are considered. The dependences of R on the feedback strength and feedback delay are discussed and compared carefully. The two-dimensional maps of R show that the TD signatures for the single polarization mode （i.e., XP or YP mode） are much more difficult to retrieve than those for the total output in the entire parameter space. Thus, by using single polarization mode as a chaotic carrier, the TD signatures are extremely difficult to be identified, which contributes a lot in the security-enhanced VCSELs-based chaotic optical communication systems.

关键词： Optics quantum optics and lasers

Effects of positive acceleration(+Gz stress) on liver enzymes,energy metabolism,and liver histology in rats

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World Journal of Gastroenterology 2019年第3期25卷 346-355页

作者： Bin Shi Xian-Qiang Wang wei-Dong Duan Guo-Dong Tan Han-Jing Gao ying-wei pan Qing-Jun Guo Hong-Yi Zhang Department of Hepatobiliary Surgery Air Force Medical Center PLA Department of Pediatrics Chinese PLA General Hospital and PLA Medical School Department of Hepatobiliary Surgery Chinese PLA General Hospital and PLA Medical School Outpatient Department Air Command Headquarters Department of Ultrasound Chinese PLA General Hospital and PLA Medical School Department of Endocrinology Changhai Hospital Second Military Medical University

BACKGROUND Exposure to high sustained +Gz(head-to-foot inertial load) is known to have harmful effects on pilots' body in flight. Although clinical data have shown that liver dysfunction occurs in pilots, the precise cause has not been well *** To investigate rat liver function changes in response to repeated +Gz *** Ninety male Wistar rats were randomly divided into a blank control group(BC group, n = 30), a +6 Gz/5 min stress group(6 GS group, n = 30), and a +10 Gz/5 min stress group(10 GS group, n = 30). The 6 GS and 10 GS groups were exposed to +6 Gz and +10 Gz, respectively, in an animal centrifuge. The onset rate of +Gz was 0.5 G/s. The sustained time at peak +Gz was 5 min for each exposure(for 5 exposures, and 5-min intervals between exposures for a total exposure and non-exposure time of 50 min). We assessed liver injury bymeasuring the portal venous flow volume, serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST), liver tissue malondialdehyde(MDA), Na+-K+-ATPase, and changes in liver histology. These parameters were recorded at 0 h, 6 h, and 24 h after repeated +Gz *** After repeated +Gz exposures in the 6 GS and the 10 GS groups, the velocity and flow signal in the portal vein(PV) were significantly decreased as compared to the BC group at 0 h after exposure. Meanwhile, we found that the PV diameter did not change significantly. However, rats in the 6 GS group had a much higher portal venous flow volume than the 10 GS group at 0 h after exposure. The 6 GS group had significantly lower ALT, AST, and MDA values than the 10 GS group 0 h and 6 h post exposure. The Na^+-K^+-ATPase activity in the 6 GS group was significantly higher than that in the 10 GS group 0 h and 6 h post *** injury, determined pathologically, was significantly lower in the 6 GS group than in the 10 GS *** Repeated +Gz exposures transiently cause hepatocyte injury and affect liver metabolism and morphologica

关键词： Positive acceleration +Gz Liver function Animal models Liver metabolism Ischemia-reperfusion injury

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： WEN Jin LIU Zhanzhi WU Zhengwei pan Yu ZHANG ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

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Science China Chemistry 2025年第1期68卷 157-162页

作者： Rong-De He Yun-Lei Luo Qiu-Quan pan Qi-wei Yao Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

关键词： nickel alkenylation asymmetric cross-coupling alkenes

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基于语谱图行投影的特定人二字汉语词汇识别

吉林大学学报（工学版） 2017年第1期47卷 294-300页

作者：梁士利魏莹潘迪张玲许廷发王双维东北师范大学物理学院长春130024 长春理工大学理学院长春130022 北京理工大学光电成像技术与系统教育部重点实验室北京100081

将图像处理技术应用到语音识别领域,在图像特征提取过程中,首先对语谱图进行等宽度分带行投影和二进宽度分带行投影,分别作为窄带语谱图的第1个特征集合和第2个特征集合,同时将语谱图进行再次图像傅里叶变换之后进行等宽度行投影,作为第... 详细信息

将图像处理技术应用到语音识别领域,在图像特征提取过程中,首先对语谱图进行等宽度分带行投影和二进宽度分带行投影,分别作为窄带语谱图的第1个特征集合和第2个特征集合,同时将语谱图进行再次图像傅里叶变换之后进行等宽度行投影,作为第3个特征集合。将上述3个特征集构造为特定人二字汉语词汇识别的特征向量,以支持向量机为分类器进行特定人二字汉语词汇整体识别。采用1000个语音样本进行仿真实验,结果表明,该方法对特定人二字汉语词汇的识别率可达92.8%,为汉语词汇的识别提供了新的思路。

关键词：通信技术语音识别语谱图行投影支持向量机

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan wei Yaru Qiao Jiming Xie Xianchao pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-wei Dong Liping Huang Xiaoping Wang wei Jiang Liu-pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

Synthesis of 2- [ (4-Hydroxylcarbomylphenyl) -methylamino ] - N- ( 2- aminophenyl ) acetamide

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有机化学 2003年第Z1期23卷 432-432页

作者： YUE Guo-Ren DU Zhen-Ting MA Jun-ying QUAN wei-Guo pan Xin-Fu National Laboratory of Applied Organic Chemistry Department of Chemistry Lanzhou University Lanzhou 730000 Department of Chemistry Hexi University Zhangye 734000 National Laboratory of Applied Organic Chemistry Department of Chemistry Lanzhou University Lanzhou 730000 National Laboratory of Applied Organic Chemistry Department of Chemistry Lanzhou University Lanzhou 730000) National Laboratory of Applied Organic Chemistry Department of Chemistry Lanzhou University Lanzhou 730000) National Laboratory of Applied Organic Chemistry Department of Chemistry Lanzhou University Lanzhou 730000)

　　Early studies revealed that the hybrid polar/apolar compound N, N′-hexamethylene bisacetaamide (HMBA) was a very effective inducer of differentiation in a transformed cell lines. [1] The use of this polar/apolar compound to induce murine erythroleukemia cells (MELC) to undergo erythoid differentiation with suppression of oncogenicity has proved a useful model to study inducer-mediated differentiation of transformed cell. [2] To search more effective inducers, we utilized the computer to design a new target compound. Herein, we reported the synthesis of title compound.……

关键词： cell lines

Substrate bias effects in p-channel GaN-on-Si transistors

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Science China(Information Sciences) 2025年第1期68卷 404-405页

作者： Mengyao ZHAO Jie MA Lanlan YANG Chuanqi pan Denggui WANG Jianjun ZHOU Sheng LI Jiaxing wei Long ZHANG Siyang LIU weifeng SUN National ASIC System Engineering Research Center School of Integrated Circuits Southeast University National Center of Technology Innovation for Electronic Design Automation Southeast University National Key Laboratory of Solid-State Microwave Devices and Circuits

The drain current （ID） of the n-channel GaN field-effecttransistor （n-FET） is influenced by the substrate-to-source bias voltage (VBS)（substrate bias effect）[1].Actually,nonzero VBSis also likely to occur in p-FET in real application,because the source electrode of p-FET is usually connected to high *** study reports the dependency between IDand VBSin p-FET for the first time,and analyzes the underlying mechanisms from the perspective of vertical electric field （EF） distribution.

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